187 results match your criteria: "Toxicity Cyclic Antidepressants"
Rolipram promotes hippocampal regeneration in mice after trimethyltin-induced neurodegeneration.
Neuroreport
September 2024
Laboratory of Veterinary Pathology, Joint Faculty of Veterinary Medicine, Yamaguchi University, Yamaguchi.
Article Synopsis
- This study explored how rolipram, a drug that inhibits an enzyme involved in breaking down cyclic AMP, affects brain tissue regeneration in mice with induced hippocampal damage.
- Mice were injected with trimethyltin to create a model for studying brain regeneration, and rolipram was administered daily to assess its effects on behavior and brain tissue.
- Results indicated that rolipram improved the regeneration of neurons, reduced neuroinflammation, and enhanced the survival of new neurons in the brain, suggesting its potential as a therapeutic option for brain injuries.
Co-catalpol alleviates fluoxetine-induced main toxicity: Involvement of ATF3/FSP1 signaling-mediated inhibition of ferroptosis.
Phytomedicine
April 2024
College of Pharmacy, Henan University of Chinese Medicine, Zhengzhou, 450046, China.
Article Synopsis
Evaluating the Role of N-Acetyl-L-Tryptophan in the Aβ 1-42-Induced Neuroinflammation and Cognitive Decline in Alzheimer's Disease.
Mol Neurobiol
July 2024
Department of Pharmacology, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Manipal, Karnataka, 576104, India.
Article Synopsis
- Alzheimer's disease (AD) is increasingly being diagnosed in younger individuals, characterized by cognitive decline and neuroinflammation linked to amyloid β (Aβ) accumulation.
- The study investigates the effects of N-acetyl-L-tryptophan (NAT) on reducing cognitive decline and neuroinflammation in a rat model of AD induced by Aβ 1-42 oligomers.
- Results showed that NAT treatment improved cognitive performance, reduced inflammatory markers and Tau levels in the brain, and indicated potential neuroprotective benefits, although the precise therapeutic concentration of NAT could not be determined due to method limitations.
5-HT receptor-AC-PKA signal pathway in the lateral habenula is involved in the regulation of depressive-like behaviors in 6-hydroxydopamine-induced Parkinson's rats.
Neurol Res
February 2023
Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Xi'an Jiaotong University Health Science Center, Xi'an, China.
Article Synopsis
- The study investigates the role of the serotonin receptor-adenylate cyclase-protein kinase A (5-HT-AC-PKA) signaling pathway in the lateral habenula (LHb) and its relation to depression in rats with Parkinson's disease.
- Researchers used various behavioral tests and biochemical analyses to assess depressive-like behaviors, the firing activity of LHb neurons, and the levels of key proteins in the LHb.
- Findings indicate that activation of this signaling pathway can alleviate depressive symptoms, while depletion of dopamine due to substantia nigra lesions negatively affects its function, linking serotonin signaling and depression in the context of Parkinson’s disease.
Crocin molecular signaling pathways at a glance: A comprehensive review.
Phytother Res
October 2022
Department of Pharmacodynamics and Toxicology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran.
Article Synopsis
- Crocin, a carotenoid from Crocus flowers, shows various biological effects, including enhancing memory, reducing anxiety, boosting mood, and protecting the brain and heart.
- It helps manage health issues like oxidative stress, inflammation, metabolic disorders, neurodegenerative diseases, and cancer through specific signaling pathways such as PI3K/AKT/mTOR and others.
- Crocin's anti-cancer properties also involve pathways like MAPK and Wnt/β-catenin, emphasizing its potential as a therapeutic agent for multiple health conditions.
Electrochemical determination of L-tryptophan in food samples on graphite electrode prepared from waste batteries.
Sci Rep
March 2022
Technical Faculty in Bor, University of Belgrade, VJ 12, P.O. Box 50, 19210, Bor, Serbia.
Article Synopsis
- - This research aimed to create a non-toxic and cost-effective electrochemical sensor for detecting L-tryptophan, utilizing a graphite rod from zinc-carbon batteries to tackle electronic waste.
- - Two electrochemical methods, differential pulse voltammetry and cyclic voltammetry, were employed, revealing that the oxidation of L-tryptophan is influenced by pH, with optimal response at pH 4.0, and operates as an irreversible two-electron/two-proton reaction.
- - The sensor demonstrated reliable detection capabilities, with a limit of detection at 1.73 µM and a quantification limit at 5.78 µM, successfully analyzing L-tryptophan in milk and apple
Phosphodiesterase 4D promotes angiotensin II-induced hypertension in mice via smooth muscle cell contraction.
Commun Biol
January 2022
State Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, Department of Pathophysiology, School of Basic Medicine, Peking Union Medical College, 100005, Beijing, China.
