441 results match your criteria: "Toyohashi Heart Center.[Affiliation]"
Association of Baseline Mitral Valve Area With Procedural and Clinical Outcomes of Mitral Transcatheter Edge-to-Edge Repair: Insights From the OCEAN-Mitral Registry.
Circ Cardiovasc Interv
December 2024
Department of Cardiology, Keio University School of Medicine, Tokyo, Japan (K.H.).
Background: A small mitral valve area (MVA) is one of the challenging anatomies for transcatheter edge-to-edge repair (TEER) for mitral regurgitation, but the relationship between baseline MVA and clinical outcomes remains unknown. This study aimed to evaluate the association of baseline MVA with procedural and clinical outcomes in patients undergoing TEER with MitraClip from the OCEAN-Mitral registry (Optimized Catheter Valvular Intervention-Mitral).
Methods: A total of 1768 patients undergoing TEER were divided into 3 groups according to baseline MVA: group 1: <4.
Balloon aortic valvuloplasty with simultaneous aortic root injection: a case report of an adjunctive strategy to computed tomography for predicting coronary obstruction in transcatheter aortic valve-in-transcatheter aortic valve procedures.
Eur Heart J Case Rep
December 2024
Department of Cardiology, Gifu Heart Center, 4-14-4 Yabuta-minami, Gifu-city, Gifu 500-8384, Japan.
Background: Computed tomography (CT) assessment is the standard for predicting coronary obstruction (CO) caused by sinus sequestration (SS) during transcatheter aortic valve (TAV) implantation in degenerated TAV (TAV-in-TAV) procedure, but it may not always be accurate. This report describes a prediction method for CO by using balloon aortic valvuloplasty (BAV) during TAV-in-TAV.
Case Summary: An 87-year-old woman with a history of balloon-expandable transcatheter heart valve (BE-THV) implantation 7 years prior was admitted with worsening dyspnoea.
Impact of Angiographically Detected Residual Trabeculation After Left Atrial Appendage Closure Using the WATCHMAN Device: Insight From the OCEAN-LAAC Registry.
J Cardiovasc Electrophysiol
December 2024
Department of Cardiology, Keio University School of Medicine, Tokyo, Japan.
Background: Research on the impact of angiographically detected residual trabeculation after left atrial appendage closure (LAAC) is limited.
Objectives: To investigate the incidence, characteristics, and clinical implications of angiographically detected residual trabeculation after LAAC using the WATCHMAN device.
Methods: We analyzed 1350 consecutive patients with atrial fibrillation undergoing LAAC using the WATCHMAN device from the OCEAN-LAAC registry, which is a prospective ongoing, multicenter Japanese registry.
Diagnostic Performance of Artificial Intelligence-Based Angiography-Derived Non-Hyperemic Pressure Ratio Using Pressure Wire as Reference.
Circ J
December 2024
Department of Cardiovascular Medicine, Gifu Heart Center.
Background: The angiography-derived non-hyperemic pressure ratio (angioNHPR) is a novel index of NHPR based on artificial intelligence (AI) that does not require pressure wires. We investigated the diagnostic accuracy of angioNHPR for detecting hemodynamically relevant coronary artery disease.
Methods And Results: In this retrospective single-center study, angioNHPR was assessed using the invasive NHPR as the reference standard.
Update on Prosthesis-Patient Mismatch Following Transcatheter Aortic Valve Replacement in Asian Patients.
JACC Asia
November 2024
Department of Cardiology, Keio University School of Medicine, Tokyo, Japan.
Background: Prosthesis-patient mismatch (PPM) after transcatheter aortic valve replacement (TAVR) is of greater concern in Asians, considering their relatively smaller annular sizes compared with Westerners. However, the prognostic significance of PPM in Asian populations has not been demonstrated.
Objectives: This study aimed to elucidate the prognostic value of PPM after TAVR in Asian patients.
Valve Performance Between Latest-Generation Balloon-Expandable and Self-Expandable Transcatheter Heart Valves in a Small Aortic Annulus.
JACC Cardiovasc Interv
November 2024
Division of Cardiology, Keio University School of Medicine, Tokyo, Japan.
Article Synopsis
- - The study compares the hemodynamic performance and clinical outcomes of self-expandable valves (SEV) and balloon-expandable valves (BEV) in patients with small aortic annulus (SAA) undergoing transcatheter aortic valve replacement (TAVR).
- - Results showed that SEV offered better hemodynamics, with a higher rate of severe prosthesis-patient mismatch and a greater mean pressure gradient in patients receiving BEV, while BEV had lower incidences of paravalvular leakage and new permanent pacemaker implantation.
