2,451 results match your criteria: "Toxicity Methamphetamine"
Interactions of VMAT2 with CDCrel-1 and Parkin in Methamphetamine Neurotoxicity.
Int J Mol Sci
December 2024
Department of Pharmaceutical Sciences, Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University, 259 Mack Ave., Detroit, MI 48201, USA.
In recent years, methamphetamine (METH) misuse in the US has been rapidly increasing, and there is no FDA-approved pharmacotherapy for METH use disorder (MUD). In addition to being dependent on the drug, people with MUD develop a variety of neurological problems related to the toxicity of this drug. A variety of molecular mechanisms underlying METH neurotoxicity has been identified, including the dysfunction of the neuroprotective protein parkin.
View Article and Find Full Text PDFThe impact of methamphetamine on liver injury in Iraqi male addicts.
Toxicol Rep
December 2024
Department of Pathology, College of Medicine, University of Baghdad, Baghdad, Iraq.
Article Synopsis
- Methamphetamine (METH) is a strong stimulant that disrupts several body processes, making it easy to abuse and causing potential liver damage through oxidative stress and metabolic disruptions.
- A study conducted in Baghdad with 196 male METH addicts revealed significant liver function impairments, particularly decreased albumin levels, compared to 187 healthy controls.
- Liver function tests indicated that certain liver enzymes (ALT, ALP, GGT) were more sensitive in detecting damage linked to METH addiction, showcasing the connection between substance abuse and liver health deterioration.
Characterizing and responding to stimulant overdoses: Findings from a mixed methods study of people who use cocaine and other stimulants in New England.
Drug Alcohol Depend
November 2024
Department of Epidemiology, Brown University School of Public Health, 121 South Main Street, Providence, RI 02912, USA; Center of Biomedical Research Excellence on Opioids and Overdose, Rhode Island Hospital, 1125 North Main Street, Providence, RI 02903, USA; The Warren Alpert School of Medicine of Brown University, 222 Richmond Street, Providence, RI 02912, USA; Brandeis University Opioid Policy Research Collaborative, 415 South Street, Waltham, MA, USA. Electronic address:
Article Synopsis
- The study investigates the experiences of individuals who use stimulants, focusing on factors influencing the decision to call 911 during overdose incidents.
- Conducted in Massachusetts and Rhode Island, the survey found that a significant percentage of participants experienced or witnessed stimulant overdoses, with variations in emergency response based on educational level and severity of symptoms.
- Despite many participants suffering from severe symptoms, less than half reported calling 911 for help, highlighting a need for more research to understand barriers to seeking emergency assistance during stimulant overdoses.
Inhibition of RtTg neurons reverses methamphetamine-induced attention deficits.
Acta Neuropathol Commun
November 2024
Institute of Neuroscience, State Key Laboratory of Neuroscience, CAS Center for Excellence in Brain Science and Intelligence Technology, Shanghai, 200031, China.
Article Synopsis
The effect of paeoniflorin on the rewarding effect of methamphetamine and the associated cognitive impairment in mice.
Metab Brain Dis
November 2024
School of Pharmacy, Health Science Center, Ningbo University, Ningbo, 315211, China.
Article Synopsis
Matrix Metalloproteinase-9 Signaling Regulates Colon Barrier Integrity in Models of HIV Infection.
J Neuroimmune Pharmacol
November 2024
Department of Pharmacology, Rush University Medical Center, 1735 W. Harrison Street Cohn Research Building Suite #424, Chicago, IL, 60612, USA.
Article Synopsis
Neuroprotective properties of a thiazolidine-2,4-dione derivative as an inhibitory agent against memory impairment and phosphorylated tau: In vitro and in vivo investigations.
Neuroscience
December 2024
Department of Biology, Faculty of Basic Sciences, University of Guilan, Rasht, Iran. Electronic address:
Article Synopsis
Methamphetamine-induced cardiotoxicity: in search of protective transcriptional mechanisms.
Herz
December 2024
Department of Psychosomatic Medicine and Psychotherapy, University of Göttingen, Waldweg 33, 37073, Göttingen, Germany.