Article Synopsis
- Hypertension is a rising chronic condition linked to serious cardiovascular issues, and the role of the PDE4-cAMP-PKA signaling pathway in this disease is still unclear.
- Research shows that the PDE4D isoform is increased in the aortas of mice with hypertension caused by angiotensin II, and its knockout reduces hypertension effects like arterial thickening and vasocontraction.
- Additionally, PDE4D deficiency activates protective pathways that reduce muscle contraction, suggesting that rolipram, a PDE4 inhibitor, could be a promising treatment for hypertension.
Antidepressants determination using an electroanalytical approach: A review of methods.
J Pharm Biomed Anal
November 2021
Laboratory of Electroanalytical Applied to Biotechnology and Food Engineering (LEABE), Chemistry Institute, Uberlândia Federal University, Major Jerônimo street, 566, Patos de Minas, MG 38700-002, Brazil. Electronic address:
Article Synopsis
- * It's essential to measure these drugs in biological fluids and water systems to understand their impact.
- * The article reviews various electroanalytical techniques for analyzing antidepressants, highlighting their cost-effectiveness, efficiency, and potential to reduce toxic waste.
Environmental level of the antidepressant venlafaxine induces behavioral disorders through cortisol in zebrafish larvae (Danio rerio).
Neurotoxicol Teratol
October 2021
State Key Laboratory of Medicinal Chemical Biology, The Key Laboratory of Bioactive Materials, Ministry of Education, College of Life Science, Nankai University, Tianjin 300071, China. Electronic address:
Article Synopsis
- The study investigates how the psychoactive drug venlafaxine affects zebrafish behavior and development, particularly focusing on its impact at different concentrations (1 μg/L, 10 μg/L, 100 μg/L).
- Results showed that 1 μg/L of venlafaxine stimulated growth and increased activity in zebrafish larvae, as well as altered gene expression related to stress response.
- Melatonin was found to reverse the behavioral changes and gene expression alterations caused by venlafaxine, highlighting potential effects of environmental pollutants on aquatic life.
Phosphodiesterase 2 inhibitor Hcyb1 reverses corticosterone-induced neurotoxicity and depression-like behavior.
Psychopharmacology (Berl)
November 2020
Department of Pharmaceutical Sciences, School of Pharmacy and Pharmaceutical Sciences, University at Buffalo, the State University of New York, Buffalo, NY, 14214, USA.
Article Synopsis
- Currently available PDE2 inhibitors are not effective for treating depression due to poor brain penetration, but a new compound called Hcyb1 shows promise for enhanced delivery across the blood-brain barrier.
- This study tested Hcyb1's ability to protect neuronal cells from damage and its antidepressant-like effects in stressed mice, demonstrating increased cell viability and neuroprotective properties in lab tests.
- Results indicated that Hcyb1 improved cell survival, restored key neurochemical levels, and reduced depression-like behavior in mice, suggesting it could be a viable option for depression treatment.
Mechanism of Chaihu Shugan Powder () for Treating Depression Based on Network Pharmacology.
Chin J Integr Med
December 2020
Department of Neurology, Jiangsu Provincial Second Chinese Medicine Hospital, The Second Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, 210017, China.
Article Synopsis
Orange peels modulate antioxidant markers and key enzymes relevant to erection in the penile tissue of paroxetine-treated rats.
Andrologia
October 2019
Functional Foods and Nutraceuticals Unit, Biochemistry Department, Federal University of Technology, Akure, Nigeria.
Article Synopsis
Multitarget-directed cotreatment with cilostazol and aripiprazole for augmented neuroprotection against oxidative stress-induced toxicity in HT22 mouse hippocampal cells.
Eur J Pharmacol
August 2019
Department of Pharmacology, School of Medicine, Pusan National University, Gyeongsangnam-do, Republic of Korea; Gene & Cell Therapy Research Center for Vessel-associated Diseases, Pusan National University, Gyeongsangnam-do, Republic of Korea. Electronic address:
Article Synopsis
- - Cerebrovascular dysfunction leads to cognitive impairment and psychotic symptoms in vascular dementia due to oxidative stress, with this study examining the effects of aripiprazole and cilostazol on neuroprotection.
- - The combination of low concentrations of aripiprazole and cilostazol significantly boosts BDNF expression and other key protein levels in HT22 cells, enhancing neurite outgrowth compared to either drug alone.
- - This synergistic treatment approach counters oxidative stress and implies potential for improved therapeutic strategies in vascular dementia, indicating the importance of BDNF, P-CK2α, β-catenin, and HO-1 activation in the neuroprotective effects.
Camellia euphlebia protects against corticosterone-induced apoptosis in differentiated PC12 cells by regulating the mitochondrial apoptotic pathway and PKA/CREB/BDNF signaling pathway.
