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PAT-12, a potential anti-nematode target, is a new spectraplakin partner essential for Caenorhabditis elegans hemidesmosome integrity and embryonic morphogenesis.
Dev Biol
February 2011
Research School of Biology, College of Medicine, Biology and Environment, Tthe Australian National University, Canberra, ACT, Australia.
Article Synopsis
- The embryonic elongation of Caenorhabditis elegans relies on interaction between epidermal and muscle cells, particularly through structures called fibrous organelles (FOs) that anchor muscles to the exoskeleton.
- Researchers identified a novel protein, T17H7.4, that interacts with the core hemidesmosome component VAB-10, suggesting its potential role in elongation processes.
- T17H7.4, linked to the uncharacterized gene pat-12, is crucial for hemidesmosome integrity, and pat-12 mutations disrupt this stability, highlighting its importance in muscle and epidermal cell interactions during development.