13,399 results match your criteria: "Toxicity Sympathomimetic"
J Appl Toxicol
November 2024
State Key Laboratory of Bioactive Substances and Function of Natural Medicine, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
The overactivation of β-adrenergic receptors (β-ARs) can result in acute myocardial ischemic injury, culminating in myocardial necrosis. Berberine (BBR) has exhibited promising potential for prevention and treatment in various heart diseases. However, its specific role in mitigating myocardial injury induced by acute β-AR overactivation remains unexplored.
View Article and Find Full Text PDFJ Pharm Biomed Anal
September 2024
Toxicological Centre, University of Antwerp, Antwerp 2610, Belgium; Exposome Center of Excellence, University of Antwerp, Universiteitsplein 1, Antwerp 2610, Belgium. Electronic address:
ACS Appl Bio Mater
July 2024
Department of Chemistry, Visva-Bharati University, Santiniketan 731235, India.
Dopamine, alongside norepinephrine and epinephrine, belongs to the catecholamine group, widely distributed across both plant and animal kingdoms. In mammals, these compounds serve as neurotransmitters with roles in glycogen mobilization. In plants, their synthesis is modulated in response to stress conditions aiding plant survival by emitting these chemicals, especially dopamine that relieves their resilience against stress caused by both abiotic and biotic factors.
View Article and Find Full Text PDFFood Res Int
August 2024
Chemistry Research Centre - Vila Real (CQ-VR), Food and Wine Chemistry Lab, Chemistry Department, University of Trás-os-Montes and Alto Douro, School of Life Sciences and Environment, 5000-801 Vila Real, Portugal. Electronic address:
Fermented beverages, including wine, can accumulate high concentrations of biogenic amines (BAs), which can pose potential health risks. BAs are produced by various yeasts and lactic acid bacteria (LAB) during winemaking. LAB are the main contributors to the formation of histamine and tyramine, the most toxic and food safety relevant biogenic amines.
View Article and Find Full Text PDFKorean J Anesthesiol
October 2024
Institute of Medical Science, Gyeongsang National University, Jinju, Korea.
Background: Epinephrine (EPI) or norepinephrine (NOR) is widely used to treat cardiovascular collapse during lipid emulsion (LE) resuscitation for drug toxicity. However, the effect of LE on the vasoconstriction caused by EPI or NOR remains unknown. The purpose of this study was to examine the effect of an LE (Intralipid) on the vasoconstriction caused by EPI and NOR in isolated rat aorta.
View Article and Find Full Text PDFEur J Pharmacol
September 2024
Clinical Pharmacology Department, Faculty of Medicine, Alexandria University, Alexandria, Egypt.
Aims: Bitter taste receptors (TAS2Rs) and their downstream signaling pathways are expressed not only in the oral tissues but also in extraoral tissues. Emerging data has demonstrated the beneficial effect of ghrelin in neurodegenerative diseases. Gaining more insight into the interaction between TAS2Rs and gut hormones may expand their therapeutic applications.
View Article and Find Full Text PDFExp Neurol
September 2024
Department of Pharmacology and Neuroscience, University of North Texas Health Science Center, Fort Worth, TX, United States of America. Electronic address:
Alleviation of motor impairment by aerobic exercise (AE) in Parkinson's disease (PD) patients points to activation of neurobiological mechanisms that may be targetable by therapeutic approaches. However, evidence for AE-related recovery of striatal dopamine (DA) signaling or tyrosine hydroxylase (TH) loss has been inconsistent in rodent studies. This ambiguity may be related to the timing of AE intervention in relation to the status of nigrostriatal neuron loss.
View Article and Find Full Text PDFJ Cardiovasc Pharmacol
July 2024
Department of Pediatrics, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan.
J Neurol
August 2024
Right Brain Bio, Inc, Pleasantville, NY, 10570, USA.
Following reports of low striatal dopamine content in Parkinson's disease, levodopa was shown to rapidly reverse hypokinesis, establishing the model of disease as one of dopamine deficiency. Dopaminergic therapy became standard of care, yet it failed to reverse the disease, suggesting the understanding of disease was incomplete. The literature suggests the potential for toxicity of dopamine and its metabolites, perhaps more relevant given the recent evidence for elevated cytosolic dopamine levels in the dopaminergic neurons of people with Parkinson's.
View Article and Find Full Text PDFNeurotoxicology
July 2024
Guangzhou Key Laboratory of Forensic Multi-Omics for Precision Identification, School of Forensic Medicine, Southern Medical University, Guangzhou 510515, PR China. Electronic address:
Environ Pollut
September 2024
Institute of Life Science and Green Development/College of Life Sciences, Hebei University, Baoding 071002, China; State Key Laboratory of Integrated Management of Pest Insects and Rodents, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China. Electronic address:
Parkinson's disease (PD) is one of the fastest-growing neurodegenerative diseases and has been linked to the exposure to numerous environmental neurotoxins. Although lead (Pb) exposure has been related to the development of PD, the molecular target of Pb to cause the onset of PD is insufficiently investigated. Herein, we explored the effects of Pb exposure on behavior, pathophysiology, and gene expression of wild-type (WT) fly (Drosophila melanogaster) by comparison with its PD model.
