Awareness among parents of individuals with intellectual disability about sexual health education.

Background: Most of the parents have no idea that how and when they should educate about sexual health to their typically growing children. It is important for parents to educate their children with intellectual disability about sexual health. The risk of sexual exploitation and abuse is very high in individuals with intellectual disability.

Investigation of Functionally Graded Adherents on Failure of Socket Joint of FRP Composite Tubes.

Fiber-reinforced polymer (FRP) matrix materials are quickly being investigated for application in concrete construction repair, reinforcement, and refurbishment. The technology has progressed to the point that its future acceptance is mainly reliant on the availability of established design guidelines based on recognized performance criteria, as well as the cost competitiveness of these technologies in contrast to conventional rehabilitation methods. The goal of this study is to evaluate the different functional grades of adhesives throughout bond length for bonded socket joints of laminated FRP composite pipes.

Impact of resistance training on muscle fatigue in type 2 diabetes mellitus patients during dynamic fatigue protocol.

Background: Type 2 diabetes mellitus (T2DM) is often accompanied with several neuromuscular complications of which muscle fatigue is one of the scantily studied and less-explored complication of this disease.

Objective: To investigate the effects of resistance training (RT) on muscle fatigue markers from electromyography (EMG) and capillary blood in T2DM patients.

Methods: Forty T2DM patients were randomized to either RT (n = 20) or control group (n = 20).

Non-bonding energy directed designing of HDAC2 inhibitors through molecular dynamics simulation.

Designing an inhibitor having strong affinity in the active site pocket is the cherished goal of structure based drug designing. To achieve this, it is considerably important to predict which structural scaffold is better suited for change to increase affinity. We have explored five HDAC2 co-crystals having PDB ligand code- (vorinostat), , , (BRD4884) and (BRD7232).

A Rare Case of Gastrointestinal Mucormycosis.

Gastrointestinal Mucormycosis (GIM) is a rare life-threatening angio-invasive infection. The classic risk factors include immunosuppression and metabolic derangement. Usually, there are classical risk factors in patients affected by Ileocecal mucormycosis.

Experimental Investigation and Optimization of Electric Discharge Machining Process Parameters Using Grey-Fuzzy-Based Hybrid Techniques.

Electrical discharge machining (EDM) has recently been shown to be one of the most successful unconventional machining methods for meeting the requirements of today's manufacturing sector by producing complicated curved geometries in a broad variety of contemporary engineering materials. The machining efficiency of an EDM process during hexagonal hole formation on pearlitic Spheroidal Graphite (SG) iron 450/12 grade material was examined in this study utilizing peak current (I), pulse-on time (T), and inter-electrode gap (IEG) as input parameters. The responses, on the other hand, were the material removal rate (MRR) and overcut.

Injectable, Self-Healing, and Biocompatible ,-Carboxymethyl Chitosan/Multialdehyde Guar Gum Hydrogels for Sustained Anticancer Drug Delivery.

Local delivery of anticancer agents via injectable hydrogels could be a promising method for achieving spatiotemporal control on drug release as well as minimizing the disadvantages related to the systemic mode of drug delivery. Keeping this in mind, we report the development of ,-carboxymethyl chitosan (,-CMCS)-guar gum-based injectable hydrogels for the sustained delivery of anticancer drugs. The hydrogels were synthesized by chemical crosslinking of multialdehyde guar gum (MAGG) and ,-CMCS through dynamic Schiff base linkages, without requiring any external crosslinker.

Comparative statement for diametric delamination in drilling of cortical bone with conventional and ultrasonic assisted drilling techniques.

Drilled hole quality is a significant parameter for successful orthopedic surgery. The present investigation is an effort to reduce the delamination produced drilling with state-of-the-art hybrid drilling i.e.

Type 2 Diabetes Mellitus Patients Manifest Greater Muscle Fatigability Than Healthy Individuals During Dynamic Fatigue Protocol.

Objective: The present study aimed to investigate the electromyographic (EMG) indices of muscle fatigue along with biochemical marker of fatigue-that is, blood lactate-during a dynamic fatigue protocol in individuals with type 2 diabetes mellitus (T2DM) vs a healthy control group. Secondarily, it aimed to examine the association between EMG indices of muscle fatigue and blood lactate in these patients.

Methods: Thirty-four participants took part in the study: 19 individuals with T2DM (age, 53.

SARS-CoV-2 spike protein interactions with amyloidogenic proteins: Potential clues to neurodegeneration.

The post-infection of COVID-19 includes a myriad of neurologic symptoms including neurodegeneration. Protein aggregation in brain can be considered as one of the important reasons behind the neurodegeneration. SARS-CoV-2 Spike S1 protein receptor binding domain (SARS-CoV-2 S1 RBD) binds to heparin and heparin binding proteins.

Finite element simulation and integration of CEM43 °C and Arrhenius Models for ultrasonic-assisted skull bone grinding: A thermal dose model.

The aim of the study was to develop a novel automated setup for bone grinding to limit the temperature to below 43 °C. The feasibility of using ultrasonic actuation during bone osteotomy was explored with different machining variables, such as rotational speed, feed rate and ultrasonic frequency, in terms of the criterion variable (i.e.

Histological evaluation of thermal damage to Osteocytes: A comparative study of conventional and ultrasonic-assisted bone grinding.

This paper addresses an important issue faced by neurosurgeons during surgical skull bone grinding, a common process used to remove bone in skull base tumour removal surgery to enable the neurosurgeon to reach the target region. The heat generated during bone grinding could harm the soft tissues and can lead to osteonecrosis and cell death. In the present study, a novel process of rotary ultrasonic bone grinding (RUBG) was proposed for osteotomy to limit the temperature to a safe level.

