Safety assessment and exploration of the mechanism of toxic effects of diallyl trisulfide: Based on acute and subacute toxicity and proteomics experiments.

Ethnopharmacological Relevance: Garlic (Allium sativum L.) is a widely consumed spice and condiment around the world, applied both as a food and as a traditional medicine, and is a natural strengthening agent for the body's circulatory and nervous systems. Diallyl trisulfide (DATS) is the major volatile organosulfur phytochemical found in garlic, with antithrombotic, anticoagulant, and antiplatelet activities as well as antioxidant, anti-infective, and other pharmacological effects.

Diallyl disulfide prevents cadmium-induced testicular injury by attenuating oxidative stress, apoptosis, and TLR-4/NF-κB and JAK1/STAT3 signaling and upregulating SIRT1 in rats.

Background: Cadmium (Cd) is a heavy metal environmental pollutant that can cause serious health problems. Cd can cause structural changes in the testes and exposure to this heavy metal is associated with the loss of sperms and male infertility. The role of oxidative stress and inflammation in Cd toxicity has been acknowledged.

Enhanced sulfide burial in low-oxygen aquatic environments could offset the carbon footprint of aquaculture production.

Carbon removal from the atmosphere is needed to keep global mean temperature increases below 2 °C. Here, we develop a model to explore how alkalinity production through enhanced iron sulfide formation in low-oxygen aquatic environments, such as aquaculture systems, could offer a cost-effective means of CO removal. We show that enhanced sulfide burial through the supply of reactive iron to surface sediments may be able to capture up to a hundred million tonnes of CO per year, particularly in countries with the highest number of fish farms, such as China and Indonesia.

Sub-ppb HS Sensing with Screen-Printed Porous ZnO/SnO Nanocomposite.

Hydrogen sulfide (HS) is a highly toxic and corrosive gas commonly found in industrial emissions and natural gas processing, posing serious risks to human health and environmental safety even at low concentrations. The early detection of HS is therefore critical for preventing accidents and ensuring compliance with safety regulations. This study presents the development of porous ZnO/SnO-nanocomposite gas sensors tailored for the ultrasensitive detection of HS at sub-ppb levels.

Synergistic degradation of refractory organic pollutant by underwater bubbling plasma combined with heterogeneous Fenton process.

Excessive discharge of the refractory organic pollutants endangers the development of the society and economy, thus seeking an efficient wastewater abatement method is an urgent need. Herein, Iron (Ⅱ) sulfide (FeS) was employed as the heterogeneous catalyst and coupled with underwater bubbling plasma (UBP) for the elimination of the refractory organic pollutant, malachite green (MG). FeS catalyst was synthesized using the solvothermal method and subsequently characterized comprehensively, focusing on its microstructure, specific surface area, chemical bonds and elements valence states.

Characterizing multifaceted environmental risks of oil and gas well leakage through soil and well methane and hydrogen sulfide emissions.

Oil and gas wells (OGWs) can lead to soil and well emissions of methane (CH), a potent greenhouse gas, and hydrogen sulfide (HS), a highly toxic gas, both of which reduce air quality and can cause explosions when emitted into confined spaces. Developments have been occurring over OGWs, posing health and safety risks. However, to our knowledge, previous studies have not conjunctively analyzed well and soil emissions while considering development on or near OGWs.

HS-releasing oridonin derivatives with improved antitumor activity by inhibiting the PI3K/AKT pathway.

Activating programmed cell death by delivering hydrogen sulfide (HS) has emerged as a promising strategy for tumor therapy. Oridonin serves as a lead compound for drug development due to its unique scaffold and wide-ranging biological effects, especially its antitumor properties. Based on the previous structure-activity relationship studies, 33 novel 1-O/14-O HS-releasing oridonin derivatives were synthesized.

Waste to Wealth: Discarded Cigarette Butt-Derived Metal-Free N-Rich Carbon Catalysts for the Selective Catalytic Oxidation of Hydrogen Sulfide to Sulfur.

The selective catalytic oxidation of toxic gas HS to elemental sulfur (HS-SCO) is a promising desulfurization process known for its dual benefits of recovering valuable sulfur resources and mitigating environmental pollution. Nevertheless, developing cost-effective and efficient catalysts for HS-SCO remains a significant challenge. In this study, we synthesized a low-cost and metal-free nitrogen-rich carbon catalyst (NrCC) by copyrolyzing discarded cigarette butts (organic solid wastes that are difficult to degrade naturally) with urea for the continuous HS-SCO process at a relatively low temperature.

Electro-stimulated biodegradation of dimethyl disulfide: Insights from biofilm spatial structure and key functional genes.

