122 results match your criteria: "Transitional Cell Carcinoma Involving the Prostate"
Primary Alveolar Soft-Part Sarcoma (ASPS) of the Prostate: Report of a Deceptive Case.
Int J Surg Pathol
October 2023
Department of Pathology, Hospital of the University of Pennsylvania, Perelman School of Medicine, Philadelphia, PA, USA.
Article Synopsis
- * Following initial treatment for what was thought to be urothelial carcinoma, further imaging and biopsies led to the identification of an atypical neoplasm, prompting a comprehensive diagnostic process that ruled out other cancers.
- * The final diagnosis revealed primary ASPS of the prostate with bladder involvement, and after receiving multiple treatments including pazopanib and radiation, the patient is currently symptom-free after 15 months of follow-up.
Investigating PSMA differential expression in canine uroepithelial carcinomas to aid disease-based stratification and guide therapeutic selection.
BMC Vet Res
December 2022
Department of Veterinary Clinical Medicine, College of Veterinary Medicine, University of Illinois at Urbana-Champaign, Urbana, IL, 61802, USA.
Article Synopsis
- The study examines the expression of prostate specific membrane antigen (PSMA) in male dogs with invasive urothelial carcinoma (iUC) and prostate carcinoma (PCA) to see if it can help differentiate between the two types of cancers for better treatment strategies.
- Results showed that there were no significant differences in PSMA expression between iUC and PCA cell lines or patient samples, indicating PSMA cannot be used to differentiate the two types of cancer.
- However, vinblastine demonstrated the greatest cytotoxic activity against both cancer types, suggesting it could be a promising chemotherapy option regardless of the cancer's origin.
The Effect of Complete Prostate Examination of Radical Cystoprostatectomy Specimen on the Final Stage of Urothelial Carcinoma of the Urinary Bladder and the Detection of Prostate Cancer.
Arch Pathol Lab Med
June 2023
The Department of Pathology, Ewha Womans University Mokdong Hospital, Ewha Womans University College of Medicine, Yangcheon-Gu, Seoul, Republic of Korea (Kim, Choi, Sung, S. Park).
Article Synopsis
- - The study investigates how different prostate sampling methods used in radical cystoprostatectomy (RCP) affect the pathologic results related to tumor stage and features.
- - It compares two groups: one with minimal and conventional embedding (group 1) and another with complete embedding (group 2), finding that group 2 showed significantly higher rates of prostate involvement by urothelial carcinoma and incidental prostatic adenocarcinoma.
- - The findings suggest that thorough examination of the prostate in RCP specimens can alter the final pathologic stage and improve detection of significant prostate conditions, supporting the use of complete prostate analysis as per AJCC guidelines.
The Prognostic Value and Immunological Role of STEAP1 in Pan-Cancer: A Result of Data-Based Analysis.
Oxid Med Cell Longev
April 2022
Department of Oncology, Renmin Hospital of Wuhan University, Wuhan 430060, China.
Article Synopsis
- The study investigates the role of STEAP1, a transmembrane protein, across various cancers, analyzing its expression, function, and prognostic significance.
- Researchers used data from multiple cancer databases to compare STEAP1 levels in normal and tumor tissues and analyze its relationship with factors like DNA methylation, immune response, and drug sensitivity.
- Findings reveal that STEAP1 is overexpressed in 19 out of 33 cancers, demonstrates prognostic value, and is linked to tumor mutational burden and microsatellite instability, positioning it as a potential biomarker for cancer treatment and prognosis.
Comparison of pathologist review protocols for cytologic detection of prostatic and urothelial carcinomas in canines: A bi-institutional retrospective study of 298 cases.
Vet Comp Oncol
June 2021
Department of Veterinary Biosciences, College of Veterinary Medicine, The Ohio State University, Columbus, Ohio, USA.
Article Synopsis
- - Urothelial carcinoma is the most common bladder tumor in dogs, and cytology is often used for diagnosis in cases involving bladder or prostate lesions.
- - A study compared how effective cytologic evaluations were between two institutions, finding that their screening protocols significantly influenced sensitivity and specificity rates.
- - Diagnostic catheterization provided the best accuracy for identifying carcinoma, while urine sediment samples had varying effectiveness based on collection methods and the institution performing the tests.
Seminal Vesicle Involvement by Carcinoma In Situ of the Bladder: Clonal Analysis Using Next-Generation Sequencing to Elucidate the Mechanism of Tumor Spread.
Cancer Res Treat
October 2020
Department of Urology, Eulji University Hospital, Eulji University School of Medicine, Daejeon, Korea.
Article Synopsis
- A 70-year-old man diagnosed with urothelial carcinoma in situ (CIS) showed significant progression, invading his prostate and seminal vesicle after initial treatment.
