372,197 results match your criteria: "Turkey; İzmir Biomedicine and Genome Center[Affiliation]"

Artificial Intelligence in Clinical Decision Making: Is It Problem-Free?

Dis Colon Rectum

January 2025

University of Health Sciences, Ankara City Hospital, Department of Surgery, Cankaya, Ankara/Turkey.

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Introduction: Telemedicine is a health service that provides diagnosis, treatment evaluation, preventive medicine by using information and communication technologies between distant locations and aims to improve the health of the individuals and society. Social restrictions were applied during the pandemic process caused by coronavirus disease-2019 due to the virus called severe acute respiratory syndrome coronavirus-2 which emerged in late 2019. Through remote communication and information technologies in the followup of asthma patients, there is a need for studies on the effectiveness of using telemedicine methods was seen.

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Introduction: Sedation is often required during flexible fiberoptic bronchoscopy (FFB) to ensure patient comfort and the success of the procedure. The choice of sedative agents may differ between anesthesiologists and pulmonologists. This pilot study aimed to investigate the current pre-procedure preparation, monitoring, premedication and sedation practices for FFB in Türkiye, focusing on the preferences and practices of pulmonologists.

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Measles, rubella, mumps and chickenpox infections are among the childhood diseases that can be prevented by vaccination. Healthcare workers are at greater risk of diseases transmitted through contact with patients' respiratory secretions, infected blood and body fluids. Students studying in the field of health are at the risk of encountering infectious diseases as much as healthcare personnel during their internship and practice experience in healthcare institutions during their education.

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[Genomic Characterization of SARS-CoV-2 Isolates Obtained from Antalya, Türkiye].

Mikrobiyol Bul

October 2024

The University of Groningen, University Medical Center Groningen, Department of Medical Microbiology and Infection Prevention, Division of Clinical Virology, Groningen, Netherlands.

As the number of coronavirus diseases-2019 (COVID-19) cases have decreased and measures have started to be implemented at an individual level rather than in the form of social restrictions, severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) still maintains its importance and has already taken its place in the spectrum of agents investigated in multiplex molecular test panels for respiratory tract infections in routine diagnostic use. In this study, we aimed to present mutation analysis and clade distribution of whole genome sequences from randomly selected samples that tested positive with SARS-CoV-2 specific real-time reverse transcription polymerase chain reaction (rRT-PCR) test at different periods of the pandemic in our laboratory with a commercial easy-to-use kit designed for next-generation sequencing systems. A total of 84 nasopharyngeal/oropharyngeal swab samples of COVID-19 suspected patients which were sent for routine diagnosis to the medical microbiology laboratory and detected as SARSCoV-2 RNA positive with rRT-PCR were randomly selected from different periods for sequence analysis.

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This study was aimed to identify the most frequently observed pathogens in uncomplicated urinary tract infections from outpatient urinary isolates obtained across seven different geographical regions in Türkiye and to determine whether the antibiotic resistance rates of these pathogens differ significantly between these regions. The study included patients aged 18 to 65 years who were diagnosed with uncomplicated urinary tract infections and had positive urine cultures from March 2021 to August 2022, across 37 different centers in Türkiye. The participating centers were selected based on their use of the disk diffusion method, in line with the European Committee on Antimicrobial Susceptibility Testing (EUCAST) guidelines, to ensure standardization of urine culture data.

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This pilot randomized controlled trial (RCT) investigated the preliminary effects of an 8-week videoconferencing Meaning-Centered Coping Program (MCCP) on women diagnosed with breast cancer. Forty-one participants with stage I, II, or III breast cancer were randomly assigned to either the MCCP or the waitlist control (WLC) group. Data were collected at baseline and after the intervention.

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Article Synopsis
  • Multiple sclerosis (MS) is an autoimmune disease affecting young adults, where the immune system attacks the protective myelin sheath of nerve cells, leading to neurological symptoms.
  • The study aims to analyze the glycosylation profiles of immunoglobulin G (IgG) in suspected MS patients through advanced techniques like MALDI-TOF mass spectrometry to identify differences in glycan patterns associated with varying oligoclonal band types.
  • Findings indicate that changes in IgG glycosylation may act as potential biomarkers for MS, aiding in understanding the disease's mechanisms and improving diagnostic methods.
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Pyoderma Gangrenosum: A Nightmare for Breast Surgery-Two Case Reports.

Eur J Breast Health

January 2025

Department of General Surgery, Gülhane Training and Research Hospital, University of Health Sciences Turkey, Ankara, Turkey.

Article Synopsis
  • Pyoderma gangrenosum (PG) is a rare skin condition that causes painful ulcers and is often incorrectly diagnosed as an infection.
  • The report discusses two cases of PG following breast surgeries, where both patients initially received ineffective treatment through debridements and antibiotics.
  • Effective treatment was achieved using oral doxycycline and topical tacrolimus, highlighting the importance of early diagnosis and proper management to prevent patient suffering and disfigurement.
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  • The study examines the shared genetic expression in breast and gynaecological cancers to identify common hub genes and associated drug components.
  • The researchers analyzed gene data from various cancer types using bioinformatics tools and found key genes that were similarly expressed across these cancers.
  • They identified potential drug-target relationships, suggesting certain drugs could be repurposed for treatment, which are not currently standard in cancer therapies.
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Objective: Triple negative breast carcinoma (TNBC) is characterized by the absence of estrogen receptor, progesterone receptor and human epidermal growth factor receptor-2 receptor expression. Carbonic anhydrase IX (CA IX) is a tumor-associated cell surface glycoprotein that is involved in adaptation to hypoxia-induced acidosis and plays a role in cancer progression. The aim of this study was to investigate CA IX expression in TNBC and its relationship with treatment effect.

