241 results match your criteria: "Trichilemmoma"
Collision of Basal Cell Carcinoma with Apocrine-Sebaceous-Follicular Unit Neoplasms.
Dermatopathology (Basel)
October 2024
Dermatology Department, Doctor Jose Molina Orosa Hospital of Lanzarote, 35500 Arrecife, Spain.
Article Synopsis
- Tumor collisions, a rare occurrence with a 0.0017% incidence rate, often involve seborrheic keratosis, melanocytic nevi, and basal cell carcinoma (BCC), and are generally considered incidental events.
- A retrospective study was conducted analyzing hospital records to identify collisions between BCCs or squamous cell carcinoma (SCC) and apocrine-sebaceous-follicular unit (ASFu) neoplasms from 2005 to 2017.
- The study identified 12 collision cases involving BCC and ASFu tumors, primarily in immunosuppressed patients, with many neoplasms located beneath the BCC, leading to new insights and hypotheses about these tumor interactions
A Conspicuous Nodule Over the Scalp: A Case Report.
Cureus
October 2024
Department of Dermatology, Venereology and Leprology, N.K.P Salve Institute of Medical Sciences and Research Centre and Lata Mangeshkar Hospital, Nagpur, IND.
Article Synopsis
- Trichilemmomas are rare, benign tumors that develop from hair follicles and appear as warty nodules made up of clear and intermediate cells.
- A 34-year-old Indian man's scalp lesion was initially misdiagnosed as a pyogenic granuloma due to its bleeding tendency.
- After surgical removal and histopathological analysis confirmed it as a trichilemmoma, the patient has been monitored for six months without any recurrence.
[Thyroid cancer in a child with Cowden syndrome].
Probl Endokrinol (Mosk)
November 2024
Izhevsk State Medical Academy.
Article Synopsis
- - Cowden syndrome, caused by mutations in the PTEN gene, increases the risk of various tumors due to disrupted cell cycle regulation, leading to unchecked cell growth throughout a person's life.
- - A clinical case presented discusses a 7-year-old patient with typical features of Cowden syndrome, including macrocephaly and skin manifestations like trichilemmomas and keratosis, alongside benign and malignant tumors.
- - Common malignancies associated with Cowden syndrome are breast, thyroid, colorectal, renal cell, and endometrial cancers, with thyroid cancer often developing early in childhood, necessitating regular screenings for affected individuals.
Cowden Syndrome: A Rare Cause of Intestinal Polyposis.
Cureus
July 2024
Department of Pediatrics, Salmaniya Medical Complex, Manama, BHR.
Article Synopsis
- - Cowden syndrome (CS) is a rare genetic disorder that leads to multiple hamartomata lesions from all embryonic layers, primarily affecting the gastrointestinal system and leading to an increased risk of certain cancers, including thyroid and breast cancer.
- - The initial symptoms of CS typically include mucocutaneous issues like trichilemmomas and oral papillomas, making early diagnosis and management crucial for improving patient outcomes.
- - A case study is presented involving a Bahraini child with macrocephaly and extensive intestinal polyposis, with genetic testing confirming CS through a pathogenic variant in the PTEN gene.
Report of Basal Cell Carcinoma Occurring With a Desmoplastic Trichilemmoma Successfully Treated With Mohs Micrographic Surgery.
Cureus
June 2024
Department of Dermatology, Baylor College of Medicine, Houston, USA.
Article Synopsis
- Desmoplastic trichilemmoma is a rare, benign skin tumor that arises from hair follicle cells and can be associated with basal cell carcinoma.
- A 67-year-old woman visited a dermatology clinic with a scalp lesion, which was biopsied to check for cancer.
- The biopsy indicated desmoplastic trichilemmoma but also found superficial basal cell carcinoma upon further analysis, highlighting the importance of thorough surgical removal for accurate diagnosis.
Pathological, histochemical, and immune-histochemical studies on some canine-skin neoplasm at Sharkia province, Egypt.