Article Synopsis
Methamphetamine-Induced Blood Pressure Sensitization Correlates with Morphological Alterations within A1/C1 Catecholamine Neurons.
Int J Mol Sci
September 2024
Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Neuromed, 86077 Pozzilli, Italy.
Article Synopsis
Methamphetamine-induced impairment of memory and fleeting neuroinflammation: Profiling mRNA changes in mouse hippocampus following short-term and long-term exposure.
Neuropharmacology
December 2024
Department of Immunology and Pathogenic Biology, College of Basic Medicine, Xi'an Jiaotong University Health Science Center, Xi'an, China. Electronic address:
Article Synopsis
- Scientists studied how methamphetamine (METH) affects memory in mice and found it messes with their learning abilities.
- They created models to see how METH changes brain cells and discovered that METH causes inflammation in the brain early on, but this doesn’t get worse with more doses.
- The researchers believe that even though the inflammation might not get worse, certain molecules linked to it stick around and are connected to the mice’s bad behavior, suggesting that treating inflammation could help with problems caused by METH.
Role of MARK4 in methamphetamine-induced acute kidney injury.
Zhong Nan Da Xue Xue Bao Yi Xue Ban
June 2024
Blood Purification Center, Third Xiangya Hospital, Central South University, Changsha 410013, China.
Article Synopsis
- - This study investigates how methamphetamine (METH) causes acute kidney injury (AKI) in mice, focusing on the protein MARK4's role in this process.
- - Ten male C57BL/6 mice were split into two groups (METH and control), with the METH group receiving daily METH injections for three days, and their kidney damage was assessed through various biochemical and staining techniques.
- - Results showed that METH treatment increased levels of MARK4 and cleaved caspase-3 in the kidneys, with proteomics revealing significant changes in 17 proteins, indicating that METH impacts kidney function and cellular activity.
The Rise of Bromazolam in Postmortem Cases from Travis County, Texas and Surrounding Areas: 2021-2023.
J Anal Toxicol
September 2024
Travis County Medical Examiner, Austin, TX.
Article Synopsis
- Novel psychoactive substances (NPS), specifically benzodiazepines like bromazolam, are becoming increasingly prevalent and pose significant public health risks, especially in combination with opioids.
- A retrospective study in Travis County, Texas, reported bromazolam in 112 deaths from 2021-2023, with a dramatic increase in related drug toxicities over the period, particularly among young males.
- The majority of bromazolam-related fatalities involved polydrug use, predominantly with fentanyl, highlighting the dangers of mixing these substances amid the fentanyl epidemic.
Death Due to Caffeine and Methamphetamine Toxicity: A Case Report.
Cureus
August 2024
Pathology, Cook County Medical Examiner's Office, Chicago, USA.
Article Synopsis
- A 34-year-old man with psychiatric issues died after taking excessive caffeine pills, with toxicology testing confirming high levels of caffeine and methamphetamine in his system.
- The investigation concluded his death was due to a combination of caffeine and methamphetamine toxicity, highlighting the need for caution when using caffeine, especially for those with pre-existing health conditions.
Systematic review protocol to determine the most effective pharmacological and non-pharmacological interventions for the management of acute methamphetamine toxicity.
BMJ Open
August 2024
Emergency Medicine, University of Calgary, Calgary, Alberta, Canada
Article Synopsis
- This study outlines a protocol for a systematic review focused on how to manage methamphetamine intoxication, particularly in terms of violence and agitation in emergency departments.
- The review will evaluate various pharmacological and non-pharmacological treatments for patients exhibiting violent behavior due to methamphetamine use and examine their effectiveness on de-escalation time, length of stay, admission rates, and provider satisfaction.
- Ethical approval has been secured for the study, and findings will be published in a peer-reviewed journal and shared at healthcare conferences in Canada.
20-year trends in Australian methamphetamine-related deaths, 2001-2020.
Int J Drug Policy
September 2024
School of Public Health and Preventive Medicine, Faculty of Medicine, Nursing and Health Sciences, Monash University, Melbourne, Australia; Harm and Risk Reduction Program, Burnet Institute, Melbourne, Australia.
