1,018 results match your criteria: "Transjugular Liver Biopsy"
A rare case of idiopathic portal hypertension with portopulmonary hypertension occurred following splenectomy with a change in portal hemodynamics.
Clin J Gastroenterol
December 2024
Department of Gastroenterology and Hepatology, Mie University Graduate School of Medicine, 2-174 Edobashi, Tsu, 514-8507, Japan.
Article Synopsis
- * She had a splenectomy to address her thrombocytopenia caused by an enlarged spleen (hypersplenism), but nine months later, she experienced exertional dyspnea and was diagnosed with portopulmonary hypertension (PoPH).
- * Treatment with the medication macitentan improved her symptoms and right heart pressure readings, marking a rare case of PoPH arising after splenectomy.
Image-Guided Liver Biopsy: Perspectives from Interventional Radiology.
Semin Intervent Radiol
October 2024
Department of Radiology, University of Chicago Medical Center, University of Chicago, Chicago, Illinois.
Liver biopsy is a crucial aspect of interventional radiology and plays a significant role in the management of hepatobiliary diseases. Radiologists commonly perform two major image-guided liver biopsy techniques: percutaneous and transjugular approaches. It is essential for radiologists to understand the role of liver biopsy in diagnosing and treating hepatobiliary conditions, the procedural details involved, and how to manage potential complications.
View Article and Find Full Text PDFNon-Invasive versus Invasive Assessment of Portal Hypertension in Chronic Liver Disease.
GE Port J Gastroenterol
December 2024
Department of Gastroenterology, Centro Hospitalar e Universitário de São João, Porto, Portugal.
Article Synopsis
Transjugular Liver Biopsy: The Key to a Rare Etiology of Cholestatic Hepatitis after Bone Marrow Transplantation.
GE Port J Gastroenterol
December 2024
Serviço de Gastrenterologia, Instituto Português de Oncologia de Lisboa Francisco Gentil, Lisboa, Portugal.
Article Synopsis
- Hematopoietic stem cell transplantation (HSCT) can lead to serious complications like sinusoidal obstruction syndrome (SOS) and graft-versus-host disease (GVHD), which may show overlapping symptoms but rarely occur together.
- A case of a 29-year-old male with acute myeloid leukemia experienced hyperbilirubinemia and signs of SOS early after HSCT, followed by the development of GVHD affecting his skin, intestines, and liver.
- The complex nature of this case highlights the need for careful diagnostics, including liver hemodynamic studies and biopsies, to distinguish between SOS and GVHD, as both conditions can severely impact patient outcomes.
Modernizing metabolic dysfunction-associated steatotic liver disease diagnostics: the progressive shift from liver biopsy to noninvasive techniques.
Therap Adv Gastroenterol
November 2024
Stravitz-Sanyal Institute of Liver Disease and Metabolic Health, Division of Gastroenterology, Hepatology, and Nutrition, Department of Internal Medicine, Virginia Commonwealth University School of Medicine, 1201 E. Broad St. P.O. Box 980341, Richmond, VA 23284, USA.
Metabolic dysfunction-associated steatotic liver disease (MASLD) is a growing public health concern worldwide. Liver biopsy is the gold standard for diagnosing and staging MASLD, but it is invasive and carries associated risks. In recent years, there has been significant progress in developing noninvasive techniques for evaluation.
View Article and Find Full Text PDFOutcome of Transjugular Intrahepatic Portosystemic Shunt in Patients with Cirrhosis and Refractory Hepatic Hydrothorax: A Systematic Review and Meta-analysis.
Indian J Radiol Imaging
October 2024
Department of Gastroenterology, All India Institute of Medical Sciences, Bhubaneswar, Odisha, India.
Around 5% of patients with cirrhosis of the liver develop hepatic hydrothorax (HH). For patients with refractory HH (RHH), transjugular intrahepatic portosystemic shunt (TIPS) has been investigated in small studies. Hence, the present meta-analysis aimed to summarize the current data on the outcome of TIPS in patients with RHH.
View Article and Find Full Text PDFAn exploration of radiological signs in post-intervention liver complications.
Eur J Radiol
November 2024
Section of Radiology - Department of Biomedicine, Neuroscience and Advanced Diagnostics (BiND), University of Palermo, Palermo, Italy.
Article Synopsis
- New radiology techniques have changed how doctors diagnose and treat liver diseases in recent years.
- These methods are less invasive and help doctors get better results, but they can also come with risks and complications.
