Dissipative Soliton Mode-Locked Erbium-Doped Fiber Laser Using NbAlC Nanomaterial Saturable Absorber.

We report the fabrication of an erbium-doped fiber-based saturable absorber (SA) of niobium aluminium carbide (NbAlC) nanomaterial that can generate a dissipative soliton mode-locked pulse. Stable mode-locked pulses operating at 1530 nm with repetition rates of 1 MHz and pulse widths of 6.375 ps were produced using polyvinyl alcohol (PVA) and the Nb2AlC nanomaterial.

Automated knowledge-assisted mitosis cells detection framework in breast histopathology images.

Based on the Nottingham Histopathology Grading (NHG) system, mitosis cells detection is one of the important criteria to determine the grade of breast carcinoma. Mitosis cells detection is a challenging task due to the heterogeneous microenvironment of breast histopathology images. Recognition of complex and inconsistent objects in the medical images could be achieved by incorporating domain knowledge in the field of interest.

Natural Sirtuin Modulators in Drug Discovery: A Review (2010 -2020).

There have been intense research interests in sirtuins since the establishment of their regulatory roles in a myriad of pathological processes. In the last two decades, many research efforts have been dedicated to the development of sirtuin modulators. Although synthetic sirtuin modulators are the focus, natural modulators remain an integral part to be further explored in this area as they are found to possess therapeutic potential in various diseases, including cancers, neurodegenerative diseases, and metabolic disorders.

Sirtuins and Their Implications in Neurodegenerative Diseases from a Drug Discovery Perspective.

Sirtuins are class III histone deacetylase (HDAC) enzymes that target both histone and non-histone substrates. They are linked to different brain functions and the regulation of different isoforms of these enzymes is touted to be an emerging therapy for the treatment of neurodegenerative diseases (NDs), including Parkinson's disease (PD), Alzheimer's disease (AD), and amyotrophic lateral sclerosis (ALS). The level of sirtuins affects brain health as many sirtuin-regulated pathways are responsible for the progression of NDs.