1,369 results match your criteria: "Toxicity Rodenticide"
Acute long-acting anticoagulant rodenticide poisoning in pregnancy: a case report.
Front Pharmacol
November 2024
Department of Obstetrics and Gynecology, West China Second University Hospital, Sichuan University, Chengdu, China.
Article Synopsis
- Brodifacoum is a highly effective rodent poison that can cause serious bleeding issues (coagulopathy), but its effects during pregnancy are not well documented.
- A case study reported a pregnant woman experiencing severe bleeding due to brodifacoum poisoning, leading to serious complications and the loss of the fetus.
- Effective management of brodifacoum poisoning is essential, with timely recognition and treatment (like vitamin K1) needed to improve outcomes for pregnant patients.
Causes of Death and Screening for Toxicants and Hemopathogens of European Hedgehogs (Erinaceus europaeus) from a Wildlife Rehabilitation Centre in Northern France.
J Wildl Dis
November 2024
Pôle EVAAS, VetAgro Sup, 1 avenue Bourgelat, Marcy l'Etoile 69280, France.
Article Synopsis
- The European hedgehog is declining in population, prompting conservation efforts, and this study focused on understanding the causes of death in hedgehogs admitted to a French rehabilitation center.
- Out of 159 dead hedgehogs analyzed, 92% had identifiable causes of death, with impaired condition (30%), bacterial infections (26%), and trauma (20%) being the most common.
- The study also found significant exposure to toxicants, such as anticoagulant rodenticides in 42% of hedgehogs, alongside a low prevalence of blood pathogens, emphasizing the need for further investigations into the health and ecological factors affecting hedgehog populations.
Exploring anticoagulant rodenticide exposure and effects in eagle owl (Bubo bubo) nestlings from a Mediterranean semiarid region.
Environ Res
January 2025
Area of Toxicology, Faculty of Veterinary, Campus de Espinardo, University of Murcia, 30100, Murcia, Spain.
Article Synopsis
- * In a study of nestling eagle owls, ARs were found in 91.5% of blood samples, with many individuals showing multiple AR compounds, primarily second-generation ARs (SGARs).
- * While the overall health of the sampled owls appeared good, there was a positive but not significant correlation between AR levels and prothrombin time; higher AR concentrations were linked to urban areas and landfills, indicating a need for better monitoring of these pollutants.
Synergistic polytherapy for the broad-spectrum treatment of chemically-induced seizures in rats.
Toxicol Appl Pharmacol
December 2024
Department of CBRN Protection, TNO Defence, Safety and Security, Lange Kleiweg 137, 2288 GJ Rijswijk, the Netherlands.
Article Synopsis
Second-Generation Anticoagulant Rodenticide Toxicosis in a Wild Carnaby's Cockatoo ().
J Avian Med Surg
October 2024
School of Veterinary Medicine, Murdoch University, Murdoch, Western Australia 6151, Australia.
Article Synopsis
- * On Day 4, the bird experienced severe bleeding, nosebleeds, and anemia, leading to its euthanasia due to ongoing health decline.
- * Testing revealed high levels of anticoagulant rodenticides in its liver, marking the first recorded case of rodenticide poisoning in this wild Australian bird species.
A Scientific Review of Pesticides: Classification, Toxicity, Health Effects, Sustainability, and Environmental Impact.
Cureus
August 2024
Microbiology, Krishna Institute of Medical Sciences, Krishna Vishwa Vidyapeeth (Deemed to be University), Karad, IND.
Article Synopsis
- Pesticides are widely used to protect crops from pests, fungi, and diseases while also helping to control diseases like malaria, but their application needs careful management to prevent harm to humans, animals, and the environment.
- The review categorizes pesticides into different types (herbicides, insecticides, fungicides, etc.) and discusses their functions, benefits such as increased crop yields, and risks like pest resistance and health hazards from residues.
- It emphasizes the importance of responsible pesticide use and integrated pest management strategies to balance agricultural productivity with environmental and health safety.
[Advances in the application of ion chromatography-mass spectrometry in the fields of life and health].
