Immunological characteristics of peripheral T cells as prognostic markers for Camrelizumab and Apatinib combination therapy in advanced squamous non-small-cell lung cancer.

Purpose: To determine the characteristic changes of peripheral blood T cells and identify potential biomarkers that associated with the clinical efficacy of combined immunotherapy and anti-angiogenic therapy in patients with advanced squamous non-small cell lung cancer (NSCLC).

Methods: We performed a comprehensive immunological assessment of peripheral blood mononuclear cell samples from advanced squamous NSCLC patients before and after combination of immunotherapy (Camrelizumab) and anti-angiogenic therapy (Apatinib) using spectral flow cytometry. Correlations between these immunological features and clinical efficacy were analyzed.

Enhancing Diagnostic Accuracy of Lung Nodules in Chest Computed Tomography Using Artificial Intelligence: Retrospective Analysis.

Background: Uncertainty in the diagnosis of lung nodules is a challenge for both patients and physicians. Artificial intelligence (AI) systems are increasingly being integrated into medical imaging to assist diagnostic procedures. However, the accuracy of AI systems in identifying and measuring lung nodules on chest computed tomography (CT) scans remains unclear, which requires further evaluation.

Geospatial and econometric approaches or older driver safety: Analysis of crash injury severity of regional highways.

This study tried to focus on the older drivers' group and explore the impact factors of injury severity involving older drivers from geo-spatial analysis. To reach the goal, a spatial analysis was proposed employing geographic information systems (GIS) with a case study application to two counties in Nevada. First, crash clusters were explored using Density-Based Spatial Clustering of Applications with Noise (DBSCAN) approach to investigate the spatial crash pattern for older drivers, and determine high risk locations of injury severity.

Forensic Assessment of Kinship, Genomic Ancestry, and Natural History of an Iconic Tiger of Harlem-New York City.

In the fall of 2003, a two-year-old tiger named Ming, weighing some four hundred pounds, was discovered living in an apartment in Harlem, New York. Ming's rescue by NYPD was witnessed, recalled, and venerated by scores of neighbors. The tiger's history and ancestry stimulated considerable media interest, investigative sleuthing, and forensic genomic analyses.

Proximity-activated guide RNA of CRISPR-Cas12a for programmable diagnostic detection and gene regulation.

The flexibility and programmability of CRISPR-Cas technology have made it one of the most popular tools for biomarker diagnostics and gene regulation. Especially, the CRISPR-Cas12 system has shown exceptional clinical diagnosis and gene editing capabilities. Here, we discovered that although the top loop of the 5' handle of guide RNA can undergo central splitting, deactivating CRISPR-Cas12a, the segments can dramatically restore CRISPR function through nucleic acid self-assembly or interactions with small molecules and aptamers.

Irregular Pulse and Cardiovascular Disease From NHANES (1999-2018): A Cross-Sectional Study.

Background And Aims: Pulse is an easily accessible life sign, while irregular pulse could be easily detected in daily life during blood pressure test. However, whether irregular pulse was associated with cardiovascular disease (CVD) or mortality has not been reported on a large population scale. Here, we investigated the association between irregular pulse, CVD, and CVD mortality, to explore the potential of irregular pulse as screening indicator for CVD and mortality, thus influencing health policy.

Utilization of Cardiac Magnetic Resonance Imaging for Assessing Myocardial Fibrosis in Prognosis Evaluation and Risk Stratification of Patients with Dilated Cardiomyopathy.

Dilated cardiomyopathy (DCM) is the ultimate manifestation of the myocardial response to various genetic and environmental changes and is characterized mainly by impaired left ventricular systolic and diastolic function. DCM can ultimately lead to heart failure, ventricular arrhythmia (VA), and sudden cardiac death (SCD), making it a primary indication for heart transplantation. With advancements in modern medicine, several novel techniques for evaluating myocardial involvement and disease severity from diverse perspectives have been developed.

A motion-responsive injectable lubricative hydrogel for efficient Achilles tendon adhesion prevention.

Achilles tendon is a motor organ that is prone to tissue adhesion during its repair process after rupture. Therefore, developing motion-responsive and anti-adhesive biomaterials is an important need for the repair of Achilles tendon rupture. Here, we report an injectable lubricative hydrogel (ILH) based on hydration lubrication mechanism, which is also motion-responsive based on sol-gel reversible transmission.

