953 results match your criteria: "Tsukuba University[Affiliation]"

Pylephlebitis is a rare infection, characterized by non-specific symptoms such as abdominal pain, that often leads to delayed diagnosis, yet it is a severe infection with a high mortality rate. Imaging studies are essential for diagnosis, and contrast-enhanced abdominal CT and abdominal ultrasound are commonly performed. A 51-year-old male was admitted to the hospital with fever and shock.

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Background We aimed to investigate the association between protein intake and quadriceps quantity and quality on the paretic and non-paretic sides during rehabilitation in people with subacute stroke. Method Eighty-six people with stroke were recruited from a rehabilitation ward. We measured quadriceps muscle quantity and quality on the paretic and non-paretic sides using ultrasonography at admission and after 4weeks.

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Signal Transduction Mechanisms of Focal Adhesions: Src and FAK-Mediated Cell Response.

Front Biosci (Landmark Ed)

November 2024

Laboratory of Human Anatomy and Cell Biology, Faculty of Health Sciences, Tsukuba University of Technology, 305-8521 Tsukuba, Japan.

Cell-to-substrate adhesion sites, also known as focal adhesion sites (FAs), are complexes of different proteins on the cell surface. FAs play important roles in communication between cells and the extracellular matrix (ECM), leading to signal transduction involving different proteins that ultimately produce the cell response. This cell response involves cell adhesion, migration, motility, cell survival, and cell proliferation.

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A Misplaced S2 Alar-Iliac Screw Causing L5 Spinal Nerve Injury: A Report of a Rare Case.

Cureus

November 2024

Orthopaedic Surgery and Sports Medicine, Tsukuba University Hospital Mito Clinical Education and Training Center, Mito Kyodo General Hospital, Mito, JPN.

Although neurovascular structures, including the superior gluteal artery, sciatic nerve, obturator nerve, internal iliac vein and artery, and lumbosacral plexus, are at risk when S2 alar-iliac (S2AI) screws are used, no cases of nerve injuries have been reported. An 84-year-old man was referred to our institute with persistent left sciatica for seven months after undergoing salvage surgery using S2AI screws for deep surgical site infection from a previous posterior interbody fusion surgery at L5-S1. Based on the radiographic and diagnostic selective nerve root block findings, a diagnosis of left L5 radiculopathy was suspected due to the left S2AI screw being caudally misplaced and severely protruding into the pelvic cavity.

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Chemical form of volatilized iodine obtained from orchard grass (Dactylis glomerata L.).

Radiat Prot Dosimetry

November 2024

Department of Radioecology, Institute for Environmental Sciences, 1-7 Ienomae, Obuchi, Rokkasho, Kamikita, Aomori, 039-3212, Japan.

Japan's first commercial nuclear fuel reprocessing plant is expected to release radioiodine into the atmosphere, and orchard grass plants grown in the vicinity of this plant may absorb this radioiodine. In this study, we investigated the mechanism underlying the absorption and volatilization of iodine in the leaves of orchard grass. Our findings suggest that iodine can be transferred from the leaves of this grass to the atmosphere via two routes: direct volatilization and absorption followed by volatilization.

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We investigated the behavior of stable Cs+ ions contained in droplets applied directly on the leaf surfaces of plumleaf crab apple trees (2-3 years old Malus domestica 'Alps Otome') at three different fruit growing stages: before bearing fruit, early fruit development and late fruit development stages. Most of the Cs was rapidly transferred from the leaf surfaces into the applied leaves after application, and then gradually transferred to the fruit through the branches. The mean proportion of Cs transferred to fruit by harvest time ranged from 11 to 30% not directly depending on the fruit growing stages.

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Quasicrystals are solid-state materials that typically exhibit unique symmetries, such as icosahedral or decagonal diffraction symmetry. They were first discovered in 1984. Over the past four decades of quasicrystal research, around 100 stable quasicrystals have been discovered.

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Anaerobic digestate animal effluent (ADAE) contains high N and P nutrients which need to be treated. In this study, an integrated process was proposed using a microalgae consortium of Chlorella and Scenedesmus. The system was designed for 71 m/d (medium-sized) and 355 m/d (large-sized) animals of ADAE.