Se Pu
October 2024
Ningbo Municipal Center for Disease Control and Prevention, Key Laboratory of Health Risk Appraisal for Trace Toxic Chemicals of Zhejiang Province, Ningbo 315010, China.
Article Synopsis
- * The review covers the progress of IC-MS over the last 20 years, detailing its application in analyzing inorganic anions, organic acids, and polar substances across food, drug, and metabolomics studies.
- * Future trends in IC-MS research are anticipated to enhance its utility in analyzing toxic compounds and further expand its application in life sciences and healthcare.
Vkorc1 polymorphisms of the Norway rats in China: Implications for rodent management and evolutionary origin of anticoagulant resistance mutations.
Sci Total Environ
December 2024
State Key Laboratory for Biology of Plant Diseases and Insect Pests, Institute of Plant Protection, Chinese Academy of Agricultural Sciences, Beijing 100193, China. Electronic address:
Article Synopsis
- The rise in use of second-generation anticoagulant rodenticides (SGARs) has sparked concerns about their safety for non-target animals and environmental effects.
- Research has identified specific mutations in the Vkorc1 gene that lead to anticoagulant resistance in Norway rats, particularly noting three mutations (A26T, C96Y, A140T) found in rat populations across China.
- Understanding these mutations and their origins can help in developing more effective rodent control strategies, emphasizing the need to adopt less toxic first-generation anticoagulant rodenticides (FGARs) in susceptible areas.
Rare electrocardiographic findings in a young woman with acute barium poisoning: A case report.
Heliyon
September 2024
State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310000, PR China.
Article Synopsis
- Barium is a toxic heavy metal used in various products, and its toxicity increases with the solubility of its compounds, posing risks through both accidental and suicidal exposure.
- A specific case of acute barium poisoning involved a patient experiencing alternating episodes of hypokalemia and hyperkalemia, leading to complications like ventricular tachycardia (VT) that may be misdiagnosed.
- The findings suggest that careful management of potassium levels is essential during treatment to avoid iatrogenic hypokalemia while addressing the complications of barium poisoning.
Pesticide exposure and rhinitis: A cross-sectional study among farmers in Pitsanulok, Thailand.
F1000Res
September 2024
Faculty of Agriculture, Natural Resources and Environment, Naresuan University, Phitsanulok, 65000, Thailand.
Article Synopsis
- Pesticide exposure is linked to rhinitis, a common health issue for many people, especially among farmers in Phitsanulok province, Thailand, according to a cross-sectional study.
- The study included data from 9,649 participants, using in-person interviews and multiple variable logistic regression to establish the association between pesticide use and rhinitis prevalence.
- Results indicated a consistent link between various types of pesticides and rhinitis, with some relationships showing a dose-response pattern, suggesting the need for increased awareness and action from public health organizations regarding pesticides and farmers' health.
Unveiling the potency of ready-to-use brodifacoum blocks in lesser bandicoot rats: exploring toxicity, blood clotting factors, and organ histology.
Toxicol Res (Camb)
August 2024
Department of Veterinary Anatomy, Guru Angad Dev Veterinary and Animal Sciences University, Ferozepur Road, Punjab, Ludhiana 141004, India.
Article Synopsis
- - The study evaluated the effectiveness of 0.005% brodifacoum blocks against field rats in Southeast Asia, highlighting their potential to manage rodent populations resistant to similar anticoagulants.
- - In tests, brodifacoum caused 100% mortality in no-choice tests within 2-3 days and varying mortality rates (50%-83.33%) in bi-choice tests within 5-8 days, with notable symptoms including bleeding and organ damage.
- - The findings suggest that brodifacoum is a promising alternative for controlling rodent populations, showing significant mortality and certain effects on blood clotting without major impacts on body or organ weights.
Abdominal radiographic features of anticoagulant rodenticide toxicity in 14 dogs and 2 cats.
Open Vet J
June 2024
Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Purdue University, 625 Harrison St., West Lafayette, Indiana, 47906, USA.
Article Synopsis
- Anticoagulant rodenticide toxicity can cause internal bleeding in pets, particularly in dogs, leading to conditions like retroperitoneal hemorrhage, which has not been widely documented in relation to radiographic changes.