- The article discusses how doctors can use imaging tools like ultrasound, CT scans, and MRIs to monitor and manage these complications after treatments.
Intrinsic Causes of Nonfibrotic Portal Hypertension-A Clinicopathologic Review of 56 Patients.
Int J Surg Pathol
August 2024
Laboratory Medicine and Pathology, Mayo Clinic in Florida, Jacksonville, FL, USA.
Article Synopsis
- The article discusses three conditions (Hepatoportal Sclerosis, Nodular Regenerative Hyperplasia, and Sinusoidal Obstruction Syndrome) that can cause portal hypertension, highlighting their clinical features and outcomes.
- A retrospective study found that patients with these conditions, often having complex medical histories, showed increased frequency in recent years and common symptoms of portal hypertension.
- Imaging suggested cirrhosis for HPS and NRH but not for SOS; liver transplantation was a common treatment, especially for HPS and NRH, while the results for SOS were mixed.
Article Synopsis
- The study reviews how cirrhosis affects older adults, specifically comparing their survival and disease progression to younger patients with the same condition.
- It analyzes data from 191 patients over 50, separating them into two age groups (50-64 and 65+) and looking at factors like survival times and risk of disease progression.
- Results indicate that older patients (≥ 65 years) have significantly shorter survival times compared to younger patients (50-64 years), with age, male gender, BMI, and decompensation identified as important factors influencing survival.
Acute presentation of autoimmune hepatitis -from acute hepatitis to ALF and ACLF.
Hepatol Int
October 2024
Department of Human Pathology, Kanazawa University School of Medical Sciences, Kanazawa, Japan.
Article Synopsis
- Acute autoimmune hepatitis (AIH) presents suddenly in 22-43% of cases, reflecting a spectrum of severity ranging from mild to acute liver failure.
- Diagnosis can be tough since classic markers like autoantibodies may not be present, making liver biopsy important for proper identification.
- Treatment typically involves corticosteroids, but if response is poor, liver transplantation should be considered, especially for severe cases like acute liver failure or advanced liver disease.
Clinical significance of transjugular liver biopsy in acute liver failure - a real-world analysis.
BMC Gastroenterol
August 2024
Department of Gastroenterology, Hepatology, Infectious Diseases and Endocrinology, Hannover Medical School, Carl-Neuberg-Str.1, 30625, Hannover, Germany.
Article Synopsis
- The study investigates the safety and significance of transjugular liver biopsy (TJLB) in diagnosing and managing acute liver failure (ALF) in patients at a transplant center over ten years.* -
- Out of 43 patients studied, TJLB confirmed the suspected causes of ALF for most, but was particularly impactful in cases where treatable conditions like autoimmune hepatitis were suspected, altering treatment plans in these scenarios.* -
- Although the degree of intrahepatic necrosis was shown to be significant in initial analyses, it did not significantly predict survival without a liver transplant when examined in more complex statistical models.*
Hepatic Veno-Occlusive Disease and Colorectal Cancer: Expect the Unexpected.
Life (Basel)
July 2024
Department of Internal Medicine I, "V Babes" University of Medicine and Pharmacy, 300041 Timisoara, Romania.
Article Synopsis
- Sinusoidal obstruction syndrome/veno-occlusive disease (SOS/VOD) is a rare but serious liver condition often linked to chemotherapy and bone marrow transplants, characterized by signs of portal hypertension.
- The case discusses a 65-year-old woman who experienced symptoms like fatigue, abdominal tenderness, and elevated liver enzymes after undergoing chemotherapy for colorectal cancer with liver metastases.
- Despite the diagnosis being complicated by her recent endometrial cancer treatment, timely identification of SOS/VOD is crucial for managing risks and improving patient outcomes.
Article Synopsis
- A patient initially diagnosed with Budd-Chiari underwent a liver biopsy, revealing HSOS without cirrhosis, and after anticoagulation failed, he successfully received a transjugular intrahepatic portosystemic shunt (TIPS).
- Follow-up over four years showed a good prognosis, highlighting that G. segetum-induced HSOS might be overlooked, especially in patients with liver issues, but TIPS can effectively manage complications when medical treatments fail.
[Endoscopic ultrasound-guided liver biopsy: current status and prospects].
Zhonghua Gan Zang Bing Za Zhi
June 2024
Department of Gastroenterology, Shanghai General Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200080, China.