- - Overall, both valve types had similar device success rates, indicating that SEV is superior in hemodynamic outcomes but BEV has advantages in reducing certain complications. *
Handgrip strength as a marker of frailty in patients with transcatheter edge-to-edge repair: Insights from the OCEAN-mitral registry.
Int J Cardiol
February 2025
Department of Cardiology, Keio University School of Medicine, Tokyo, Japan.
Article Synopsis
- This study explores the relationship between handgrip strength and all-cause mortality in patients undergoing transcatheter edge-to-edge repair (TEER) for heart issues, suggesting that weaker grip strength could indicate a higher risk of death post-procedure.
- It includes data from the OCEAN-Mitral Registry, which analyzed handgrip tests of 2077 patients before TEER, with follow-ups showing varied changes in strength based on the success of the procedure.
- The findings suggest that improving mitral regurgitation (MR) post-TEER can positively impact frailty and resilience, making this research a significant insight into patient outcomes in heart-related treatments.
Predictors and clinical impact of worsening left ventricular ejection fraction after mitral transcatheter edge-to-edge repair.
EuroIntervention
November 2024
Department of Cardiology, Keio University School of Medicine, Tokyo, Japan.
Article Synopsis
- This study examined how left ventricular ejection fraction (LVEF) changes after a specific heart valve repair procedure called transcatheter edge-to-edge valve repair (TEER) in patients with mitral regurgitation (MR).
- Findings revealed that 32% of patients experienced worsened LVEF after the procedure, linked to increased end-systolic volumes in the heart and certain predictors like higher LVEF and levels of B-type natriuretic peptide.
- Despite the LVEF worsening, long-term outcomes (like death or hospitalization for heart failure) were similar for both patients with worsened and preserved LVEF, indicating that LVEF change might not significantly impact overall health results post-TEER
Association Between Direct Oral Anticoagulant Score and Bleeding Events in Patients With Atrial Fibrillation Following Transcatheter Aortic Valve Replacement: A Retrospective Multicenter Cohort Study.
J Am Heart Assoc
November 2024
Department of Cardiology Keio University School of Medicine Tokyo Japan.
Background: The Direct Oral Anticoagulant (DOAC) Score can predict bleeding risk in patients with atrial fibrillation taking DOACs; however, it lacks external validation. Therefore, this study aimed to assess the association between the DOAC Score and bleeding events in patients with atrial fibrillation who underwent transcatheter aortic valve replacement.
Methods And Results: This retrospective multicenter cohort study included patients with atrial fibrillation who underwent transcatheter aortic valve replacement, as registered in a Japanese multicenter registry.
Long-Term Clinical Outcomes of Drug-Coated Balloon Following Directional Coronary Atherectomy for Bifurcated or Ostial Lesions in the DCA/DCB Registry.
Catheter Cardiovasc Interv
November 2024
Cardiology and Vascular Medicine, Hoshi General Hospital, Fukushima, Japan.
Article Synopsis
- The study investigates the long-term effectiveness of a treatment method (directional coronary atherectomy followed by drug-coated balloon angioplasty) for large bifurcation lesions, especially those affecting the left main trunk.
- It analyzed 129 cases, primarily involving left main trunk lesions, and measured outcomes like target lesion revascularization and adverse events over a follow-up period averaging 53.4 months.
- Results showed low rates of target lesion revascularization and other adverse events at 24 and 36 months, suggesting that this treatment is a viable option for managing complex coronary conditions.
Initial Findings Concerning the Latest Self-Expandable Evolut FX Valve: A Report Using OCEAN-TAVI Registry Data.
Am J Cardiol
January 2025
Department of Cardiology, Keio University School of Medicine, Tokyo, Japan.
Data concerning the clinical effect of the latest-generation self-expandable transcatheter heart valve (Evolut FX) remain limited. We aimed to assess the in-hospital outcomes of 3 bioprosthetic valves (Evolut EPO, PRO+, and FX). We analyzed data from a Japanese multicenter registry involving 634 consecutive patients who underwent transcatheter aortic valve replacement with Evolut FX up until October 2023.
View Article and Find Full Text PDFCorrelations Between Plasma BNP Level and Risk of Thrombotic-Hemorrhagic Events After Left Atrial Appendage Closure.
J Clin Med
October 2024
Department of Cardiology, Keio University School of Medicine, Tokyo 160-8582, Japan.
Article Synopsis
- Percutaneous left atrial appendage closure (LAAC) helps reduce stroke and bleeding events in patients with non-valvular atrial fibrillation, particularly those who cannot take anticoagulants, but patients with heart failure remain at risk.