- The study aimed to examine the abdominal and thoracic radiographic features of this toxicity in affected dogs and cats, involving a review of radiographs by certified radiologists.
- Results indicated that retroperitoneal effusion was the most common finding in dogs, alongside significant thoracic issues like pleural effusion, suggesting that abdominal radiographs could be crucial for diagnosing hemorrhage related to coagulation problems.
Widespread use of anticoagulant rodenticides in agricultural and urban environments. A menace to the viability of the endangered Bonelli's eagle (Aquila fasciata) populations.
Environ Pollut
October 2024
Service of Toxicology and Forensic Veterinary Medicine, Department of Health Sciences, Faculty of Veterinary Medicine, Campus de Espinardo, Universidad de Murcia, 30100, Murcia, Spain; Toxicology and Risk Assessment Research Group, IMIB-Pascual Parrilla, University of Murcia, 30120 El Palmar, Spain.
Article Synopsis
- * A study analyzed 17 Bonelli's eagle carcasses in Eastern Spain, finding that all had been exposed to at least 5 of the 10 ARs tested, with second generation ARs being the most common.
- * The significant presence of ARs in these eagles, along with liver concentrations suggesting potential poisoning, raises concerns about their impact on the eagle population and associated risks to public health due to the diet of these birds.
Exposure to anticoagulant rodenticides in steppe polecat (Mustela eversmanii) and European polecat (Mustela putorius) in central Europe.
Sci Total Environ
October 2024
HUN-REN Balaton Limnological Research Institute, Klebelsberg Kunó utca 3, 8237 Tihany, Hungary; Institute of Animal Science, Hungarian University of Agriculture and Life Sciences, Guba Sándor út 40, 7400 Kaposvár, Hungary. Electronic address:
Article Synopsis
- Coumarin-type anticoagulant rodenticides (ARs) are widely used to control rodents, but they pose significant threats to predatory animals through both lethal and sublethal effects.
- A study conducted in Hungary from 2005 to 2021 found AR residues in 53% of steppe polecats and 39% of European polecats, with higher concentrations in steppe polecats and a diverse array of compounds in European polecats.
- Findings indicate that AR accumulation correlates with human population density and negatively with natural habitats, highlighting a pressing issue of secondary poisoning in food webs and the need for improved pesticide management for wildlife safety.
Unilateral retrobulbar haemorrhage in a cat secondary to suspected anticoagulant rodenticide intoxication.
Vet Med Sci
July 2024
Veterinary Emergency Medicine, Department of Veterinary Clinical Science, College of Veterinary Medicine and Research Institute for Veterinary Science, Seoul National University, Seoul, South Korea.
Article Synopsis
- * Diagnostic tests revealed increased pressure in the left eye and prolonged coagulation panels, indicating severe anemia and the presence of blood in the eye socket from retrobulbar fluid.
- * The kitten received treatments including surgery to relieve pressure, blood transfusions, and medications, resulting in improved health over 14 days, although it suffered from permanent optic nerve damage and blindness.
The possible therapeutic role of intravenous lipid emulsion in acute aluminium phosphide poisoning: a randomized controlled clinical trial.
Toxicol Res (Camb)
June 2024
Forensic Medicine and Clinical Toxicology at Department of Forensic Medicine and Clinical Toxicology, Faculty of Medicine, Tanta University-Medical collages complex-Al-Geish Street-Tanta,Gharbia 31527, Egypt.
Article Synopsis
- Aluminum phosphide (ALP) is a highly toxic rodenticide with mortality rates between 70-100%, and there's currently no specific antidote for its poisoning.* -
- In this study, 64 patients with acute ALP poisoning received either intravenous lipid emulsion (ILE) alongside conventional treatment or just conventional treatment, allowing researchers to assess the efficacy and safety of ILE.* -
- Results showed that ILE improved survival time, arterial blood pressure, and metabolic status in patients, but it did not significantly reduce mortality rates or the need for intubation and ventilation.*
Integrating metabolomics and network toxicology to reveal the mechanism of hypoaconitine-induced hepatotoxicity in mice.
