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Intraperitoneal chemotherapy with mitoxantrone in malignant ascites.
Surg Oncol Clin N Am
July 2003
Department of Visceral and Oncologic Surgery, Asklepios Paulinen Klinik and Asklepios, Tumor Center Rhein-Main (ATC), Geisenheimer Str. 10, D 65197 Wiesbaden, Germany.
A retrospective analysis of intraperitoneal mitoxantrone instillation therapy for malignant ascites in advanced breast and gynecologic pelvic cancers was performed to confirm the efficacy and safety of this therapy. Several smaller phase II trials had suggested good palliative effects. In 143 patients (37 breast cancer and 106 gynecologic cancers), 257 instillations were registered.
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