13,399 results match your criteria: "Toxicity Sympathomimetic"
Paracentrotus lividus sea urchin gonadal extract mitigates neurotoxicity and inflammatory signaling in a rat model of Parkinson's disease.
PLoS One
December 2024
Faculty of Science, Department of Zoology, Alexandria University, Alexandria, Egypt.
The present study investigates the neuroprotective effects of the sea urchin Paracentrotus lividus gonadal extract on rotenone-induced neurotoxicity in a Parkinson's disease (PD) rat model. Parkinson's disease, characterized by the progressive loss of dopaminergic neurons in the substantia nigra (SN), is exacerbated by oxidative stress and neuroinflammation. The study involved fifty Wistar rats divided into five groups: control, dimethyl sulfoxide (DMSO) control, Paracentrotus lividus gonadal extract-treated, rotenone-treated, and combined rotenone with Paracentrotus lividus gonadal extract-treated.
View Article and Find Full Text PDFInteractions of VMAT2 with CDCrel-1 and Parkin in Methamphetamine Neurotoxicity.
Int J Mol Sci
December 2024
Department of Pharmaceutical Sciences, Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University, 259 Mack Ave., Detroit, MI 48201, USA.
In recent years, methamphetamine (METH) misuse in the US has been rapidly increasing, and there is no FDA-approved pharmacotherapy for METH use disorder (MUD). In addition to being dependent on the drug, people with MUD develop a variety of neurological problems related to the toxicity of this drug. A variety of molecular mechanisms underlying METH neurotoxicity has been identified, including the dysfunction of the neuroprotective protein parkin.
View Article and Find Full Text PDFIntegrated Analysis of Neuroendocrine and Neurotransmission Pathways Following Developmental Atrazine Exposure in Zebrafish.
Int J Mol Sci
December 2024
School of Health Sciences, Purdue University, West Lafayette, IN 47907, USA.
Atrazine is an endocrine-disrupting herbicide, with exposure impacting adverse outcomes along multiple endocrine pathways. This study investigated the neuroendocrine system as the central target of atrazine toxicity, examining effects of early developmental exposures on neurohormones and genes associated with kisspeptin, hypothalamic, pituitary, and dopamine systems. Zebrafish were exposed to 0, 0.
View Article and Find Full Text PDFEnrichment of Ginseng Rare Sapogenin 25-OH-PPT and Its Protective Effect on Myocardial Fibrosis.
Molecules
December 2024
School of Functional Food & Wine, Shenyang Pharmaceutical University, Shenyang 110016, China.
Ginseng ( C. A. Meyer), a traditional Chinese medicine, and the rare ginsenosides contained in it have various physiological activities.
View Article and Find Full Text PDFTargeted Liposomal Co-Delivery Dopamine with 3-n-Butylphthalide for Effective Against Parkinson's Disease in Mice Model.
Int J Nanomedicine
December 2024
School of Pharmacy, Chengdu Medical College, Chengdu, 610500, People's Republic of China.
Article Synopsis
Yin Yang 1 and guanine quadruplexes protect dopaminergic neurons from cellular stress via transmissive dormancy.
Nat Commun
December 2024
Department of Molecular Biology; University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA.
Article Synopsis
Irisin Treatment Prevents Isoproterenol-Induced Cardiac Fibrosis in Mice.
Discov Med
November 2024
Department of Precision and Regenerative Medicine and Ionian Area - DiMePRe-J, University of Bari "Aldo Moro", 70124 Bari, Italy.
Article Synopsis
Acute Paraoxon-Induced Neurotoxicity in a Mouse Survival Model: Oxidative Stress, Dopaminergic System Alterations and Memory Deficits.
Int J Mol Sci
November 2024
Department of Pharmacology, Toxicology and Therapeutic Chemistry, Pharmacology Section and Institute of Biomedicine (IBUB), Faculty of Pharmacy, University of Barcelona, 08028 Barcelona, Spain.
Article Synopsis
- The study investigates the secondary neurotoxicity resulting from severe organophosphorus (OP) poisoning, specifically paraoxon (POX), and its impact on cognitive functions in surviving mice.
- Mice were injected with POX followed by various treatments, resulting in high survival rates but significant neurological changes such as increased lipid peroxidation and alterations in neurotransmitter levels in key brain areas linked to memory.
- Despite no signs of depression or anxiety, the study found long-term memory impairments in the mice, highlighting the model's usefulness for exploring the effects of OP exposure and strategies to combat associated cognitive deficits.
Inhibition of RtTg neurons reverses methamphetamine-induced attention deficits.
Acta Neuropathol Commun
November 2024
Institute of Neuroscience, State Key Laboratory of Neuroscience, CAS Center for Excellence in Brain Science and Intelligence Technology, Shanghai, 200031, China.
Article Synopsis
Modeling of Isoproterenol-Induced Chronic Heart Failure in 24-Month-Old Rats.
Bull Exp Biol Med
November 2024
Cardiology Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences, Tomsk, Russia.
Article Synopsis
Adverse effects of diethyl phthalate and butyl benzyl phthalate on circadian rhythms and sleep patterns in zebrafish larvae.
Ecotoxicol Environ Saf
December 2024
Center for Predictive Model Research, Division of Advanced Predictive Research, Korea Institute of Toxicology, Daejeon, 34114, Korea; Human and Environmental Toxicology, University of Science and Technology, Daejeon 34113, South Korea. Electronic address:
The zebrafish, a diurnal vertebrate, is commonly used in circadian rhythm studies due to its genetic and neurological similarities to humans. Circadian rhythms, which regulate sleep, neurotransmitter, behavior, and physiological responses to environmental changes, can be disrupted by various environmental factors. Phthalic acid esters (PAEs) are pervasive endocrine disruptors that individuals are frequently exposed to in daily life.
