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A Pilot Randomized Control Trial of Holding During Hypothermia and Effects on Maternal and Infant Salivary Cortisol Levels.

Adv Neonatal Care

March 2025

Author Affiliations: Department of Pediatrics, Barbara Bush Children's Hospital at Maine Medical Center, Portland, Maine (Dr Fox, Dr Deerwester, and Mr Evans); Center for Outcomes Research and Evaluation at Maine Medical Center Research Institute (Ms Cutler), Portland, Maine; Mother Infant Research Institute, Tufts Medical Center (Dr Kaneko-Tarui), Boston, Massachusetts.

Background: The lack of physical contact during therapeutic hypothermia (TH) is challenging for parents of newborns with hypoxic ischemic encephalopathy. Holding is often avoided due to concerns for effects on infant temperature and for dislodging equipment.

Purpose: We assessed the effect of holding during TH on maternal and infant salivary cortisol levels and on infant vital signs.

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