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117 results match your criteria: "Tufts University School of Engineering[Affiliation]"
Environ Epidemiol
December 2021
Department of Public Health and Community Medicine, Tufts University School of Medicine, Boston, Massachusetts.
Vaccine
January 2022
Department of Public Health & Community Medicine, Tufts University School of Medicine, Boston, MA, United States; Department of Civil and Environmental Engineering, Tufts University School of Engineering, Medford, MA, United States.
Introduction: COVID-19 morbidity and mortality has disproportionately affected vulnerable populations such as minority racial/ethnic groups. Understanding disparities in vaccine intentions and reasons for vaccine hesitancy are important for developing effective strategies for ameliorating racial/ethnic COVID-19 inequities.
Methods: Using six waves of the large, nationally representative Census Bureau's Household Pulse Survey data from January 6-March 29, 2021 (n = 459,235), we examined national and state estimates for vaccination intent, defined as receipt of ≥ 1 dose of the COVID-19 vaccine or definite intent to be vaccinated, by race/ethnicity with stratification by household income and age group.
Environ Sci Technol Lett
November 2021
Lancon Environmental, LLC, Cambridge, Massachusetts 02140, United States.
Initial recommendations for surface disinfection to prevent SARS-CoV-2 transmission were developed using previous evidence from potential surrogates. To the best of our knowledge, no appropriate surrogate for SARS-CoV-2 has been identified or confirmed for chlorine and antimicrobial surface disinfection. We completed a study to evaluate the efficacy of two hypothesized antimicrobial surfaces, and four chlorine solutions on nonporous and porous surfaces, against SARS-CoV-2 and three potential SARS-CoV-2 surrogates [coronavirus mouse hepatitis virus (MHV) and bacteriophages Phi6 and MS2], to identify a BSL-1 or BSL-2 virus to use in future studies.
View Article and Find Full Text PDFAnn Med
December 2021
Department of Public Health & Community Medicine, Tufts University School of Medicine, Boston, MA, USA.
Introduction: Previous studies suggested that almost one-third of U.S. adults did not plan to get a COVID-19 vaccine once it is available to them.
View Article and Find Full Text PDFCell Syst
November 2021
Department of Molecular Biology and Microbiology, Tufts University School of Medicine, Boston, MA 02111, USA; Stuart B. Levy Center for Integrated Management of Antimicrobial Resistance, Boston, MA 02111, USA; Graduate School of Biomedical Sciences, Tufts University School of Medicine, Boston, MA 02111, USA; Laboratory of Systems Pharmacology, Harvard Program in Therapeutic Science, Harvard Medical School, Boston, MA 02115, USA; Department of Biomedical Engineering, Tufts University School of Engineering, Medford, MA 02155, USA. Electronic address:
Lengthy multidrug chemotherapy is required to achieve a durable cure in tuberculosis. However, we lack well-validated, high-throughput in vitro models that predict animal outcomes. Here, we provide an extensible approach to rationally prioritize combination therapies for testing in in vivo mouse models of tuberculosis.
View Article and Find Full Text PDFPrev Med Rep
December 2021
Department of Public Health and Community Medicine, Tufts University School of Medicine, Boston, MA, USA.
Understanding reasons for COVID-19 vaccine hesitancy is necessary to ensure maximum uptake, needed for herd immunity. We conducted a cross-sectional online survey between May 29-June 20, 2020 among a national sample of U.S.
View Article and Find Full Text PDFMethods Mol Biol
August 2021
Department of Molecular Biology and Microbiology and Stuart B. Levy Center for Integrated Management of Antimicrobial Resistance, Tufts University School of Medicine, Boston, MA, USA.
Treatment of tuberculosis necessitates combination therapy. Therefore, development of new tuberculosis therapies should consider multidrug effects because specific combinations may improve or reduce treatment efficacy through synergistic or antagonistic drug interactions, respectively. The standard assay of drug interactions is a checkerboard assay, wherein the drug-dose combinations are well-sampled across broad dose ranges.
View Article and Find Full Text PDFJNCI Cancer Spectr
June 2021
Department of Public Health and Community Medicine, Tufts University School of Medicine, Boston, MA, USA.
