2,201 results match your criteria: "Toxicity Digitalis"
Nonparoxysmal junctional tachycardia associated with 3:2 Wenckebach exit block in the absence of digitalis therapy.
J Electrocardiol
December 2024
Cardiology Department, University Hospitals Leuven, Herestraat 49, 3000 Leuven, Belgium. Electronic address:
Article Synopsis
- - Nonparoxysmal junctional tachycardia with Wenckebach exit block is usually linked to digitalis toxicity.
- - This report highlights a case where the arrhythmia appeared without the use of digitalis medication.
- - The patient in this case had underlying structural heart disease, suggesting that other factors may trigger this type of arrhythmia.
Falling into complexity: A case of digitalis-induced fall, trauma, symptomatic bradycardia, and syncope.
J Family Med Prim Care
August 2024
Department of Anaesthesiology, Pain Medicine and Critical Care, All India Institute of Medical Sciences, New Delhi, Delhi, India.
Article Synopsis
- - Digoxin is a cardiac medication that works by blocking the sodium potassium ATPase pump, but it has a very narrow therapeutic range, meaning the amount in the body needs to be tightly monitored.
- - Factors like age, body weight, kidney and liver function, and other medications can affect digoxin levels in the blood, increasing the risk of toxicity, which can lead to serious heart rhythm issues.
- - A case study of an elderly man showed that digoxin toxicity, exacerbated by chronic kidney disease and lack of dose adjustment, led to fainting and a mild brain injury, highlighting the dangers of improper management of digoxin in vulnerable populations.
Botrytis cinerea combines four molecular strategies to tolerate membrane-permeating plant compounds and to increase virulence.
Nat Commun
July 2024
Laboratory of Phytopathology, Wageningen University, Wageningen, The Netherlands.
Article Synopsis
- Saponins are toxic compounds found in plants that help defend against pests and pathogens, with known mechanisms for fungal resistance focused on enzyme secretion.
- Researchers investigated how the fungus Botrytis cinerea tolerates specific saponins from tomato and Digitalis purpurea, discovering four mechanisms that help it overcome the toxicity.
- One novel mechanism involves enzymatic deglycosylation, while the others function in the fungal membrane, suggesting implications for understanding tolerance in both plant pathogenic fungi and potential human pathogens.
Bidirectional ventricular tachycardia due to digoxin-diuretic interaction in post-cardiac surgery patient: a case report.
Arch Peru Cardiol Cir Cardiovasc
June 2024
Hospital Regional Primero de Octubre ISSSTE, Mexico City, Mexico. Hospital Regional Primero de Octubre ISSSTE Mexico City Mexico.
Article Synopsis
- Bidirectional ventricular tachycardia (BVT) is a rare and serious heart rhythm issue marked by changes in the QRS axis with each heartbeat, often linked to digitalis toxicity.
- A 62-year-old woman who had heart surgery developed BVT after being treated with digoxin and diuretics, leading to concerns about the interaction between these medications.
- The case stresses the need for careful monitoring of digoxin levels in patients on diuretics and suggests supportive treatments if BVT occurs, like stopping digoxin and providing potassium and magnesium supplements.
"Cardiac glycosides"-quo vaditis?-past, present, and future?
Naunyn Schmiedebergs Arch Pharmacol
December 2024
Institute of Pharmacology and Toxicology, University of Würzburg, Versbacher Straße 9, 97078, Würzburg, Germany.
Article Synopsis
- Digitalis glycosides, or cardiac glycosides, are drugs that inhibit the Na/K-ATPase and are commonly used to treat heart failure and atrial fibrillation.
- Despite their effectiveness, these drugs have a narrow therapeutic range, leading to debates about their necessity and safety in these conditions.
- The article aims to review the historical context, key research findings, and the overlooked advantages and disadvantages of using digitalis glycosides in clinical practice.
Non-paroxysmal junctional tachycardia complicating disseminated intravascular coagulation during massive surgical hemorrhage: A case report.
Medicine (Baltimore)
April 2024
Department of Anesthesiology and Pain Medicine, Yeungnam University College of Medicine, Daegu, Republic of Korea.
Article Synopsis
- Non-paroxysmal junctional tachycardia (NPJT) is a type of fast heart rhythm linked to heart issues, surgery, or imbalances in the body, and can be dangerous if not treated, even without existing heart disease.
- A 74-year-old woman undergoing surgery experienced NPJT during massive bleeding, leading to severe low blood pressure and complications.
- Despite initial treatment efforts with medication, the patient's condition worsened due to ongoing bleeding, resulting in shock and fatal complications, highlighting the need for prompt management of bleeding to prevent NPJT issues.
An account on the history of pharmacology in Spain.
Pharmacol Res
April 2024
Universidad de Alcalá de Henares, Madrid, Spain.