As a typical sulfur-containing volatile organic compound, dimethyl disulfide (DMDS) is known for its high toxicity and resistance to degradation, necessitating efficient control in environmental media. To address the limitations of biological treatment in degradation capacity, this study employs electro-stimulation to promote DMDS elimination by a porous polyaniline@carbon nanotube bioanode developed on graphite sheet (PANI@CNT/GS). Compared with the unmodified GS bioanode, the PANI@CNT/GS bioanode demonstrates significant advantages in biofilm activity, redox property, and DMDS degradation efficiency.

Influence of Atmospheric Gas Species on an Argyrodite-Type Sulfide Solid Electrolyte During Moisture Exposure.

Sulfide solid electrolytes have potential in practical all-solid-state batteries owing to their high formability and ionic conductivity. However, sulfide solid electrolytes are limited by the generation of toxic hydrogen sulfide and conductivity deterioration upon moisture exposure. Although numerous studies have investigated the hydrolysis degradation induced by "moisture," the influence of "atmospheric gases" during moisture exposure has not been extensively investigated despite the importance for practical fabrication.

Diallyl Disulfide Mitigates Cadmium Hepatotoxicity by Attenuating Oxidative Stress and TLR-4/NF-κB Signaling and Upregulating PPARγ.

Background: Heavy metals can cause serious health problems that affect different organs. Cadmium (Cd) is an environmental contaminant known for its toxicological consequences on different organs. Hepatotoxicity is a serious effect of exposure to Cd with oxidative stress (OS) and inflammation playing a central role.

Enhancing cisplatin efficacy in hepatocellular carcinoma with selenocystine: The suppression of DNA repair and inhibition of proliferation in hepatoma cells.

Cisplatin (cDDP) is a crucial chemotherapy drug for treating various cancers, including hepatocellular carcinoma (HCC). However, its effectiveness is often hindered by side effects and drug resistance. Selenocystine (SeC) demonstrates potential as an anticancer agent, particularly by inhibiting DNA repair mechanisms.

Hydrogen Sulfide Modulates Astrocytic Toxicity in Mouse Spinal Cord Cultures: Implications for Amyotrophic Lateral Sclerosis.

Hydrogen sulfide (HS), a known inhibitor of the electron transport chain, is endogenously produced in the periphery as well as in the central nervous system, where is mainly generated by glial cells. It affects, as a cellular signaling molecule, many different biochemical processes. In the central nervous system, depending on its concentration, it can be protective or damaging to neurons.

Hydrosulphide-methaemoglobin-albumin cluster: a hydrogen sulphide donor.

Methaemoglobin (metHb) possesses inherent characteristics that facilitate reversible binding to hydrogen sulphide. Exogenous hydrogen sulphide supplementation imparts beneficial bioactive effects, including antioxidant and anti-inflammatory; hence, we hypothesized that the metHb-hydrogen sulphide complex could act as a hydrogen sulphide donor for medication. In this study, we prepared a hydrosulphide-metHb-albumin (HS-metHb-albumin) cluster and examined its applicability as a hydrogen sulphide donor in the mice model of hepatic ischemia-reperfusion injury.

Polydimethylsiloxanes - Based Fluorescent Probe for HS Detection in Living Cells.

The development of fluorescent probes for HS detection especially in living cells is of great significance due to its fundamental role as signal molecule. A promising scaffold for the development of such probes is polydimethylsiloxanes (PDMS), which is cost-effectiveness, non-toxicity, flexibility, and biocompatibility and easy to post-functionalize. Surprisingly, fluorescent probes for HS detection based on PDMS have not been investigated.

Building Metabolically Stable and Potent Anti-HIV Thioether-Lipid Analogues of Tenofovir Exalidex: A thorough Pharmacological Analysis.

Inherently limited by poor bioavailability, antiviral agent tenofovir (TFV) is administered to people living with HIV in prodrug form. However, current prodrugs are prematurely metabolized, compromising access to HIV-infected cells and inducing toxicity. Inspired by lipid conjugate TFV exalidex (TXL), we recently disclosed TXL analogs with potent activity and robust hepatic stability in vitro, as well as attractive oral PK profiles in vivo.

Preparation and identification of a fluorescent probe with CsPbBrperovskite quantum dots and CD44v6 specific peptide for gastric cancer imaging.

Since the sensitivity and accuracy of traditional detection for early gastric cancer diagnosis are still insufficient, it is significant to continuously optimize the optical molecular imaging detection technology based on an endoscopic platform. The signal intensity and stability of traditional chemical fluorescent dyes are low, which hinders the clinical application of molecular imaging detection technology. This work developed a probe based on perovskite quantum dots (PQDs) and peptide ligands.

Generatable and Recyclable Oxygen Vacancy-Modified FeO-Decorated WO Nanowires with Super Stability for ppb-Level HS Sensing.

Detecting hydrogen sulfide (HS) odor gas in the environment at parts-per-billion-level concentrations is crucial. However, a significant challenge is the rapid deactivation caused by SO deposition. To address this issue, we developed a sensing material comprising FeO-decorated WO nanowires (FWO) with strong interfacial interaction.