Background: Observational studies indicate that periodontal disease may increase the risk of colorectal, lung, and pancreatic cancers. Using a 2-sample Mendelian randomization (MR) analysis, we assessed whether a genetic predisposition index for periodontal disease was associated with colorectal, lung, or pancreatic cancer risks.
Methods: Our primary instrument included single nucleotide polymorphisms with strong genome-wide association study evidence for associations with chronic, aggressive, and/or severe periodontal disease (rs729876, rs1537415, rs2738058, rs12461706, rs16870060, rs2521634, rs3826782, and rs7762544).
Background: Provision of safe water, sanitation, and hygiene (WASH) to affected populations in humanitarian emergencies is necessary for dignity and communicable disease control. Additional evidence on WASH interventions is needed in humanitarian settings. Between 2008 and 2019, we completed six multi-country, mixed-methods effectiveness studies in humanitarian response on six different WASH interventions.
View Article and Find Full Text PDFFront Microbiol
January 2021
Department of Medical Education, Tufts University School of Medicine, Boston, MA, United States.
Emerging resistance to all classes of antimicrobials is one of the defining crises of the 21st century. Many advances in modern medicine, such as routine surgeries, are predicated on sustaining patients with antimicrobials during a period when their immune systems alone cannot clear infection. The development of new antimicrobials has not kept pace with the antimicrobial resistance (AR) threat.
View Article and Find Full Text PDFBiochem Mol Biol Educ
May 2021
Department of Chemistry and Biochemistry, San Diego State University, San Diego, California, USA.
While science students are well prepared for careers in biotechnology and pharmaceutical sciences in terms of technical expertise and critical thinking, they rarely have an opportunity to practice the due diligence required for success in industry in their coursework. This includes framing their expertise as solutions to challenges a company may be experiencing, an important skill for the interview process. As most academics have not applied for positions in industry, they may feel ill equipped to help students practice the important skills of framing their expertise within company goals and to discuss the business and financial concepts relevant to careers in scientific industry.
View Article and Find Full Text PDFmSphere
January 2021
Department of Molecular Biology and Microbiology, Tufts University School of Medicine, Boston, Massachusetts, USA
The mammalian gut microbiota is a complex community of microorganisms which typically exhibits remarkable stability. As the gut microbiota has been shown to affect many aspects of host health, the molecular keys to developing and maintaining a "healthy" gut microbiota are highly sought after. Yet, the qualities that define a microbiota as healthy remain elusive.
View Article and Find Full Text PDFBackground Proteomic biomarkers related to cardiovascular disease risk factors may offer insights into the pathogenesis of cardiovascular disease. We investigated whether modifiable lifestyle risk factors for cardiovascular disease are associated with distinctive proteomic signatures. Methods and Results We analyzed 1305 circulating plasma proteomic biomarkers (assayed using the SomaLogic platform) in 897 FHS (Framingham Heart Study) Generation 3 participants (mean age 46±8 years; 56% women; discovery sample) and 1121 FOS (Framingham Offspring Study) participants (mean age 52 years; 54% women; validation sample).
View Article and Find Full Text PDFJ Water Health
December 2020
Tufts University School of Engineering, Medford, MA 02155, USA E-mail:
Disinfecting surfaces with chlorine is commonly conducted in cholera outbreaks to prevent ongoing fomite-based transmission, yet evidence gaps have led to contradictory guidance. In this study, we tested the efficacy of spraying and wiping chlorine on five representatives non-porous and five porous surfaces to remove Vibrio cholerae. In total, 120 disinfection tests were run in replicate on carriers inoculated with 1.
View Article and Find Full Text PDFOsteoarthritis Cartilage
February 2021
Department of Biomedical Engineering, Washington University in St. Louis, St. Louis, MO, 63130, USA; Department of Orthopaedic Surgery, Washington University School of Medicine, St. Louis, MO, 63110, USA; Musculoskeletal Research Center, Washington University School of Medicine, St. Louis, MO, 63110, USA. Electronic address:
Objective: This study aimed to examine the temporal activation of NF-κB and its relationship to the development of pain-related sensitivity and behavioral changes in a non-invasive murine knee loading model of PTOA.
