Efficacy and safety of pharmacological treatments in inclusion body myositis: a systematic review.

Objective: To identify the best evidence on the efficacy of treatment interventions for inclusion body myositis (IBM) and to describe their safety.

Methods: Systematic review of randomised controlled trials (RCTs) of pharmacological treatments of adults with IBM, conducted according to the Cochrane Handbook, updating a previous Cochrane review. The search strategy was run on Cochrane Neuromuscular Disease Group Specialized Register, CENTRAL, MEDLINE and EMBASE, ClinicalTrials.

Determination of physicochemical, functional,and morphological properties of Prosopis farcta (Çeti̇) seed galactomannan as a new hydrocolloid source: Comparison with locust bean gum.

The present study investigated the properties of galactomannan, a water-soluble polysaccharide extracted from the Prosopis farcta (Çeti) plant. These properties encompassed its functional characteristics, chemical composition, rheological behavior, and morphological structure. The results were systematically compared with those of the commercially utilized locust bean gum (LBG).

Comparative Evaluation of Health Status of Syrian Refugee and Tur CCH_70042 kish Children, Alongside the Factors Influencing Sociocultural Adaptation of Syrian Children in Türkiye.

Background: The objective of this study encompasses two distinct facets. First, it aims to provide a comprehensive analysis of the comparative assessment of psychosocial wellbeing and oral health status among Syrian and Turkish children in Türkiye. Secondly, it aims to elucidate the factors that play a role in shaping the sociocultural adaptation of Syrian children.

Disruption of Epistemic Trust in Borderline Personality Disorder: A Possible Adaptation to Avoid Making Costly Mistakes.

This paper applies error management theory (EMT) (Haselton and Buss 2000) to explore how disruptions in epistemic trust-trust in communicated information-can be understood as adaptive responses to early adversity in individuals with borderline personality disorder (BPD). I propose that epistemic mistrust (EM) and epistemic credulity (EC), characterized by inappropriate trust patterns, arise from the differential costs of trusting unreliable versus mistrusting reliable information. Although these biases may seem maladaptive, they function as evolutionary survival mechanisms in response to harsh environments.

Anthropometric Measurements and Weight Management Nutrition Knowledge: A Cross-Sectional Study in Turkey.

This study aimed to examine the relationships between academic programs, gender, anthropometric measurements, and the Weight Management Nutrition Knowledge Questionnaire (WMNKQ) score. Results indicated that 37.7% of male and 15.

The Clinical Efficacy of Extracorporeal Shock Wave Therapy Combined with Platelet Rich Plasma and Exercise for Lateral Epicondylitis: Prospective Randomized Sham-Controlled Ultrasonographic Study.

Objectives: To evaluate the combined effect of two different regenerative therapies, extracorporeal shock wave therapy (ESWT) and platelet-rich plasma (PRP), along with therapeutic exercise, in patients with lateral epicondylitis (LE).

Design: Prospective, Randomized, Sham-Controlled Trial.

Settings: Outpatient clinic.

Fructose-Derived Glycation and Immune Function: Effects on Antigen Binding in Human IgG and Lymphocytes.

Diabetes Mellitus (DM), one of the oldest known metabolic disorders, dates back to 3000 BC and continues to have a profound impact on health and the economy. Nutrition plays a critical role in managing diabetes and enhancing overall quality of life. It is also vital for immune system function, as well as in the prevention and treatment of aging-related diseases.

Effect of pet therapy on sleep and life quality of elderly individuals.

Aim: The study aimed to determine the sleep and life quality of elderly individuals living in a nursing home using pet therapy, a complementary and supportive therapy.

Methods: The study was conducted with elderly individuals in a nursing home in Tokat province in Turkey. The study sample consisted of 59 elderly individuals, with 30 in the intervention group and 29 in the control group, who met the inclusion criteria.

The Effect of Providing Video-Animated Information to Female Patients With Stress Urinary Incontinence Before the Urodynamic Study on the Patient's Anxiety, Pain, Satisfaction, and Willingness to Repeat the Procedure.

Objectives: To investigate the effect of providing video-animated information to female patients with stress urinary incontinence before urodynamics on the patient's anxiety, pain, satisfaction, and willingness to repeat the procedure.

Methods: Before the procedure, patients were divided into two groups with 1:1 randomization. While one group was given written and verbal information, the other group was additionally given animated video information accompanied by a doctor.

Pancreatic cancer cells infiltrate nerves through TGFbeta1-driven perineural epithelial-to-mesenchymal-like transdifferentiation.

Neural invasion is a prognostic hallmark of pancreatic ductal adenocarcinoma (PDAC), yet the underlying mechanisms behind the disruption of perineural barriers and access of cancer cells into intrapancreatic nerves remain poorly understood. This study aimed to investigate the role of epithelial-mesenchymal transformation (EMT) in perineural epithelial cells during neural invasion.Histopathological analysis of human and murine primary tumors using perineurium-specific GLUT1 antibody revealed a reduction in perineural integrity, which positively correlated with the extent of neural invasion in human PDAC cases.

L-cysteine modulates the Maillard reaction: Impacts on PhIP and pyrazine formation.

L-Cysteine (L-Cys) serves as both an inhibitor of the carcinogen 1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) and an enhancer of food flavor, supporting efforts to improve food safety and quality. Using a glucose/phenylalanine/creatinine model system, this study assessed the effects of varying L-Cys concentrations on PhIP inhibition and pyrazine flavor enhancement through UPLC-MS/MS and GC-MS analyses. The optimal PhIP reduction (82.

Is magnesium level significant in prognosis of geriatric patients admitted to the emergency department?

