Comparison of survival between unilateral and bilateral breast cancers using propensity score matching: a retrospective single-center analysis.

Purpose: The characteristics of patients with bilateral and unilateral breast cancer at the time of diagnosis or during follow-up have been compared, focusing on the differences in disease-free survival and overall survival between these groups.

Methods: A total of 1,947 patients diagnosed with invasive carcinoma were included in the study. 1876 ​​(96.

Healthy Lifestyle Behaviours and Associated Factors in Caregivers of Patients With Chronic Mental Illnesses: A Cross-Sectional Study.

Background: According to the community-based model, caregivers play a major role in the care of patients with chronic mental illness. However, caregivers have little time to attend to their own health needs and tend to ignore their health. Caregivers with healthy lifestyle behaviours are likely to achieve greater physical and psychological well-being.

Changes in Sleep Quality After Total Knee Arthroplasty: A Systematic Review.

Background: Total knee arthroplasty (TKA) is a surgical procedure to improve the quality of life of patients with osteoarthritis. However, postoperative recovery can be difficult due to sleep disturbance, such as poor sleep quality, and postsurgical pain.

Purpose: The aim of this systematic review was to examine recent evidence regarding changes in sleep quality after TKA and to explore factors affecting the postoperative recovery process.

Comparing the Impact of Titanium and Stainless Steel Retainers on Lower Incisor Stability, Periodontal Health, and Retainer Survival: A Preliminary Study.

Objective: This study aims to compare the impact of titanium and stainless steel (SS) retainer wires on lower incisor stability and periodontal health.

Methods: Fifty patients between the ages of 14.1 and 29.

Determination of the relationship between frailty level and quality of life in elderly individuals with type 2 diabetes.

The aim of the study was to examine the relationship between frailty level and quality of life in elderly individuals with Type 2 diabetes. This descriptive and correlational study was conducted with 211 patients who applied to the diabetes outpatient clinic of a private and a public hospital in Istanbul between September and November 2022. The data were obtained by using the Personal Information Form, Edmonton Frail Scale and the Quality of Life in the Elderly Scale.

Evaluation of auditory pathways and comorbid inner ear malformations in pediatric patients with Duane retraction syndrome.

Aims And Objectives: This study aimed to investigate the presence, type, and severity of hearing losses in individuals with Duane Retraction Syndrome (DRS), and to ascertain if there are anomalies in the auditory pathways at the brainstem level in DRS, believed to arise from aberrant interaction between cranial nerves and brainstem nuclei.

Study Design: Cross-sectional observational study.

Setting: Tertiary referral centre.

Effect of ultrasound-assisted extraction on phenolic profile, bio-accessibility, OVCAR-3, and SKOV-3 cytotoxicity in blackthorn (Prunus spinosa L.).

This study aimed to examine the extraction of specific phenolic compounds from blackthorn using ultrasound-assisted extraction (UAE) and to evaluate the influence of UAE on the phenolic composition, bioaccessibility, and cytotoxic effect evaluated on ovarian cancer (OVCAR-3 and SKOV-3) and healthy (HaCaT) cell lines. The UAE parameters were optimized by modeling with the response surface method. Temperature, time, and ultrasound amplitude were utilized to determine the optimal extraction conditions.

Synthesis and molecular docking analysis of novel hydrazone and thiosemicarbazide derivatives incorporating a pyrimidine ring: exploring neuroprotective activity.

The increasing global prevalence of Alzheimer's disease necessitates the development of novel therapeutic approaches. Neurodegenerative diseases are associated with increased oxidative stress and levels of cholinesterase enzymes. Hence, the development of cholinesterase inhibitors and antioxidants may provide neuroprotective effects.

The effects of sleep deprivation on the balance system: following normal sleep, 24 h of sleep deprivation, and rest under eyes-open and eyes-closed conditions.

Objective: This study investigated the effects of sleep deprivation (SD) on balance after normal sleep, 24 h of SD, and subsequent rest under eyes-open (EO) and eyes-closed (EC) conditions. Our aim was to ascertain whether the reduced efficiency of balance control following SD is generalized or selective.

Method: Nineteen participants (12 females, 7 males) completed the Pittsburgh Sleep Quality Index (PSQI).

miR-124, miR-126-3p, and miR-200b: Potential therapeutic targets for VEGF-mediated complications in proliferative diabetic retinopathy.

