372,968 results match your criteria: "Turkey; **Koc University Research Center for Translational Medicine KUTTAM[Affiliation]"

This is the first study to evaluate the adequacy and reliability of the ChatGPT and Gemini chatbots on viral hepatitis. A total of 176 questions were composed from three different categories. The first group includes "questions and answers (Q&As) for the public" determined by the Centers for Disease Control and Prevention (CDC).

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Clinical prediction models and future directions.

Am J Emerg Med

January 2025

Department of Internal Medicine, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands; Department of Clinical Pharmacy & Pharmacology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.

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Background: Healthcare-associated infections pose a significant global challenge, highlighting the need for enhanced knowledge and practices among healthcare professionals. This study investigates the impact of clinical observations on nursing students' compliance with standard precautions.

Methods: Employing a cross-sectional descriptive design, the study surveyed 405 nursing students using a 'Personal Information Form', the 'Nurses' Observations on Infection Control and Prevention Questionnaire', the 'Standard Precautions Scale', and the 'Factors Affecting Compliance with Standard Precautions Scale'.

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Review of advanced sensor system applications in grinding operations.

J Adv Res

January 2025

Department of Mechanics and Strength of Materials, Politehnica University Timisoara, 1 Mihai Viteazu Avenue, 300 222 Timisoara, Romania. Electronic address:

Background: Today, in a wide variety of industries, grinding operations are an extremely important finishing process for obtaining precise dimensions and meeting strict requirements for roughness and shape accuracy. However, the constant wear of abrasive tools during grinding negatively affects the dimensional and surface conditions of the workpiece. Therefore, effective monitoring of the wear process during grinding operations helps to predict tool life, plan maintenance and ensure consistent product quality.

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Three symptomatic cases of myoma uteri in adolescence, one of which is STUMP tumor.

J Pediatr Adolesc Gynecol

January 2025

Department of Obstetrics and Gynecology, University of Health Sciences, Bagcilar Training and Research Hospital, Istanbul, Turkey. Electronic address:

Article Synopsis
  • Uterine leiomyomas, although rare in adolescents, can present with symptoms like abnormal bleeding and pelvic pain, with smooth muscle tumors of unknown malignant potential (STUMP) being even rarer.
  • In a hospital case study, three 19-year-old patients presented with significant symptoms, leading to the identification of varying sizes of uterine myomas; one was diagnosed as a STUMP tumor while the others were benign fibroids.
  • Despite their rarity, it is important for healthcare providers to consider uterine myomas and STUMP tumors as potential diagnoses in young patients experiencing pelvic symptoms.
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Optic Nerve Head Changes in Acute Central Serous Chorioretinopathy: Implications for Glaucoma Risk.

Photodiagnosis Photodyn Ther

January 2025

Istanbul Medeniyet University, Faculty of Medicine, Department of Ophthalmology, Istanbul, Turkey. Electronic address:

Objective: Imaging techniques have demonstrated changes in the choroid and retina in acute central serous chorioretinopathy (CSCR), but the effects on the optic nerve head (ONH) remain unclear. This study investigates ONH structural changes in acute CSCR using enhanced deep imaging optic coherence tomography (EDI-OCT).

Methods: A prospective cohort study included 51 acute CSCR patients and 51 healthy controls aged 18-65 years.

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Microwave-assisted extraction conditions were optimized using response surface methodology to evaluate the effects of extraction parameters on the yield and carbohydrate content of Luffa aegyptiaca mucilage. Extraction at 540 W for 2 min with a 1:20 (g/mL) was determined as the optimal parameter, resulting in a maximum yield of 5.90 % (w/w) with 63 % carbohydrate content consisting of glucose, galactose, maltose, mannose, and galacturonic acid, with structural linkages of β (1 → 4) and β (1 → 6) glycosidic bonds.