View Article and Find Full Text PDFTalanta
September 2024
Bioinformatics Center of AMMS, Beijing, 100850, China. Electronic address:
Neurosci Lett
July 2024
Department of Anatomy, Faculty of Medical Science, Naresuan University, Phitsanulok 65000, Thailand; Centre of Excellence in Medical Biotechnology, Faculty of Medical Science, Naresuan University, Phitsanulok 65000, Thailand. Electronic address:
Life Sci
August 2024
Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research (NIPER), S.A.S Nagar (Mohali) 160062, Punjab, India. Electronic address:
Aim: Chronic sympathetic stimulation has been identified as a primary factor in the pathogenesis of cardiac hypertrophy (CH). However, there is no appropriate treatment available for the management of CH. Recently, it has been revealed that pyruvate kinase M2 (PKM2) plays a significant role in cardiac remodeling, fibrosis, and hypertrophy.
View Article and Find Full Text PDFAnaesthesia
September 2024
London School of Anaesthesia, London, UK.
Neuropharmacology
October 2024
Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Xi'an Jiaotong University Health Science Center, Xi'an, 710061, China. Electronic address:
The anteroventral bed nucleus of stria terminalis (avBNST) is a limbic forebrain region involved in the regulation of anxiety, and expresses GABA receptors, which are located at both pre- and post-synaptic sites. However, it is unclear how blockade of these receptors affects anxiety-like behaviors, particularly in Parkinson's disease (PD)-related anxiety. In the present study, unilateral 6-hydroxydopamine (6-OHDA) lesions of the substantia nigra pars compacta in rats induced anxiety-like behaviors, and increased GABA release and decreased glutamate release in the avBNST, as well as decreased level of dopamine (DA) in the basolateral amygdala (BLA).
View Article and Find Full Text PDFInt J Drug Policy
July 2024
San Francisco Department of Public Health, 25 Van Ness Ave Suite 500, San Francisco, CA 94102, United States; University of California San Francisco, 1001 Potrero Ave, San Francisco, CA 94110, United States.
Sci Rep
June 2024
Medical Cellular and Molecular Research Center, Golestan University of Medical Sciences, Gorgan, Iran.
Radiation therapy and phototherapy are commonly used cancer treatments that offer advantages such as a low risk of adverse effects and the ability to target cancer cells while sparing healthy tissue. A promising strategy for cancer treatment involves using nanoparticles (NPs) in combination with radiation and photothermal therapy to target cancer cells and improve treatment efficacy. The synthesis of gold NPs (AuNPs) for use in biomedical applications has traditionally involved toxic reducing agents.
View Article and Find Full Text PDFNeurotoxicology
July 2024
Department of Environmental Health Sciences, Mailman School of Public Health at Columbia University, New York, NY 10032, USA; Department of Molecular Pharmacology and Therapeutics, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA. Electronic address:
Biochim Biophys Acta Mol Basis Dis
October 2024
Guangzhou Key Laboratory of Forensic Multi-Omics for Precision Identification, School of Forensic Medicine, Southern Medical University, Guangzhou 510515, PR China. Electronic address:
J Hazard Mater
August 2024
Guangdong Provincial Key Laboratory of Food Quality and Safety / National-Local Joint Engineering Research Center for Machining and Safety of Livestock and Poultry Products, South China Agricultural University, 510642 Guangzhou, China; Guangdong Laboratory for Lingnan Modern Agriculture, 510642 Guangzhou, China; Heyuan Branch, Guangdong Laboratory for Lingnan Modern Agriculture, 517000 Heyuan, China. Electronic address:
The disturbed gut microbiota is a key factor in activating the aflatoxin B (AFB)-induced liver pyroptosis by promoting inflammatory hepatic injury; however, the pathogen associated molecular pattern (PAMP) from disturbed gut microbiota and its mechanism in activating liver pyroptosis remain undefined. By transplanting AFB-originated fecal microbiota and sterile fecal microbial metabolites filtrate, we determined the association of PAMP in AFB-induced liver pyroptosis. Notably, AFB-originated sterile fecal microbial metabolites filtrate were more active in triggering liver pyroptosis in mice, as compared to parental fecal microbiota.
View Article and Find Full Text PDFEur J Pharmacol
August 2024
Department of Pharmacology, SVKM's Dr. Bhanuben Nanavati College of Pharmacy, Vile Parle (W), Mumbai, India. Electronic address:
Cardiac Hypertrophy is an adaptive response of the body to physiological and pathological stimuli, which increases cardiomyocyte size, thickening of cardiac muscles and progresses to heart failure. Downregulation of SIRT1 in cardiomyocytes has been linked with the pathogenesis of cardiac hypertrophy. The present study aimed to investigate the effect of Artesunate against isoprenaline induced cardiac hypertrophy in rats via SIRT1 inhibiting NF-κB activation.
View Article and Find Full Text PDFAquat Toxicol
July 2024
Biotechnology Department, Institute of Graduate Studies and Research, Alexandria University, Alexandria, Egypt.
Bisphenol A (BPA), a common industrial chemical with estrogenic activity, has recently gained attention due to its well-documented negative effects on humans and other organisms in the environment. The potential immunotoxicity and neurotoxicity of BPA remain poorly understood in marine invertebrate species. Therefore, the impacts of exposure to BPA on a series of behaviours, immune responses, oxidative stress, neural biomarkers, histology, and the ultrastructure of gills were investigated in the date mussel, Lithophaga lithophaga.
View Article and Find Full Text PDFEcotoxicol Environ Saf
July 2024
State Key Laboratory of Organ Failure Research; Key Laboratory of Infectious Diseases Research in South China, Ministry of Education; Guangdong Provincial Key Laboratory of Viral Hepatitis Research; Guangdong Provincial Clinical Research Center for Viral Hepatitis; Department of Infectious Diseases, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong 510515, China. Electronic address: