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CIG-P: Circular Interaction Graph for Proteomics.

BMC Bioinformatics

October 2014

Applied Research Lab, Faculty of Natural and Applied Sciences, Trinity Western University Canada, Langley, BC, Canada.

Background: A typical affinity purification coupled to mass spectrometry (AP-MS) experiment includes the purification of a target protein (bait) using an antibody and subsequent mass spectrometry analysis of all proteins co-purifying with the bait (aka prey proteins). Like any other systems biology approach, AP-MS experiments generate a lot of data and visualization has been challenging, especially when integrating AP-MS experiments with orthogonal datasets.

Results: We present Circular Interaction Graph for Proteomics (CIG-P), which generates circular diagrams for visually appealing final representation of AP-MS data.

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