Historical inventories and future scenarios of multiple hazardous air pollutants (HAPs) emissions from the iron and steel production industry in China.

Iron and steel production (ISP) is one of significant atmospheric pollution emission sources in China. With the implementation of ultra-low emission (ULE) standards, a detailed and new updated emission inventory is urgently needed for better understanding of the temporal trends and spatial variation of emission characteristics. In this study, a unit-based comprehensive emission inventory of multiple hazardous air pollutants (HAPs) for the Chinese ISP spanned from 2012 to 2021, including the conventional pollutants, 13 kinds of Trace elements as well as 2 unconventional but toxic pollutants (PCDD/Fs, F), was dedicatedly developed by integrating dynamic localized emission factors with unit-based information of both the detailed activity level and abatement technology application.

Biogenic iron mineral formation and the fate of arsenic driven by its coupling with ferrous iron in acid mine drainage environment.

Acid mine drainage (AMD) containing arsenic produced during coal mining is a global environmental problem. However, the coupled driving process of the key element Fe and the associated element As in the AMD environment has received little attention. Therefore, in this study, we investigated the A.

Bicarbonate ions promote rapid degradation of pollutants in Co(II)Fe(II)/peroxyacetic acid systems.

Peroxyacetic acid (PAA), as an oxidizing agent, has gained significant attention in the field of advanced oxidation because of its low toxicity and high degradation capacity. In this study, cobalt-iron-based Prussian blue analogs (Co-PBAs) were utilized for the first time to activate PAA for tetracycline degradation. In the Co-PBAs/PAA system, organic radicals (RO•) and high-valent metal oxides are mainly produced.

Early-warning ecological risk assessments of multi-element pollution in the surface soil of karst basins in southwest China based on the delayed geochemical hazard model.

Soil potentially toxic element (PTE) pollution, especially in karst regions, poses significant ecological risks due to the unique geological features and environmental conditions. This study focuses on the delayed geochemical hazard (DGH) model to assess the progressive risks of cadmium (Cd) and lead (Pb) contamination in the surface soils of karst regions in southwestern China. The study found that Pb and Cd pollution in karst areas presents ecological risks, with the region's high porosity and alkaline soils facilitating the transformation of pollutants from stable to mobile forms.

STEAP3-SLC39A8-mediated microglia ferroptosis involved in neurotoxicity in rats after exposure to lead and cadmium combined.

The exposure of humans and animals to environmental compounds is rarely restricted to a single chemical. Unfortunately, very few studies were conducted to determine cadmium and lead combined effect. The aim of this study was to clarify the neurotoxicity induced by combined exposure to lead and cadmium and its mechanism of action.

Intrinsic structure-function connections of carbon-encapsulated nanoscale zero-valent-iron using various pyrolysis atmospheres.

Carbon-encapsulated nanoscale zero-valent-iron (C@Fe) derived from plant-based extracts has been the subject of growing interest due to its environmental friendliness. However, the effects of various pyrolysis atmospheres on the structure-function connections of C@Fe are still unclear. In this study, three pyrolytic atmospheres, namely Air, N, and 5% H/Ar were selected to fabricate X-C@Fe (X represented as A, N, H) for removing 2,4,6-Trichlorophenol (TCP), and the relationships between their structures and functions were demonstrated.

Scutellaria barbata D.Don and Hedyotis diffusa Willd herb pair combined with cisplatin synergistically inhibits ovarian cancer progression through modulating oxidative stress via NRF2-FTH1 autophagic degradation pathway.

Background: Cisplatin (DDP) is one of the most effective anticancer drugs, commonly used to treat advanced ovarian cancer (OC). However, DDP has significant limitations of platinum-based drugs, including chemical resistance and high-dose toxic side effects. Traditional Chinese medicines (TCMs) often presented in the form of formula, in which the herb pair was the basic unit.

Rutin Synergizes with Colistin to Eradicate Salmonellosis in Mice by Enhancing the Efficacy and Reducing the Toxicity.

The wide dissemination of multidrug-resistant (MDR) Gram-negative bacteria poses a significant global health and security concern. As developing new antibiotics is generally costly, fastidious, and time-consuming, there is an urgent need for alternative therapeutic strategies to address the gap in antibiotic discovery void. This study aimed to investigate the activity of colistin (CS) in combination with a natural product, rutin (RT), to combat against Typhimurium ( Tm) in vitro and in vivo.

A rare case report of severe aplastic anaemia caused by long-term use of zidovudine.

Background: Zidovudine is an antiviral drug used to treat acquired immune deficiency syndrome (AIDS). Anaemia is a common adverse effect of zidovudine that usually occurs in the first 2 to 4 weeks of initial treatment. Here, we describe a patient with HIV infection who developed severe aplastic anaemia 11 years after taking zidovudine.

Antimicrobial activity of iron-depriving pyoverdines against human opportunistic pathogens.

The global rise of antibiotic resistance calls for new drugs against bacterial pathogens. A common approach is to search for natural compounds deployed by microbes to inhibit competitors. Here, we show that the iron-chelating pyoverdines, siderophores produced by environmental spp.

Reduced number of alveoli after birth in rats exposed to iron in utero.

Background: Clinical studies have shown that diffuse chorioamniotic hemosiderosis (DCH) is a risk factor for bronchopulmonary dysplasia (BPD). However, the details of the underlying mechanism are unknown. We focused on iron, one of the blood components that diffuses within the amniotic cavity in DCH.

Liver-targeting iron oxide nanoparticles and their complexes with plant extracts for biocompatibility.