Article Synopsis
- Liver biopsy is a key method for diagnosing and treating liver diseases, but patients often resist it due to invasiveness.
- The endoscopic ultrasound-guided liver biopsy (EUS-LB) is a newer technique that offers high safety and simultaneous sampling from both liver lobes, though it's not widely used in China yet.
- The article reviews recent research on EUS-LB, highlighting its benefits and drawbacks, as well as its feasibility for clinical use.
Distinct ways to perform a liver biopsy: The core technique setups and updated understanding of these modalities.
Endosc Ultrasound
December 2023
Center of Portal Hypertension, Department of Radiology, Zhongda Hospital, Medical School, Southeast University, Nanjing, Jiangsu Province, China.
Article Synopsis
- The prevalence of liver diseases is rising globally, creating a need for better diagnostic and staging techniques, particularly through liver biopsy (LB).
- EUS-guided liver biopsy (EUS-LB) has emerged as a promising alternative to traditional methods, with benefits including improved diagnostic yield and fewer adverse events.
- Ongoing research is essential to validate the effectiveness and safety of EUS-LB as a standard procedure in managing various liver conditions.
A Clinical Case of Timely Diagnosis and Successful Treatment of Budd-Chiari Syndrome With Fulminant Cytolysis in the Setting of a First-time Diagnosed Myeloproliferative Disease.
Mil Med
June 2024
Military Therapy Department, Ukrainian Military Medical Academy, Kyiv 01015, Ukraine.
Article Synopsis
- * The patient, a 32-year-old female, was found to have a JAK2 mutation in myeloid cells, and her diagnosis was confirmed through various examinations including ultrasound.
- * Treatment included symptomatic therapy and a transjugular intrahepatic portosystemic shunt, resulting in significant improvement and a satisfactory condition seven years later, emphasizing the importance of timely diagnosis and intervention.
Experience of Performing Hepatic Interventional Radiological Procedures in a Tertiary Care Hospital in Odisha: A Case Series.
J Clin Exp Hepatol
May 2024
Department of Gastroenterology and Hepatology, KIMS and PBM Hospital, Bhubaneswar, Odisha, India.
Article Synopsis
- Radiological interventions have become essential in treating chronic liver diseases, with techniques like TIPS, TJLB, TACE/TARE, BRTO, and PARTO significantly benefiting patient outcomes.
- The study reviewed 25 hepatic interventions conducted in one center, focusing on five cases with notable complications and their successful management.
- Case highlights include patients with conditions like Budd Chiari Syndrome and decompensated cirrhosis, showcasing the need for careful patient selection and the importance of addressing complications quickly to improve patient outcomes.
Histologic Findings of Sinusoidal Dilatation and Congestion in Liver Grafts Do Not Correlate with Hepatic Venous Anastomotic Gradients.
Cardiovasc Intervent Radiol
August 2024
Division of Interventional Radiology, Department of Radiology, Mayo Clinic Florida, 4500 San Pablo Road, Jacksonville, FL, 32224, USA.
Article Synopsis
- The study investigates whether sinusoidal dilatation and congestion in liver biopsies can predict outflow obstruction in hepatic vein anastomoses during transplantation.
- It involved a retrospective analysis of 166 liver biopsies from 139 patients, assessing the relationship between histologic findings and venous anastomotic pressure gradient.
- The findings conclude that there is no significant correlation between the histologic changes and the pressure gradient, suggesting that these histological features are not reliable indicators for selecting patients for stenting.
Hepatic-associated vascular morphological assessment to predict overt hepatic encephalopathy before TIPS: a multicenter study.
Hepatol Int
August 2024
Zhuhai Interventional Medical Centre, Zhuhai Clinical Medical College of Jinan University (Zhuhai People's Hospital), No. 79 Kangning Road, Zhuhai, 519000, Guangdong Province, China.
Article Synopsis
- A study aimed to enhance predictive accuracy for overt hepatic encephalopathy (HE) risks in patients undergoing transjugular intrahepatic portosystemic shunt (TIPS) by assessing changes in hepatic-associated vascular morphology.
- The research involved 621 patients across multiple centers, creating predictive models that compared traditional clinical factors with vascular changes, ultimately finding that a combined model outperformed others in accuracy.
- The findings indicate that evaluating vascular morphology can significantly improve predictions of HE risks, thus ensuring more patients have access to potentially curative TIPS rather than just palliative treatments.