Aim: This study aims to evaluate the impact of serum magnesium (Mg) level on hospitalization and 28-day mortality in a nonspecific geriatric patient population.

Method: This single-center retrospective and observational clinical study involved patients aged over 70 years who presented to the emergency department for any complaint. Those whose Mg levels were not assessed and those who presented due to trauma, treated in another hospital before coming to our hospital, presented in cardiopulmonary arrest, refused treatment and/or left the hospital without permission, and were referred to another hospital were excluded from this study.

Evaluation of balance in children with hemophilia and the effect of balance on quality of life.

Background: Repeated joint bleeds are reported to decrease static balance in children with hemophilia (CwH).

Research Question: Is dynamic balance affected in CwH? Does dynamic balance affect the quality of life in these patients?

Methods: This cross-sectional study included thirty male children aged 7-18 years diagnosed with hemophilia, along with thirty healthy male children as controls. Dynamic balance was evaluated using the limits of stability (LOS) test and a fall risk test, both conducted via the Biodex Balance System.

Platelet mass index, systemic immune-inflammation index, and neutrophil-lymphocyte ratio as practical markers in childhood brucellosis.

Objective: Brucellosis is a multisystem infectious disease and may cause an increase in acute phase reactants. This study aimed to examine the platelet mass index (PMI), the neutrophil-lymphocyte ratio (NLR), and systemic immune-inflammation index (SII) in children with brucellosis and to determine their roles in focal involvement.

Methods: This retrospective observational study included 69 patients with brucellosis and a control group of 69 healthy children.

The effects of changes in thrombocyte indices, on-on-pump time on prognosis in open heart surgery.

Extracorporeal perfusion systems utilized in open-heart surgeries with cardiopulmonary bypass can affect multiple body systems. The primary adverse effects of Extracorporeal Perfusion Systems (EPS) on the hematological system include postoperative bleeding and coagulation issues. The aim of this study is to evaluate the effects of on-pump time and cross-clamp duration on total platelet count (PLT) and platelet indices in open-heart surgeries performed using cardiopulmonary bypass.

Correlations between the blink reflex and magnetic resonance imaging in patients with trigeminal neuralgia.

Background: Trigeminal neuralgia is a disease characterized by severe facial pain that significantly reduces patients quality of life. Trigeminal neuralgia is subcategorized as idiopathic, classic or secondary. Magnetic resonance imaging is the basis for classification, but neurophysiological tests are also used.

Cancer and Secretomes: HLA-G and Cancer Puzzle.

Among the mechanisms, cancer cells develop to elude immune system, immune regulation and the use of molecules that play important roles in immune escape stand out. One of these molecules, the human leukocyte antigen G (HLA-G), plays an important role in the maintenance of immune tolerance and contributes to the progression of cancer by exerting an immunosuppressive effect. By creating an immunosuppressive field in the microscopic environment of the tumor, the aberrant expression of HLA-G facilitates the evading of cancer cells from the immune system and contributes to the progression of the disease.

Peptide Nanofibers and Skin Regeneration.

Peptide nanofibers have been attractive targets for regenerative medicine applications due to their tailorability to be easily functionalized for specific bioactivity, biocompatibility, ease of synthesis, adjustability of their physicochemical characteristics, and lack of biological contamination. Research groups have investigated their use for the regeneration of various tissues, such as bone, cartilage, brain, peripheral nerves, cardiac tissue, vascular tissues, endocrine cells, muscles, etc., for the treatment of degenerative diseases or tissue loss due to accidents or aging.

The Role of Mesenchymal Stem Cell-Derived Exosomes in Skin Regeneration, Tissue Repair, and the Regulation of Hair Follicle Growth.

Skin regeneration, repair, and the promotion of hair growth are intricate and dynamic processes essential for preserving the overall health, functionality, and appearance of both skin and hair. These processes involve a coordinated interplay of cellular activities and molecular signaling pathways that ensure the maintenance and restoration of skin integrity and hair vitality. Recent advancements in regenerative medicine have underscored the significant role of mesenchymal stem cell (MSC)-derived exosomes as key mediators in these processes.

Evaluating CK20 and MCPyV Antibody Clones in Diagnosing Merkel Cell Carcinoma.

Merkel cell carcinoma (MCC) is diagnosed through histopathological and immunohistochemical examination of biopsies from skin or other organs. Its distinguishing features include perinuclear dot-like staining with Cytokeratin 20 (CK20) and detection of Merkel cell polyomavirus (MCPyV) using various methods. However, CK20 and MCPyV negative MCC cases have been reported at varying rates.

Comparison of the effect of different irrigation activation systems on the amount of apical extrusion of irrigation solution in teeth with severely curved canals.

Objective: This study aims to quantitatively compare the effects of standard needle irrigation (SNI), passive ultrasonic irrigation (PUI), EDDY, photon-initiated photoacoustic streaming (PIPS), and shock wave-enhanced emission photoacoustic streaming (SWEEPS) on the apical extrusion of irrigation solutions in teeth with severe canal curvature.

Materials And Methods: Seventy-five teeth with a single root and canal, and curvature angles ranging from 20° to 40°, were selected for this study. Root canal curvatures were measured from buccolingual and mesiodistal radiographs using ImageJ software (version 1.

Clinical presentation and outcome of patients with endogenous endophthalmitis.

Purpose: The study aims to evaluate the clinical characteristics, risk factors, microbiological findings, and visual outcomes, as well as patient and eye survival, of patients diagnosed with endogenous endophthalmitis (EE).

Methods: A retrospective study was conducted on 29 eyes from 21 patients diagnosed with EE.

Results: The mean age of presentation was 56.