2,259 results match your criteria: "Transjugular Intrahepatic Portosystemic Shunt - Radiology"

Hepatic encephalopathy (HE) is a neuropsychiatric condition frequently associated with cirrhosis and portosystemic shunting (PSS). It imposes a significant clinical and economic burden, with increasing attention toward identifying modifiable factors that could improve outcomes. Emerging evidence suggests that vitamin D deficiency (VDD), prevalent in patients with cirrhosis, may contribute to the development and severity of HE.

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Transjugular intrahepatic portosystemic shunt for the patients on the liver transplant list.

Liver Transpl

January 2025

Department of Internal Medicine IV (Gastroenterology, Hepatology, Infectious Diseases and Interdisciplinary Endoscopy), Jena University Hospital, Jena, Germany.

Patients with cirrhosis-associated and portal hypertension-associated complications may benefit from TIPS and/or liver transplantation. In many patients, the decision of whether or not TIPS should be placed prior to liver transplantation is fairly clear-cut. Nevertheless, there are some patients in whom the decision can be more complex.

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Development of overt hepatic encephalopathy (oHE) is a particularly feared complication when considering treatment with transjugular intrahepatic portosystemic shunt (TIPS). However, the pathophysiology of HE, in particular after TIPS-insertion, is complex and valid predictors remain scarce. We aimed to investigate whether systemic inflammation markers (SIM) are linked to minimal (mHE) and overt HE (oHE) development before and after TIPS.

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Challenges and Opportunities in the Adoption of p-TIPS for Acute Variceal Bleeding: Insights from a US Tertiary Center.

Dig Dis Sci

November 2024

Division of Gastroenterology, Hepatology & Nutrition, University of Pittsburgh Medical Center, 200 Lothrop Street, Kaufmann Building, Suite 201, Pittsburgh, PA, 15213, USA.

Background And Aims: Since the overwhelmingly positive results of the 'early use of TIPS' published in 2010, studies in Europe and Asia have confirmed early/pre-emptive transjugular intrahepatic portosystemic shunt (p-TIPS) in high-risk patients with acute variceal bleed (AVB) reduces treatment failure and mortality compared to standard of care (SOC). There are no studies evaluating p-TIPS in a US cohort.

Methods: A review of patients with cirrhosis from June 2010 to June 2020 with AVB was conducted from a single large US center.

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Background: Chronic total occlusion (CTO) of the portal vein is one of the main causes of portal hypertension, which may result in life-threatening complications often managed by interventional radiology (IR). The aim of this study is to report the innovative experience with percutaneous revascularization therapy in the management of portal vein CTO in paediatric and adult patients.

Materials And Methods: From January 2020 to December 2023 consecutive paediatric and adult patients with severe portal hypertension resulting from portal vein CTO who underwent attempts at percutaneous recanalization were retrospectively reviewed.

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TIPS insertion leads to sustained reversal of systemic inflammation in patients with decompensated liver cirrhosis.

Clin Mol Hepatol

November 2024

Department of Gastroenterology, Hepatology, Infectious Diseases and Endocrinology, Hannover Medical School, 30625 Hannover, Germany.

Background And Aims: Systemic Inflammation (SI) is considered a key mechanism in disease progression and development of complications in decompensated liver cirrhosis. SI is mainly driven by portal hypertension and bacterial translocation. Transjugular intrahepatic portosystemic shunt (TIPS)-insertion represents an effective treatment for portal hypertension.

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Left-sided portal hypertension (LPH) refers to increased splenic venous pressure caused by splenic vein stenosis or occlusion. Pancreatitis is the leading cause of LPH. Typically, LPH remains asymptomatic, but it can lead to life-threatening hemorrhage from ruptured fundal varices in about 10% of patients.

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Sequential endoscopic treatment for esophageal and gastric variceal bleeding significantly reduces patient mortality and rebleeding rates.

Therap Adv Gastroenterol

November 2024

Department of Gastroenterology, Nanchong Central Hospital, The Second Clinical Medical College, North Sichuan Medical College, Nanchong, China.

Background: Esophageal-gastric variceal bleeding (EGVB) is a serious complication in patients with liver cirrhosis, characterized by high mortality and rebleeding rates. The effect of sequential endoscopic therapy on patient mortality and rebleeding rates remains unclear.

Objectives: This study aimed to evaluate the effects of sequential endoscopic therapy on mortality and rebleeding rates in patients with EGVB.

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Article Synopsis
  • The study aimed to compare ultrasound Doppler velocities between two different stent diameters (8 mm vs. 10 mm) in patients with transjugular portosystemic shunts (TIPS) and direct intrahepatic portosystemic shunts (DIPS).
  • A total of 69 patient cases were analyzed retrospectively, revealing that mean Doppler velocities were significantly higher in the 8 mm stents compared to the 10 mm stents at mid-stent and hepatic-venous-end locations.
  • The findings suggest that Doppler screening thresholds may need to be adjusted based on shunt diameter, as normal flow velocities show significant variation between the two sizes.
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CIRSE Standards of Practice on Transjugular Intrahepatic Portosystemic Shunts.

