13,399 results match your criteria: "Toxicity Sympathomimetic"
Mass Spectrometry Analysis of Neurotransmitter Shifting during Neurogenesis and Neurodegeneration of PC12 Cells.
Int J Mol Sci
September 2024
Department of Chemistry, Tunghai University, No. 1727, Sec. 4, Taiwan Boulevard, Xitun District, Taichung 40704, Taiwan.
Article Synopsis
Methamphetamine-Induced Blood Pressure Sensitization Correlates with Morphological Alterations within A1/C1 Catecholamine Neurons.
Int J Mol Sci
September 2024
Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Neuromed, 86077 Pozzilli, Italy.
Article Synopsis
Tyramine Derivatives as Versatile Pharmacophores With Potent Biological Properties: Sex Hormone-Binding Globulin Inhibition, Colon Cancer Antimigration, and Antimicrobial Activity.
Chem Biol Drug Des
October 2024
University of Kragujevac, Faculty of Science, Department of Chemistry, Kragujevac, Serbia.
Article Synopsis
One-Pot Synthesis of Fe-Norepinephrine Nanoparticles for Synergetic Thermal-Enhanced Chemodynamic Therapy.
Nano Lett
October 2024
Center for Nanomedicine and Department of Anesthesiology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, United States.
Article Synopsis
- * The study introduces Fe-norepinephrine nanoparticles (Fe-NE NPs) that use ferrous ions and norepinephrine to efficiently deliver iron, releasing it within tumor cells to trigger the Fenton reaction.
- * Fe-NE NPs also harness photothermal conversion to produce heat from light, boosting the Fenton reaction and improving antitumor efficiency through a combination of both therapies.
The relationship between alcohol bingeing in the gestational period of wistar rats and the development of schizophrenia in the offspring adult life.
Brain Res
December 2024
Translational Psychiatry Laboratory, Graduate Program in Health Sciences, Universidade do Extremo Sul Catarinense (UNESC), Criciúma, SC, Brazil. Electronic address:
Article Synopsis
- The study explores how alcohol consumption during pregnancy affects the development of schizophrenia-like behaviors in rat offspring, linking intrauterine factors to adult mental health outcomes.
- Pregnant Wistar rats were given either alcohol or water, and their offspring underwent various behavioral tests and biochemical analyses at different ages to assess the impacts of prenatal alcohol exposure and subsequent ketamine injections.
- Results showed that alcohol exposure led to increased hyperactivity and cognitive impairments, particularly in male offspring, indicating that early stressors can have lasting effects on behavior and brain chemistry, potentially increasing vulnerability to additional stressors later in life.
Mexican calea (Calea zacatechichi Schltdl.) interferes with cholinergic and dopaminergic pathways and causes neuroglial toxicity.
J Ethnopharmacol
January 2025
REQUIMTE/LAQV, Laboratório de Farmacognosia, Departamento de Química, Faculdade de Farmácia, Universidade do Porto, R. Jorge Viterbo Ferreira, nº 228, 4050-313, Porto, Portugal. Electronic address:
Article Synopsis
Co-abuse of amphetamine and alcohol harms kidney and liver.
Sci Rep
October 2024
Department of Pharmacology and Toxicology, College of Pharmacy, Qassim University, Al Qassim, 51452, Buraydah, Saudi Arabia.
Article Synopsis
- The study found that people who abused both alcohol and amphetamines had a much higher risk of health problems compared to those who only used one or neither!
- Researchers tested 100 participants (75 with substance abuse issues and 25 healthy individuals) to see how these drugs affected the liver and kidneys!
- Results showed that all drug abusers had liver problems and changes in blood tests, but those who only drank alcohol had different blood sugar levels compared to others!
Metformin's cardioprotective role in isoprenaline-induced myocardial infarction: Unveiling insights into the AMPK, NF-κB, JAK2/STAT3 pathways, and cholinergic regulation.
Life Sci
November 2024
Department of Pharmacology and Biochemistry, Faculty of Pharmacy, Delta University for Science and Technology, International Coastal Road, Gamasa, Dakahliya, Egypt; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Mansoura University, Mansoura, Dakahliya, Egypt.
Article Synopsis
Methamphetamine-induced impairment of memory and fleeting neuroinflammation: Profiling mRNA changes in mouse hippocampus following short-term and long-term exposure.
Neuropharmacology
December 2024
Department of Immunology and Pathogenic Biology, College of Basic Medicine, Xi'an Jiaotong University Health Science Center, Xi'an, China. Electronic address:
Article Synopsis
- Scientists studied how methamphetamine (METH) affects memory in mice and found it messes with their learning abilities.