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Article Synopsis
  • The study examined how Poly(ethylene-co-(acrylic acid)) and maleic anhydride influence the properties of EPDM elastomers filled with cellulose and lignin.
  • Adding these compounds improved thermal stability and elongation, while slowing down the vulcanization process.
  • Maleic anhydride particularly enhanced tensile strength due to better chain mobility and stress transfer, making these modified elastomers beneficial for industrial applications involving biopolymers.
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Fish gelatin, a sustainable substitute for mammalian gelatin, frequently exhibits weaker gel strength and thermal stability, limiting its industrial uses. This study investigated an in vivo method to improve functional characteristics by supplementing Nile tilapia diets with Aronia extract. The control diet (A0) contained no Aronia extract, while the remaining four diets consisted of commercial pelleted feed enriched with 250 mg/kg (A250), 500 mg/kg (A500), 750 mg/kg (A750), and 1000 mg/kg (A1000) of Aronia extract.

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Article Synopsis
  • The human microbiome consists of microorganisms like bacteria and fungi that impact health, with imbalances (dysbiosis) linked to diseases such as asthma and obesity.
  • Current research is exploring how the gut microbiome specifically affects joint health and diseases like osteoarthritis through inflammatory responses triggered by dysbiosis.
  • The review aims to enhance our understanding of the microbiome's role in disease and emphasizes the need for further studies on the joint microbiome's impact on conditions like periprosthetic joint infection.
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Context: Limited information exists regarding the immediate and short-term effects of scapula retraction exercises (SREs) on acromiohumeral distance (AHD) in subacromial pain syndrome (SPS). This study's 2 main objectives were to investigate (1) the immediate effect of the SRE on AHD at varying shoulder abduction angles in patients with SPS and healthy controls and (2) the effect of the 8-week SRE program on AHD in patients with SPS.

Design: Cross-sectional and pre-post intervention designs were utilized on this study.

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Objective: This study aims to investigate the relationship between HPV-associated LSIL and HSIL lesions and overactive bladder (OAB) symptoms in postmenopausal women, highlighting the role of severe histopathological lesions.

Materials And Methods: A retrospective analysis was conducted on postmenopausal women aged 40-65 years who presented at Istanbul Bakırköy Sadi Konuk Training and Research Hospital between January 2021 and March 2023. The study included HPV-positive patients with low-grade squamous intraepithelial lesions (LSIL) and high-grade squamous intraepithelial lesions (HSIL), as well as HPV-negative controls.

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Recycling of protein-rich environmental wastes and obtaining more valuable products from these recycled products is a topic of interest for researchers. This study aims to produce, purify, and characterize the physicochemical and structural properties of the protease enzyme produced from Brevibacillus agri SAR25 using salmon fish waste as substrate and also to evaluate the effect of protease on the chicken feather, enzyme-ligand interactions, and active site surface area. The production of protease was optimum on 50 g/L fish waste, pH 8, 40 °C, 96 h, and 150 rpm.

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Investigation of corneal topographic and ocular surface parameters in ocular rosacea based on skin subtypes.

J Fr Ophtalmol

January 2025

Department of Ophthalmology, Cochin Hospital, Université Paris-Cité, Assistance Publique-Hôpitaux de Paris, Paris, France; Inserm, Centre de Recherche des Cordeliers, Unit 1138 team 17, Paris, France.

Objective: To compare the corneal topographic parameters and ocular surface parameters of ocular rosacea (OR) patients across skin subtypes of the disease and healthy controls.

Methods: This prospective study included 180 eyes of 90 OR patients and 60 eyes of 30 healthy controls. Among the OR patients, 30 had phymatous (60 eyes), 30 had erythematotelangiectatic (60 eyes) and 30 had papulopustular skin types (60 eyes).

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Etiology-specific subgroup analysis of initial pharmacotherapy in infantile epileptic spasm syndrome: A single-center cohort study.

Eur J Paediatr Neurol

January 2025

Division of Pediatric Neurology, Department of Pediatrics, Faculty of Medicine, Ege University, İzmir, Turkey. Electronic address:

Aim: To evaluate the efficacy of initial pharmacotherapy for infantile epileptic spasm syndrome (IESS) with electro-clinical outcome characteristics.

Method: A retrospective comparative cohort study with 280 IESS patients was designed; I. vigabatrin monotherapy (n = 129, 46 %); II.

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Background: While clinical indicators for synchronized cardioversion in regular supraventricular tachycardias are well-established, their application by prehospital emergency medical services (EMS) still needs to be explored.