Cardiovasc Intervent Radiol

December 2024

Department of Diagnostic Medicine and Radiology, Interventional Radiology Unit, Sapienza University of Rome, Rome, Italy.

Article Synopsis
  • * It aims to provide interventional radiologists with best practice guidelines for performing TIPS, including patient selection, procedural management, and follow-up care, particularly in pediatric cases.
  • * A group of European clinicians reviewed recent literature and reached a consensus to develop updated recommendations, demonstrating TIPS's proven effectiveness in treating portal hypertension and outlining safe operational practices.
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TIPS, a Trick for Transcaval TEVAR Access.

J Endovasc Ther

November 2024

Department of Interventional Radiology, University Hospital Leuven, Leuven, Belgium.

Purpose: We described an alternative access for thoracic endovascular aortic repair (TEVAR) deployment using a transjugular intrahepatic portosystemic shunt (TIPS) needle for gaining transcaval access to the abdominal aorta.

Case Report: A 63-year-old man presented with a penetrating atherosclerotic ulcer in the descending aorta. Traditional transfemoral and transaxillary access were not possible.

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Background And Aims: Portal hypertension is the main pathophysiological driver of decompensation in patients with liver cirrhosis. Epithelial cell death markers, m30 and m65, correlate with hepatic injury and predict outcomes across various stages of liver disease. We aim (i) to evaluate whether portal hypertension itself contributes to liver outcome-relevant epithelial injury, and (ii) to analyse the capacity of m30/m65 to predict outcome in patients receiving a transjugular intrahepatic portosystemic shunt (TIPS) for refractory ascites.

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A 51-year-old man, with a history of cirrhotic portal hypertension and recurrent transjugular intrahepatic portosystemic shunt (TIPS) stenoses, presented with an acute gastro-esophageal variceal hemorrhage in the setting of an acute and massive thrombotic TIPS shunt occlusion. The clinical presentation was complicated by patient's severe, chronic thrombocytopenia which had precluded empiric anticoagulation previously for recurrent TIPS dysfunction. Following endoscopic treatment of the variceal bleeding, the CAT 12 Indigo aspiration system (Penumbra) was used to remove a large burden of thrombus from the TIPS, allowing successful re-stenting and restoration of blood flow through the TIPS.

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Portal Hypertensive Gastropathy and MELD-Na Score Predict Recurrent Gastrointestinal Bleeding After TIPSS: An ALTA Group Study.

Aliment Pharmacol Ther

November 2024

Department of Medicine, Division of Gastroenterology and Hepatology, Stanford University, Stanford, California, USA.

Background: Transjugular intrahepatic portosystemic shunt (TIPSS) is highly effective for treatment of variceal bleeding; however, factors contributing to rebleeding complications remain unclear.

Aims: In this study, we aim to determine risk factors for recurrent portal hypertensive gastrointestinal bleeding following TIPSS.

Methods: Utilising the Advancing Liver Therapeutic Approaches multicentre database, we retrospectively identified adult patients who underwent TIPSS for secondary prophylaxis of variceal bleeding and had a gastrointestinal rebleeding event within 1 year.

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Percutaneous thermal ablation in hepatocellular carcinoma patients with and without TIPS.

Abdom Radiol (NY)

November 2024

Department of Diagnostic and Interventional Radiology, CHU Nantes, Nantes, France.

Purpose: Managing hepatocellular carcinoma (HCC) in patients with a transjugular intrahepatic portosystemic shunt (TIPS) is becoming increasingly common. This study aimed to evaluate the safety and efficacy of percutaneous thermal ablation for treating HCC in patients with TIPS.

Methods: This retrospective longitudinal study was conducted at Nantes University Hospital.

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Sarcopenia in patients receiving TIPS is independently associated with increased risk of complications and mortality.

Dig Liver Dis

October 2024

Department of Gastroenterology and Hepatology, University Hospital Leuven, Herestraat 49, Leuven, Belgium; Department of Chronic Diseases, Metabolism and Aging (CHROMETA), Catholic University of Leuven, Herestraat 49, Leuven, Belgium.

Background: Sarcopenia is an acknowledged risk factor for individuals with chronic liver disease, however, the influence on outcomes in patients receiving transjugular intrahepatic portosystemic shunt (TIPS) remains underexplored.

Aims: This study aimed to investigate the association between sarcopenia and incidence of complications and mortality post-TIPS.

Methods: A retrospective analysis was performed on 175 patients who underwent TIPS between 2011-2021 at a Belgian tertiary care center.

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Transjugular Intrahepatic Portosystemic Shunt for Budd-Chiari Syndrome: A Single-Centre Experience.

J Clin Med

October 2024

Department of Liver & Small Bowel Health Centre, Organ Transplant Centre of Excellence, King Faisal Specialist Hospital & Research Centre, Riyadh 11451, Saudi Arabia.