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Background: The current study aimed to evaluate the bone union rate between infected vertebrae after minimally invasive posterior fixation without bone grafting in thoracolumbar pyogenic spondylitis.

Methods: This retrospective multicenter cohort study evaluated 75 patients of posterior fixation for thoracolumbar pyogenic spondylitis that have been recorded at six relevant institutions from January 2016 to December 2022. Data on age, sex, location of infected vertebrae, number of infected disks, comorbidity, Pola classification, number of vertebrae fixed according to surgery, implant failure requiring revision surgery, and distance according to the type of infected vertebrae after surgery were evaluated.

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Focal Adhesion Kinase (FAK) and c-Src Dependent Signal Transduction in Cell Adhesion.

Discov Med

October 2024

Laboratory of Human Anatomy and Cell Biology, Faculty of Health Sciences, Tsukuba University of Technology, 305-8521 Tsukuba, Japan.

This review predominantly acquaints the role of focal adhesion kinase (FAK) and cellular-Src (c-Src) in cell adhesion. Cell adhesion is a crucial phenomenon that causes the cells to interact with the extracellular matrix (ECM) or with each other. There are different proteins involved in cell adhesion including cell adhesion molecules (CAMs)/receptors that are present on the cell surface and various cytoplasmic proteins.

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Purpose: A standard 6-12-week course of antibiotics is recommended for pyogenic spondylitis. Recent evidence supports early minimally invasive posterior fixation surgery; however, its effect on antibiotic treatment duration is unclear. This study aims to identify factors associated with prolonged antibiotic treatment in thoracolumbar pyogenic spondylitis patients resistant to conservative treatment and assess whether early surgery can reduce treatment duration.

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Objectives: To examine the effects of distractor sounds presented to the contralateral ear on speech intelligibility in patients with listening difficulties without apparent peripheral pathology and in control participants.

Design: This study examined and analyzed 15 control participants (age range, 22 to 30 years) without any complaints of listening difficulties and 15 patients (age range, 15 to 33 years) diagnosed as having listening difficulties without apparent peripheral pathology in the outpatient clinic of the Department of Otolaryngology-Head and Neck Surgery, Tohoku University Hospital. Speech intelligibility for 50 Japanese monosyllables presented to the right ear was examined under the following three different conditions: "without contralateral sound," "with continuous white noise in the contralateral ear," and "with music stimuli in the contralateral ear.

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Article Synopsis
  • The study aimed to investigate how the frequency and duration of physical therapy (PT) impact hospitalization-associated disability (HAD) in elderly patients with heart failure (HF).
  • It involved analyzing data from hospitalized patients aged 65 and older who received PT, categorizing them into three groups based on their PT frequency and duration.
  • Results indicated that patients with lower frequency and shorter duration of PT faced a significantly higher risk of developing HAD, suggesting that more intensive therapy could help mitigate this risk.
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Purpose: The effect of increased physical activity duration on functional recovery in older inpatients in subacute settings is not well established. This study aimed to investigate the relationship between physical activity and functional recovery in older patients receiving post-acute and subacute care.

Methods: We analyzed cohort data of hospitalized older patients (age ≥ 65 years) in the post-acute rehabilitation units.

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Purpose: This study aimed to evaluate the difference in treatment duration and unplanned additional surgeries between patients with unidentified causative organisms on empiric antibiotics and those with identified organisms on selective antibiotics in treating thoracolumbar pyogenic spondylitis with minimally invasive posterior fixation.

Methods: This multicenter retrospective cohort study included patients with thoracolumbar pyogenic spondylitis refractory to conservative treatment who underwent minimally invasive posterior fixation. Patients were divided into the identified (known causative organism) and unidentified groups (unknown causative organism).

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Purpose: This study aimed to clarify surgical complications associated with open surgery for congenital diaphragmatic hernia (CDH).

Methods: We performed an exploratory data analysis of the clinical characteristics of surgical complications of neonates with CDH who underwent laparotomy or thoracotomy between 2006 and 2021. Data of these patients were obtained from the database of the Japanese CDH Study Group.

