Targeting prostate cancer with docetaxel-loaded peptide 563-conjugated PEtOx-co-PEI-b-PCL polymeric micelle nanocarriers.

Prostate cancer is a global disease that negatively affects the quality of life. Although various strategies against prostate cancer have been developed, only a few achieved tumor-specific targeting. Therefore, a special emphasis has been placed on the treatment of cancer using nano-carrier-encapsulated chemotherapeutic agents conjugated with tumor-homing peptides.

Investigation of simultaneous effects of noise barriers on near-road noise and air pollutants.

Noise barriers are one of the common solutions to control road traffic noise. Many studies have also shown that noise barriers cause reductions in near-road air pollutant concentrations. In this study, the simultaneous effects of a specific noise barrier application on near-road noise and air pollution at a specific location were investigated.

Electrochemical aptasensors for pathogenic detection toward point-of-care diagnostics.

A biosensor system refers to a biomedical device, which detects biological, chemical, or biochemical components by converting those signals to an electrical signal by utilizing and uniting physical or chemical transducer with biorecognition elements. An electrochemical biosensor is generally based on the reaction of either production or consumption of electrons under a three-electrode system. Biosensor systems are exploited in a wide range of areas, such as medicine, agriculture, husbandry, food, industry, environment protection, quality control, waste disposal, and the military.

Rapid and efficient ambient temperature X-ray crystal structure determination at Turkish Light Source.

High-resolution biomacromolecular structure determination is essential to better understand protein function and dynamics. Serial crystallography is an emerging structural biology technique which has fundamental limitations due to either sample volume requirements or immediate access to the competitive X-ray beamtime. Obtaining a high volume of well-diffracting, sufficient-size crystals while mitigating radiation damage remains a critical bottleneck of serial crystallography.

Investigation of the Antiviral Effects of Saussurea lappa Root Extract against SARS-CoV-2 Virus.

Scope: The purpose of this study was to look into the antiviral activity of a plant extract derived from the roots of the Saussurea lappa as a food supplement against SARS-CoV-2 infection.

Methods And Results: Vero E6 cells are employed in the study to test the neutralizing effect of Saussurea lappa extract against the SARS-CoV-2 virus. For anti-viral activity detection, a sensitive real-time cell analyzer (xCELLigence RTCA) with a high repetition rate is used.

Chewable tablet with herbal extracts and propolis arrests Wuhan and Omicron variants of SARS-CoV-2 virus.

Prevention of COVID-19 is of paramount importance for public health. Some natural extracts might have the potential to suppress COVID-19 infection. Therefore, this study aimed to design a standardised, efficient, and safe chewable tablet formulation (with propolis and three herbal extracts) for possible prevention against two variants (Wuhan B.

Silk-derived nitrogen-doped porous carbon electrodes with enhanced ionic conductivity for high-performance supercapacitors.

Supercapacitors are attracting extensive attention in energy storage fields thanks to their high safety, cost-effectiveness, and environmental friendliness. The carbon materials, especially for the porous carbon materials derived from renewable biomass materials, are important electrode materials with cost-effective feature for supercapacitors. However, the inferior ionic conductivity of biomass materials inhibits their electrochemical performance in energy storage devices.

Dried Fruits: Bioactives, Effects on Gut Microbiota, and Possible Health Benefits-An Update.

Dried fruits contain many bioactive compounds broadly classified as phytochemicals including phenolics, flavonoids, carotenoids, proanthocyanidins, stilbenes, chalcones/dihydrochalcones, and phytoestrogens. These compounds have antioxidant effects that may benefit health. Dried fruits are also a diverse group of foods with varying fibre contents.

Process development for an effective COVID-19 vaccine candidate harboring recombinant SARS-CoV-2 delta plus receptor binding domain produced by Pichia pastoris.

Recombinant protein-based SARS-CoV-2 vaccines are needed to fill the vaccine equity gap. Because protein-subunit based vaccines are easier and cheaper to produce and do not require special storage/transportation conditions, they are suitable for low-/middle-income countries. Here, we report our vaccine development studies with the receptor binding domain of the SARS-CoV-2 Delta Plus strain (RBD-DP) which caused increased hospitalizations compared to other variants.

A Novel Peptide-Based Detection of SARS-CoV-2 Antibodies.

The need for rapidly developed diagnostic tests has gained significant attention after the recent pandemic. Production of neutralizing antibodies for vaccine development or antibodies to be used in diagnostic tests usually require the usage of recombinant proteins representing the infectious agent. However, peptides that can mimic these recombinant proteins may be rapidly utilized, especially in emergencies such as the recent outbreak.

The impact of livestock activities and geochemical processes on groundwater quality of fractured volcanic rock aquifer: Lake Çıldır watershed (NE Turkey).

This paper presents the impact of livestock activities and geochemical processes on the water quality of a fractured volcanic rock aquifer in the Lake Çıldır watershed, located at the northeastern part of Turkey. The existence of a high livestock population and animal grazing activities in meadow and pasturelands of the watershed during the short summer period poses serious stress on both surface and groundwater resources being the only drinking water supply for the local communities. Therefore, understanding the effect of grazing and livestock breeding activities occurring in the recharge areas of the fractured volcanic rock aquifer is vital to take precautions in order to protect limited water supplies at the watershed and vulnerable lake ecosystem as well.

One-Pot Synthesis of Melamine Formaldehyde Resin-Derived -Doped Porous Carbon for CO Capture Application.

The design and synthesis of porous carbons for CO adsorption have attracted tremendous interest owing to the ever-soaring concerns regarding climate change and global warming. Herein, for the first time, nitrogen-rich porous carbon was prepared with chemical activation (KOH) of commercial melamine formaldehyde resin (MF) in a single step. It has been shown that the porosity parameters of the as-prepared carbons were successfully tuned by controlling the activating temperature and adjusting the amount of KOH.

