Prevent and Reverse Metabolic Dysfunction-Associated Steatohepatitis and Hepatic Fibrosis via mRNA-Mediated Liver-Specific Antibody Therapy.

Chronic exposure of the liver to multiple insults culminates in the development of metabolic dysfunctionassociated steatohepatitis (MASH), a complicated metabolic syndrome characterized by hepatic steatosis and inflammation, typically accompanied by progressive fibrosis. Despite extensive clinical evaluation, there remain challenges in MASH drug development, which are primarily due to unsatisfactory efficacy and limited specificity. Strategies to address the unmet medical need for MASH with fibrosis before it reaches the irreversible stage of decompensated cirrhosis are critically needed.

Oral Health, Inflammation, and Cardiometabolic Factors in the VA Million Veteran Program.

Introduction: Associations between cardiometabolic comorbidities and self-reported oral health (OH) are often underexplored in large biobank datasets. While these associations are unaffected by dental care access, they could be mediated by immune responses and inflammation.

Objectives: This study assessed the associations between cardiometabolic comorbidities and self-reported OH, periodontitis, and tooth loss using the (ICD) codes in participants from the U.

'Once that's worn off, we could discuss whether you need more': provider perspectives on communicating with patients and other providers about prescription opioids.

Background: Prescriber-patient communication plays a crucial role in understanding patients' needs, while reducing risks for developing an opioid use disorder (OUD), yet research on this is sparse. As such, the need to understand healthcare providers' skills, comfort, and confidence when discussing opioids with patients and other providers is an important step in balancing patients' needs from a pain perspective and risks from an OUD perspective.

Method: We interviewed 32 Massachusetts providers (physicians, physician associates, nurse practitioners, and dental practitioners) to assess their communication strategies with patients and other providers.

Accuracy of a facebow record: A comparison between a conventional facebow and a smartphone 3D scanner.

Statement Of Problem: Accurately transferring the maxillary cast to the articulator is an essential step in most prosthodontics procedures in both digital and conventional workflows. Recently, the use of a smartphone 3-dimensional (3D) scanner-based virtual facebow record has been reported, but its accuracy is unclear.

Purpose: The purpose of this clinical study was to compare the trueness and precision of a virtual facebow record made with a smartphone 3D scanner with that of a conventional facebow technique.

Multi-omic analyses of a twin pair with mirror image cleft lip identifies pathogenic variant in modified by differential methylation upstream of .

Background: Disturbances in the intricate processes that control craniofacial morphogenesis can result in birth defects, most common of which are orofacial clefts (OFCs). Nonsyndromic cleft lip (nsCL), one of the phenotypic forms amongst OFCs, has a non-random laterality presentation with the left side being affected twice as often compared to the right side. This study investigates the etiology of nsCL and the factors contributing to its laterality using a pair of monozygotic twins with mirror-image cleft lip.

Models of DEIB: Part I - Approaches to Inclusion from Other Health Professions for Consideration by Dentistry.

This article represents a prologue of the discussion of the article "Models of DEIB: Part II-Exploring Models of Inclusion from other Health Professions for Dentistry". It explores existing practices and philosophies from other disciplines that could be applied toward creating environments of inclusion and belonging in dentistry. The primary focus here is to provide an opportunity for the dental profession to leverage knowledge and experiences from other health professions to enhance and expand inclusion efforts and provide enhance engagement at all levels.

Histomorphometric and Micro-CT Evaluation of Cerabone and Bio-Oss in Maxillary Sinus Lifting: A Randomized Clinical Trial.

: The loss of teeth in the posterior maxillary region often leads to significant alveolar bone resorption and maxillary sinus pneumatization, complicating dental implant placement. Maxillary sinus grafting, typically using autogenous bone, is a common solution. However, autogenous bone grafts require additional surgical procedures, leading to increased morbidity.

Role of Chemokines and Cytokines in Prostate Cancer Skeletal Metastasis.

Purpose Of Review: Once prostate cancer (PCa) bone metastases develop, the prognosis dramatically declines. The precise mechanisms regulating bone metastasis remain elusive. This review will explore recent findings related to cytokines and chemokines in the process of bone metastases.

EFFECTIVENESS OF XYLITOL TOOTHPASTE IN CARIES PREVENTION: A REVIEW ARTICLE.

This study aims to summarize the evidence of the effectiveness of xylitol toothpastes with a focus on caries, namely on its prevention and reduction. Materials and methods: A thorough literature review was performed after conducting an electronic search through Medline, PubMed (Central), Scopus, Web of Science (Scielo), Google scholar, and the Cochrane Library (from 2000 to November 2022) to identify studies relevant to the effectiveness of xylitol toothpastes in caries prevention. Results: The number of studies that have been found in the literature to meet the criteria for inclusion in this article has been limited.

Prescription of potentially inappropriate medications in older adults: data from a dental institution.

Objectives: The objectives of this study were to determine the types and frequency of potentially inappropriate medications (PIMs) prescribed to geriatric patients while considering the patients' age groups and their American Society of Anesthesiologists (ASA) physical status.

Study Design: We performed a 5-year retrospective chart review of patients aged 65 years and above who were seen in a dental institution. Patients' medical history, PIM prescriptions, and prescribers' specialty and professional status were analyzed.

Assessing trends for developed INBDE questions: A dental school experience.