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Background: Older adults requiring care often have multiple morbidities that lead to polypharmacy, including the use of potentially inappropriate medications (PIMs), leading to increased medical costs and adverse drug effects. We conducted a cross-sectional study to clarify the actual state of drug prescriptions and the background of polypharmacy and PIMs.

Methods: Using long-term care (LTC) and medical insurance claims data in the Ibaraki Prefecture from April 2018 to March 2019, we included individuals aged ≥ 65 who used LTC services.

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Insulinoma presenting with anti-insulin antibodies.

Endocrinol Diabetes Metab Case Rep

July 2024

Department of Endocrinology and Metabolism, Tsukuba University Hospital Mito Clinical Education and Training Center, Mito Kyodo General Hospital, Mito, Ibaraki, Japan.

Summary: An 89-year-old woman presented with a 6-year history of occasional episodes of impaired consciousness that were relieved by ingestion of a snack. Three months before presenting to our hospital, she had been hospitalized in a local hospital with subdural hematoma caused by a head contusion, where previously unrecognized hypoglycemia was discovered. Fasting plasma glucose concentration was 37 mg/dL, with a relatively high serum level of insulin (34.

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The Fukushima Daiichi Nuclear Power Plant accident released considerable radionuclides into the environment. Radioactive particles, composed mainly of SiO, emerged as distinctive features, revealing insights into the accident's dynamics. While studies extensively focused on high-volatile radionuclides like Cs, investigations into low-volatile nuclides such as Sr and Pu remain limited.

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Study Design: A post-hoc analysis of a prospective cohort study.

Purpose: This study aimed to identify factors at the time of injury associated with declining activities of daily living (ADLs) in the chronic phase of osteoporotic vertebral fractures (OVFs) managed conservatively.

Overview Of Literature: Although a conservative approach is the treatment of choice for OVFs, ADLs do not improve or eventually decrease in some cases.

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Postoperative surgical site infection in the lumbar spine is one of the serious complications that sometimes results in death. Herein, we describe a case in which a patient was found to have coagulopathy due to vitamin K deficiency when he was transferred to a hospital for treatment for a postoperative infection of the lumbar spine. The coagulation disorder was caused by antimicrobial agents administered to the patient, who was suffering from hyponutrition.

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Article Synopsis
  • The study evaluated a new device called the Stabilizer, designed to enhance the safety and efficacy of neuroendovascular procedures that require exchanging medical instruments, which can be risky due to potential vessel injury.! -
  • Conducted across nine centers in Japan, the trial involved 31 patients with conditions like intracranial aneurysms and artery stenosis, with the Stabilizer achieving a 100% technical success rate and no device-related complications.! -
  • The findings of this first multicenter trial underscore the Stabilizer's potential as a reliable tool in managing complex neuroendovascular cases where traditional exchange methods might pose challenges.!
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Article Synopsis
  • This study assesses the effectiveness of stereotactic radiosurgery (SRS) for treating vestibular schwannomas (VS) in patients aged 75 and older, highlighting concerns about severe facial palsy in this age group after surgery.* -
  • A total of 156 patients aged 65 and older underwent gamma knife SRS, with the outcomes compared between those ≥75 years (35 patients) and those aged 65-74 years (121 patients), revealing high tumor control rates in both groups.* -
  • The findings suggest that SRS is a safe and effective treatment for VS in late elderly patients, with no adverse effects observed, and it offers advantages in preserving facial nerve function compared to surgical removal.*
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The pathology of idiopathic intracranial hypertension (IIH), a disease characterized by papillary edema and increased intracranial pressure (IICP), is not yet understood; this disease significantly affects quality of life due to symptoms including vision loss, headache, and pulsatile tinnitus. By contrast, superficial siderosis (SS), a disorder in which hemosiderin is deposited on the surface of the cerebral cortex and cerebellum, potentially causes cerebellar ataxia or hearing loss. So far, no cases of IIH with infratentorial and supratentorial cortical SS have been reported.

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