Article Synopsis
- The history of pharmacology in Spain began gaining independence as a science in Europe with the establishment of university chairs, notable with Osswald Shmiedeberg’s appointment in 1872 in Germany, which influenced Spanish pharmacology.
- Teófilo Hernando emerged as a significant figure in early 20th century Spain, pioneering the integration of modern pharmacology into medical education and directly training various pharmacologists, fostering growth in this field across Spanish universities.
- Despite interruptions from historical events like the Spanish Civil War and World Wars, the discipline evolved, leading to the formation of the "Sociedad Española de Farmacología" in 1972, as the impact of Hernando's students continued to expand pharmacological research and education
Deliberate Self-Poisoning with Plants in Southeastern France, a Poison Center 20-Year Report.
Toxins (Basel)
November 2023
Aix Marseille Univ, APHM, INSERM, IRD, SESSTIM, Hôpital Sainte Marguerite, Clinical Pharmacology and Poison Control Centre, 13009 Marseille, France.
Article Synopsis
- * The majority of poisonings (71%) stemmed from a predominant native species, and only four fatalities were reported, with most patients experiencing mild to moderate symptoms.
- * The study highlights the need for a specific treatment protocol due to a lack of standardized care, noting that only a small number of patients required antidotes such as Digifab or physostigmine.
Development and validation of a risk prediction nomogram for serious arrhythmias in acute digoxin toxicity among pediatrics: A multicenter study.
Toxicon
September 2023
Forensic Medicine and Clinical Toxicology Department, Faculty of Medicine, Tanta University, Tanta, Egypt.
Article Synopsis
- Digoxin, derived from the foxglove plant, can lead to serious cardiac issues like arrhythmias, requiring quick identification of at-risk patients for better outcomes.
- A study aimed to create a bedside nomogram to help identify pediatric patients at risk of severe digoxin-induced arrhythmias, showing high predictive accuracy (96.2%).
- Validation of the nomogram highlighted it as a significant tool for predicting serious arrhythmias by combining factors like age and serum levels of glucose, sodium, and potassium.
A Novel Module Based Method of Teaching Electrocardiogram Interpretation for Emergency Medicine Residents.
J Educ Teach Emerg Med
October 2022
Thomas Jefferson University Hospital, Department of Emergency Medicine, Philadelphia, PA.
Article Synopsis
- * It aims to teach residents how to accurately identify critical ECG abnormalities, such as abnormal P waves and ST elevations, which are vital for diagnosing life-threatening conditions like cardiac ischemia.
- * The module utilizes Articulate 360 for interactive learning, covering common ECG findings encountered in emergency settings, and emphasizes the importance of recognizing arrhythmias that could lead to sudden cardiac death.
Toxicological Emergencies.
Crit Care Nurs Q
November 2022
Division of Pulmonary and Critical Care Medicine, (Drs Azharuddin, Ogbebor, Arshad, and Cheema and Ms Smith), Division of Infectious Disease (Dr Ogbebor), Allegheny Health Network, Pittsburgh, Pennsylvania and Department of Pharmacy, Allegheny General Hospital, Pittsburgh, Pennsylvania (Dr Shuster).
Article Synopsis
- * Diagnosis typically relies on physical exams and basic lab tests to assess the patient's condition.
- * Treatment focuses on supportive care, airway management, and may involve using specific antidotes for certain poisons after stabilizing the patient.
Comparative Therapeutic Potential of Cardioactive Glycosides in Doxorubicin Model of Heart Failure.
Cardiovasc Toxicol
January 2022
Escola de Veterinária da Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
Article Synopsis
- The study explored the effects of cardioactive glycosides oleandrin, ouabain, and digoxin on heart damage caused by doxorubicin in adult rats.
- Rats were divided into four groups, injected with doxorubicin, and then treated with glycosides or saline for seven days, with various health evaluations conducted afterward.
- Results showed that while oleandrin and digoxin reduced some heart remodeling effects from doxorubicin, none of the glycosides demonstrated effective treatment for congestive heart failure in this model.
A Case of Digoxin Toxicity Due to Acute Renal Failure.
Cureus
August 2021
Internal Medicine, University of Alabama, Tuscaloosa, USA.
Article Synopsis
- Since the 1997 Digitalis Investigation Group trial, the use of digoxin has decreased as doctors prefer other medications like ACE inhibitors, ARBs, and beta-blockers, which are more effective in reducing health risks.
- Despite this decline in usage and better monitoring, digoxin toxicity continues to be a serious issue, leading to significant health complications.
- In cases of suspected digoxin toxicity, supportive care is crucial, including stopping the medication and possibly using digoxin-specific antibody fragments, especially in patients with conditions like acute renal failure, emphasizing the need for doctors to remain vigilant about this risk.