Transfemoral-Transcaval Liver Biopsy (TFTC) and Transjugular Liver Biopsy (TJLB) in Patients with Fontan-Associated Liver Disease (FALD).
Cardiovasc Intervent Radiol
July 2024
Division of Vascular and Interventional Radiology, Department of Radiology, Montefiore Medical Center, 111 E 210th St, Bronx, NY, 10467, USA.
Article Synopsis
- This study reviews the use of transfemoral-transcaval (TFTC) and transjugular liver biopsies (TJLB) in patients with Fontan-associated liver disease (FALD), involving 30 procedures at a single center from 2011 to 2023.
- All liver biopsies were technically and histopathologically successful, with 93% performed during cardiac catheterization and only minor complications reported, indicating the procedures are safe for these patients.
- The transfemoral approach is preferred due to its compatibility with cardiac catheterization and reduced risk associated with the Fontan shunt, making it a beneficial option for managing FALD.
Sarcopenia is an independent risk factor for short-term mortality in patients undergoing transjugular intrahepatic portosystemic shunt.
Eur J Gastroenterol Hepatol
August 2024
Gastroenterology Unit, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.
Article Synopsis
- Sarcopenia, a condition characterized by loss of muscle mass, is prevalent in patients with cirrhosis and contributes to increased mortality, particularly in those undergoing Transjugular Intrahepatic Portosystemic Shunt (TIPS) procedures.
- In a study of 232 cirrhotic patients who received TIPS, researchers found that 41.38% were diagnosed with sarcopenia, which negatively impacted survival rates compared to those without sarcopenia.
- The analysis revealed that sarcopenia is an independent risk factor for a higher chance of death within one year after TIPS, indicating its importance in pre-procedure assessments.
Severe acute liver disease in adults: Contemporary role of histopathology.
Histopathology
October 2024
Faculty of Medical Sciences, Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UK.
Article Synopsis
- Liver biopsies have been crucial in understanding the causes and development of acute liver diseases, although their role has evolved with new diagnostic methods.
- While they are not mandatory in clinical guidelines for acute liver failure (ALF) and acute-on-chronic liver failure (ACLF), many medical centers continue to perform them because they are relatively safe and provide important prognostic information.
- The increasing use of liver biopsies for diagnosing less severe acute liver injuries has led to a shift in the types of specimens analyzed, emphasizing the need for histopathologists to be prepared for these complex cases.
Acute liver failure histopathology: A 5-year retrospective study.
Indian J Gastroenterol
April 2024
Aakash Hospital, New Delhi, 110 017, India.
Article Synopsis
- Acute liver failure (ALF) is a critical condition defined by severe liver injury lasting under 26 weeks, characterized by encephalopathy and impaired liver function, with diagnosis based mainly on clinical signs.
- A study involving 22 cases of ALF from a larger dataset analyzed histological patterns in liver biopsies and explants, with a mean age of 40 years and a notable female predominance.
- The leading causes of ALF identified were viral hepatitis (36.3%) and autoimmune hepatitis (22.7%), highlighting distinct histological features that could aid in diagnosing the underlying conditions.
Does depressurization of the portal vein before liver transplantation affect the recurrence of HCC? A nested case-control study.
BMC Cancer
May 2024
Department of Liver transplantation center, West China Hospital of Sichuan University, Chengdu, Sichuan Province, China.
Article Synopsis
- Portal hypertension (PHT) is linked to hepatocellular carcinoma (HCC), and the study investigates whether treating PHT before liver transplantation (LT) affects HCC recurrence.* -
- In a study of 440 patients, those who underwent depressurization of the portal vein (DPV) before LT showed a significantly lower recurrence rate and higher tumor-free survival rate for early-stage HCC.* -
- The results suggest that treating PHT with DPV before HCC diagnosis can lead to better outcomes post-transplant, but no differences in recurrence were noted for later-stage HCC.*
Acute Hepatitis E Virus Infection Triggering Autoimmune Hepatitis in a Patient With Chronic Liver Disease: Case Report and the Review of the Literature.
Cureus
March 2024
Gastroenterology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, IND.
Article Synopsis
- Acute viral hepatitis E (HEV) is common in India and usually results in self-limited disease, but chronic forms are becoming more recognized.
- A case involved a 72-year-old diabetic woman who initially had elevated liver enzymes related to metabolic dysfunction and later developed acute-on-chronic liver failure, testing positive for HEV.
- Despite management, her liver enzymes remained high, leading to a biopsy that indicated autoimmune hepatitis.