4,405 results match your criteria: "Toxicity Fluoride"

MXenes (two-dimensional (2D) transition-metal carbides, nitrides, and carbonitrides) are gaining significant interest as alternative electrocatalysts for the hydrogen evolution reaction due to their excellent properties, such as high electrical conductivity, large surface area, and chemical stability. MXenes are traditionally synthesized using hydrofluoric acid (HF), which raises safety and environmental concerns due to its highly corrosive and toxic nature. HF introduces fluoride functional groups on the surface of MXenes, which have been reported to have a detrimental effect on electrocatalysis.

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Background: Oral health represents a public health problem due to its remarkable social impact and medical costs. Crenotherapy with sulfur water is shown to be a complementary, less toxic, and traumatizing therapy, but the number of studies that evaluate the effect of natural mineral waters effect on oral health are scarce. The aim of this pilot study is to evaluate the impact of thermal water therapy on the oral health of the participants, assessing parameters such as plaque index, gingival bleeding index and periodontal probing depth as well on the perception of symptoms of oral mucosa diseases (OMD).

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High fluoride (F) concentrations negatively affect the seed germination, plant growth, development, and yield of crops. L. is an F-sensitive crop frequently grown on marginal lands affected by F salts.

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Enriching fluorotelomer carboxylic acids-degrading consortia from sludges and soils.

Sci Total Environ

December 2024

Department of Chemistry and Environmental Science, New Jersey Institute of Technology, Newark, NJ, United States. Electronic address:

Fluorotelomer carboxylic acids (FTCAs) has drawn increasing attention due to their prevalent occurrence, high toxicity, and bioaccumulating effects. In this study, microbial consortia with sustainable FTCA removal abilities were enriched and characterized from two activated sludges and five soils when no external carbon sources were supplemented. After four generations of enrichment, stable 6:2 FTCA and 5:3 FTCA biodegradation were achieved, reaching 0.

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Confronting PFAS persistence: enzymes catalyzing C-F bond cleavage.

Trends Biochem Sci

December 2024

Department of Biochemistry, Molecular Biology & Biophysics, University of Minnesota, Minneapolis, MN 55455, USA. Electronic address:

Article Synopsis
  • Research on enzymes that break carbon-fluorine (C-F) bonds has mostly centered on a few natural microbial hydrolases interacting with fluoroacetate.
  • There is a growing need to identify and engineer new enzymes to help biodegrade commercial fluorinated compounds, especially PFAS, which are harmful substances.
  • One challenge in developing these enzymes is that the process releases toxic fluoride, requiring improvements in both enzyme efficiency and bacterial fluoride tolerance.
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The chronic intake of excessive fluoride (F) (>  1.5 mg/L) affects several tissues, organs, and systems. This represents a worldwide issue due to the presence of the compound in nature, with drinking water being the main source of exposure.

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Fluoride (F) is a major groundwater contaminant spread across the world. In excess concentrations, F can be detrimental to living beings. F exposure is linked to cellular redox dyshomeostasis, leading to oxidative stress-mediated pathologies including heart dysfunction.

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Curcumin mitigates sodium fluoride toxicity in Caenorhabditis elegans.

Ecotoxicol Environ Saf

December 2024

School of Life Sciences, Beijing University of Chinese Medicine, Beijing 102488, China; Key Laboratory of Endemic and Ethnic Diseases, Ministry of Education, Guizhou Medical University, Guiyang 550004, China. Electronic address:

Fluoride, a naturally occurring element found in water, soil, food, and atmospheric precipitation, can lead to fluorosis and various health issues when consumed excessively. However, the mechanism of fluorosis is still under investigation. This study utilizes Caenorhabditis elegans as a model organism to investigate the effects of fluoride exposure on biological systems and to explore the mechanisms by which curcumin mitigates fluoride-induced toxicity.

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Electro-activated peroxymonosulfate based on hollow cubic skeleton nanoflower cathode catalyst MoSe/cubic nanocage (CNC) for enhanced degradation of norfloxacin: Performance, mechanism, degradation pathways and toxicity.

