1,021 results match your criteria: "Translational Lung Research Center Heidelberg[Affiliation]"
Eur Radiol
November 2024
Clinic for Diagnostic and Interventional Radiology, University Hospital Heidelberg, Heidelberg, Germany.
Breathe (Sheff)
October 2024
Division of Immunology, Immunity to Infection and Respiratory Medicine, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester and Manchester University NHS Foundation Trust, Manchester, UK.
COPD is a heterogeneous condition, with tobacco smoking being the main environmental risk factor. The presence of type 2 (T2) inflammation is a well-recognised feature of asthma; however, it is now apparent that a subset of COPD patients also displays evidence of T2 inflammation with respect to elevated eosinophil counts and altered gene and protein expression of several T2 inflammatory mediators. T2 inflammatory mediators represent an attractive therapeutic target in both COPD and asthma; however, the efficacy of pharmaceutical interventions varies between diseases.
View Article and Find Full Text PDFChest
November 2024
Department for Pneumology and Critical Care Medicine, Thoraxklinik at University of Heidelberg, Heidelberg, Germany; Translational Lung Research Center Heidelberg, German Center for Lung Research (DZL), Heidelberg, Germany.
Background: Pneumothorax is a major complication after endoscopic lung volume reduction with valves, with a prevalence of up to 34%. Although some patients benefit from valve implantation despite pneumothorax, others are significantly impaired after lung collapse.
Research Question: What are the differences in the severity grades of pneumothorax and how do these affect clinical practice?
Study Design And Methods: This single-center retrospective study analyzed patients undergoing endoscopic valve implantation with and without pneumothorax after intervention.
Pneumologie
November 2024
Medizinische Klinik und Poliklinik V, Klinikum der Universität München (LMU), Comprehensive Pneumology Center (CPC), Deutsches Zentrum für Lungenforschung (DZL), München, Deutschland.
Bronchiectasis is an etiologically heterogeneous, chronic, and often progressive respiratory disease characterized by irreversible bronchial dilation. It is frequently associated with significant symptom burden, multiple complications, and reduced quality of life. For several years, there has been a marked global increase in the prevalence of bronchiectasis, which is linked to a substantial economic burden on healthcare systems.
View Article and Find Full Text PDFCardiovasc Diagn Ther
October 2024
Department of Pediatric Cardiology, University Hospital for Pediatrics and Adolescent Medicine Ulm, Ulm, Germany.
Cardiovasc Diagn Ther
October 2024
Department of Pediatric Cardiology, University Hospital for Pediatrics and Adolescent Medicine Ulm, Ulm, Germany.
JTCVS Tech
October 2024
Department of Thoracic Surgery, Thoraxklinik, Heidelberg University, Heidelberg, Germany.
Respiration
October 2024
Department of Pneumology and Critical Care Medicine, Thoraxklinik University Hospital Heidelberg, Heidelberg, Germany,
Background: Established structured weaning approaches, which are effective for patients in simple and difficult weaning, are often not appropriate for patients undergoing prolonged weaning. Addressing the complexity of weaning failure requires personalized precision medicine. The therapeutic concept of treatable traits (TTs) has been proposed as a new paradigm for the management of chronic respiratory diseases.
View Article and Find Full Text PDFRadiol Cardiothorac Imaging
October 2024
From the Department of Diagnostic and Interventional Radiology, Translational Lung Research Center (TLRC), Subdivision of Pulmonary Imaging, University Hospital of Heidelberg, Im Neuenheimer Feld 420, 69120 Heidelberg, Germany (A.B., O.W., R.R., H.U.K., C.P.H., M.O.W.); Translational Lung Research Center Heidelberg (TLRC), German Center for Lung Research (DZL), Heidelberg, Germany (A.B., O.W., R.R., H.U.K., F.T., C.P.H., F.J.F.H., M.O.W.); Department of Diagnostic and Interventional Radiology with Nuclear Medicine (A.B., O.W., R.R., H.U.K., C.P.H., M.O.W.) and Department of Pulmonary Medicine (F.T., F.J.F.H.), Thoraxklinik at the University Hospital of Heidelberg, Heidelberg, Germany; Department of Radiology, Division of Pediatric Radiology, Medical University of Graz, Graz, Austria (A.D.); Department of Internal Medicine II, Division of Pulmonology, Medical University of Vienna, Vienna, Austria (D.G.); Department of Pneumology and Critical Care Medicine, Asklepios Klinik Barmbek, Hamburg, Germany (R.E.); and Institute of Medical Informatics, University of Lübeck, Lübeck, Germany (M.H., F.F.).
Am J Physiol Lung Cell Mol Physiol
December 2024
Translational Lung Research Center Heidelberg (TLRC), German Center for Lung Research (DZL), Heidelberg, Germany.
Idiopathic pulmonary fibrosis (IPF) is a fatal lung disease, which is usually diagnosed late in advanced stages. Little is known about the subclinical development of IPF. We previously generated a mouse model with conditional deficiency () that develops IPF-like lung disease.
View Article and Find Full Text PDFEur J Cancer
December 2024
Clinic for Internal Medicine I, University Hospital Carl Gustav Carus, TU Dresden, Dresden, Germany; National Center for Tumor Diseases, Dresden, Germany; National Network Genomic Medicine Lung Cancer (nNGM), Germany. Electronic address:
Introduction: Small cell transformation (SCT) is a typical mechanism of adaptive resistance to third generation epidermal growth factor receptor inhibitors (EGFRi) which have become the standard of care for EGFR-driven non-small cell lung cancer (EGFR+ NSCLC). Little is known about the optimal management of SCT patients. This study aimed to compare outcomes under platinum/etoposide chemotherapy alone (chemo) or in combination with EGFR inhibitors (EGFRi+chemo) or immune checkpoint inhibitors (ICI+chemo).