Food Chem Toxicol
April 2019
School of Life Science and Biotechnology, Dalian University of Technology, Dalian, 116024, China; Ministry of Education Center for Food Safety of Animal Origin, Dalian University of Technology, Dalian, 116620, China. Electronic address:
Article Synopsis
- - Camellia euphlebia is a traditional Chinese medicine with demonstrated antidepressant effects through various animal studies and possible mechanisms related to neuroprotection.
- - Research shows that extracts of Camellia euphlebia (CEE) can significantly reduce neuronal cell death induced by corticosterone in lab studies, suggesting it has a protective role against depression-related neuronal damage.
- - The anti-apoptotic effects of CEE are linked to the regulation of mitochondrial pathways and increased levels of specific proteins (PKA and CREB) that enhance the expression of the BDNF gene, which is important for brain health.
Adeno-associated virus-mediated over-expression of CREB-regulated transcription coactivator 1 in the hippocampal dentate gyrus ameliorates lipopolysaccharide-induced depression-like behaviour in mice.
J Neurochem
April 2019
Zhejiang Provincial Key Laboratory of Pathophysiology, Ningbo University, Ningbo, Zhejiang, PR China.
Article Synopsis
- Depression is a complex psychiatric disorder with limited effectiveness of current antidepressants, prompting the need for molecular-level research to identify new treatment targets.
- The study focused on the role of the CRTC1 protein in depression, using a viral system to manipulate its expression in mice, leading to depression-like behaviors and changes in specific brain factor levels.
- Results showed that reducing CRTC1 increased depressive symptoms, while boosting its expression counteracted these effects, suggesting it could be a potential target for developing new depression therapies.
Fluoxetine reverses brain radiation and temozolomide-induced anxiety and spatial learning and memory defect in mice.
J Neurophysiol
January 2019
Department of Pathology, The First Affiliated Hospital of Bengbu Medical College, Bengbu, China.
Article Synopsis
- Radiation therapy and temozolomide used for brain tumor treatment can lead to anxiety and cognitive issues in patients.
- A study on mice showed these treatments resulted in increased anxiety, cognitive impairment, and deficits in brain function and neurogenesis.
- Administering fluoxetine helped reverse these behavioral problems, enhancing brain function and promoting neurogenesis in the hippocampus.
Standardized Citrus unshiu peel extract ameliorates dexamethasone-induced neurotoxicity and depressive-like behaviors in mice.
Metab Brain Dis
December 2018
Research group of Functional Food Materials, Research Division of Food Functionality, Korea Food Research Institute (KFRI), 245, Nongsaengmyeong-ro, Iseo-myeon, Wanju-gun, Jeollabuk-do, 55365, Republic of Korea.
Article Synopsis
- Dried Citrus unshiu peel (Chinpi) has traditional medicinal uses for allergies, inflammation, and liver issues, with some citrus flavonoids known for neuroprotective effects.
- This study investigates the antidepressant-like effects of standardized C. unshiu peel extract (SCP) using depression models in mice that received dexamethasone (DEX), finding that SCP significantly reduces depressive behaviors.
- SCP treatment also restored levels of brain-derived neurotrophic factor (BDNF) and other key proteins in the brain, suggesting its potential to counteract neurotoxicity induced by stress hormones.
Methylene Blue Analogues with Marginal Monoamine Oxidase Inhibition Retain Antidepressant-like Activity.
ACS Chem Neurosci
December 2018
Pharmaceutical Chemistry, School of Pharmacy , North-West University, Private Bag X6001 , Potchefstroom 2520 , South Africa.
Article Synopsis
- * Researchers have created five new MB analogues that are less potent MAO-A inhibitors compared to MB, yet still demonstrate similar antidepressant-like effects in rat tests without affecting locomotion.
- * These newly synthesized compounds could reduce the risks of adverse effects associated with MAO-A inhibition while still providing antidepressant benefits, suggesting a new class of antidepressant medications.
Efficient Intracellular Delivery of Cell-Impermeable Cargo Molecules by Peptides Containing Tryptophan and Histidine.
Molecules
June 2018
Center for Targeted Drug Delivery, Department of Biomedical and Pharmaceutical Sciences, Chapman University School of Pharmacy, Harry and Diane Rinker Health Science Campus, Irvine, CA 92618, USA.
Article Synopsis
- The study focuses on the design and evaluation of new decapeptides composed of histidine and tryptophan for intracellular delivery of cell-impermeable phosphopeptides and the anti-HIV drug emtricitabine.
- Two types of peptides, linear and cyclic, were synthesized and tested for toxicity in ovarian and leukemia cancer cells, showing no significant toxicity up to 100 µM.
- Results indicated that the cyclic peptide significantly enhanced the uptake of both the phosphopeptide and the anti-HIV drug in cancer cells, demonstrating their potential for improving drug delivery.