Open Vet J
January 2024
Department of Pathology, Faculty of Veterinary Medicine, Zagazig University, Zagazig, Egypt.
Article Synopsis
- The study investigates skin tumors in dogs, focusing on their clinical, pathological, and immunohistochemical characteristics, conducted at Zagazig University's veterinary clinic from March 2022 to October 2023.
- A total of 25 dogs with skin swelling were analyzed, revealing that 65.52% of the tumors were malignant, with malignant melanomas being the most common at 17.24%.
- The research highlights the prevalence of various skin neoplasias in dogs, identifying multiple types of tumors while noting that benign tumors were less frequent.
Utilizing PTEN immunohistochemistry as a screening test for Cowden syndrome.
Am J Clin Pathol
May 2024
Department of Pathology, Massachusetts General Hospital, Boston, MA, US.
Article Synopsis
- Cowden syndrome (CS) is a serious condition that increases the risk of certain cancers, and this study looks at using a specific test called PTEN immunostain to help screen for it.
- Researchers examined patients from 2008 to 2022 to find out how well the PTEN test could identify tumors linked to CS compared to other tumors.
- The results showed that the PTEN test worked really well, picking up 96% of CS-related tumors and being accurate enough to be a good screening tool for detecting Cowden syndrome.
Nectin-4 expression in a subset of cutaneous adnexal carcinomas: A potential target for therapy with enfortumab vedotin.
J Cutan Pathol
May 2024
Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
Article Synopsis
- Enfortumab vedotin (EV) is a targeted therapy for urothelial carcinoma, and this study evaluates its effectiveness for treating certain skin tumors by assessing Nectin-4 expression.
- Researchers analyzed various skin adnexal carcinomas and benign tumors through immunohistochemical staining, finding that malignant tumors had significantly higher Nectin-4 expression than benign ones.
- The study concludes that since many cutaneous adnexal carcinomas, particularly sebaceous carcinomas, exhibit high Nectin-4 levels, EV could be a viable treatment option for these cancers.
Orofacial Manifestations in a Middle-Aged Woman with Cowden Syndrome: A Case Image.
Head Neck Pathol
December 2023
Department of Oral Diagnosis and Pathology, School of Dentistry, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.
Article Synopsis
- * Biopsies revealed specific cellular changes in both oral and skin lesions, consistent with trichilemmoma and fibroepithelial hyperplasia.
- * The case is an example of Cowden syndrome, a rare genetic disorder affecting multiple body systems, particularly involving the mouth and skin, with fewer than 40 documented cases in middle-aged adults.
Pigmented Desmoplastic Trichilemmoma Arising in Nevus Sebaceous: A Potential Mimicker of Pigmented Basal Cell Carcinoma.
Skin Appendage Disord
August 2023
College of medicine, Qassim University, Buraydah, Saudi Arabia.
Article Synopsis
- Trichilemmomas are benign skin tumors that originate from the outer sheath of hair follicles, while nevus sebaceous (NS) is a congenital skin abnormality that can lead to the development of other skin growths, both benign and sometimes malignant.
- A case involving a 36-year-old male showed a pigmented desmoplastic trichilemmoma (DT) that appeared similar to a pigmented basal cell carcinoma (BCC) and was successfully removed.
- It’s important to conduct a histological evaluation to differentiate between pigmented DT and BCC, as they can look alike in clinical examinations.
A young female of Cowden syndrome presenting with Lhermitte-Duclos disease: An illustrative case.
Surg Neurol Int
August 2023
Department of Neurosurgery, Dhaka Medical College Hospital, Dhaka, Bangladesh.
Article Synopsis
- Lhermitte-Duclos Disease (LDD) is a benign brain condition linked to Cowden syndrome (CS), which is caused by mutations in the PTEN gene and is associated with tumor growth.
- A case study describes a young woman who experienced severe headaches, vertigo, and other symptoms. After imaging revealed a lesion in her brain, she underwent surgery, which led to recovery and a diagnosis of LDD.