View Article and Find Full Text PDFCancers (Basel)
October 2024
Department of Thoracic Surgery, Thoraxklinik, University Hospital Heidelberg, Röntgenstraße 1, 69126 Heidelberg, Germany.
Immunotherapy has significantly improved overall survival in patients with pleural mesothelioma, yet this benefit does not extend to those with the epithelioid subtype. Tumor growth is believed to be influenced by the immune response. This study aimed to analyze the tumor microenvironment to gain a better understanding of its influence on tumor growth.
View Article and Find Full Text PDFChin Med J Pulm Crit Care Med
September 2024
Pneumology and Critical Care Medicine, Thoraxklinik, University of Heidelberg, Heidelberg 69126, Germany.
Respiration
October 2024
Department of Pneumology and Critical Care Medicine, Thoraxklinik, University of Heidelberg and Translational Lung Research Center Heidelberg, German Center for Lung Research, Heidelberg, Germany.
Curr Probl Diagn Radiol
October 2024
Department of Respiratory Medicine, Odense University Hospital, Denmark; Odense Respiratory Research Unit (ODIN), University of Southern Denmark, Denmark.
Med Biol Eng Comput
February 2025
Institute of Biomedical Engineering, University of Stuttgart, Seidenstraße 36, 70174, Stuttgart, Germany.
Inert gas washout methods have been shown to detect pathological changes in the small airways that occur in the early stages of obstructive lung diseases such as asthma and COPD. Numerical lung models support the analysis of characteristic washout curves, but are limited in their ability to simulate the complexity of lung anatomy over an appropriate time period. Therefore, the interpretation of patient-specific washout data remains a challenge.
View Article and Find Full Text PDFCancers (Basel)
September 2024
Translational Lung Research Center Heidelberg (TLRC-H), German Center for Lung Research (DZL), Im Neuenheimer Feld 130.3, 69126 Heidelberg, Germany.
Contrast-enhanced computed tomography (CT) is the standard radiologic examination for evaluating the extent of mediastinal tumors. If tumor infiltration into the large central thoracic vessels, the pericardium, or the myocardium is suspected, cine magnetic resonance imaging (cine-MRI) can provide additional valuable information. We conducted a retrospective study of patients with mediastinal tumors who were staged with CT, cine-MRI, and a T1-weighted turbo spin echo (T1TSE) prior to surgical resection.
View Article and Find Full Text PDFInt J Cancer
February 2025
Department of Thoracic Oncology, Thoraxklinik, Heidelberg University Hospital, Heidelberg, Germany.
Lung Cancer
October 2024
Department of Oncology, Università degli Studi Di Torino - San Luigi Hospital Orbassano, Italy.
Front Immunol
September 2024
Airway Innate Immunity Research (AiiR) Group, Wellcome-Wolfson Institute for Experimental Medicine, School of Medicine, Dentistry and Biomedical Sciences, Queen's University Belfast, Belfast, United Kingdom.
Front Med (Lausanne)
September 2024
Institute for Diagnostic and Interventional Radiology, Hannover Medical School, Hannover, Germany.
Introduction: Validation of functional free-breathing MRI involves a comparison to more established or more direct measurements. This procedure is cost-intensive, as it requires access to patient cohorts, lengthy protocols, expenses for consumables, and binds working time. Therefore, the purpose of this study is to introduce a synthetic lung model (ASYLUM), which mimics dynamic MRI acquisition and includes predefined lung abnormalities for an alternative validation approach.
View Article and Find Full Text PDFEur J Cancer
November 2024
Institute of Pathology, Heidelberg University Hospital, Heidelberg, Germany; Centers for Personalized Medicine (ZPM), Germany; Translational Lung Research Center Heidelberg (TLRC), Member of the German Center for Lung Research (DZL), Heidelberg, Germany; German Cancer Consortium (DKTK), Germany. Electronic address:
Respiration
January 2025
Department of Pulmonary Medicine, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Introduction: Currently, there is a lack of bronchoscopic lung volume reduction options that do not depend on fissure integrity. Endobronchial coils have been extensively studied to address this need but exhibited variable patient response and have been discontinued. Lung tension device (LTD) coils represent the next-generation coil treatment.
View Article and Find Full Text PDFEur J Cancer
November 2024
Institute of Pathology, Charité Universitätsmedizin, Berlin, Germany; BIFOLD, Berlin, Germany; German Cancer Consortium, German Cancer Research Center (DKTK/DKFZ), Munich Partner Site, Germany; Institute of Pathology, LMU München, München, Germany. Electronic address:
Introduction: Molecular profiling of lung cancer is essential to identify genetic alterations that predict response to targeted therapy. While deep learning shows promise for predicting oncogenic mutations from whole tissue images, existing studies often face challenges such as limited sample sizes, a focus on earlier stage patients, and insufficient analysis of robustness and generalizability.
Methods: This retrospective study evaluates factors influencing mutation prediction accuracy using the large Heidelberg Lung Adenocarcinoma Cohort (HLCC), a cohort of 2356 late-stage FFPE samples.
Ann Am Thorac Soc
September 2024
Charité Universitätsmedizin Berlin, Department of Pediatric Respiratory Medicine, Immunology and Critical Care Medicine and Cystic Fibrosis Center, Berlin, Germany.
Rationale: The progression of lung changes in cystic fibrosis (CF) from infancy through adolescence remains poorly understood due to limited longitudinal imaging data.
Objectives: To assess changes in lung morphology and perfusion in children with CF through the pediatric age range by longitudinal chest magnetic resonance imaging (MRI).
Methods: 1112 annual chest MRI were performed in 226 patients with CF aged 0-18yr.