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The effects of chronotype and diet on obese individuals have been reported in previous studies. This study aimed to examine the relationship between the Mediterranean-DASH intervention for neurodegenerative delay (MIND) diet, chronotype and lifestyle factors in different types of overweight and obese people. 1100 obese individuals participated in this cross-sectional study.

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Background: Nusinersen and risdiplam are U.S. Food and Drug Administration (FDA)-approved treatments for spinal muscular atrophy (SMA).

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Objective: The aim of this study was to evaluate the relationship between subclinical lymphedema identified prior to surgical intervention and clinical lymphedema observed in the late period, the incidence of lymphedema in our cohort, and the associated risk factors.

Materials And Methods: This prospective study was conducted with early-stage breast cancer patients who had been enrolled in a previous study. For diagnosing lymphedema, physical examination, L-Dex® score, and circumferential measurement was used.

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Objective: To investigate integrating an artificial intelligence (AI) system into diagnostic breast ultrasound (US) for improved performance.

Materials And Methods: Seventy suspicious breast mass lesions (53 malignant and 17 benign) from seventy women who underwent diagnostic breast US complemented with shear wave elastography, US-guided core needle biopsy and verified histopathology were enrolled. Two radiologists, one with 15 years of experience and the other with one year of experience, evaluated the images for breast imaging-reporting and data system (BI-RADS) scoring.

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Research on natural antioxidants derived from plants has surged due to their potential health benefits. In the current study, the chemical composition, enzyme inhibitory activity, and antimicrobial effects of the Elaeagnus angustifolia L. plant, including leaves, flowers, and flower stalks extracts, were analyzed.

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A significant number of scientific data concerning breast cancer is generated in Turkey. The present research reviewed postgraduate theses examining the psychological evaluation of breast cancer patients conducted in Turkey. The objective of the review study was to ascertain the focal topics of the theses, identify commonly examined psychological variables, determine research gaps, compare the frequency of experimental and intervention studies with other kinds of research, and provide recommendations for literature.

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Fractal analysis of jawbone structure in patients with rheumatoid arthritis.

Imaging Sci Dent

December 2024

Department of Biostatistics and Medical Informatics, Faculty of Medicine, Suleyman Demirel University, Isparta, Turkey.

Purpose: Periarticular and generalized osteoporosis are well-known comorbidities of rheumatoid arthritis (RA), associated with either the disease itself or glucocorticoid therapy. This study was performed to quantitatively evaluate changes in the jawbones of patients with RA using fractal analysis (FA).

Materials And Methods: The study comprised 186 participants, including 144 women and 42 men.

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Insight into the history and trends of liver transplantation for echinococcosis: A bibliometric analysis.

World J Hepatol

December 2024

Department of Liver & Laparoscopic Surgery, Center of Digestive and Vascular Surgery, First Affiliated Hospital of Xinjiang Medical University, Urumqi 830054, Xinjiang Uygur Autonomous Region, China.

Background: Liver transplantation (LT) has demonstrated favorable efficacy in managing end-stage alveolar echinococcosis. Nevertheless, the current research focal points and advancement trends remain ambiguous.

Aim: To map the research landscape to underscore critical areas of focus, influential studies, and future directions of LT for echinococcosis treatment.

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Article Synopsis
  • The study compared the readability of patient education materials from the Turkish Ophthalmological Association (TOA) on retinopathy of prematurity (ROP) with those generated by large language models (LLMs) like GPT-4.0, GPT-4o mini, and Gemini.
  • The TOA materials were found to exceed the recommended 6th-grade reading level, while GPT-4.0 and Gemini provided significantly clearer responses.
  • GPT-4.0 stood out for its superior accuracy and comprehensiveness in generating understandable patient education materials, but caution is needed regarding regional medical differences when applying LLMs in healthcare.
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Objectives: This study aimed to examine the publication rates of abstracts related to oculoplastic surgery and orbital diseases presented at the Turkish Ophthalmological Association National Congresses (TOA-NCs) in 2013-2022.

Materials And Methods: The study included abstracts in the field of oculoplastic surgery and orbital diseases accepted for presentation at TOA-NCs between 2013 and 2022. These abstracts were reviewed in terms of presentation type (oral, poster), number of authors, study setting (university, training and research, private, public, or abroad hospital), study type (case, clinical, or basic science), study topic (eyelid, lacrimal system, orbit, or thyroid eye disease), journal publication status, time to publication (months), publishing journal (national, international), and journal impact factor.

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Article Synopsis
  • This study aimed to compare the effects of two orthodontic appliances, the Twin block and Herbst, on the structure of the mandible using fractal dimension analysis (FDA) of panoramic radiographs in patients with skeletal Class II malocclusion.
  • Fifty subjects treated with each appliance and a control group were analyzed, focusing on specific regions in the mandible, with significant changes in the condylar region and corpus observed across both treatment groups.
  • Results indicated that both appliances caused remodeling of the mandibular trabecular structure, with the Twin block showing greater variances in the condyle compared to the Herbst appliance, thus rejecting the null hypothesis of no effect.
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Objectives: To assess the post-earthquake trauma and hopelessness levels of nursing students due to the earthquakes that occurred on February 6, 2023.

Methods: This study was conducted between April and May 2023 in the Nursing Department in a province located in Southeastern Türkiye using the face-to-face interview technique. The study was completed with 276 students in line with the power analysis.

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