Article Synopsis
- Over the past two decades, methamphetamine-related deaths in Australia have risen significantly, prompting a comprehensive analysis of mortality trends across various causes from 2001 to 2023.
- The study found that nearly half of these deaths were due to unintentional drug toxicity, with other causes including self-harm and injuries, revealing fluctuating trends over time with periods of both increase and decrease in mortality rates.
- The latest data indicate a slight rise in unintentional drug toxicity deaths, a stabilization in intentional self-harm rates, and continued growth in deaths attributed to natural causes like circulatory diseases.
Angiopep-2 conjugated biomimetic nano-delivery system loaded with resveratrol for the treatment of methamphetamine addiction.
Int J Pharm
September 2024
Department of Geriatircs, First Affiliated Hospital of Nanjing Medical University, 300 Guangzhou Road, Nanjing 210029, Jiangsu, China. Electronic address:
Article Synopsis
- * A modified erythrocyte membrane (Ang-RBCm) was developed to carry resveratrol (RSV) using nanoparticles, enhancing delivery across the blood-brain barrier for better treatment of METH addiction.
- * Experiments showed that Ang-RBCm@RSVNPs effectively reduced METH preference in mice and improved synaptic plasticity without causing any significant harm to tissues, indicating its potential as a promising treatment for METH addiction.
Article Synopsis
- The study looked at accidental deaths from opioids and stimulants in Québec between 2012 and 2021.
- Mortality rates from these drugs increased, hitting a high point in 2020 and staying elevated in 2021, with more deaths linked to fentanyl rather than prescription opioids.
- The findings suggest a need for better drug policies and support systems to help reduce these dangerous drug-related deaths.
Prenatal methamphetamine hydrochloride exposure downregulates miRNA-151-3p and CACNA1C in testis rats' offspring.
Cell Mol Biol (Noisy-le-grand)
July 2024
Department of Physiology, Faculty of Medicine, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran.
Article Synopsis
- There is a significant concern regarding methamphetamine (METH) use among women of reproductive age, prompting the need for research on its effects on fetal development.
- This study investigates the impact of METH on two specific regulatory genes, miRNA-151-3p and CACNA1C, in mice exposed to the drug during pregnancy.
- Results show that METH exposure significantly reduces the expression of these genes in the offspring, suggesting potential adverse effects on male reproductive health due to disrupted genetic regulatory pathways.
Neurotoxic Methamphetamine Doses Alter CDCel-1 Levels and Its Interaction with Vesicular Monoamine Transporter-2 in Rat Striatum.
bioRxiv
July 2024
Department of Pharmaceutical Sciences, Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University, 259 Mack Ave, Detroit, MI, USA 48201.
Article Synopsis
- Methamphetamine misuse is rapidly increasing in the US, and there is currently no FDA-approved treatment for meth use disorder (MUD), leading to neurological issues from the drug's toxicity.
- This study explores the role of the protein parkin and its relationship with CDCrel-1 and VMAT2 in the neurotoxic effects of methamphetamine in male rats, demonstrating that binge METH alters CDCrel-1 levels and its interaction with VMAT2.
- Findings indicate significant individual differences in responses to meth's neurotoxicity, suggesting that understanding these genetic and molecular variations can help improve treatments for humans affected by MUD and associated neurological damage.
The emergence of bromazolam in Jefferson County, AL: a case series.
J Anal Toxicol
October 2024
Department of Pathology, University of Alabama at Birmingham, Birmingham, AL 35249, United States.
Article Synopsis
- Postmortem toxicology is evolving, with trends in benzodiazepines, particularly diazepam, alprazolam, and clonazepam, influenced by prescription habits and street use.
- Bromazolam, a newly identified designer benzodiazepine, has been detected in increasing cases and poses a risk of contributing to CNS depression in opioid overdose situations.
- Analysis of ten cases from the University of Alabama at Birmingham revealed a predominance of male, young white decedents with polydrug toxicity, underscoring the importance of documenting emerging drugs on death certificates for public health awareness and prevention efforts.