Utilizing Big Data to Identify Tiny Toxic Components: .
Foods
August 2021
Center for Food Safety and Applied Nutrition, Office of Regulatory Science, U.S. Food and Drug Administration, College Park, MD 20740, USA.
Article Synopsis
- The text discusses a botanical genus known for its colorful yet toxic and medicinal properties, highlighting its long history in therapeutic use and the risks of toxicity at low doses.
- A 1997 case of toxicity linked to contaminated dietary supplements was investigated by the FDA, and the text explores whether modern genome sequencing could have expedited this investigation.
- The study developed a method to detect the toxic species using genomic techniques, generating a significant number of genetic markers to identify and differentiate species, which could lead to faster identification of harmful substances in food and supplements.
A Young Woman With Palpitations: A Poison or a Remedy?
Circulation
June 2021
Department of Cardiology, Vardhman Mahavir Medical College and Safdarjung Hospital, New Delhi, India. Now with Department of Cardiology, Government Medical College and Hospital, Chandigarh, India.
OCT Findings in Presumed Digoxin Retinal Toxicity.
Ophthalmol Retina
November 2021
Retina Service, Weill Cornell Medicine, New York, New York. Electronic address:
In vitro and in vivo antileishmanial activity of β-acetyl-digitoxin, a cardenolide of Digitalis lanata potentially useful to treat visceral leishmaniasis.
Parasite
April 2021
Programa de Pós-Graduação em Ciências da Saúde: Infectologia e Medicina Tropical, Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte, 30130-100 Minas Gerais, Brazil - Departamento de Patologia Clínica, COLTEC, Universidade Federal de Minas Gerais, Belo Horizonte, 31270-901 Minas Gerais, Brazil.
Article Synopsis
- - Current treatments for visceral leishmaniasis have issues like side effects, high costs, and emerging drug resistance, creating a need for new low-cost antileishmanial agents.
- - The study identifies β-acetyl-digitoxin (b-AD), a compound from Digitalis lanata, showing strong antileishmanial activity both in vitro and in vivo, effectively reducing parasite load in infected mice and enhancing anti-parasite immune responses.
- - b-AD delivered in polymeric micelles (b-AD/Mic) showed higher efficacy than other treatments, including the standard drug miltefosine, with low toxicity observed, suggesting it could be a promising option for treating visceral leishmaniasis.
Bidirectional Ventricular Tachycardia in a Young Female: A Case of Andersen-Tawil Syndrome.
Mil Med
January 2023
Department of Cardiology, William Beaumont Army Medical Center, El Paso, TX 79920, USA.
Article Synopsis
- - Bidirectional ventricular tachycardia (VT) is a rare heart rhythm disorder linked to conditions like digitalis toxicity and Andersen-Tawil syndrome (ATS), which is caused by mutations in the KCNJ2 gene.
- - A young female patient with a family history of heart issues was diagnosed with ATS after showing symptoms like palpitations and physical features such as mandibular hypoplasia; she was treated successfully with a beta-blocker, leading to reduced ectopy.
- - There are no established treatment guidelines for ventricular dysrhythmias in ATS patients, but this case suggests that beta-blockers can improve symptoms, and patients may not need exercise restrictions as her ectopy burden decreased during activity.
Transient bilateral chorea secondary to digoxin toxicity in a female with acute kidney injury: a case report.
Eur Heart J Case Rep
February 2021
Cardiology Department, University Hospital Waterford, Waterford, Ireland.
Article Synopsis
- A 78-year-old woman with a history of chronic kidney disease and atrial fibrillation experienced vomiting and diarrhea after antibiotic treatment, leading to an emergency department visit.
- Her examination revealed digoxin toxicity indicated by abnormal heart rate and high digoxin levels, prompting treatment with digoxin-specific antibodies and fluid resuscitation.
- Following treatment, she developed temporary chorea, a movement disorder, which resolved as her digoxin levels normalized, confirming previous rare cases of digoxin-induced chorea associated with neurochemical changes.
[A poisonous spring smoothie with wild herbs: accidental intoxication with foxglove (Digitalis purpurea)].
Ned Tijdschr Geneeskd
November 2020
St. Antonius ziekenhuis, afd. Klinische Farmacie,Nieuwegein.
Article Synopsis
- - The ingestion of wild plants is becoming more common in society, but this increases the risk of poisoning, particularly from the toxic foxglove plant, which contains harmful cardiac glycosides.
- - A case study involves a 43-year-old woman who experienced severe symptoms after mistakenly drinking a smoothie made with foxglove instead of a safe plant.
- - Clinicians should be vigilant for foxglove poisoning in patients presenting with ongoing gastrointestinal issues and specific heart abnormalities after consuming wild plants.