- In a study involving 937 patients, researchers evaluated the effect of baseline plasma B-type natriuretic peptide (BNP) levels on outcomes after LAAC, with 98% of the procedures being successfully completed.
- Results showed that higher baseline plasma BNP levels were linked to an increased risk of stroke, bleeding events, and mortality, indicating the need for further research to optimize treatment strategies for these patients.
Background: The Clinical Frailty Scale (CFS) is a useful frailty marker for predicting clinical outcomes in patients undergoing invasive therapy. However, the clinical impact of CFS after transcatheter edge-to-edge repair in patients with mitral regurgitation (MR) remains unclear. This study aimed to elucidate the association between the baseline frail status defined by the CFS and clinical outcomes with or without postprocedural MR ≥2+ (post-MR ≥2+) after transcatheter edge-to-edge repair.
View Article and Find Full Text PDFPercutaneous Coronary Intervention for Aorto-Ostial Chronic Total Occlusion: Evaluating Lesion Complexity and Procedural Outcomes.
JACC Cardiovasc Interv
October 2024
Department of Cardiology, Kurashiki Central Hospital, Okayama, Japan.
Background: PCI for aorto-ostial CTO remains challenging. The techniques for guidewire in aorto-ostial CTO may differ from those used in non-aorto-ostial CTOs, influenced by clinical and angiographic characteristics.
Objectives: This study aimed to assess the technical aspects and outcomes of percutaneous coronary intervention (PCI) in patients with aorto-ostial chronic total occlusion (CTO).
Prediction of fractional flow reserve using intravascular ultrasound.
EuroIntervention
October 2024
Department of Cardiovascular Medicine, Toyohashi Heart Center, Aichi, Japan.
Article Synopsis
- The study aimed to develop a real-time measurement of fractional flow reserve (FFR) using intravascular ultrasound (IVUS), which improves upon traditional offline methods that take about 10 minutes.
- It involved analyzing coronary lesions with at least 25% stenosis, taking measurements of IVUS and FFR before and after stent placement.
- Results showed a strong correlation (r=0.896) between the newly developed IQ-FFR and traditional wire-derived FFR, indicating high accuracy (87.5%) in predicting post-stent FFR levels, making IQ-FFR a promising tool for assessing coronary lesions.
Transcatheter Aortic Valve Implantation in Japanese Patients With Large Annulus: The OCEAN-TAVI Registry.
JACC Asia
September 2024
Division of Cardiology, Keio University School of Medicine, Tokyo, Japan.
Article Synopsis
- East Asians typically have smaller aortic valve complexes compared to Western populations, and there’s limited data on TAVI outcomes in Asian patients with large annuli.
- This study analyzes TAVI results in Asian patients, comparing outcomes between balloon-expandable valves (BEVs) and self-expandable valves (SEVs) by examining data from the OCEAN-TAVI registry.
- Findings show no significant differences in 3-year all-cause mortality, heart failure rehospitalization rates, or valve function after 2 years between BEV and SEV groups, although SEVs had higher rates of paravalvular leakage and pacemaker implantation.
Impact of beta-blocker uptitration on patients after transcatheter edge-to-edge mitral valve repair for secondary mitral regurgitation: The OCEAN-mitral registry.
Int J Cardiol
January 2025
Department of Cardiology, Keio University School of Medicine, Tokyo, Japan. Electronic address:
Article Synopsis
- * Out of 1474 patients analyzed, 18.4% received higher doses of beta-blockers one month post-surgery, showing a significant association with lower risks of all-cause and cardiovascular mortality.
- * The findings suggest that adjusting beta-blocker therapy after M-TEER can lead to improved outcomes, particularly for patients with a low left ventricular ejection fraction (LVEF) of 40% or less.
Mismatch Between Residual Mitral Regurgitation and Left Atrial Pressure Predicts Prognosis After Transcatheter Edge-to-Edge Repair.
JACC Cardiovasc Interv
September 2024
Department of Cardiology, Keio University School of Medicine, Tokyo, Japan.
Article Synopsis
- - The study investigates how mismatched residual mitral regurgitation (MR) and left atrial pressure (LAP) after a specific heart procedure (TEER) can negatively impact clinical outcomes in patients with severe MR and heart failure.
- - Researchers categorized 1,477 patients into three groups based on their MR and LAP levels, finding that those with mismatched or poor conditions faced higher risks of death and heart failure hospitalization compared to those in an optimal state.
- - Six key factors were identified as predictors of hemodynamic mismatch after TEER, including body mass index and pre-procedural pressures, suggesting that monitoring these could help improve patient outcomes.
