[Protective effect of hydrogen sulfide on intestinal ischemia/reperfusion injury in rats by regulating c-Jun N-terminal kinase/activator protein-1 signaling pathway].

Objective: To investigate whether hydrogen sulfide (HS) protects against intestinal ischemia/reperfusion (I/R) injury in rats by regulating c-Jun N-terminal kinase/activator protein-1 (JNK/AP-1) signaling pathway.

Methods: Thirty male Wistar rats were divided into sham operated group (Sham group), I/R group, and HS donor sodium hydrosulfide (NaHS) intervention group (I/R+NaHS group), with 10 rats in each group. The I/R injury model was established by blocking the superior mesenteric artery with a non-traumatic vascular clip, with 60 minutes of ischemia followed by 120 minutes of reperfusion.

Treatment-Resistant Chromoblastomycosis Successfully Managed With Surgical Excision.

Chromoblastomycosis is an uncommon, chronic granulomatous fungal infection of the skin and subcutaneous tissue. Chromoblastomycosis is most commonly caused by the traumatic inoculation of dematiaceous (pigmented) fungi, most commonly species,  species, and species. Chromoblastomycosis usually affects agricultural workers in tropical and subtropical climates.

Incidence of pressure injury in patients with moderate and severe traumatic brain injury: a systematic review.

Background: Patients with moderate and severe traumatic brain injury (TBI) admitted to the intensive care unit (ICU) may develop pressure injury (PI) due to haemodynamic instability caused by the disease, lack of mobility in bed, as well as intense and prolonged compression in prominent bone areas.

Objective: The objective of this review is to assess the incidence and identify risk factor for the development of PI in patients with moderate and severe TBI admitted to the ICU.

Method: Searches were conducted in the PubMed, CINAHL, Scopus, Embase, Web of Science, Google Scholar, Trove and Open Grey databases, including all records found up to May 2023.

Profiles of Peripheral Neuropathy and Risk Factors in People With Treatment-Naive Type 2 Diabetes Mellitus and Prediabetes.

Background: Diabetic peripheral neuropathy (DPN) is the most common complication of both type 2 diabetes mellitus (T2DM) and type 1 diabetes mellitus (T1DM) occurring in a majority of the affected people. DPN is the key initiating factor for the development of diabetic foot ulceration and the most common cause of non-traumatic lower-limb amputations. Whether chronic hyperglycaemia per se or altered levels of intermediate conventional risk factors in these people are responsible for the increased risk of DPN, is a matter of debate.

[The surgical case reports of Hippocrates of Cos. Medical Practice in Ancient Greece].

Objective: Which theoretical and practical competences do the surgical case histories of the Hippocratic Corpus convey?

Method: The 431 Hippocratic case histories have been studied for reports and communication on diagnosis, therapy and prognosis of single persons and groups of patients suffering from surgical diseases.

Results: Within the 7 books of the Hippocratic "Epidemics", a total of 18 patients with general and visceral surgical diseases are described. The main signs of the disorders were fever, pain, looseness, constipation, colic, swelling and bleeding, the most common affections abscesses, ruptures, ulcers and necroses.

The Effectiveness of Early Treatment With Intense Pulsed Light Combined With Fractional Erbium Laser in Preventing Post-traumatic Hypertrophic Scar Formation.

Background: Once scars form and begin to proliferate, treatment becomes challenging. Traditional methods of scar treatment often provide suboptimal results. Therefore, early intervention has become widely accepted, with a focus on prevention during the wound-healing phase rather than later treatment.

A Rare Case of Congenital Factor XIII Deficiency Secondary to Hyperconsumption: A Case Report.

Acquired Factor XIII (FXIII) deficiency is a rare condition often associated with underlying medical conditions or medications. We present a case of a 23-year-old male, who presented with prolonged bleeding from a traumatic ulcer site on his left leg. Initial laboratory investigations revealed a severe deficiency in FXIII activity (30%) and antigen levels (25%), with no evidence of congenital disorders or other underlying pathologies.

The Clinical Management of Traumatic Palatal Ulcers in an Adolescent Patient: A Common Lesion in Mini-Implant-Assisted Rapid Maxillary Expansion.