- They created models to see how METH changes brain cells and discovered that METH causes inflammation in the brain early on, but this doesn’t get worse with more doses.
- The researchers believe that even though the inflammation might not get worse, certain molecules linked to it stick around and are connected to the mice’s bad behavior, suggesting that treating inflammation could help with problems caused by METH.
Effects of exposure to chronic ergot alkaloids on phenylephrine contractile response of maternal pedal artery, umbilical artery, and umbilical vein in pregnant ewes.
Can J Vet Res
October 2024
Department of Veterinary Pathology (Yonpiam, Al-Dissi), Department of Veterinary Biomedical Sciences (Blakley), and Department of Pharmacology (Desai), College of Medicine, University of Saskatchewan, 52 Campus Drive, Saskatoon, Saskatchewan S7N 5B4.
Article Synopsis
- Ergot alkaloids have harmful effects on livestock, prompting a study on their impact on pregnant sheep's blood vessels and the role of -1 adrenergic receptors.
- Twelve pregnant sheep were divided into control and exposure groups, with the exposure group receiving ergot-contaminated feed for 45 days.
- Results showed significant increases in contractile response in the umbilical artery and vein of the exposed group, leading to lower fetal weights, indicating that current ergot safety limits may need reassessment.
KLF6 aggravates myocardial fibrosis by promoting mitochondrial division.
Pak J Pharm Sci
May 2024
Department of Biochemistry and Molecular Biology, College of Basic Medicine, Hebei University of Chinese Medicine, Shijiazhuang, Hebei, China/Hebei Higher Education Institute Applied Technology Research Center on TCM Formula Preparation, Shijiazhuang, Hebei, China/Hebei Key Laboratory of Chinese Medicine Research on Cardio-cerebrovascular Disease, Shijiazhuang, China.
The dysregulation of mitochondrial dynamics in cardiac fibroblasts (CFs) is closely linked to myocardial fibrosis, which can induce cardiac dysfunction and even lead to heart failure. As an essential multifunctional zinc-finger transcriptional factor of cardiovascular remodeling, the role of KLF6 mediating the link between mitochondrial fission and myocardial fibrosis remains unclear. Next, we want to explore whether the effect of KLF6 on mitochondrial fission might influence cardiac fibroblasts, we established a model of Transforming growth factor β1 (TGF-β1) and Isoprenaline (ISO)-induced myocardial fibrosis.
View Article and Find Full Text PDFPathogenic SHQ1 variants result in disruptions to neuronal development and the dopaminergic pathway.
Exp Neurol
December 2024
Department of Pediatric Neurology, National Taiwan University Children's Hospital, Taipei, Taiwan; Graduate Institute of Brain and Mind Sciences, and Department of Pediatrics, National Taiwan University College of Medicine, Taipei, Taiwan. Electronic address:
Background: Compound heterozygous variants of SHQ1, an assembly factor of H/ACA ribonucleoproteins (RNPs) involved in critical biological pathways, have been identified in patients with developmental delay, dystonia, epilepsy, and microcephaly. We investigated the role of SHQ1 in brain development and movement disorders.
Methods: SHQ1 expression was knocked down using short-hairpin RNA (shRNA) to investigate its effects on neurons.
Determination of 4-n-butylresorcinol by fluorescence derivatization based on dopamine.
Talanta
January 2025
Hubei Key Laboratory of Bioinorganic Chemistry & Materia Medica, China; Key Laboratory of Material Chemistry for Energy Conversion and Storage (HUST), Ministry of Education, China; School of Chemistry and Chemical Engineering, Huazhong University of Science and Technology, 430074, Wuhan, China. Electronic address:
Article Synopsis
- - 4-n-butylresorcinol (4nBR) is a common whitening agent in skincare products, known for its effectiveness at inhibiting tyrosinase with lower toxicity compared to other ingredients.
- - In alkaline conditions, 4nBR can react with dopamine to produce azamonardine, a fluorescent compound that allows for a new method of fluorescence analysis with a detection range of 1.0-24.0 nmol L and a limit of 0.25 nmol L.
- - The fluorescence method for detecting 4nBR in cosmetics showed high sensitivity and selectivity, yielding results consistent with HPLC and recovery rates between 98.2% and 108%.
Role of MARK4 in methamphetamine-induced acute kidney injury.
Zhong Nan Da Xue Xue Bao Yi Xue Ban
June 2024
Blood Purification Center, Third Xiangya Hospital, Central South University, Changsha 410013, China.
Article Synopsis
- - This study investigates how methamphetamine (METH) causes acute kidney injury (AKI) in mice, focusing on the protein MARK4's role in this process.