Investigation of Biocrude Production from Spirulina via Catalytic Hydrothermal Liquefaction with the Ru/ZrO-SiO Catalyst.

Hydrothermal liquefaction (HTL) is a promising technology for converting wet biomass to liquid fuels. However, the biocrude yield and quality in this process are unsatisfactory without catalysts. Herein, a Ru/ZrO-SiO catalyst was prepared with the NaBH reducing method for the HTL of .

An ictogenic marker in the mesial temporal epilepsy and its temporal evolutionary features.

Objective: To observe and measure the morphological and temporal evolutionary features of the hypersynchronous (HYP) pattern in the mesial temporal seizure.

Methods: The HYP patterns during preictal and interictal states of 16 mesial temporal epileptic patients were analyzed. The wave components of the HYP transients were firstly observed and measured.

City-level estimation of vehicle CO emission factors regarding driving behaviors: The case of Tianjin, China.

The estimation of CO emission factors (EFs) is a key step in calculating automobile CO emissions. However, city-level research on the integrated estimation of vehicle CO EFs under real conditions is insufficient. To enrich the research methods of city-level vehicle CO EFs, this paper constructs a vehicle-road-driver three-layer regression model and estimates vehicle CO EFs empirical parameters for Tianjin.

Elucidating genetic intersections: Co-differentially expressed genes in myasthenia gravis and idiopathic inflammatory myopathies and their role in comorbid pathogenesis.

Background: Myasthenia gravis (MG) and idiopathic inflammatory myopathies (IIM) are autoimmune disorders that can co-occur, complicating diagnosis and treatment. The molecular mechanisms underlying this comorbidity are not well understood.

Objective: This study aims to identify common differentially expressed genes (co-DEGs) between MG and IIM to elucidate shared pathogenic pathways and potential therapeutic targets.

Isolated Metal Centers Activate Small Molecule Electrooxidation: Mechanisms and Applications.

Electrochemical oxidation of small molecules shows great promise to substitute oxygen evolution reaction (OER) or hydrogen oxidation reaction (HOR) to enhance reaction kinetics and reduce energy consumption, as well as produce high-valued chemicals or serve as fuels. For these oxidation reactions, high-valence metal sites generated at oxidative potentials are typically considered as active sites to trigger the oxidation process of small molecules. Isolated atom site catalysts (IASCs) have been developed as an ideal system to precisely regulate the oxidation state and coordination environment of single-metal centers, and thus optimize their catalytic property.

Influence of Free Space on Lithium Growth Behavior at Open Surfaces and Internal Cracks of Sulfide-Based Solid Electrolyte.

Lithium dendrite penetration through solid electrolyte has been the major obstacle for practical sulfide-based all-solid-state lithium metal batteries (ASSLMBs). Herein, a series of tailored model solid cells are designed to investigate the intrinsic lithium growth behavior at open surfaces and internal cracks of sulfide solid electrolyte. It is shown that when plating lithium on the open surface of electrolyte (free space), the lithium exhibits an intrinsic columnar growth behavior perpendicular to the electrolyte surface, preferentially along the (110) crystal axis.

Microfluidic-Enabled Self-Directed Hydrogel Microspheres for Multiplexed MicroRNA Assays.

Multiplexed microRNA (miRNA) detection has proven valuable in disease diagnosis; yet, the development of advanced tools for their analysis remains a subject of broad interest. Here, we propose a novel single-particle method for multiplexed miRNA detection using self-directed hydrogel microspheres, which feature supersegmented compartments for loading analyte probes and an air-encapsulated region that grants the microsphere a unique preferred posture in aqueous solutions. By exploiting microfluidic technology, we can widely adjust the size of the microspheres and the number of compartments can be widely adjusted.

Chain-mediated effect of physical activity between Chinese language-based L2 motivational self-system and intended effort.

The L2 Motivational Self System (L2MSS) determines an individual's motivation in second language learning and influences the learning experience and intended effort. Although physical activity (PA) has been shown to enhance academic efficacy, the role of PA in whether it promotes second language learning efficacy has not been elucidated. Therefore, the present study examined PA as a mediator and explored its ameliorative effects in L2MSS.

