Immunohistochemical expression of epidermal growth factor receptor: prognostic value in HER2 positive breast cancer.

Introduction: Epidermal Growth Factor Receptor (EGFR) expression is not well-studied in Human Epidermal Growth Factor Receptor 2 (HER2) positive breast cancer. We aim to study the prevalence of EGFR immunohistochemical expression in HER2-positive breast carcinomas and to correlate this expression with different anatomo-clinical parameters.

Methods: It was a retrospective study involving cases of HER2-positive breast carcinoma collected at the Immuno-Histo-Cytology Department of Salah Azaïez Institute of Tunis between 2018 and 2020.

Inflammatory myofibroblastic tumour of the spleen: A diagnostic challenge.

Introduction: Inflammatory myofibroblastic tumour (IMT) is a rare mesenchymal neoplasm with intermediate biological behavior. Splenic IMT, first described in 1980, is an exceptionally uncommon presentation, with approximately 120 cases reported in the literature by 2021.

Case Presentation: A 52-year-old female presented to the gastroenterology department with complaints of left hypochondrial pain.

Brachiocephalic trunk injuries after central venous catheterization: A case series of surgical management and outcomes.

Introduction And Importance: Central venous catheter (CVC) placement is a common procedure, particularly in critically ill patients. However, it carries the risk of vascular complications, including rare and severe injuries to the brachiocephalic trunk (BCT). We present a case series of two patients who developed BCT injuries following tunneled CVC placements, highlighting the critical importance of early diagnosis to prevent fatal outcomes.

A swarm-optimization based fusion model of sentiment analysis for cryptocurrency price prediction.

Social media has attracted society for decades due to its reciprocal and real-life nature. It influenced almost all societal entities, including governments, academics, industries, health, and finance. The Social Network generates unstructured information about brands, political issues, cryptocurrencies, and global pandemics.

Theoretical characterization of hydroxyacetone (CH-CO-CHOH) in the gas phase. Study of the far infrared region.

Accurate structural and rovibrational parameters of hydroxyacetone, CH-CO-CHOH, are computed using highly correlated ab initio methods (CCSD(T)-F12), second order perturbation theory, and a variational procedure of reduced dimensionality, contemplating the interconversion of the conformers by internal rotation at low temperatures. Hydroxyacetone presents four different stable geometries. The preferred one, whose stability is prominent, is a quasi-planar structure slightly distorted due to the formation of an intramolecular hydrogen bond involving the OH hydrogen and the C=O oxygen atom.

Toxicological Alterations Induced by Subacute Exposure of Cobalt Oxide Nanoparticles in Aged Rats: Behavioral, Biochemical, Molecular, and Histopathological Evidence.

Currently, evidence has pointed out that metal-based nanomaterials may have potentially harmful outcomes in the development of such diseases related to neurodegenerative disorders, oxidative stress, and inflammation. Among them, cobalt oxide nanoparticles (Co3O4-NPs), nano metal-oxides, are widely used in several areas such as industries and as wastewater treatment. Although Co3O4-NPs have a large scale in biological and industrial applications, there is a growing concern to their toxic effect on human health and the environment due to their reduced size and high reactivity, both chemically and biologically.

Explainable AI analysis for smog rating prediction.

Smog poses a direct threat to human health and the environment. Addressing this issue requires understanding how smog is formed. While major contributors include industries, fossil fuels, crop burning, and ammonia from fertilizers, vehicles play a significant role.

Probabilistic and deep learning approaches for conductivity-driven nanocomposite classification.

To foster greater trust and adoption of machine learning models, particularly neural networks, it is essential to develop approaches that quantify and report epistemic uncertainties alongside random uncertainties, which often affect the accuracy of Recurrent Neural Networks (RNNs). Addressing these challenges, this study proposes a hybrid approach integrating Bayesian techniques and deep learning to improve the classification of nanocomposites with a focus on evaluating their conductivity properties. The proposed framework begins with a Bayesian Network (BN) model, which provides probabilistic insights into the conductive behavior of nanocomposites by analyzing the distribution and interaction of their constituent nanoparticles.

