2 results match your criteria: "Trauma Research Center of Allgemeine Unfallversicherungsanstalt[Affiliation]"
A non-lethal traumatic/hemorrhagic insult strongly modulates the compartment-specific PAI-1 response in the subsequent polymicrobial sepsis.
PLoS One
September 2013
Ludwig Boltzmann Institute for Experimental and Clinical Traumatology, Trauma Research Center of Allgemeine Unfallversicherungsanstalt, Vienna, Austria.
Article Synopsis
- PAI-1 is crucial in understanding coagulopathy arising from trauma and sepsis, and this study focuses on how trauma-hemorrhage affects PAI-1 levels in septic situations.
- The research involved experiments on mice, comparing PAI-1 levels in plasma and tissues before and after a cecal ligation and puncture (CLP) procedure to assess outcomes for survivors and non-survivors.
- Findings showed that trauma-induced changes in PAI-1 are compartment-specific and that elevated levels of circulating PAI-1 post-CLP could predict septic deaths, highlighting the significance of monitoring PAI-1 in trauma and sepsis management.
Relationship between age/gender-induced survival changes and the magnitude of inflammatory activation and organ dysfunction in post-traumatic sepsis.
PLoS One
June 2013
Ludwig Boltzmann Institute for Experimental and Clinical Traumatology in the Trauma Research Center of Allgemeine Unfallversicherungsanstalt, Vienna, Austria.
Age/gender may likely influence the course of septic complications after trauma. We aimed to characterize the influence of age/gender on the response of circulating cytokines, cells and organ function in post-traumatic sepsis. We additionally tested whether post-traumatic responses alone can accurately predict outcomes in subsequent post-traumatic sepsis.
View Article and Find Full Text PDF