- He underwent a transurethral resection of the bladder and subsequent BCG therapy, but experienced recurrence within three months, leading to a radical cystectomy.
- Next-generation sequencing illustrated distinct genetic differences in tumor cells from the bladder compared to those from the seminal vesicles, suggesting a multicentric origin of the cancer consistent with a field-cancerization effect.
Seminal Vesicle Tumor Microenvironment.
Adv Exp Med Biol
July 2021
Department of Urologic Robotic Surgery and Renal Transplantation, University of Florence, Careggi Hospital, Florence, Italy.
Article Synopsis
- Primary diseases of the seminal vesicles are rare, with nonneoplastic lesions like amyloidosis, inflammation, and calcification being more common, while tumors usually originate from nearby organs.
- Seminal vesicle adenocarcinoma is the most common primary tumor of the seminal vesicles, characterized by a unique growth pattern and less than 100 documented cases in literature.
- Recent studies suggest a connection between tumorigenesis and the tumor microenvironment, specifically how factors like the extracellular matrix and immune cells may influence prostate cancer progression, with limited research focusing on the environment of seminal vesicle tumors.
Small-cell Carcinomas of the Urinary Bladder and Prostate: TERT Promoter Mutation Status Differentiates Sites of Malignancy and Provides Evidence of Common Clonality Between Small-cell Carcinoma of the Urinary Bladder and Urothelial Carcinoma.
Eur Urol Focus
December 2018
Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN, USA; Department of Urology, Indiana University School of Medicine, Indianapolis, IN, USA. Electronic address:
Article Synopsis
- * Analyzing 53 urinary bladder SCC cases and 26 prostate SCC cases revealed that 55% of bladder SCC samples had TERT mutations, while none of the prostate cases did.
- * The findings suggest that TERT mutations indicate a common clonal origin in bladder SCC and urothelial carcinoma, while also highlighting the potential to differentiate bladder SCC from prostate SCC for diagnostic purposes.
Bladder urothelial carcinoma extending to rectal mucosa and presenting with rectal bleeding.
World J Gastrointest Endosc
June 2017
Andrew M Aneese, Vinayata Manuballa, Mitchell S Cappell, Division of Gastroenterology and Hepatology, Department of Medicine, William Beaumont Hospital, Royal Oak, MI 48073, United States.
Article Synopsis
- An 87-year-old male with a history of prostate and bladder cancers presented with daily bright red blood in his stools for five months, leading to an examination that revealed a 2.5 cm mass at the prostate location.
- Imaging and colonoscopy confirmed poorly differentiated carcinoma of urothelial origin invading the rectum, and the patient underwent an embolization procedure for hemostasis.
- Despite treatment, the patient developed new metastases and passed away 13 months later, contributing to literature showing similar cases of rectal involvement from bladder urothelial carcinoma.
Morphological changes in peri-prostatic sympathetic ganglion cells in aging males.
Mol Clin Oncol
May 2017
Department of Pathology, Hasharon Hospital, Rabin Medical Center, Affiliated with Sackler Faculty of Medicine, Tel Aviv University, Petach Tikva, Tel Aviv 6997801, Israel.
Article Synopsis
- * A total of 5,075 ganglion cells were analyzed, with significant pathological changes observed in 1,696 of them, including neuronophagia, vacuolization, and cell pyknosis.
- * Notably, these changes were more pronounced in patients with prostate cancer compared to those with benign prostate issues, suggesting that malignancy affects local cellular environments as men age.
Multiple primary cancers: Simultaneously occurring prostate cancer and other primary tumors-our experience and literature search.
Niger J Clin Pract
March 2017
Department of Surgery, College of Health Sciences, University of Ilorin, Ilorin, Nigeria.
Article Synopsis
- Prostate cancer is a significant health issue for men globally, especially in sub-Saharan Africa, where it often occurs alongside other cancers, complicating treatment.
- A study examined the medical records of patients from 2012 to 2014, focusing on those with prostate cancer and additional primary tumors, revealing six patients affected by various types of cancers.
- Although the reasons for this co-existence remain unclear, further research may uncover links that could improve patient management.
Penile metastasis from primary transitional cell carcinoma of the bladder sparing the urethra.
Can Urol Assoc J
November 2016
Division of Urology, Memorial University of Newfoundland, St. John's, NL, Canada.
Article Synopsis
- * A 59-year-old male initially presented with phimosis and later exhibited gross hematuria, leading to the diagnosis of high-grade urothelial carcinoma after surgery on the prostate and bladder.
- * After treatment, the patient developed primary penile squamous cell carcinoma, resulting in a partial penectomy, which revealed TCC infiltration in the penis while the urethra remained unaffected.