- - Ten male C57BL/6 mice were split into two groups (METH and control), with the METH group receiving daily METH injections for three days, and their kidney damage was assessed through various biochemical and staining techniques.
- - Results showed that METH treatment increased levels of MARK4 and cleaved caspase-3 in the kidneys, with proteomics revealing significant changes in 17 proteins, indicating that METH impacts kidney function and cellular activity.
Characteristic Cardiac Magnetic Resonance (CMR) Imaging Findings of Cocaine-Induced Myocardial Injury.
Cureus
August 2024
Cardiology, Baylor Scott & White Medical Center - Temple, Temple, USA.
Article Synopsis
- - Cocaine use can lead to serious heart conditions such as heart attacks and cardiomyopathy, posing significant health risks and burdens on healthcare systems.
- - Cardiac magnetic resonance (CMR) imaging is essential for identifying and assessing heart damage, allowing for the differentiation between acute and chronic injuries linked to cocaine use.
- - Early detection through CMR can help reverse damage caused by cocaine, making it a crucial tool for better management of cocaine-related heart issues.
Treatment with quercetin mitigates polystyrene nanoparticle-induced reduction in neuron capacity by inhibiting dopaminergic neurodegeneration and facilitating dopamine metabolism in Caenorhabditis elegans.
Chemosphere
September 2024
Environment and Health research division, Public Health Research Center, Wuxi School of Medicine, Jiangnan University, Wuxi, 214122, Jiangsu, China. Electronic address:
Article Synopsis
- - Long-term exposure to nanopolystyrenes (PS-NPs) in organisms causes neurotoxicity, leading to impaired movement and sensory perception, particularly at higher concentrations.
- - In a study using the worm model Caenorhabditis elegans, quercetin was found to improve locomotion and sensory behavior while protecting against neurodegeneration caused by PS-NPs exposure, suggesting its potential as a neuroprotective agent.
- - Quercetin treatment increased dopamine levels and altered gene expression related to neurodegeneration and dopamine metabolism, indicating its role in countering PS-NPs toxicity on neuronal function.
Etched-suppressed gold nanorods providing highly distinctive plasmonic patterns: Towards multiplex analysis of neuroblastoma biomarkers.
Anal Chim Acta
October 2024
Department of Chemistry, Sharif University of Technology, Tehran, 111559516, Iran; Institute for Nanoscience and Nanotechnology, Sharif University of Technology, Tehran, 11155-9516, Iran. Electronic address:
Article Synopsis
- On-site monitoring of vanillylmandelic acid (VMA), homovanillic acid (HVA), and dopamine (DA) is crucial for diagnosing neurological disorders, highlighting the need for non-toxic and reliable colorimetric sensors.
- This study introduces a new multi-colorimetric probe using gold nanorods that can effectively identify and differentiate between VMA, HVA, DA, and their mixtures through controlled etching with N-bromosuccinimide.
- The probe, enhanced with machine learning techniques for classification and quantification, demonstrated high sensitivity and accuracy, successfully detecting VMA:HVA in human urine.
Exploring the potential mechanism of atrazine-induced dopaminergic neurotoxicity based on integration strategy.
Environ Health Prev Med
September 2024
Department of Occupational and Environmental Health, College of Public Health, Xuzhou Medical University.
Article Synopsis
- Atrazine (ATR), a widely used herbicide, is linked to neurotoxic effects that may mirror symptoms of Parkinson's disease, prompting this study to explore the underlying molecular mechanisms.
- The research utilized network toxicology and various analytical methods to identify key protein targets involved in ATR-induced dopaminergic injury, ultimately identifying five significant hub targets.
- The findings suggested that these targets are crucial in ATR's neurotoxic effects, indicating a need for deeper exploration into ATR's molecular toxicity mechanisms.
Risperidone suppresses caffeine-induced hyperthermia and hyperactivity in rats.
Neurosci Lett
September 2024
Department of Psychiatry, Jichi Medical University, Japan.
Article Synopsis
- * A study investigated the effects of risperidone and other drugs on caffeine-induced symptoms in rats, finding that risperidone significantly reduced hyperthermia and hyperactivity by blocking certain receptor activities.
- * The research suggests that risperidone may be a potential treatment for caffeine intoxication by specifically affecting serotonin levels, while other drugs had varied effects on hyperthermia and activity levels.
Poweromin X Ten, a polyherbal formulation improves male sexual function: and network pharmacology study.
F1000Res
September 2024
Department of Pharmacology, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Manipal, Karnataka, 576104, India.