J Colloid Interface Sci

March 2025

College of Resources and Environment, Key Laboratory of Agricultural Environment, National Engineering Research Center for Efficient Utilization of Soil and Fertilizer Resources, Shandong Agricultural University, Tai'an 271018, China. Electronic address:

Recently, antibiotic wastewater pollution has become increasingly serious. In this study, a novel hollow cubic framework self-supported nanoflower-like cathode catalyst (MoSe/CNC) based on Co Fe prussian blue analogues (CoFePBA)-derived cubic nanocage (CNC) loaded with MoSe was successfully prepared and utilized in an electro-activated peroxymonosulfate (PMS) system for norfloxacin (NOR) degradation. Benefit from the combined structures of MoSe, MoC, and Co/FeNC, the electrocatalytic activity and specific surface area were greatly improved.

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A prescription for engineering PFAS biodegradation.

Biochem J

December 2024

Department of Environmental Microbiology, Swiss Federal Institute of Aquatic Science and Technology (Eawag), Ueberlandstrasse 133, 8600 Duebendorf, Switzerland.

Per- and polyfluorinated chemicals (PFAS) are of rising concern due to environmental persistence and emerging evidence of health risks to humans. Environmental persistence is largely attributed to a failure of microbes to degrade PFAS. PFAS recalcitrance has been proposed to result from chemistry, specifically C-F bond strength, or biology, largely negative selection from fluoride toxicity.

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Fluoride induces immune-inflammatory disorder in the kidneys via histone lysine crotonylation in vivo.

Ecotoxicol Environ Saf

December 2024

Department of Toxicology, School of Public Health, Shenyang Medical College, Shenyang 110034, PR China. Electronic address:

Fluoride is an essential trace element for human. Adequate levels of fluoride are crucial for maintaining skeletal growth, but excessive fluoride exposure entering the body can cause renal damage, including damaged renal tubules and impaired renal function. However, the mechanism on fluoride-induced kidney injury remains unclear.

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Chronic exposure to inorganic arsenic (iAs) and fluoride (F) affect gut health and potentially damage organs. The present study investigates the interplay between gut bacteria and oxidative stress (measured by MDA level, GSH level, catalase activity, Nrf2 translocation and expression) in zebrafish exposed to F (NaF 15 ppm) and As (AsO 50 ppb) alone or in combination. Combined exposure to As and F reduced gut bacterial alteration and imposed less oxidative stress compared to F- exposure alone.

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The correlation between fluoride-induced bone damage and reduced DLAV formation in Zebrafish Larvae.

Ecotoxicol Environ Saf

December 2024

Judicial Appraisal Center, Guizhou University of Traditional Chinese Medicine, Guiyang, Guizhou 550000, PR China; Key Laboratory of Forensic Toxicology of Herbal Medicines, Guizhou Education Department, Guiyang, Guizhou 550000, PR China. Electronic address:

In this study, we aimed to investigate the mechanism by which fluoride exposure causes bone damage and the relationship with the loss of dorsal longitudinal anastomotic vessel (DLAV) formation in zebrafish larvae to further understanding of skeletal fluorosis. We assessed the development of chondrogenesis, osteogenesis, and DLAV angiogenesis, and reactive oxygen species (ROS) in zebrafish larvae subjected to blank control group (Con), low-fluoride group (LF), and high-fluoride group (HF). Abnormal development of the cartilage area, bone mineralization accompanied with abnormal mRNA expression of osteoblast-related OC, ALP, and Runx2b genes and osteoclast-related OPG and RANKL genes, and abnormal DLAV angiogenesis and ROS levels in zebrafish larvae were affected to varying degrees with the increase of fluoride exposure.

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Excessive fluoride exposure beyond the tolerable limit may adversely impacts brain functionality. Betaine (BET), a trimethyl glycine, possesses antioxidant, anti-inflammatory and anti-apoptotic functions, although the underlying mechanisms of the role of BET on fluoride-induced neurotoxicity remain unelucidated. To assess the mechanism involved in the neuro-restorative role of BET on behavioural, neurochemical, and histological changes, we employed a rat model of sodium fluoride (NaF) exposure.

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Influence of Qingzhuan Tea Polysaccharides on F Adsorption: Molecular Structure, Binding Behavior, and and Digestion and Metabolism.

J Agric Food Chem

November 2024

Department of Food Science and Engineering, School of Agriculture and Biology, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240, P. R. China.