- Due to the lack of genetic testing in her country, a clinical scoring system indicated a high likelihood of a PTEN mutation, allowing for family counseling and necessary future monitoring for potential cancer development.
Epidermodysplasia Verruciformis: A Study of Clinicopathologic Features, Biomarkers, and Associated Malignancies in Indian Patients.
Am J Dermatopathol
September 2023
Department of Dermatology, St. John's Medical College and Hospital, Bangalore, Karnataka, India.
Article Synopsis
- Epidermodysplasia verruciformis (EDV) is a rare skin condition linked to human papilloma virus (HPV), which can develop into cancer, and its diagnosis may benefit from new biomarkers to differentiate it from similar conditions.
- A study examining 20 EDV cases revealed a male predominance, with patients aged 6 to 52, many showing common skin symptoms like hypopigmented papules; some tested positive for immunosuppression or had a family history of skin issues.
- The research noted that despite clear signs of keratinocyte abnormalities, these changes were often subtle, and using biomarkers like p16 and Ki67 could enhance diagnosis in cases where typical histopathological features are not evident
Expression of Ber-EP4 and CD34 can distinguish clear-cell basal cell carcinoma from trichilemmoma: A case series.
Indian J Dermatol Venereol Leprol
January 2024
Department of Dermatology, Veteran Affairs Hospital Mather & University of California Davis, Mather, CA, United States.
Expression of BerEP4 and CD10 IHC Markers in Basal Cell Carcinoma, Squamous Cell Carcinoma and Adnexal Tumours of Follicular Differentiation: A Comparative Study.
Indian J Dermatol
January 2023
From the Department of Pathology, Government Medical College, Trivandrum, Kerala, India.
Article Synopsis
- - Basal cell carcinoma (BCC) is the most common skin cancer and can often be identified by its unique histological features, with CD10 and BerEP4 used as helpful markers for differentiation from similar cancers like squamous cell carcinoma (SqCC) and certain follicular tumors.
- - A study involving 28 BCC cases, 34 SqCC cases, and 16 adnexal tumors assessed the expression of CD10 and BerEP4, revealing all BCC samples tested positive for both markers while SqCC samples showed no positivity.
- - The findings confirm that BerEP4 reliably identifies BCC and differentiates it from SqCC; however, it struggles with some adnexal tumors, and CD10 serves as an
A Case of Cowden Syndrome Presenting with Diverse Cutaneous Manifestations.
Ann Dermatol
April 2023
Department of Dermatology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
Article Synopsis
- * Key skin features include various lesions like trichilemmomas and oral papillomas, along with an elevated risk for several cancers, particularly breast and thyroid.
- * Early diagnosis and ongoing monitoring are crucial for managing the increased cancer risk in Cowden syndrome patients, as illustrated by a reported case involving skin manifestations and thyroid cancer.
PTEN hamartoma tumour syndrome: case report based on data from the Iranian hereditary colorectal cancer registry and literature review.
Diagn Pathol
April 2023
Pharmaceutical Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
Article Synopsis
- PTEN hamartoma tumor syndrome (PHTS) is a rare genetic disorder linked to mutations in the PTEN gene, often resulting in multiple gastrointestinal polyps and a family history of certain cancers.
- A case study of a 39-year-old Iranian woman revealed over 20 rectosigmoid polyps, leading to a genetic evaluation that confirmed PHTS despite a lack of typical physical symptoms.
- A literature review identified 43 PHTS cases, highlighting common signs such as breast, thyroid, and endometrial cancers, as well as the presence of specific skin lesions, emphasizing the need for thorough investigation in patients with multiple polyps.
Treatment of Trichilemmomas With Topical Sirolimus.
JAMA Dermatol
March 2023
Department of Dermatology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma.
Use of Cytokeratin 17 in the Differentiation Between Desmoplastic Trichilemmoma and Cutaneous Basal Cell Carcinoma.