Influence of Forward Head Posture on Cervicocephalic Kinesthesia and Electromyographic Activity of Neck Musculature in Asymptomatic Individuals.

Objective: The purpose of this study was to compare cervicocephalic kinesthesia and electromyographic (EMG) activity of neck muscles-upper trapezius (UT) and sternocleidomastoid (SCM)-between individuals with and without forward head posture (FHP) and to examine the correlation between cervicocephalic kinesthesia and craniovertebral angle (CVA).

Methods: Twenty-two asymptomatic individuals with FHP and 22 without FHP were recruited for the present study. Craniovertebral angle was measured, and those with CVA ≤53° were assigned to the FHP group, whereas those with CVA >53° were assigned to the control group.

COVID-19 Infection: Epidemiology, Virology, Clinical Features, Diagnosis and Pharmacological Treatment.

Coronavirus was first discovered during the year 1930 and since then, various coronaviruses like HKU1, MERS-CoV , NL63 and SARS-CoV-2 have been found to infect humans. The COVID-19 pandemic caused by SARS-CoV-2 is spreading at an alarming rate, thereby creating a health emergency around the world. SARS-CoV2 is reported to be originated from a wet animal market of Wuhan, China.

Designing therapeutic strategies to combat severe acute respiratory syndrome coronavirus-2 disease: COVID-19.

A highly contagious coronavirus disease COVID-19 caused by a recently identified severe acute respiratory syndrome CoV-2 (SARS-CoV-2) initially detected in Wuhan, China has spread worldwide and become a major health crisis in the absence of specific vaccine or antiviral drugs. SARS-CoV-2 infection has resulted in overwhelming number of reported deaths. Unfortunately it is still spreading uncontrollably despite implementing stringent protective measures.

Magneto-Rheological Fluid Assisted Abrasive Nanofinishing of β-Phase Ti-Nb-Ta-Zr Alloy: Parametric Appraisal and Corrosion Analysis.

The present work explores the potential of magneto-rheological fluid assisted abrasive finishing (MRF-AF) for obtaining precise surface topography of an in-house developed β-phase Ti-Nb-Ta-Zr (TNTZ) alloy for orthopedic applications. Investigations have been made to study the influence of the concentration of carbonyl iron particles (CIP), rotational speed (Nt), and working gap (Gp) in response to material removal (MR) and surface roughness (Ra) of the finished sample using a design of experimental technique. Further, the corrosion performance of the finished samples has also been analyzed through simulated body fluid (SBF) testing.

Individualized homeopathic medicines and mother tincture in treatment of hyperuricemia: an open, randomized, pragmatic, pilot trial.

Objectives: The quality of management of hyperuricemia has remained sub-optimal owing to unavoidable toxicities, limitations, and dearth of novel advances. Homeopathy has remained under-researched in hyperuricemia. We investigated the clinical effectiveness of three treatment regimens - individualized homeopathy (IH), mother tincture (UUMT), and both (IH + UUMT) along with lifestyle modifications in a sample of 90 patients with hyperuricemia.

Peak Alpha Frequency in Relation to Cognitive Performance.

 Peak alpha frequency (PAF) is reported to be a nervous system property which is genetically endowed and reflected in individual's cognitive functioning. Cognitive performance denotes the mental processes for effective changes in response to situations in general and mental task in particular. None of the study has till now used reading comprehension as a measure of cognitive functioning, which is considered to be a measure of higher cognitive processes.

Levels of 25-hydroxy Vitamin D3 and Vitamin D Receptor Polymorphism in Severe Dengue Cases from New Delhi.

Dengue is the "phoenix" that never went to ashes. First identified in 1943, in Japan, dengue virus has worldwide distribution and is a grave public health concern in developing countries like India; Methods: A cross sectional study was conducted among adults suspected of having dengue fever and attending Lok Nayak Hospital, New Delhi. Restriction Fragment Length Polymorphism was completed for the detection of vitamin D receptor (VDR) gene polymorphism; Results: Serum 25-hydroxy vitamin D3 (vitamin D) levels were found to be 1.

Decreasing Target Behavior in a Child Using Functional Behavior Assessment and Differential Reinforcement.

Techniques of behavior modification were employed to address the target behavior of functional excessive coughing-psychogenic cough in a 12-y-old boy referred by a pediatrician who found no identifiable medical reasons. To identify the purpose that maintains the behavior, functional behavior assessment was carried out and in order to reduce the frequency of target behavior, extinction and differential reinforcement of behavior analysis was incorporated. The management resulted in significant decrease of the target behavior of coughing without any medical intervention.

Leveraging the Global Influenza Surveillance and Response System for global respiratory syncytial virus surveillance-opportunities and challenges.

Background: Respiratory syncytial virus (RSV)-associated acute lower respiratory infection is a common cause for hospitalization and hospital deaths in young children globally. There is urgent need to generate evidence to inform immunization policies when RSV vaccines become available. The WHO piloted a RSV surveillance strategy that leverages the existing capacities of the Global Influenza Surveillance and Response System (GISRS) to better understand RSV seasonality, high-risk groups, validate case definitions, and develop laboratory and surveillance standards for RSV.

Cholinesterase inhibitors as Alzheimer's therapeutics (Review).

Alzheimer's disease (AD) is one of the most common forms of dementia. AD is a chronic syndrome of the central nervous system that causes a decline in cognitive function and language ability. Cholinergic deficiency is associated with AD, and various cholinesterase inhibitors have been developed for the treatment of AD, including naturally‑derived inhibitors, synthetic analogues and hybrids.