Objectives: The aim of this study was to assess trends related to integrated questions created by fourth-year dental students as a part of the Basic Science and Clinical Science Spiral Seminar Series (BaSiCSsss) at Tufts University School of Dental Medicine (TUSDM).

Methods: Deidentified BaSiCSsss presentations from 2019 to 2023 were obtained from the Office of Academic Affairs at TUSDM. The integrated questions created by fourth-year dental students were extracted and compiled into an Excel sheet.

Safety and Efficacy of Ianalumab in Patients With Sjögren's Disease: 52-Week Results From a Randomized, Placebo-Controlled, Phase 2b Dose-Ranging Study.

Objective: The objective of this study was to report 52-week safety and efficacy of ianalumab from phase 2b dose-finding study in patients with Sjögren's disease (SjD).

Methods: Patients randomly received (1:1:1:1) ianalumab (5, 50, or 300 mg) or placebo subcutaneously every 4 weeks until week 24 (treatment period [TP]1). At week 24, patients on 300 mg were rerandomized to continue 300 mg or receive placebo until week 52 (TP2), patients on placebo were switched to ianalumab 150 mg, and patients on 5 and 50 mg directly entered posttreatment safety follow-up.

Does salivary cortisol serve as a potential biomarker for temporomandibular disorders in adults?

Background: The etiology of temporomandibular disorders (TMD) is multifactorial, involving a complex interplay of psychological and physiological factors. While salivary biomarkers, particularly cortisol, play an important role in TMD pathophysiology, evidence in the literature is still scarce and inconsistent. Hence, this study aims to evaluate the applicability of salivary cortisol as a potential biomarker for TMD in adults.

Investigating the Biological Efficacy of Albumin-Enriched Platelet-Rich Fibrin (Alb-PRF): A Study on Cytokine Dynamics and Osteoblast Behavior.

The development of effective biomaterials for tissue regeneration has led to the exploration of blood derivatives such as leucocyte- and platelet-rich fibrin (L-PRF). A novel variant, Albumin-Enriched Platelet-Rich Fibrin (Alb-PRF), has been introduced to improve structural stability and bioactivity, making it a promising candidate for bone regeneration. This study aimed to evaluate Alb-PRF's capacity for cytokine and growth factor release, along with its effects on the proliferation, differentiation, and mineralization of human osteoblasts in vitro.

Parameters to Improve the Accuracy of Intraoral Scanners for Fabricating Tooth-Supported Restorations.

Objectives: To review the factors that impact the accuracy of intraoral scanners (IOSs) when fabricating tooth-supported restorations.

Overview: Factors can have a different impact on IOS accuracy depending on the scanning purpose. If the goal is to fabricate tooth-supported restorations, it is essential to review the following operator-related factors: IOS technology and system, scan extension and starting quadrant, scanning pattern, scanning distance, and rescanning methods.

Magnetically coupled tooth arrangement for an implant-supported fixed complete denture: A dental technique.

Magnets have been used to help position dental components, including magnetic mounting plates for articulators and magnetic attachments for implant surgical guides. A magnetically coupled tooth arrangement technique used the fixed reference point of integrated implants to determine maxillomandibular relations and the tooth arrangement, thus improving the efficiency of the clinical appointment. The magnetic framework was screwed into the implants only once for the duration of a clinical appointment.

Intralesional corticosteroid therapy for non-healing persistent radiation-induced oropharyngeal mucositis.

Purpose: Oropharyngeal mucositis is a common complication of anticancer therapy. This study aimed to determine the effectiveness and safety of intralesional corticosteroid therapy (ICT) in the management of persistent mucositis.

Methods: A retrospective chart review of patients who underwent ICT in the oral cavity to manage oral mucositis managed with basic oral care and preventive modalities and persisting at least 6 weeks after head and neck radiation or chemoradiation therapy completion between November 2017 and September 2023 was performed.

Impact of Implant Surface and Smoking on Peri-Implant Human Bone: What we Learned from The Last 20 Years?

The present review summarizes the findings from human histological studies conducted over the past 20 years at the University of Guarulhos, Brazil, examining the impact of various implant surface topographies and smoking on peri-implant bone response. Seven different implant surfaces were evaluated in 90 partially or completely edentulous individuals using a total of 123 micro-implants. Histometric parameters, including bone-implant contact (BIC%), bone area within the threads (BA%), and bone density (BD), were assessed after an 8-week healing period.

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This in vitro study aimed to investigate the effect of plasma ion implantation nitriding on titanium's surface properties and initial cell response. Grade 4 titanium discs (12.7 × 2 mm) were blasted with aluminum oxide particles to create moderately rough surfaces.

Comparison of trueness, time, and number of images among different denture digitization protocols.

Purpose: To compare trueness, time, and number of images of different denture digitization protocols.

Materials And Methods: Maxillary and mandibular complete prostheses (n = 10) were fabricated and attached with four fiducial markers. Reference scans were obtained using a laboratory scanner.

Head and Neck Cancer in Pan-American Notable People: An International Survey.

The study of notable people as advocates for raising cancer awareness began in the latter decades of the 20th century. This research aimed to identify Pan-American notable people with head and neck cancer (HNC) and to explore senior health professionals' perspectives on communicating stories of notable patients with HNC to promote prevention. A cross-sectional survey was conducted using an online questionnaire designed in REDCap and administered to 32 senior health professionals with long-standing academic and clinical backgrounds in HNC.