Objective: The purpose of this study was to evaluate the factors influencing the decision-making process of prehospital EMS personnel to perform synchronized cardioversion in adults with narrow QRS regular tachyarrhythmias.

Methods: This descriptive study included 598 paramedics actively engaged in prehospital EMS.

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Objectives: Acute exacerbations of chronic obstructive pulmonary disease (AECOPD) frequently result in emergency department (ED) visits, necessitating accurate risk stratification. The aim of this study was to evaluate and compare the prognostic utility of the DECAF score and serum procalcitonin levels in predicting clinical outcomes in patients with AECOPD.

Methods: This retrospective cohort study encompassed AECOPD patients presenting to the ED over a three-year period who had serum procalcitonin levels measured.

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Neural invasion severity is a strong predictor of local recurrence in pancreatic ductal adenocarcinoma.

Surgery

January 2025

Department of Surgery, School of Medicine and Health, Technical University Munich, TUM University Hospital, Klinikum rechts der Isar, Munich, Germany; Institute of Pathology, School of Medicine, Technical University of Munich, Klinikum rechts der Isar der Technischen Universität München, Munich, Germany.

Background: In pancreatic ductal adenocarcinoma, neural invasion is being increasingly recognized as an unfavorable predictor of patient outcomes. Neural invasion severity seems to have a stronger clinical impact on patient prognosis than neural invasion status alone. Therefore, this study aims to assess the impact of severity of neural invasion on overall survival and disease-free survival in pancreatic ductal adenocarcinoma.

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Biosimilars in pediatric rheumatology: innovations, challenges, and opportunities.

Expert Opin Biol Ther

January 2025

Department of Pediatric Rheumatology, Kocaeli University, Kocaeli, Turkey.

Article Synopsis
  • Biosimilars are biologic drugs that mimic established medications for treating rheumatic diseases and become available as cost-effective alternatives once original patents expire.
  • Since their introduction in pediatric rheumatology in 2013, several biosimilars have been launched, offering more treatment options for children with conditions like juvenile idiopathic arthritis.
  • The article emphasizes the need for education and effective communication among healthcare providers and patients to enhance understanding and ensure proper use of biosimilars.
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Objective: This retrospective study aimed to evaluate the predictive value of the preoperative dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) and diffusion-weighted imaging (DWI) findings of mass lesions for predicting sentinel lymph node (SLN) metastasis in early breast cancer.

Methods: A total of 310 patients with suspicious mass lesions detected in preoperative MRI who subsequently underwent surgery and SLN biopsy (SLNB) between September 2015 and September 2022 were analyzed. The relationship between DCE-MRI and DWI findings and SLNB positivity was analyzed.

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Protocol to study neuronal membrane proteasome function in mouse peripheral sensory neurons.

STAR Protoc

January 2025

Department of Molecular Pharmacology and Neuroscience, Loyola University Chicago Stritch School of Medicine, Maywood, IL 60153, USA; Center for Translational Research and Education, Health Sciences Campus, 2160 South First Avenue, Maywood, IL 60153, USA. Electronic address:

Neuronal membrane proteasomes (NMPs) are expressed on a subset of somatosensory dorsal root ganglion (DRG) neurons and influence mechanical and pain sensitivity. Here, we present a protocol for studying NMP function in mouse peripheral sensory neurons. We describe steps for procuring and culturing primary DRG neurons.

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Motile cilia modulate neuronal and astroglial activity in the zebrafish larval brain.

Cell Rep

January 2025

Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology, Erling Skjalgssons Gate 1, 7491 Trondheim, Norway; Kavli Institute for Systems Neuroscience and Centre for Algorithms in the Cortex, Norwegian University of Science and Technology, Olav Kyrres Gate 9, 7030 Trondheim, Norway. Electronic address:

The brain uses a specialized system to transport cerebrospinal fluid (CSF), consisting of interconnected ventricles lined by motile ciliated ependymal cells. These cells act jointly with CSF secretion and cardiac pressure gradients to regulate CSF dynamics. To date, the link between cilia-mediated CSF flow and brain function is poorly understood.

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