: Despite several challenges in clinical management, there has been significant progress in understanding the aetiology, natural history and outcomes of Budd-Chiari syndrome (BCS) treatments. This study aims to evaluate the outcomes of transjugular intrahepatic portosystemic shunt (TIPS) using covered stent in management of BCS. : We conducted a retrospective analysis of 70 BCS patients who underwent TIPS using covered stents between January 2010 and December 2022 at a single tertiary liver transplant centre.

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Introduction: There is no established scoring model focused on viral hepatitis patients to predict the prognosis after transjugular intrahepatic portosystemic shunt (TIPS). We aimed to develop and validate a novel model based on the largest cohort for better prediction of both short-term (1 year) and long-term (3 years) postoperative prognoses after TIPS in viral hepatitis cirrhosis-related portal hypertension patients.

Methods: A total of 925 viral hepatitis cirrhosis-related portal hypertension patients who underwent TIPS from nine hospitals were divided into the training and external validation cohorts.

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Article Synopsis
  • The study evaluates the effectiveness of machine learning models in predicting improvements in refractory ascites for patients undergoing TIPS placement, analyzing data from 218 patients.
  • Results show that 77% of patients experienced improvement, with certain clinical factors like sodium and albumin levels significantly associated with better outcomes.
  • Two ML models, SVM and CatBoost, showed high accuracy (83% and 87%) in predicting improvements, suggesting these models could aid in selecting suitable patients for the procedure.
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Optimal timing for TIPS and PSE combination treatment in patients with cirrhosis-related variceal bleeding and hypersplenism.

Acad Radiol

October 2024

Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China (J.L., W.Y., Y.B., S.S., X.L., Y.R., F.Y., C.Z., B.L.); Hubei Province Key Laboratory of Molecular Imaging, Wuhan, China (J.L., W.Y., Y.B., S.S., X.L., Y.R., F.Y., C.Z., B.L.). Electronic address:

Article Synopsis
  • There is no consensus on the best timing for combining transjugular intrahepatic portosystemic shunt (TIPS) and partial splenic embolization (PSE) in patients with cirrhosis-related issues, prompting this study to compare early versus late treatment combinations.
  • The study involved 84 patients and found that those who received the late combination of TIPS and PSE had better survival rates and lower instances of overt hepatic encephalopathy (OHE) compared to those who underwent the early combination.
  • Key factors affecting mortality and OHE included the timing of the procedure and serum albumin levels, with early combination therapy linked
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Four-dimensional Flow MRI-based Computational Fluid Dynamics Simulation for Noninvasive Portosystemic Pressure Gradient Assessment in Patients with Cirrhosis and Transjugular Intrahepatic Portosystemic Shunt.

Radiology

October 2024

From the Department of Diagnostic and Interventional Radiology and Nuclear Medicine (C.R., A.L., I.R., G.A., B.P.S., P.B.) and I. Department of Medicine (F.P., J.K.), University Medical Center Hamburg-Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany; Institute of Multiphase Flows, Hamburg University of Technology, Hamburg, Germany (M.H., M.I., M.S.); and Departments of Radiology, Medical Physics, Biomedical Engineering, Medicine, and Emergency Medicine, University of Wisconsin-Madison, Madison, Wis (S.B.R.).

Background Transjugular intrahepatic portosystemic shunt (TIPS) dysfunction in patients with liver cirrhosis and recurrent symptoms of portal hypertension is primarily assessed with US and confirmed with invasive catheter venography, which can be used to measure the portosystemic pressure gradient (PSPG) to identify TIPS-refractory portal hypertension. To avoid the risks and costs of invasive catheter venography, noninvasive PSPG evaluation strategies are needed. Purpose To demonstrate the feasibility of the combination of four-dimensional (4D) flow MRI with computational fluid dynamics (CFD) for noninvasive PSPG assessment in participants with cirrhosis and TIPS.

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Article Synopsis
  • The transjugular intrahepatic portosystemic shunt (TIPS) is a key treatment for portal hypertension in cirrhosis patients, and interest in this topic is growing, as indicated by rising publication numbers.
  • Using CiteSpace software, a bibliometric analysis was conducted, examining 985 research papers from 2013 to 2022, revealing trends in publications, influential authors, and key terms like "portal hypertension" and "hepatic encephalopathy."
  • The findings highlight postoperative hepatic encephalopathy as a major research challenge and current focus area within the TIPS field.
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Background: Transjugular intrahepatic portosystemic shunt (TIPS) is a pivotal intervention for managing esophagogastric variceal bleeding in patients with chronic hepatic schistosomiasis.

Aim: To evaluate the efficacy of digital subtraction angiography image overlay technology (DIT) in guiding the TIPS procedure.

Methods: We conducted a retrospective analysis of patients who underwent TIPS at our hospital, comparing outcomes between an ultrasound-guided group and a DIT-guided group.

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