Method: Following knee injury NF-κB activity was assessed longitudinally via in vivo imaging in FVB. Cg-Tg (HIV-EGFP,luc)8Tsb/J mice.
Environ Sci Technol
April 2021
Tufts University School of Engineering, Medford, Massachusetts, 02155, United States.
We conducted a systematic review of hygiene intervention effectiveness against SARS-CoV-2, including developing inclusion criteria, conducting the search, selecting articles for inclusion, and summarizing included articles. Overall, 96 268 articles were screened and 78 articles met inclusion criteria with outcomes in surface contamination, stability, and disinfection. Surface contamination was assessed on 3343 surfaces using presence/absence methods.
View Article and Find Full Text PDFProc Natl Acad Sci U S A
August 2020
Department of Molecular Biology and Microbiology, Tufts University School of Medicine, Boston, MA 02111;
Morphological profiling is a method to classify target pathways of antibacterials based on how bacteria respond to treatment through changes to cellular shape and spatial organization. Here we utilized the cell-to-cell variation in morphological features of bacilli to develop a rapid profiling platform called Morphological Evaluation and Understanding of Stress (MorphEUS). MorphEUS classified 94% of tested drugs correctly into broad categories according to modes of action previously identified in the literature.
View Article and Find Full Text PDFSupplying safe drinking water in humanitarian emergencies is critical, and source water chlorination is a commonly implemented intervention to provide safe water. We evaluated three different source water chlorination programs (bucket, in-line, and piped water chlorination) in the ongoing humanitarian response in Cox's Bazar refugee camps in Bangladesh. We used a mixed-methods research protocol including key informant interviews, water point observations, focus group discussions, household surveys, and water quality testing.
View Article and Find Full Text PDFInt J Hyg Environ Health
June 2020
Tufts University School of Arts and Sciences, Medford, MA, USA.
Sustainable Development Goal (SDG) 6 aims to achieve universal access to safe drinking water sources. However, the health benefits of meeting this goal will only be fully realized if improved sources are used to the exclusion of unimproved sources. Very little is known about how rural African households balance the use of improved and unimproved water sources when multiple options are present.
View Article and Find Full Text PDFSci Total Environ
December 2019
Tufts University School of Engineering, Department of Civil and Environmental Engineering, Medford, MA, USA.
Particle inhalation rate (PIR) is an air pollution exposure metric that relies on age-, sex-, and physical activity-specific estimates of minute respiratory volume (MRV; L/min-kg) to account for personal inhalation patterns. United States Environmental Protection Agency (USEPA)-generated MRV estimates derive primarily from relatively homogenous populations without substantial cardiorespiratory challenges. To determine if these MRV estimates are relevant to populations in generally poor cardiorespiratory health (e.
View Article and Find Full Text PDFmBio
November 2019
Department of Biomedical Engineering, University of Michigan, Ann Arbor, Michigan, USA
The rapid spread of multidrug-resistant strains has created a pressing need for new drug regimens to treat tuberculosis (TB), which kills 1.8 million people each year. Identifying new regimens has been challenging due to the slow growth of the pathogen (MTB), coupled with the large number of possible drug combinations.
View Article and Find Full Text PDFInt J Environ Res Public Health
October 2019
Department of Civil and Environmental Engineering, Tufts University School of Engineering, Medford, MA 02155, USA.
Residents in the Eastern Region, Ghana with access to improved water sources (e.g., boreholes and covered wells) often choose to collect water from unimproved sources (e.
View Article and Find Full Text PDFMethods Mol Biol
November 2020
Tufts Medical Center, Boston, MA, USA.
Conventional cell cultures utilizing transformed or immortalized cell lines or primary human epithelial cells have played a fundamental role in furthering our understanding of Cryptosporidium infection. However, they remain inadequate with respect to their inability to emulate in vivo conditions, support long-term growth, and complete the life cycle of the parasite. Previously, we developed a 3D silk scaffold-based model using transformed human intestinal epithelial cells (IECs).
View Article and Find Full Text PDFScience
June 2019
Department of Molecular Biology and Microbiology, Tufts University School of Medicine, Boston, MA, USA.