Spectrum of Kidney Biopsy Findings Associated With Methamphetamine Use.
Kidney Int Rep
July 2024
Department of Pathology and Laboratory Medicine, Cedars Sinai Medical Center, Los Angeles, California, USA.
Article Synopsis
- Methamphetamine (METH) is widely used and known to cause significant kidney dysfunction, but research on its specific toxic effects on the kidneys is limited.
- A study of 112 METH-abusing patients revealed that almost all had kidney issues, with common conditions including acute tubular necrosis (ATN) and focal segmental glomerulosclerosis (FSGS).
- The findings suggest that METH use frequently results in acute kidney injury (AKI) and associated proteinuria, highlighting the need for better understanding and management of renal complications in METH users.
Betaine improves METH-induced depressive-like behavior and cognitive impairment by alleviating neuroinflammation via NLRP3 inflammasome inhibition.
Prog Neuropsychopharmacol Biol Psychiatry
December 2024
College of Forensic Medicine, Hebei Medical University, Hebei Key Laboratory of Forensic Medicine, Collaborative Innovation Center of Forensic Medical Molecular Identification, Hebei Province, Shijiazhuang 050017, PR China; Research Unit of Digestive Tract Microecosystem Pharmacology and Toxicology, Chinese Academy of Medical Sciences, Hebei Province, Shijiazhuang 050017, PR China. Electronic address:
Article Synopsis
- * The study tested whether betaine could protect against these negative effects in mice given METH, showing that higher doses of betaine improved depressive-like behaviors and cognitive function.
- * Betaine not only helped restore synaptic health and reduced inflammation in the brain but also showed promise as a potential treatment for preventing and mitigating substance abuse issues.
The General Neurocognitive Decline in Patients with Methamphetamine Use and Transient Methamphetamine-induced Psychosis is Primarily Determined by Oxidative and AGE-RAGE Stress.
Curr Top Med Chem
September 2024
Department of Chemistry, College of Science, University of Kufa, Iraq.
Article Synopsis
- Chronic Methamphetamine use is linked to oxidative stress and neurocognitive impairments, but the relationship between biological changes and cognitive deficits remains unclear.
- The study involved 67 participants, comparing 40 with MA use to 27 controls, assessing cognitive performance and various oxidative stress biomarkers.
- Results indicated that increased oxidative toxicity and fewer antioxidant defenses significantly contributed to cognitive decline in MA users, suggesting new targets for preventing related psychosis and cognitive issues.
Pathological polarizations from microglia to astrocyte contributes to spatial memory deficit in methamphetamine abstinence mice.
Cereb Cortex
July 2024
Department of Human Anatomy and Histoembryology, Nanjing University of Chinese Medicine, 138 Xianlin Avenue, Nanjing, Jiangsu 210023, China.
Article Synopsis
- A study found that the polarization of astrocytes (A1-like) is linked to spatial memory deficits in mice that have stopped using methamphetamine.
- In these mice, there was an increase in M1-like microglia and heightened levels of pro-inflammatory cytokines (Interleukin 1α and tumor necrosis factor α) in a brain region called dCA1.
- Administering minocycline to inhibit M1-like microglia improved astrocyte function, reduced neurotoxicity, and restored spatial memory, highlighting that treatment is most effective during methamphetamine exposure rather than after abstinence.
In vitro biotransformation of 3-methylmethcathinone (3-MMC) through incubation with human liver microsomes and cytosol and application to in vivo samples.
J Pharm Biomed Anal
September 2024
Toxicological Centre, University of Antwerp, Antwerp 2610, Belgium; Exposome Center of Excellence, University of Antwerp, Universiteitsplein 1, Antwerp 2610, Belgium. Electronic address:
Article Synopsis
- * A study examined how 3-MMC is metabolized in the human body using liver samples and human matrices like plasma, urine, and hair, identifying three main metabolites of the substance.
- * This research is significant as it confirmed the presence of the metabolites in a large sample set, suggesting their potential use as biomarkers for monitoring 3-MMC usage in various contexts.