Article Synopsis
- Poweromin X Ten (PXT) is a traditional polyherbal supplement aimed at improving male sexual function, but its safety and effectiveness had not been previously researched.
- In a study, male rats were given PXT for 28 days, showing increased sexual activity and no reproductive toxicity, while also assessing brain chemicals linked to sexual behavior.
- The results indicated that PXT boosts sexual function through specific signaling pathways and is linked to key compounds like macelignan and testosterone, suggesting it may be a safer alternative for enhancing male sexual health.
BBPT attenuated 6-OHDA-induced toxicity by modulating oxidative stress, apoptotic, and inflammatory proteins in primary neurons and rat models of Parkinson's disease.
Neurotoxicology
December 2024
Neuropharmaceutical Chemistry Laboratory, Dr. B. R. Ambedkar Centre for Biomedical Research, North Campus, University of Delhi, Delhi 110007, India. Electronic address:
Parkinson's disease (PD) results from the degeneration of dopaminergic neurons in substantia nigra pars compacta (SNpc). Adenosine AR acting through the striato-pallidal pathway has emerged as a non-dopaminergic target in the therapy of PD. In the present work, the anti-parkinsonian potential of (4E)-4-(4-bromobenzylideneamino)-3-phenyl-2,3-dihydro-2-thioxo- thiazole-5-carbonitrile (BBPT) was explored.
View Article and Find Full Text PDFToxic Features and Metabolomic Intervention of Glabrene, an Impurity Found in the Pharmaceutical Product of Glabridin.
Int J Mol Sci
August 2024
Shaanxi Key Laboratory of Natural Products & Chemical Biology, College of Chemistry & Pharmacy, Northwest A&F University, Yangling 712100, China.
Article Synopsis
- - Glabridin, commonly used in cosmetics and pharmaceuticals, is extracted from licorice but can contain harmful impurities, specifically glabrene, which poses significant toxicity risks.
- - Toxicity tests using zebrafish revealed that glabrene has a lethal concentration (LC) of 2.8 μM, causing severe malformations, disrupted development, reduced mobility, and brain damage in the larvae.
- - Analysis showed that glabrene triggers abnormal activation of the phenylalanine metabolic pathway, leading to increased levels of dopamine and acetylcholine, highlighting the need for improved safety and quality control in licorice-based products.
Predictors of Serotonin Syndrome in Acute Poisoning with 5-Hydroxytryptamine Modulators.
Toxics
July 2024
Emergency Medicine Department, King Fahad Medical City, Sulimaniyah, Riyadh 12231, Saudi Arabia.
5-Hydroxytryptamine (5-HT) modulators are commonly prescribed medications with potentially life-threatening outcomes, particularly serotonin syndrome (SS). Early prediction of SS is critical not only to avoid lethal drug combinations but also to initiate appropriate treatment. The present work aimed to recognize the significant predictors of SS through a retrospective cross-sectional study that was conducted among patients exposed to an overdose of 5-HT modulators and admitted to a poison control center where 112 patients were enrolled.
View Article and Find Full Text PDFSystematic review protocol to determine the most effective pharmacological and non-pharmacological interventions for the management of acute methamphetamine toxicity.
BMJ Open
August 2024
Emergency Medicine, University of Calgary, Calgary, Alberta, Canada
Article Synopsis
- This study outlines a protocol for a systematic review focused on how to manage methamphetamine intoxication, particularly in terms of violence and agitation in emergency departments.
- The review will evaluate various pharmacological and non-pharmacological treatments for patients exhibiting violent behavior due to methamphetamine use and examine their effectiveness on de-escalation time, length of stay, admission rates, and provider satisfaction.
- Ethical approval has been secured for the study, and findings will be published in a peer-reviewed journal and shared at healthcare conferences in Canada.
Dopamine-modified hyaluronic acid (DA-HA) as a novel dopamine-mimetics with minimal autoxidation and cytotoxicity.
Redox Biol
October 2024
Human and Environmental Toxicology, University of Science and Technology (UST), Daejeon, 34114, South Korea; Department of Advanced Toxicology Research, Korea Institute of Toxicology (KIT), KRICT, Daejeon, 34114, South Korea. Electronic address:
Article Synopsis
- Dopamine-modified hyaluronic acid (DA-HA) was originally created for industrial uses, but its effects on brain health are still not well understood.
- Recent research shows that DA-HA works similarly to dopamine (DA) but has significantly lower toxicity due to reduced autoxidation, which is linked to neuron death.
- In tests on animals, DA-HA demonstrated lower toxicity compared to a known toxic form of DA and helped improve motor function in a model for Parkinson's disease, suggesting it could be a promising treatment for dopamine-related conditions.