Article Synopsis
  • High fluoride levels in Qingzhuan tea pose health risks, prompting research on how purified Qingzhuan tea polysaccharides (pTPS) interact with fluoride ions.
  • The study assessed pTPS's structural properties and its ability to adsorb fluoride under different conditions, revealing a strong binding affinity.
  • Results showed that pTPS can lower serum fluoride levels and reduce fluoride accumulation in vital organs, suggesting its potential as a natural remedy to mitigate fluoride toxicity in consumers of Qingzhuan tea.
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Case report: Mixed hydrofluoric and nitric acid mist inhalation poisoning.

Front Med (Lausanne)

October 2024

Department of Pharmacy, The Hospital of Shandong University, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, China.

Article Synopsis
  • Hydrofluoric and nitric acids are highly corrosive and can cause chemical pneumonia when inhaled, leading to serious respiratory issues and requiring supportive treatment to manage symptoms.* -
  • The case study discusses three individuals who suffered from chemical pneumonia after a workplace accident involving a mixture of these acids, highlighting the need for emergency treatments like oxygenation.* -
  • The report emphasizes the rarity of lung damage from hydrogen fluoride exposure, suggesting that improved safety measures in workplaces and awareness among medical professionals are essential to prevent severe health consequences.*
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Previous research on the well-known environmental pollutant fluoride has demonstrated that fluoride exposure can lead to oxidative stress-related male infertility. Obesity is another public health issue that has a detrimental impact on male fertility. Previously, findings on fluoride toxicity in high-fat diet (HFD) conditions associated with oxidative stress have been evidenced.

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This experimental study was performed to evaluate the alterations in the expression of a few subunits composing glutamate AMPA (a-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid) and NMDA (N-methyl-D-aspartate) receptors in the hippocampal cells of Wistar rats in response to long-term fluoride (F) exposure. The animals were given water with background 0.4 (control), 5, 20, and 50 ppm F (as NaF) for 12 months.

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Fluoride, an environmental toxicant, not only arouses intestinal microbiota dysbiosis, but also causes neuronal apoptosis and a decline in learning and memory ability. The purpose of this study was to explore whether fecal microbiota transplantation (FMT) from healthy mice and bacteria-derived metabolites short-chain fatty acids (SCFAs) supplement protect against fluoride-induced learning and memory impairment. Results showed that FMT reversed the elevated percentage of working memory errors (WME) and reference memory errors (RME) in fluorosis mice during the eight-arm maze test.

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Fluoride stimulates the MAPK pathway to regulate endoplasmic reticulum stress and heat shock proteins to induce duodenal toxicity in chickens.

Poult Sci

December 2024

Heilongjiang Key Laboratory of Animal Disease Pathogenesis and Comparative Medicine, College of Veterinary Medicine, Northeast Agricultural University, Harbin, China; Animal Clinical Teaching Hospital, Northeast Agricultural University, Harbin, China. Electronic address:

Fluoride is one of the essential trace elements for body. However, excessive fluoride poses a major threat to human and animal health. Fluorosis may cause pathological damage of the duodenum, but the underlying mechanism needs to be further studied.

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Low cost materials for fluoride removal from groundwater.

J Environ Manage

November 2024

Environmental Engineering and Management, Asian Institute of Technology, P. O. Box 4, Klongluang, Pathumthani 12120, Thailand.

Article Synopsis
  • High fluoride concentrations in groundwater, exceeding the WHO's safe level of 1.5 mg/L, pose serious health risks to communities, leading to conditions like dental and skeletal fluorosis, and other serious health issues.
  • The presence of fluoride is primarily linked to geological factors, particularly rocks that contain fluorine, which release fluoride into the water supply.
  • Adsorption is highlighted as a cost-effective and efficient method for fluoride removal, especially in developing countries where conventional methods are often too expensive or complex, thus providing a promising solution for safe drinking water access.
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Fluoride effect on renal and hepatic functions: A comprehensive decade review of In vitro and In vivo studies.

J Oral Biol Craniofac Res

October 2024

Department of Oral Pathology, Saveetha Dental college and hospital, Saveetha University of Medical Sciences, Chennai, Tamilnadu, India.

Article Synopsis
  • This systematic review examines how fluoride exposure affects kidney and liver functions, bringing attention to potential health risks and encouraging cautious use of fluoride.
  • It involved a comprehensive analysis of studies from 2013 to 2023, focusing on various methodologies and findings related to fluoride's toxic effects on renal and hepatic systems.
  • The results show significant damage to kidneys and livers in animal studies with high fluoride doses, while also highlighting the need for further research to determine safe exposure levels and understand the mechanisms of fluoride toxicity.
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