Emergence of a methicillin-resistant Staphylococcus aureus strains with an unusual susceptibility antibiotic pattern in Tunisia.

Typically, methicillin-resistant Staphylococcus aureus (MRSA) strains exhibit concurrent resistance to numerous commonly used antibiotics. Between June and December 2023, five MRSA strains with an unusual antibiotic susceptibility pattern (susceptible to all antibiotics tested, except cefoxitin) were isolated at Charles Nicolle Hospital of Tunis. Isolates were characterized by whole genome sequencing using the Illumina DNA Prep kit.

Sudden death due to Crohn's colitis: An autopsy case report.

Crohn's colitis is an inflammatory bowel disease affecting the colon, which can result in serious complications such as intestinal perforation and peritonitis. Clinically, it presents with symptoms like abdominal pain, diarrhea, and vomiting, which can be misinterpreted or overlooked, leading to diagnostic delays. We present an autopsy case of a 43-year-old woman with no significant past medical history, who initially consulted the Emergency Department for persistent abdominal pain, vomiting, and diarrhea over a 10-day period.

Chronic coronary syndrome in Africa: current management and service challenges, and opportunities for optimizing patient care.

African populations have traditionally been considered at relatively low risk of cardiovascular diseases (CVD), such as chronic coronary syndrome (CCS), but this is rapidly changing in association with ageing populations, uncontrolled urbanization and lack of control of classical CV risk factors. In sub-Saharan Africa, CVD deaths have increased by more than 50% in the past three decades. For CCS care, limited availability of clinical expertise, diagnostic facilities, and access to optimal medical therapy (OMT), lack or inadequate reimbursement of healthcare costs, and scarcity of universal health coverage (UHC) are major challenges.

Biocontrol of Agroathelia rolfsii associated with stem rot disease in tomato (Solanum lycopersicum L.) and growth promotion using compost-associated actinobacteria.

Stem rot disease (Agroathelia rolfsii) biocontrol is an environmentally safe alternative that could potentially decrease disease severity and limit plant and yield losses. In the present investigation, 11 actinomycetes isolates, recovered from disease-suppressive composts, were tested as whole cell suspensions and cell-free culture filtrates for their ability to suppress tomato stem rot and to stimulate plant growth. Five isolates (namely A5-3, A2-4, A3-4, A4-4 and A5-4), applied as cell suspensions, were found to be the most effective in suppressing disease severity by 37.

Strategies for periprosthetic joint infection management in resource-limited settings: the applicability of EBJIS criteria.

Background And Purpose: Periprosthetic joint infection (PJI) is a significant and challenging healthcare issues. Accurate diagnosis is essential for effective treatment. The aim of our study is to underscore the usefulness of the new EBJIS definition and criteria when applied in a developing country department.

Zoonotic threat of cystic echinococcosis in Tunisia: insights into livestock prevalence and identification of the G1 genotype.

Introduction: Cystic echinococcosis (CE) is a zoonosis caused by the larval stage of the (.) complex. CE is globally distributed, with a particularly high prevalence in North African countries, especially Tunisia.

Predicting climate-driven shift of the East Mediterranean endemic Lindl.

Introduction: Climate change poses significant challenges to the distribution of endemics in the Mediterranean region. Assessing the impact of climate change on the distribution patterns of Mediterranean endemics is of critical importance for understanding the dynamics of these terrestrial ecosystems under the uncertainty of future changes. The population size of the has declined significantly over the previous century across its geographical region.

Dermoid cyst associated with segmental multicystic renal dysplasia: A rare case.

Most multicystic dysplastic kidneys (MCDKs) are detected prenatally, yet there is no clear consensus on initial evaluation and follow-up. We report the case of a 4-year-old male diagnosed with right pyelocalyceal dilation in utero, confirmed postnatally as MCDK. Follow-up ultrasounds revealed rapid growth of three upper pole cysts, reaching 8 cm.

