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CTXphi immunity: application in the development of cholera vaccines.
Proc Natl Acad Sci U S A
June 1998
Division of Geographic Medicine and Infectious Diseases, Tupper Research Institute, Tufts-New England Medical Center 041, 750 Washington Street, Boston, MA 02111, USA.
CTXphi is a filamentous bacteriophage that encodes cholera toxin, the principal virulence factor of Vibrio cholerae. CTXphi is unusual among filamentous phages because it encodes a repressor and forms lysogens. CTXphi can infect the existing live-attenuated V.
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