View Article and Find Full Text PDFThe effect of paeoniflorin on the rewarding effect of methamphetamine and the associated cognitive impairment in mice.
Metab Brain Dis
November 2024
School of Pharmacy, Health Science Center, Ningbo University, Ningbo, 315211, China.
Article Synopsis
Nutmeg Poisoning With Electrolyte Abnormalities: A Case Report.
Cureus
October 2024
Department of Dermatology, Sakura Medical Center, Toho University, Sakura, Sakura, JPN.
Article Synopsis
Dopamine D receptors in the lateral habenula regulate anxiety-related behaviors in a rat model of Parkinson's disease.
Brain Res Bull
December 2024
Department of Neurology, The Affiliated Hospital of Northwest University, Xi'an No.3 Hospital, Xi'an, China. Electronic address:
Article Synopsis
Diffuse Alveolar Hemorrhage Due to Bupropion Inhalation.
Chest
November 2024
Mather Hospital at Northwell, Port Jefferson, NY.
Article Synopsis
Noradrenaline Protects Human Microglial Cells (HMC3) Against Apoptosis and DNA Damage Induced by LPS and Aβ Aggregates In Vitro.
Int J Mol Sci
October 2024
Department of Clinical Chemistry and Biochemistry, Medical University of Lodz, 92-215 Lodz, Poland.
Article Synopsis
Heat shock protein 27 downregulation attenuates isoprenaline-induced myocardial fibrosis and diastolic dysfunction by modulating the endothelial-mesenchymal transition.
Biochem Pharmacol
December 2024
Department of Cardiology, Second Hospital of Jilin University, No. 4026 Yatai Street, Changchun 130041, China. Electronic address:
Article Synopsis
Matrix Metalloproteinase-9 Signaling Regulates Colon Barrier Integrity in Models of HIV Infection.
J Neuroimmune Pharmacol
November 2024
Department of Pharmacology, Rush University Medical Center, 1735 W. Harrison Street Cohn Research Building Suite #424, Chicago, IL, 60612, USA.
Article Synopsis
Neuroprotective properties of a thiazolidine-2,4-dione derivative as an inhibitory agent against memory impairment and phosphorylated tau: In vitro and in vivo investigations.
Neuroscience
December 2024
Department of Biology, Faculty of Basic Sciences, University of Guilan, Rasht, Iran. Electronic address:
Article Synopsis
miR-421-mediated suppression of FGF13 as a novel mechanism ameliorates cardiac hypertrophy by inhibiting endoplasmic reticulum stress.
Eur J Pharmacol
December 2024
Department of Cardiology, The Second Hospital of Hebei Medical University, Shijiazhuang, 050000, China. Electronic address:
Article Synopsis
- Pathological cardiac hypertrophy significantly increases the risk of heart failure, and current treatments are not very effective, highlighting the need for new interventions.
- This study found that FGF13 levels are elevated in hypertrophic heart tissues and are linked to key hypertrophy markers, indicating its role in the condition.
- The research also identified miR-421 as a regulator that negatively affects FGF13, providing insight into a potential new therapeutic strategy for treating cardiac hypertrophy.
5-Demethylnobiletin Ameliorates Isoproterenol-Induced Cardiac Fibrosis and Apoptosis by Repressing the Sirt1/FOXO3a/NF-κB and Wnt/β-Catenin Pathways.
Biol Pharm Bull
October 2024
Department of General Practice, Affiliated Hospital of Inner Mongolia Medical University.
Article Synopsis
The effect of adrenalectomy on bleomycin-induced pulmonary fibrosis in mice.
Am J Physiol Lung Cell Mol Physiol
January 2025
Department of Internal Medicine, Section of Pulmonary, Critical Care, and Sleep Medicine, Yale School of Medicine, New Haven, Connecticut, United States.
Article Synopsis
- Progressive lung fibrosis is a serious condition with limited treatments, and it is linked to hormones like adrenaline and aldosterone from the adrenal glands.
- A study using mice found that removing the adrenal glands (adrenalectomy) did not change collagen buildup due to bleomycin but improved lung remodeling and reduced certain inflammatory cells.
- These findings suggest that the adrenal glands play a role in lung fibrosis and that adrenalectomy might be protective, highlighting the need for further research to explore new treatment options.
Methamphetamine-induced cardiotoxicity: in search of protective transcriptional mechanisms.
Herz
December 2024
Department of Psychosomatic Medicine and Psychotherapy, University of Göttingen, Waldweg 33, 37073, Göttingen, Germany.
Article Synopsis
Cardioprotective effect of tofisopam against isoprenaline-induced myocardial infarction in rats via modulation of NLRP3\IL-1β\caspase-1 pathway.
Immunopharmacol Immunotoxicol
December 2024
Department of Pharmacology, Faculty of Medicine, Minia University, Minia, Egypt.
Article Synopsis
Artificial intelligence application for identifying toxic plant species: A case of poisoning with Datura stramonium.
Toxicon
November 2024
Department of Emergency Medicine, Aksaray Training and Research Hospital, Aksaray, Turkey; Department of Emergency Medicine, Aksaray University School of Medicine, Aksaray, Turkey.
Article Synopsis
- Managing plant poisonings in the emergency department is complicated, mainly due to the difficulty in identifying the specific toxic plant species involved, which is critical for determining the appropriate treatment.
- A case of a 23-year-old male who experienced severe symptoms after consuming herbal tea led to the identification of Datura stramonium (jimson weed) using AI software, as timely access to botanical expertise was unavailable.
- The case suggests that AI tools with visual recognition can aid healthcare providers in accurately identifying toxic plants, enhancing patient safety and treatment effectiveness.