Modulation of Co spin state at CoO crystalline-amorphous interfaces for CO oxidation and NO decomposition.

Modulation of electronic spin states in cobalt-based catalysts is an effective strategy for molecule activations. Crystalline-amorphous interfaces often exhibit unique catalytic properties due to disruptions of long-range order and alterations in electronic structure. However, the mechanisms of molecule activation and spin states at interfaces remain elusive.

A principle-based framework to determine countries' fair warming contributions to the Paris Agreement.

Equity is a cornerstone of global climate policy, yet differing perspectives mean that international agreement on how to allocate mitigation efforts remains elusive. A rich literature informs this question, but a gap remains in approaches that appropriately consider non-CO emissions and their warming contributions. In this study, we address this gap and define a global warming budget applicable to all anthropogenic greenhouse gases that is allocated to countries based on principles drawn from international treaties and environmental law.

Research of Orthodontic Soft Tissue Profile Prediction Based on Conditional Generative Adversarial Networks.

Objective: This study constructed a new conditional generative adversarial network (CGAN) model to predict changes in lateral appearance following orthodontic treatment.

Methods: Lateral cephalometric radiographs of adult patients were obtained before (T1) and after (T2) orthodontic treatment. The expanded dataset was divided into training, validation, and test sets by random sampling in a ratio of 8:1:1.

Neuroimaging features for cognitive fatigue and its recovery with VR intervention: An EEG microstates analysis.

Introduction: Cognitive fatigue is mainly caused by enduring mental stress or monotonous work, impairing cognitive and physical performance. Natural scene exposure is a promising intervention for relieving cognitive fatigue, but the efficacy of virtual reality (VR) simulated natural scene exposure is unclear. We aimed to investigate the effect of VR natural scene on cognitive fatigue and further explored its underlying neurophysiological alterations with electroencephalogram (EEG) microstates analysis.

OCDet: A comprehensive ovarian cell detection model with channel attention on immunohistochemical and morphological pathology images.

Background: Ovarian cancer is among the most lethal gynecologic malignancy that threatens women's lives. Pathological diagnosis is a key tool for early detection and diagnosis of ovarian cancer, guiding treatment strategies. The evaluation of various ovarian cancer-related cells, based on morphological and immunohistochemical pathology images, is deemed an important step.

Highly efficient recovery of total components from spent hydroprocessing catalysts (HPCs) with minimal CO & SO emissions.

It is imperative to recover the valuable components of spent HPCs. We have proposed a hydrometallurgical process and recovered 99.9% of V, 99.

Fast optimization of the emission reduction pathways of major air pollutants in China: From the perspective of different decision preferences.

To address the concern of optimization problem of China's PM control and the limitation of computational efficiencies for traditional air quality models, we developed an integrated analysis framework to efficiently establish the identification and cost-benefit assessment of PM control pathways in China by constructing a rapid PM exposure response method based on the high-order decoupled direct method (HDDM) and coupling the sequential least square algorithm (SLSQP) and health impact assessment model. Six emission reduction scenarios with varying decision preferences were analyzed. Our study provides a methodological approach for the rapid optimization of emission pathways of major air pollutants in China with flexible options in terms of objectives and constraints, fully considering the diverse differences in environmental, health, and economic impacts among different pollution sources simultaneously.

[Expert consensus on visualized tele-round and quality control management based on the improvement of clinical practice ability].

Turning to critical illness is a common stage of various diseases and injuries before death. Patients usually have complex health conditions, while the treatment process involves a wide range of content, along with high requirements for doctor's professionalism and multi-specialty teamwork, as well as a great demand for time-sensitive treatments. However, this is not matched with critical care professionals and the current state of medical care in China.

Topologically constrained DNA-mediated one-pot CRISPR assay for rapid detection of viral RNA with single nucleotide resolution.

Background: The widespread and evolution of RNA viruses, such as the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), highlights the importance of fast identification of virus subtypes, particularly in non-laboratory settings. Rapid and inexpensive at-home testing of viral nucleic acids with single-base resolution remains a challenge.

Methods: Topologically constrained DNA ring is engineered as substrates for the trans-cleavage of Cas13a to yield an accelerated post isothermal amplification.