Thanks to their simple synthesis, controlled physical properties, and minimal toxicity, iron oxide nanoparticles (FeO NPs) are widely used in many biomedical applications (e.g., bioimaging, drug delivery, biosensors, diagnostics, and theranostics).

A health risk assessment of toxic metals and aflatoxin contamination in homemade and industrial noodles.

Environmental pollution is a problem that affects food safety throughout the world. In this study, a health risk assessment of possible toxic metal and aflatoxin contamination in homemade and industrial noodles produced in Türkiye was carried out. Samples were taken from 67 kinds of homemade and five kinds of industrial noodles from different cities.

Heart failure of very rare aetiology-haemochromatosis Type 3: a case report.

Background: Haemochromatosis is a pathological condition characterized by the accumulation of iron in parenchymal organs, leading to toxic damage and dysfunction. Cardiac haemochromatosis represents one of the rare causes of severe heart failure (HF) that can be potentially prevented with targeted treatment.

Case Summary: We present the case of a 41-year-old female who was hospitalized for decompensated HF.

Enhancing the Stability and Anticancer Activity of Asparaginase Through Nanoparticle Immobilization: A Biotechnological Perspective on Nano Chitosan.

There is a shortage in the experimental research directly comparing the effectiveness of different nanoparticles in boosting asparaginase (ASNase) activity. This study assessed the impact of various nanoparticles on enhancing ASNase activity, stability, and anticancer effects through immobilization. ASNase was immobilized on different nanoparticles, and its efficiency was measured.

Remediation of Cr(VI) Polluted Groundwater Using Zero-Valent Iron Composites: Preparation, Modification, Mechanisms, and Environmental Implications.

The extensive application of chromium (Cr) in many industries has inevitably resulted in the release of Cr(VI) into the groundwater environment, thus posing damage to the ecosystem and human health. Nano zero-valent iron (nZVI) has been widely studied and applied in the remediation of Cr(VI)-contaminated water as an ideal material with high reductive capacity, which enables the transformation of teratogenic and carcinogenic Cr(VI) into less toxic Cr(III). This review comprehensively summarizes the preparation and modification methods of nZVI Cr(VI) removal performance and mechanisms by nZVI and modified nZVI materials.

Iron-Doped Cadmium Sulfide/Graphene Oxide (CdFeS/GO) Nanocomposites for Photocatalytic Degradation of Toxic Pollutants.

Heterogeneous photocatalysis has been widely explored as a promising solution for dye degradation due to its cost-effectiveness, ease of recovery, and use of green technology. Precisely, iron-doped cadmium sulfide (CdS) exhibits greater efficiency because of its higher charge separation, more electron transfer efficiency, and adsorption under visible region. In this study, two different ratios of iron-doped cadmium sulfide (CdFeS/GO) nanocomposites such as CdFeS/GO and CdFeS/GO were synthesized using the coprecipitation method and characterized with UV-Vis DRS, XRD, FT-IR, Raman, XPS, and HR-TEM.

Cellular mechanisms of copper neurotoxicity in human, differentiated neurons.

Copper (Cu) is an essential trace element involved in fundamental physiological processes in the human body. Even slight disturbances in the physiological Cu homeostasis are associated with the manifestation of neurodegenerative diseases. While suggesting a crucial role of Cu in the pathogenesis, the exact mechanisms of Cu neurotoxicity involved in the onset and progression of neurological diseases are far from understood.

Update on current and emerging treatment paradigms for hyperphosphatemia in chronic kidney disease.

Introduction: Hyperphosphatemia in advanced CKD often accompanies high PTH and FGF23 levels, impaired bone mineralization, ectopic calcifications, and increased cardiovascular risks. Novel treatments are now available to lower serum phosphorus effectively. However, safety, tolerability, and patient adherence must be evaluated to determine the best therapeutic option for hyperphosphatemia.

Switchable surface Fe sites for water/sediment remediation through enhanced selective oxidation and ROS regulation: Performance, mechanism and application.

Selective oxidation relying on high-valent iron-oxo species (Fe(IV/V)) is a promising way of effective organic decontamination. However, Fe(IV/V) formation and further purposeful reinforcement production are commonly insufficient and unsustainable. Herein, cerium (Ce) modification strategy was adopted for efficient micropollutants removal through boosting Fe(IV/V) generation.

Targeting mitochondrial dynamics: A promising approach for intracerebral hemorrhage therapy.

Intracerebral hemorrhage (ICH) is a major global health issue with high mortality and disability rates. Following ICH, the hematoma exerts direct pressure on brain tissue, and blood entering the brain directly damages neurons and the blood-brain barrier. Subsequently, oxidative stress, inflammatory responses, apoptosis, brain edema, excitotoxicity, iron toxicity, and metabolic dysfunction around the hematoma further exacerbate brain tissue damage, leading to secondary brain injury (SBI).

ACS2 and ACS6, especially ACS2 is involved in MPK6 evoked production of ethylene under Cd stress, which exacerbated Cd toxicity in Arabidopsis thaliana.

As one of the heavy metal pollutants with strong biological toxicity, cadmium (Cd) is easily absorbed by plant roots, which seriously restricts the growth of plants, causes the quality of agricultural products to decline and threatens human health. Many complex signal transduction pathways are involved in the process of plant response to Cd stress. Among them, plant hormone ethylene is an important signal molecule for plant response to various environmental stresses, and its regulatory mechanism and signal transduction pathway in Cd stress response need to be further clarified.