Impact of infection prevention measures on the occurrence of cutaneous lesions and the quality of life of frontline and non-frontline healthcare workers: A multicentre cross-sectional study.

Background: Infection prevention measures are crucial to prevent contamination among frontline healthcare workers (FL-HCWs) and non-frontline healthcare workers (NFL-HCWs). However, these measures can lead to skin lesions, potentially affecting their quality of life.

Objectives: Determine the prevalence of skin lesions caused by infection prevention measures and assess the impact of skin lesions on the quality of life.

Study of Eye Movements Abnormalities in Epilepsy.

Idiopathic epilepsy (IE), is a group of epileptic syndromes with no structural brain lesion, but with microstructural changes in neuronal networks leading to neuropsychological consequences. Therefore, the assessment of saccadic eye movements can provide insight into the integrity of cerebral networks as it involves large cortical and subcortical brain areas and circuitries. Describe saccadic eye movement abnormalities in patients with IE and correlate them with disease characteristics and antiseizure medication.

Loneliness and susceptibility to social pain mediate the association between autistic traits and psychotic experiences in young non-clinical adults.

Understanding of the mechanisms involved in the occurrence of psychotic experiences (PEs) in highly autistic individuals is crucial for identifying appropriate prevention and intervention strategies. This study aimed to investigate the mediating role of susceptibility to social pain and loneliness in the relationship between autistic traits (ATs) and PEs in adults from the general population of 12 Arab countries. This cross-sectional study is part of a large-scale multi-country research project.

Molecular epidemiology of a multidrug-resistant outbreak in Tunisia (2022-2023) using whole-genome sequencing.

The prevalence of multidrug-resistant (MDR) is increasing globally, raising concerns for public health. In 2022, an outbreak of MDR was observed in Tunisia. We aimed to evaluate the genetic profile of isolates during the outbreak, including their clonal relationship, antimicrobial determinants and connection to international strains.

Case Report: Giant lung hamartoma : An usual cause of lobectomy in a five-year child.

Pulmonary hamartomas are the most common benign tumors of the lung in adults. They are usually asymptomatic because of their small size and their slow-growing character. We report the case of a 5-year-old child presenting with a giant lung mass causing recurrent right pneumonia.

Domestication history and genetic changes for the newly evolved flower color in the ornamental plant (Brassicaceae).

(sweet alyssum) is a popular ornamental plant that displays a range of flower colors, particularly white and purple. However, the genetic underpinning and evolutionary history of flower colors have remained unknown. To address this, we performed a assembly of a chromosome-level genome for this species and conducted comparative population genomic analyses of both domestic and wild representatives.

Efficacy of a natural herbal topical analgesic versus oral paracetamol in patients with soft tissue injury. A randomized, double-blind, placebo-controlled study.

Objective: This study aims to evaluate the effectiveness and tolerability of a phytotherapeutic topical gel (Douloff®) compared to oral paracetamol for acute pain resulting from minor limb soft tissue injuries.

Methods: A prospective, multicenter, randomized, double-blind study conducted over 13 months in three EDs. Patients aged 18 years and older, with minor limb soft tissue injuries, were randomized into Douloff® (n = 765) and paracetamol (n = 750) groups.

Use of anthropogenic debris as nesting materials in a south-Mediterranean yellow-legged gull (Larus michahellis) breeding colony in relation to their environmental availability.

The use of plastics and other anthropogenic debris (AD) as nesting materials by the yellow-legged gull Larus michahellis (YLG) has been previously reported in different north Mediterranean and Atlantic breeding colonies. This behavior is also suspected to widely occur in south-Mediterranean areas, and possibly to a greater extent because of high AD availability related to inefficient waste management systems, but data are lacking. The aim of our study was therefore to investigate AD incorporation into YLG nests in a southern Tunisian breeding colony and determine to what degree this integration was associated with debris availability in the environment.