Introduction: This study aimed to investigate alterations in intravitreal microRNA and vascular endothelial growth factor (VEGF) levels in patients with proliferative diabetic retinopathy (PDR) as these factors are implicated in PDR pathogenesis.

Methods: Fifty-two participants, including 26 patients with PDR and 26 controls without diabetes, were included in this study. VEGF levels were assessed using ELISA, and seven microRNAs (miRNAs) (miR-19a, miR-20b, miR-27a, miR-124, miR-126-3p, miR-146a, and miR-200b) were analyzed using quantitative real-time PCR.

Sex differences in clinical and polysomnographic features of obstructive sleep apnea: The Turkish sleep apnea database (TURKAPNE) cohort.

Background: Previous reports from relatively small clinical cohorts have suggested that the clinical presentation of obstructive sleep apnea (OSA) differs between men and women.

Objective: We aimed to explore sex differences in clinical and polysomnographic features of OSA in a large nationwide registry.

Methods: Participants from the ongoing Turkish Sleep Apnea Database (TURKAPNE) Study from 34 centers were included in the current analysis.

Drug-refractory irritability and related factors in autistic children.

Objectives: Autistic children frequently exhibit irritability, which can manifest as aggression, self-injurious behaviour, and severe tantrums, leading to significant impairments. Two atypical antipsychotics have been licensed by the Food and Drug Administration for the treatment of irritability in autistic children, although a significant percentage of these children do not respond to this treatment. This study aimed to determine the frequency of drug refractory irritability (DRI) and identify the risk factors in a large clinical sample of autistic children.

Treatment Patterns and Attrition in Metastatic Renal Cell Carcinoma: Real-Life Experience from the Turkish Oncology Group Kidney Cancer Consortium (TKCC) Database.

Introduction: Despite the rapid evolution in management of metastatic renal cell carcinoma (mRCC) over the past decade, challenges remain in accessing new therapies in some parts of the world. Despite therapeutic advancements, attrition rates remain persistently high. This study aims to assess the treatment patterns and attrition rates of patients with mRCC in oncology clinics across Turkey.

Piperine induces cellular stresses, apoptosis, and cytotoxicity via JNK signaling and has concentration-dependently additive or synergistic effects with sorafenib in hepatocellular carcinoma: an in-vitro study.

We aimed to determine the effects of piperine on cell viability, cellular stresses, and apoptosis first, then the relationship of piperine's effects with the c-Jun N-terminal kinase (JNK) signaling pathway, and also the interaction of piperine with sorafenib in hepatocellular carcinoma. Hepatocellular carcinoma (HepG2 and Hep3B) and non-cancerous hepatocyte (AML12) cell lines were used. The cell viability was determined by using MTT assay.

Development of lacosamide-loaded in-situ gels through experimental design for evaluation of ocular irritation in vitro and in vivo.

Lacosamide (LCM) selectively increases the slow inactivation of voltage-gated sodium channels (VGSCs) and is a N-methyl d-aspartate acid (NMDA) receptor glycine site antagonist. Therefore, it can be used in dryness-related hyperexcitability of corneal cold receptor nerve terminals. Ocular in-situ gels remain in liquid form until they reach the target site, where they undergo a sol-gel transformation in response to specific stimuli.

Digital media use and its effects on digital eye strain and sleep quality in adolescents: A new emerging epidemic?

This study examines the association between excessive digital media use and adverse health outcomes, specifically Digital Eye Strain (DES) and Poor Sleep Quality (PSQ), in adolescents. A cross-sectional survey of 512 participants (aged 11-18 years) assessed DES and PSQ using the Computer Vision Syndrome Questionnaire and the Pittsburgh Sleep Quality Index. We found a high prevalence of DES (63.

A new strategy for enhancing S-Adenosyl-L-Methionine (SAMe) oral bioavailability: Preparation of SAMe loaded inulin nanoparticles for colon targeting with in vivo validation.

S-Adenosylmethionine (SAMe) is a crucial endogenous molecule in vital biochemical processes such as DNA, RNA, and protein methylation. It has been found beneficial in the treatment of liver disease, osteoarthritis, and particularly depression. However, SAMe's therapeutic potential is limited by low bioavailability due to poor permeability and extensive liver metabolism.