A novel PDE9 inhibitor WYQ-C36D ameliorates corticosterone-induced neurotoxicity and depression-like behaviors by cGMP-CREB-related signaling.
CNS Neurosci Ther
October 2018
Department of Pharmaceutical Sciences, School of Pharmacy and Pharmaceutical Sciences, The State University of New York at Buffalo, Buffalo, NY, USA.
Article Synopsis
- Major depressive disorder (MDD) is characterized by symptoms like depressed mood, anxiety, and issues with learning and memory, with PDE9 inhibitors showing promise in improving cognitive function in studies with rodents.
- The study tested a novel PDE9 inhibitor, WYQ-C36D (C36D), for its protective effects against stress-induced damage in cell cultures and its behavioral impacts in stressed mice, focusing on depression, anxiety, and memory.
- Results indicated that C36D not only protected cells from stress but also enhanced behavior, reducing signs of depression and anxiety while improving memory, suggesting PDE9 inhibitors could be a new treatment avenue for MDD.
The neuroprotective and antidepressant-like effects of Hcyb1, a novel selective PDE2 inhibitor.
CNS Neurosci Ther
July 2018
Department of Pharmaceutical Sciences, School of Pharmacy and Pharmaceutical Sciences, University at Buffalo, The State University of New York, Buffalo, NY, USA.
Article Synopsis
- * The study found that Hcyb1 selectively inhibited PDE2A, significantly improved cell viability in brain cells, and increased levels of key molecules (cAMP and cGMP) associated with neuroprotection.
- * In mouse models, Hcyb1 demonstrated antidepressant-like effects by reducing behavioral signs of depression without affecting overall movement, indicating its potential as a therapeutic agent.
Particulate Matter Triggers Depressive-Like Response Associated With Modulation of Inflammatory Cytokine Homeostasis and Brain-Derived Neurotrophic Factor Signaling Pathway in Mice.
Toxicol Sci
July 2018
State Key Laboratory of Pollution Control and Resources Reuse, School of the Environment, Nanjing University, Nanjing 210023, China.
Article Synopsis
- Long-term exposure to particulate matter (PM) in mice may lead to depressive-like behaviors linked to inflammation and changes in the brain's signaling pathways related to neurotrophic factors.
- The study found that after 4 weeks of HEPA-filtered air exposure, mice exhibited antidepressant-like effects, while continuous PM exposure for 12 weeks resulted in increased depressive behaviors, elevated proinflammatory cytokines, and decreased levels of BDNF and related proteins.
- Overall, the research indicates that sustained exposure to high levels of PM can disrupt the balance of damage and repair in the brain, contributing to mental health challenges in mice.
Selective HCN1 block as a strategy to control oxaliplatin-induced neuropathy.
Neuropharmacology
March 2018
Department of Neuroscience, Psychology, Drug Research and Child Health - NEUROFARBA - Pharmacology and Toxicology Section, University of Florence, Florence, Italy.
Article Synopsis
- Chemotherapy-Induced Peripheral Neuropathy (CIPN) is a common and debilitating side effect of cancer treatment that impacts patients' quality of life and may cause treatment to be halted.
- Current treatments for CIPN, such as anticonvulsants and antidepressants, are not very effective or carry risks of addiction.
- This research identifies HCN1 channels as a potential target for new drugs, demonstrating that a selective HCN1 inhibitor can reduce pain in a model of CIPN without affecting heart function, suggesting a safer and more effective treatment option.
Effects of the antidepressant, mianserin, on early development of fish embryos at low environmentally relevant concentrations.
Ecotoxicol Environ Saf
April 2018
Shanghai Applied Radiation Institute, Shanghai University, Shanghai 200444, China. Electronic address:
Article Synopsis
- * The study conducted acute and short-term exposure tests on zebrafish embryos to ascertain the toxicity and physiological impacts of varying concentrations of mianserin.
- * Results indicated that mianserin exposure led to reduced body length and altered key physiological functions in zebrafish, including changes in antioxidant capacity and enzymatic activities, highlighting the drug's significant impact on aquatic organisms.
Reduction of cancer cell viability by synergistic combination of photodynamic treatment with the inhibition of the Id protein family.
J Photochem Photobiol B
January 2018
Department of Molecular Biology, University of Salzburg, Billrothstrasse 11, 5020 Salzburg, Austria. Electronic address:
Article Synopsis
- Id proteins are important regulators in development and cancer, and reducing their activity can slow down cancer cell growth and chemoresistance.
- A synthetic Id-protein ligand (1Y) showed to decrease the viability of certain breast and bladder cancer cells by around 50% at higher doses while still inhibiting their growth at much lower doses by increasing a protein that regulates the cell cycle.
- Combining the Id-ligand with light-activated photosensitizers enhances the cancer-killing effects of the treatment, making it a promising strategy for improving cancer therapy outcomes.