Intraductal Carcinoma of the Prostate Gland: Recent Advances.
Yonsei Med J
September 2016
Department of Pathology and Genomic Medicine, Houston Methodist Hospital, Weill Medical College of Cornell University, Houston, TX, USA.
Article Synopsis
- Intraductal carcinoma of the prostate (IDC-P) involves cancer in the ducts or acini of the prostate and is often linked to high-grade tumors and poor prognosis factors such as tumor spread.
- * IDC-P falls under a broader category of atypical cribriform lesions, which includes other conditions like high-grade prostatic intraepithelial neoplasia, affecting treatment decisions due to their varying implications.
- * The review emphasizes the significance of recognizing and documenting IDC-P in biopsy and surgery samples to better guide treatment and follow-up care for patients.
Relevance of prostate cancer in patients with synchronous invasive bladder urothelial carcinoma: a monocentric retrospective analysis.
Arch Ital Urol Androl
March 2015
Department of Urology, University Hospital "S. Anna", Ferrara.
Article Synopsis
- The study reviewed data from 64 patients with incidental prostate cancer (PCa) who underwent radical cystoprostatectomy (RCP) for invasive bladder cancer, focusing on the incidence and characteristics of the PCa.
- Out of these patients, 17.2% were found to have incidental PCa, with 27.3% classified as clinically significant and 72.7% as insignificant, illustrating a low impact of incidental PCa on bladder cancer prognosis.
- The follow-up showed a low rate of biochemical recurrence, and there was no significant difference in cancer-specific survival between those with significant and insignificant PCa.*
Usefulness of transurethral biopsy for staging the prostatic urethra before radical cystectomy.
J Urol
January 2015
Scott Department of Urology, Department of Pathology, Baylor College of Medicine, Houston, Texas; Department of Pathology and Genomic Medicine, Houston Methodist Hospital (LDT, SSS), Houston, Texas. Electronic address:
Article Synopsis
- A study was conducted to assess how effective transurethral resection biopsy of the prostatic urethra is for detecting prostatic involvement of urothelial carcinoma in bladder cancer patients.
- The research involved comparing biopsy results from 272 patients to those from radical cystoprostatectomy, and it found that 37.1% had prostatic involvement.
- The biopsy showed a sensitivity of 71.3% and a specificity of 100%, effectively detecting most invasive cases, but missed many tumors that spread from the bladder, indicating its potential role in clinical decision-making for treatment plans.
Incidental prostate cancer at the time of cystectomy: the incidence and clinicopathological features in Chinese patients.
PLoS One
December 2014
Department of Urology, Renji Hospital, Affiliated to Shanghai Jiao Tong University, School of Medicine, Shanghai, China.
Article Synopsis
- - The study analyzed the occurrence and characteristics of incidental prostate cancer in 504 Chinese men who underwent radical cystoprostatectomy for bladder cancer between 1999 and 2013.
- - Incidental prostate cancer was found in 6.8% of patients, with a significant disease rate of 35.2%; however, follow-up showed that biochemical recurrence occurred in only 3 cases without any prostate cancer-related deaths.
- - The findings indicated a lower prevalence of incidental prostate cancer in Chinese patients compared to Western populations, with most cases considered clinically insignificant and suggesting only a 1.0% risk of remaining significant cancer when sparing the prostate apex during surgery.
Challenges in the pathological reporting of urothelial carcinoma involving prostatic transurethral resection specimens within a single institution.
Pathology
December 2013
*Department of Pathology, Washington University, St Louis, Missouri †Departments of Pathology ‡Urology, The Ohio State University Medical Center, Columbus, Ohio, USA.
Article Synopsis
- * A review from 2007 to 2010 showed that 50.4% of patients diagnosed with UC after prostate TUR had instances of invasive tumor, but there were inconsistencies in reporting the extent of this invasion.
- * The findings highlight issues like unclear terminology and lack of documentation regarding tumor extent, suggesting better reporting practices to improve diagnosis clarity.
Urothelial carcinoma involving the prostate: the association of revised tumour stage and coexistent bladder cancer with survival after radical cystectomy.
BJU Int
December 2014
Department of Urology, Mayo Clinic, Rochester, MN, USA.
Article Synopsis
- The study aimed to evaluate survival rates among patients with urothelial carcinoma involving the prostate, focusing on how the depth of tumor invasion and the presence of bladder tumors affect outcomes.
- Researchers analyzed data from 201 patients who underwent radical cystectomy, finding that the depth of invasion significantly influenced 5-year cancer-specific survival rates, which were 73% for the least invasive (pTis) to just 21% for the most invasive (pT4a).