Severe allergic dysregulation due to a gain of function mutation in the transcription factor STAT6.

Background: Inborn errors of immunity have been implicated in causing immune dysregulation, including allergic diseases. STAT6 is a key regulator of allergic responses.

Objectives: This study sought to characterize a novel gain-of-function STAT6 mutation identified in a child with severe allergic manifestations.

Facile synthesis of NiTe-CoTe@rGO nanocomposite for high-performance hybrid supercapacitor.

The design of bimetallic tellurides that exhibit excellent electrochemical properties remains a huge challenge for high-performance supercapacitors. In the present study, tellurium is consolidated on CoNi@rGO for the first time, to synthesize NiTe-CoTe@rGO nanocomposite by using a facile hydrothermal method. As-prepared NiTe-CoTe@rGO nanocomposite was characterized by EDS, TEM, FESEM, Raman, BET, XRD, and XPS techniques to prove the structural transformation.

Fabrication of a Dual-Drug-Loaded Smart Niosome-g-Chitosan Polymeric Platform for Lung Cancer Treatment.

Changes in weather conditions and lifestyle lead to an annual increase in the amount of lung cancer, and therefore it is one of the three most common types of cancer, making it important to find an appropriate treatment method. This research aims to introduce a new smart nano-drug delivery system with antibacterial and anticancer capabilities that could be applied for the treatment of lung cancer. It is composed of a niosomal carrier containing curcumin as an anticancer drug and is coated with a chitosan polymeric shell, alongside Rose Bengal (RB) as a photosensitizer with an antibacterial feature.

A comprehensive assessment, source input determination and distribution of persistent organic pollutants (POPs) along with heavy metals (HMs) in reservoir lake sediments from Çanakkale province, Türkiye.

This study presents the distribution of persistent organic pollutants (POPs), polycyclic aromatic hydrocarbons (PAHs) and heavy metals (HMs) in the sediments from four dams and two ponds in the Çanakkale city, Türkiye. The total concentration varied from 41.47 to 145.

Antimicrobial and antioxidant activity of phenolic extracts from walnut () green husk by using pressure-driven membrane process.

Unlabelled: In this study, antioxidant (DPPH and metal chelating), DNA cleavage, biofilm, and antimicrobial properties of extracted phenol from the walnut green husk (WGH) and its different concentrate and permeate samples were evaluated. For maximum phenolic compound extraction from the WGH first, the effects of solvent type (deionized water, methanol, n-hexane, acetone, and ethanol), solvent temperature (25-75 °C), and extraction time (0.5-24 h) were optimized.

Biochemical, pharmacological, and toxicological attributes of caper () flowering buds and berries pickles.

is a natural plant that grows widely in Turkey and its flowering buds and berry pickle are used in traditional medicine. Thus, the current study was expanded to evaluate the biochemical, pharmacological, and toxicological aspects of the water extract (COWE). To determine the biochemical properties of COWE, mineral and fatty acid content, elemental analysis, flavonoid/phenolic content, radical-scavenging capacity, and pesticide analysis were performed.

Four-Winged Propeller-Shaped Indole-Modified and Indole-Substituted Tetraphenylethylenes: Greenish-Blue Emitters with Aggregation-Induced Emission Features for Conventional Organic Light-Emitting Diodes.

Aggregation-induced emission (AIE) is an extraordinary photochemical phenomenon described by Tang's group in 2001, where the aggregation of some organic molecules enhances their light emission by limiting intramolecular activity in the aggregate state. This phenomenon offers new opportunities for researchers due to its potential applications in optoelectronics, energy, and biophysics. Tetraphenylethylenes (TPEs) are reliable AIE luminogens with a wide range of successful applications in material chemistry.

Catalyst-Tuned Electrophilic Chlorination of Diverse Aromatic Compounds with Sulfuryl Chloride and Regioselective Chlorination of Phenols with Organocatalysts.

In this work, we demonstrate that diverse aromatic compounds can be selectively chlorinated through the fine-tuning of the reactivity of sulfuryl chloride (SOCl) by organocatalysts. Acetonitrile has been identified to activate SOCl most strongly, thus enabling even chlorination of -xylene with high yields. 1,4-Dioxane effects chlorination of oxidation-labile aromatic compounds such as -cresol and 2-naphthol with high yields, 95% and 85%, respectively.

Pulmonary delivery of favipiravir inhalation solution for COVID-19 treatment: characterization, stability, cytotoxicity, and antiviral activity using real time cell analysis.

Favipiravir, an RNA-dependent RNA polymerase (RdRp) inhibitor, is used to treat patients infected with influenza virus and most recently with SARS-CoV-2. However, poor accumulation of favipiravir in lung tissue following oral administration has required an alternative method of administration that directly targets the lungs. In this study, an inhalation solution of favipiravir at a concentration of 2 mg mL was developed and characterized for the first time.

and outer membrane vesicles.

is the causative agent of a respiratory infection called pertussis (whooping cough) that can be fatal in newborns and infants. The pathogen produces a variety of antigenic compounds which alone or simultaneously can damage various host cells. Despite the availability of pertussis vaccines and high vaccination coverage around the world, a resurgence of the disease has been observed in many countries.

Development of propolis and essential oils containing oral/throat spray formulation against SARS-CoV-2 infection.

A broad range of evidence has confirmed that natural products and essential oils might have the potential to suppress COVID-19 infection. Therefore, this study aimed to develop an oral/throat spray formulation for prophylactic use in the oral cavity or help treatment modalities. Based on a reference survey, several essential oils, a cold-pressed oil, and propolis were selected, and cytotoxicity and antiviral activity of each component and the developed spray formulation were examined against severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection using Vero E6 cells.