Pestic Biochem Physiol
June 2024
School of Life Sciences, Beijing University of Chinese Medicine, Liangxiang Town, Fangshan District, Beijing 102488, China. Electronic address:
Article Synopsis
- Hypoaconitine (HA) is a highly toxic compound derived from aconite plants, primarily studied for its cardiotoxic effects, with limited research on its impact on the liver.
- This study utilized metabolomics and network toxicology to identify specific metabolites and metabolic pathways affected by HA exposure, revealing alterations in processes like arginine metabolism and oxidative stress.
- The findings suggest that HA contributes to liver toxicity by inducing oxidative stress, inflammation, and apoptosis, affecting various signaling pathways and cellular targets.
Anticoagulant rodenticide exposure in common buzzards: Impact of new rules for rodenticide use.
Sci Total Environ
September 2024
Chemistry Dept, SASA, Edinburgh, UK.
Article Synopsis
- Rodenticides are important for managing rodent populations, but they also pose a risk to birds of prey, like buzzards, which can be unintentionally poisoned.
- In the UK, a stewardship scheme was introduced in 2016 to reduce the risk of bird exposure to second generation anticoagulant rodenticides (SGARs), but a study found no significant decrease in SGAR exposure among buzzards after this change.
- The study revealed a troubling increase in brodifacoum exposure and multiple SGARs in buzzards post-stewardship, suggesting that the current measures may not be effective and further revisions may be needed.
A rodent and tick bait for controlling white-footed mice (Peromyscus leucopus) and blacklegged ticks (Ixodes scapularis), the respective pathogen host and vector of the Lyme disease spirochetes.
Ticks Tick Borne Dis
September 2024
Genesis Laboratories, P.O Box 1195, Wellington, CO 80549, USA.
Article Synopsis
- Researchers are exploring a new bait that combines rodenticide and acaricide to tackle both rodent populations and ticks, which are responsible for diseases like Lyme disease, prevalent in the U.S. with around 500,000 cases annually.
- A previous study showed that a low dose of fipronil was effective against tick larvae on white-footed mice, leading to the idea of a combined rodent and tick bait (RTB) to enhance community involvement in controlling tick threats.
- The research evaluated RTB's effectiveness on white-footed mice and tick larvae through lab tests and simulated field conditions, finding that the bait was successfully consumed even when alternative food sources were available.
The missing toxic link: Exposure of non-target native marsupials to second-generation anticoagulant rodenticides (SGARs) suggest a potential route of transfer into apex predators.
Sci Total Environ
July 2024
Deakin University, Geelong School of Life and Environmental Sciences, Faculty of Science, Engineering and the Built Environment, 221 Burwood Highway, Burwood 3125, Vic., Australia.
Article Synopsis
- Anticoagulant rodenticides (ARs), especially second-generation ARs (SGARs), are widely used to control pests but pose risks of bioaccumulation and secondary poisoning in non-target species, including predators like the powerful owl.
- A study found that 91% of brushtail possums and 40% of ringtail possums tested positive for SGARs, with concentrations potentially lethal for a substantial portion of brushtail possums.
- The pervasive presence of SGARs across different landscapes suggests a critical need for regulatory measures and routine testing in non-target animals to mitigate their ecological impact.
The Enigma of Norbormide, a -Selective Toxicant.
Cells
May 2024
Department of Pharmaceutical and Pharmacological Sciences, University of Padova, Via 8 Febbraio 2, 35122 Padova, Italy.
Article Synopsis
- Norbormide (NRB) was discovered in 1964 as a rodenticide thought to be safe for non-target species, but its use declined after 2003 due to inconsistent effectiveness and competition from second-generation anticoagulants.
- NRB causes lethal effects in rats through specific mechanisms like vasoconstriction of peripheral arteries and mitochondrial effects, although the exact processes remain unclear.
- Recent research on NRB derivatives has led to a promising new prodrug designed to be a selective and eco-friendly toxicant, while also exploring NRB's potential as a non-toxic fluorescent probe for cell imaging.