Am J Dermatopathol
December 2022
Dermatopathology Unit, Department of Pathology, Massachusetts General Hospital, Boston, MA.
Article Synopsis
- - Desmoplastic trichilemmoma (DTL) is a benign skin tumor that can resemble invasive basal cell carcinoma (BCC) due to its dense stroma and tumor cell arrangement, making diagnosis challenging, especially in small biopsies.
- - The study investigated the role of cytokeratin 17 (CK17) as a marker to differentiate DTL from BCC, with findings showing that BCC consistently exhibited strong CK17 staining compared to DTL.
- - Results indicated that while all BCC cases scored high for CK17, only 18% of DTL cases did, suggesting CK17 expression is a valuable tool for distinguishing between these two types of skin lesions in diagnostic settings.
Neurofibroma Within a Nevus Sebaceus: A Case Report.
Cureus
August 2022
Department of Dermatology, Texas Tech University Health Sciences Center, Lubbock, USA.
Article Synopsis
- - Nevus sebaceus is typically a yellow, hairless patch on the head or neck in children that can change to a warty appearance during puberty.
- - It can lead to secondary tumors, including rare types from mesenchymal origin.
- - A unique case detailed the removal of a nevus sebaceus from a patient's scalp, revealing a desmoplastic trichilemmoma and a neurofibroma, marking an unusual incidence of these tumors associated with nevus sebaceus.
Article Synopsis
- - This study aimed to explore the characteristics of tumors that develop secondary to nevus sebaceus (NS) by analyzing patient data from two hospitals in China and reviewing existing literature.
- - A total of 497 cases were assessed, revealing that 90.3% were benign tumors, with syringocystadenoma papilliferum being the most prevalent, while basal cell carcinoma was the most common malignant tumor.
- - The research highlights notable racial differences in the age of onset of secondary malignancies, indicating potential healthcare disparities among Caucasians, Hispanics, and Asians.
Recurrent PTPN14 Mutations in Trichilemmoma: Evidence for Distinct Pathways of Molecular Pathogenesis.
Am J Dermatopathol
August 2022
Assistant Professor, Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA.
Article Synopsis
- Trichilemmoma is a benign skin tumor linked to the outer root sheath of hair follicles, occurring either sporadically or associated with Cowden syndrome due to PTEN gene mutations.
- A recent study analyzed 9 sporadic trichilemmoma cases, finding that 78% had HRAS mutations, while 44% also showed recurrent mutations in the PTPN14 gene.
- The findings suggest that sporadic trichilemmomas may develop through at least three different genetic pathways, highlighting the potential importance of PTPN14 in their growth and development.
The PTEN hamartoma tumor syndrome: how oral clinicians may save lives.
Clin Adv Periodontics
March 2023
Western Norway Familial Cancer Center, Department of Medical Genetics, Haukeland University Hospital, Bergen, Norway.
Article Synopsis
- * A case study involving a father and his three children revealed common symptoms, including gingival overgrowth and macrocephaly, along with challenging periodontal issues that required surgical treatment but often recurred.
- * It's essential for oral health professionals to recognize the signs of PHTS and refer patients for genetic consultations, as ongoing management and monitoring of oral health are necessary due to the potential for benign or malignant changes.
Development of seven secondary neoplasms in a nevus sebaceous: a case report and literature review.
Arch Craniofac Surg
April 2022
International Aesthetic Medical Center, E-Da Dachang Hospital, Kaohsiung, Taiwan.
Article Synopsis
- Nevus sebaceous of Jadassohn is a congenital skin growth present at birth that contains various skin structures and can develop into different types of tumors as the person ages.
- The risk of developing secondary tumors increases with age, with rare instances of having more than five tumors arise from the same lesion.
- This report details a unique case where seven tumors, including different types of skin neoplasms, were found in one nevus sebaceous, highlighting the need for thorough biopsies for accurate diagnosis.