- Key findings indicate that advanced prostate tumor stages, positive lymph nodes, and concurrent advanced bladder cancer were all linked to an increased risk of death, highlighting the importance of thorough staging and reporting in treatment planning.
Incidental prostate cancer in patients with bladder urothelial carcinoma: comprehensive analysis of 1,476 radical cystoprostatectomy specimens.
J Urol
November 2013
Department of Urology, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands.
Article Synopsis
- A study analyzed 1,476 patients treated with radical cystoprostatectomy for bladder urothelial carcinoma to identify risk factors and determine the incidence and prognosis of prostatic cancers and HGPIN.
- Findings revealed that 51% of patients had prostate cancer, with clinically significant prostatic adenocarcinoma affecting 8.3% of the cohort and various forms of prostatic urothelial carcinoma present in 21.1% of patients.
- The study concluded that despite risk factors indicating potential presence, they don't guarantee the absence of these cancers, and the overall survival rate varied significantly based on the type of prostatic involvement.
Cancer identified incidentally in the prostate following radical cystoprostatectomy: an Australian study.
ANZ J Surg
June 2014
Urological Cancer Outcomes Centre, Discipline of Surgery, The University of Sydney, Sydney, New South Wales, Australia.
Article Synopsis
- - The study aimed to evaluate the incidence and characteristics of incidental prostate cancer in Australian men with primary bladder cancer who underwent radical cystoprostatectomy (RCP).
- - Over a 10-year review, it was found that 39% of patients had prostate cancer, with 70% of those cases being clinically significant; also, the presence of bladder carcinoma in situ (CIS) was linked to urethral disease.
- - The findings highlighted a high rate of significant prostatic adenocarcinoma in patients with bladder cancer, indicating a need for more awareness in surgical considerations during treatment.
[Prostatic involvement by urothelial carcinoma in patients with bladder cancer and their implications in the clinical practice].
Actas Urol Esp
October 2012
Servicio de Urología, Hospital Clínic, Barcelona, España. jor
Article Synopsis
- * Analysis of studies from 1985-2011 shows that UC primarily involves the prostate in patients with a history of non-muscle invasive bladder cancer (NMIBC), with several risk factors identified such as multifocality and prior tumor recurrences.
- * Patients with UC involvement in the prostate may benefit from different treatment approaches, including conservative options for superficial cases, but have increased risks of recurrence after cystectomy, highlighting the need for careful treatment planning.
Transitional cell carcinoma involving the ductus deferens in a dog.
J Am Vet Med Assoc
February 2012
VRCC Veterinary Referrals, 1 Bramston Way, Southfields, Laindon, Essex, SS15 6TP, England.
Article Synopsis
- - A 12-year-old male Springer Spaniel experienced recurring urinary tract infections that improved with antibiotics but returned shortly after treatment stopped.
- - Ultrasound and exploratory surgery revealed abnormalities including a fluid-filled structure near the bladder and evidence of transitional cell carcinoma affecting the ductus deferens and prostate.
- - The dog underwent surgery and was treated with medication for 9 months before being euthanized, highlighting the need to consider transitional cell carcinoma in dogs with urinary tract issues.
Clinically unconfirmed positive urinary cytology: diagnostic implications and oncological outcomes.
BJU Int
October 2011
Institute of Urology, Rabin Medical Center - Beilinson, Petah Tikva Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
Article Synopsis
- The study aimed to understand the natural progression of patients with positive urinary cytology but no visible disease symptoms.
- Out of 48 patients evaluated, 67% were eventually diagnosed with various types of cancer, primarily high-grade bladder cancer, with a significant number being undiagnosed for an average of 19 months.
- Despite the lengthy diagnosis period, a considerable percentage (74%) of patients remained disease-free four years later, indicating a generally positive long-term outcome.
A rare cause of scrotal swelling: transitional cell carcinoma of the bladder presenting as a testicular metastasis.
Adv Urol
July 2011
Department of Urology, York District Hospital, Wigginton Road, York YO31 8HE, UK.
Article Synopsis
- * In 2008, he underwent another surgery for prostate issues, which revealed poorly differentiated transitional cell carcinoma (TCC) that had invaded the prostate.
- * By 2010, he had surgery for a suspicious testicular mass, which was confirmed to be metastatic TCC, marking a rare development in his pre-existing urological condition.
Article Synopsis
- * The 2009 pTNM classification differentiates between carcinoma in situ (pT2) and direct invasion into the prostatic stroma (pT4).
- * For non-metastatic muscle invasive bladder cancer with significant lymphatic invasion, the typical treatment involves neoadjuvant chemotherapy followed by surgery, but only some patients may respond completely, allowing for a possible bladder-conserving strategy in select cases.