Clinical and Angiographic Outcomes of Bilateral Internal Thoracic Artery Revascularization: In Situ vs Free Grafts.
Ann Thorac Surg
September 2024
Department of Cardiovascular Surgery, Japanese Red Cross Aichi Medical Center Nagoya Daiichi Hospital, Nagoya, Japan.
Background: Bilateral internal thoracic artery (ITA) grafting is associated with improved long-term outcomes; however, the appropriate graft configuration remains controversial. We compared the long-term outcomes of different graft configurations.
Methods: Between 2009 and 2015, 1171 patients underwent isolated bilateral ITA grafting for left-sided complete revascularization at 4 Japanese cardiac surgery centers: underwent in situ left ITA to the left anterior descending artery plus in situ right ITA to the left circumflex artery (LR group, n = 278), in situ right ITA to the left anterior descending artery plus in situ left ITA to the left circumflex artery (RL group, n = 665), and in situ left ITA to the left anterior descending artery plus free right ITA to the left circumflex artery (free group, n = 228).
Prognostic impact of being underweight in patients undergoing mitral TEER: The OCEAN-Mitral registry.
ESC Heart Fail
September 2024
Department of Cardiology, Keio University School of Medicine, Tokyo, Japan.
Article Synopsis
- The study evaluates the outcomes of mitral transcatheter edge-to-edge repair (M-TEER) in patients with severe mitral regurgitation, focusing on the impact of body mass index (BMI) on mortality rates.
- Researchers analyzed data from 2,149 M-TEER patients, categorizing them as underweight, normal weight, or overweight/obese, finding that underweight individuals had significantly higher rates of all-cause, cardiovascular, and non-cardiovascular mortality.
- The findings suggest that underweight status is a critical risk factor for worse outcomes post-M-TEER, highlighting the importance of thorough risk assessment and management in these patients.
Difference in cardiac response after transcatheter aortic valve implantation according to flow and gradient pattern.
Eur Heart J Cardiovasc Imaging
December 2024
Department of Cardiology, Keio University School of Medicine, Tokyo, Japan.
Article Synopsis
- The study analyzes the outcomes of 4,523 patients who underwent transcatheter aortic valve implantation (TAVI) for severe aortic stenosis, categorized into three groups based on flow gradient patterns: high-gradient AS (HG-AS), classical low-flow low-gradient AS (cLFLG-AS), and paradoxical low-flow low-gradient AS (pLFLG-AS).
- Results indicated that cLFLG-AS and pLFLG-AS had about 1.5 times higher two-year all-cause mortality rates compared to HG-AS, with cLFLG-AS showing more significant improvements in heart structure and function post-procedure.
- Specifically, cLFLG-AS patients experienced a greater reduction in left ventricular
Transcatheter aortic valve implantation for combined aortic and mitral stenoses: Insights from the OCEAN-TAVI Registry.
ESC Heart Fail
December 2024
Department of Cardiology, Keio University School of Medicine, Tokyo, Japan.
Article Synopsis
- - The study explores outcomes of patients with mitral stenosis (MS) who underwent transcatheter aortic valve implantation (TAVI) alongside those with aortic stenosis (AS) but no MS, focusing on factors like mitral annulus calcification (MAC), transmitral gradient (TMG), and mitral valve area (MVA).
- - Findings showed that patients with MS were generally older, predominantly female, and had a higher surgical risk score compared to those without MS; however, their 30-day mortality rates were similar.
- - Over a median follow-up of 2.1 years, patients with MS had a significantly higher rate of adverse events than the control group, indicating that MS adversely affects clinical outcomes post
Successful percutaneous left atrial appendage closure using reshaped curve sheath created by simultaneous virtual reality simulator.
Eur Heart J Case Rep
August 2024
Department of Cardiology, Gifu Heart Center, 1-14-4, Yabutaminami, Gifu 500-8384, Japan.
Initial Results of Intra-Annular Self-Expandable Valves: Insights From the OCEAN-TAVI Registry.
JACC Asia
July 2024
Department of Cardiology, Keio University School of Medicine, Tokyo, Japan.
Article Synopsis
- The Navitor intra-annular self-expanding heart valve (IA-SEV) is a new transcatheter heart valve introduced in Japan in April 2022, aimed at improving patient outcomes compared to the previous Portico valve.
- A study assessed the patient-prosthesis mismatch (PPM) and other outcomes in 463 Asian patients, finding that 91.7% of patients had no PPM, with a low in-hospital mortality rate of 1.9%.
- Overall, the IA-SEV demonstrated excellent hemodynamic results and reduced paravalvular leakage, making it particularly beneficial for Asian patients who often have smaller annulus sizes.