: This case report describes the clinical management of a traumatic palatal ulcer, a complication associated with mini-implant-assisted rapid maxillary expansion (MARPE). : A 13-year-old female patient with maxillary constriction underwent MARPE treatment using a custom acrylic expander anchored by four mini-implants. Despite proper planning and device design, the patient missed her first follow-up appointment and continued activations, resulting in tissue inflammation and embedding of the device.

Psychological factors in diabetes-related foot complications: A cohort study.

Living with diabetes has been linked with an increased prevalence of psychological distress. Psychological problems may interfere diabetes-related foot complication (DRFC) self-management. We aimed to characterise psychological functioning in DRFC, and identify clinical factors that may be associated with psychological problems.

[Translated article] AEDV Expert Document on the Management of Ulcerative Venereal Infections.

Currently, ulcerative sexually transmitted infections, including syphilis, herpes simplex virus (HSV), lymphogranuloma venereum (LGV), chancroid, donovanosis and, more recently, monkeypox (MPOX), represent a growing challenge for health care professionals. The incidence of syphilis and LGV has increased in recent years in Spain. Additionally, HSV, syphilis and chancroid can also increase the risk of HIV acquisition and transmission.

Comparative study of cutaneous malignant melanoma according to anatomical site: plantar versus non-plantar melanoma.

Plantar melanomas have more aggressive clinicopathological characteristics and higher mortality rates than melanomas in other anatomical regions. To compare clinicopathological features and define prognostic factors between melanoma in the plantar region and melanoma at other anatomical sites. A retrospective comparative analysis was conducted on all cutaneous melanoma patients seen at a tertiary referral center over 20 years.

Traumatic Ulcerative Granuloma With Stromal Eosinophilia (TUGSE): A Case Report.

Traumatic ulcerative granuloma with stromal eosinophilia (TUGSE) is a rare, benign lesion often misdiagnosed due to its clinical and histological similarities with malignant conditions. It typically presents as a persistent, non-healing ulcer in the oral cavity. This case report describes a 64-year-old female patient who presented with a solitary ulcer caused by chronic trauma from a supra-erupted tooth.

Like a Punch in the Gut: A Novel Perspective On Annual Recurrences of Ulcerative Colitis.

Background: Ulcerative colitis (UC), a chronic inflammatory bowel disease, causes stomach pain, diarrhea, and rectal bleeding. The exact cause is unknown, but it is thought to involve genetic, environmental, and psychological factors. Some people experience annual flare-ups without obvious reason.

Traumatic Ulceration of the Vestibular Mucous Membrane After Insertion of Four Mini-Implants in the Atrophied Mandible: A Case Report.

This clinical report describes how a decubital ulcer arose from the direct contact of the vestibular movable mucous membrane against mini-implant balled-type heads after the mini-implant insertion in the edentulous atrophic mandible of a 78-year-old patient who was not wearing a conventional mandibular complete denture for more than 10 years. Due to severe alveolar ridge atrophy, mini-implant insertion (2.0 mm wide) was an option without extensive surgical procedures.

Natural biopolymer-based hydrogels: an advanced material for diabetic wound healing.

A diabetic foot ulcer (DFU) is an open sore or wound that typically develops on the bottom of the foot. Almost 15% of people with diabetes are suffering from delayed wound healing worldwide. The main vehicle for the development of ulcers in the diabetic population is poor circulation and peripheral neuropathy.

Free fillet flap: Outcomes in emergency microsurgical reconstruction of upper and lower limb.

Introduction: Despite its infrequency, 'spare-part surgery' represents a reconstructive strategy that uses segments of amputated limbs as donor tissue to preserve function in other injured anatomical regions. The purpose of this study was to review our 14-year experience in emergency microsurgical reconstruction of traumatised limbs using free fillet flaps obtained from non-salvageable amputated parts.

Materials And Methods: A retrospective observational study was conducted on patients who underwent urgent free fillet flap transfer for upper or lower limb reconstruction between 2007 and 2021.

From Bank Preparation to Clinical Use of Homologous Skin Allografts in Wound Healing: A Sustainable Approach.

Given progressive population ageing and the increase in the number of patients with comorbidities, the management of chronic and/or hard-to-heal wounds (HHWs) nowadays represents a common problem in many clinical settings. In these cases, standard strategies may not be sufficient. Autologous grafting represent the gold standard for permanent wound closure, but is almost never realized when the skin loss is extensive/the patient is young.