6 results match your criteria: "Tumor and Breast Center Eastern Switzerland[Affiliation]"
Axillary Surgery in Breast Cancer - Primary Results of the INSEMA Trial.
N Engl J Med
December 2024
From the Department of Obstetrics and Gynecology, University of Rostock, Rostock, Germany (T.R., A.S., B.G.); University Hospital Ulm, Ulm, Germany (K.V., I.B.); Hospital Esslingen, Esslingen, Germany (T.K.); University Hospital Heidelberg, Heidelberg, Germany (J. Heil, M.G.); the Breast Unit, Sankt Elisabeth Hospital, Heidelberg, Germany (J. Heil, M.G.); Evang. Waldkrankenhaus Spandau, Berlin (S.P.); the Faculty of Medicine Mannheim, Department of Obstetrics and Gynecology, University of Heidelberg, Mannheim, Germany (F.M.); the Department of Obstetrics and Gynecology, Hanau City Hospital, Hanau, Germany (T.M.); the Department of Radiation Oncology, University Hospital Rostock, Rostock, Germany (G.H.); the Department of Radiotherapy and Radiation Oncology, University Hospital Hamburg-Eppendorf (UKE), Hamburg, Germany (D.K.); the Department of Radiation Oncology, University Medical Center Schleswig-Holstein, Kiel, Germany (D.K.); Medical School and University Medical Center OWL, Department of Gynecology and Obstetrics, Bielefeld University, Klinikum Lippe, Detmold, Germany (B.A.); Salzburg Regional Hospital, Salzburg, Austria (R.R.); Johanniter-Hospital Genthin-Stendal, Genthin, Germany (S.R.); the Institute of Pathology, Philipps-University Marburg and University Hospital Marburg (UKGM), Marburg, Germany (C.D.); Breast Center St. Gallen, Kantonsspital, St. Gallen, Switzerland (I.B.); SRH Wald-Klinikum Gera, Gera, Germany (D.-M.Z.); the Department of Gynecology and Gynecologic Oncology, Agaplesion Markus Hospital, Frankfurt am Main, Germany (M.T.); the German Breast Group, Neu-Isenburg, Germany (J. Holtschmidt, V.N., S.L.); and the Tumor and Breast Center Eastern Switzerland, St. Gallen, Switzerland (M.K.).
Background: Whether surgical axillary staging as part of breast-conserving therapy can be omitted without compromising survival has remained unclear.
Methods: In this prospective, randomized, noninferiority trial, we investigated the omission of axillary surgery as compared with sentinel-lymph-node biopsy in patients with clinically node-negative invasive breast cancer staged as T1 or T2 (tumor size, ≤5 cm) who were scheduled to undergo breast-conserving surgery. We report here the per-protocol analysis of invasive disease-free survival (the primary efficacy outcome).
Anticancer Activity of the Marine Triterpene Glycoside Cucumarioside A-2 in Human Prostate Cancer Cells.
Mar Drugs
December 2023
Department of Oncology, Hematology and Bone Marrow Transplantation with Section Pneumology, Hubertus Wald Tumorzentrum-University Cancer Center Hamburg (UCCH), University Medical Center Hamburg-Eppendorf, 20251 Hamburg, Germany.
Despite recent advances in the treatment of metastatic castration-resistant prostate cancer (CRPC), treatment is inevitably hampered by the development of drug resistance. Thus, new drugs are urgently needed. We investigated the efficacy, toxicity, and mechanism of action of the marine triterpene glycoside cucumarioside A-2 (CA-2) using an in vitro CRPC model.
View Article and Find Full Text PDFImpact of Imaging-Guided Localization on Performance of Tailored Axillary Surgery in Patients with Clinically Node-Positive Breast Cancer: Prospective Cohort Study Within TAXIS (OPBC-03, SAKK 23/16, IBCSG 57-18, ABCSG-53, GBG 101).
Ann Surg Oncol
January 2024
Tumor and Breast Center Eastern Switzerland, St. Gallen, Switzerland.
Background: Tailored axillary surgery (TAS) is a novel surgical concept for clinical node-positive breast cancer. It consists of the removal of the sentinel lymph nodes (LNs), as well as palpably suspicious nodes. The TAS technique can be utilized in both the upfront and neoadjuvant chemotherapy (NACT) setting.
View Article and Find Full Text PDFAssociation of Axillary Dissection With Systemic Therapy in Patients With Clinically Node-Positive Breast Cancer.
JAMA Surg
October 2023
Breast Center, St Gallen Cantonal Hospital, St Gallen, Switzerland.
Importance: The role of axillary lymph node dissection (ALND) to determine nodal burden to inform systemic therapy recommendations in patients with clinically node (cN)-positive breast cancer (BC) is currently unknown.
Objective: To address the association of ALND with systemic therapy in cN-positive BC in the upfront surgery setting and after neoadjuvant chemotherapy (NACT).
Design, Setting, And Participants: This was a prospective, observational, cohort study conducted from August 2018 to June 2022.
Trends in use of neoadjuvant systemic therapy in patients with clinically node-positive breast cancer in Europe: prospective TAXIS study (OPBC-03, SAKK 23/16, IBCSG 57-18, ABCSG-53, GBG 101).
Breast Cancer Res Treat
September 2023
University of Basel, Basel, Switzerland.
Purpose: The aim of this study was to evaluate clinical practice heterogeneity in use of neoadjuvant systemic therapy (NST) for patients with clinically node-positive breast cancer in Europe.
Methods: The study was preplanned in the international multicenter phase-III OPBC-03/TAXIS trial (ClinicalTrials.gov Identifier: NCT03513614) to include the first 500 randomized patients with confirmed nodal disease at the time of surgery.
Uncertainties and controversies in axillary management of patients with breast cancer.
Cancer Treat Rev
June 2023
Austrian Breast and Colorectal Study Group ABCSG, Vienna, Austria; Comprehensive Cancer Center Medical University Vienna, Vienna, Austria.
The aims of this Oncoplastic Breast Consortium and European Breast Cancer Research Association of Surgical Trialists initiative were to identify uncertainties and controversies in axillary management of early breast cancer and to recommend appropriate strategies to address them. By use of Delphi methods, 15 questions were prioritized by more than 250 breast surgeons, patient advocates and radiation oncologists from 60 countries. Subsequently, a global virtual consensus panel considered available data, ongoing studies and resource utilization.
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