326 results match your criteria: "Toxicity Caustic Ingestions"
Caustic ingestion remains a complex public health problem worldwide, both in adults and children. The consequences of caustic ingestion depend on the severity of the injuries, the general condition of the patient at presentation and the promptness of medical management. Long-term complications include strictures or stenoses, resulting in dysphagia.
View Article and Find Full Text PDFPodophyllin Toxicity: Case Report of a Rare Poisoning.
J Assoc Physicians India
July 2024
Medical Officer, Department of Medicine, Deen Dayal Upadhyay Hospital, Delhi, India.
Article Synopsis
- - Podophyllin poisoning is a serious and often fatal emergency that primarily affects the nervous system, caused by a toxic plant resin containing podophyllotoxin, which disrupts cellular functions.
- - Symptoms can take time to appear, leading to potential misdiagnosis as CNS infections or strokes, highlighting the need for high suspicion and quick treatment to avoid severe outcomes.
- - A reported case involved a 23-year-old male who ingested podophyllin, experiencing severe neurological symptoms and multisystem failure resulting in death within four days.
Early topical mitomycin-C prevents stricture formation in children with caustic ingestion.
J Paediatr Child Health
September 2024
Pediatric Gastroenterology Department, Cairo University, Giza, Egypt.
Aim: Stricture formation is the most common remote complication of caustic ingestion. The aim of this study was evaluation of the efficacy of early topical endoscopic application of mitomycin C (MMC) in prevention of stricture formation after corrosive ingestion in children.
Methods: We enrolled 78 children with a history of caustic ingestion within 48 h in a prospective, randomised-controlled study.
[Results of emergency management of esophageal lesions related to caustic ingestion in children in the emergency department of the General Reference Hospital of Niamey (Niger)].
Med Trop Sante Int
March 2024
Faculté des sciences de la santé, Université Abdou Moumouni, Niamey, Niger.
Article Synopsis
- Caustic ingestion in children is a significant public health issue, often resulting from improper storage and packaging of hazardous products, leading to potential medical emergencies that can affect vital functions in about 10% of cases.
- A retrospective study was conducted at the General Reference Hospital of Niamey (Niger) over two years, focusing on children under 15 who ingested caustics, with a notable male predominance and caustic soda being the most common substance.
- The study analyzed 17 cases, revealing symptoms like dysphagia and general condition deterioration, with 24% requiring esogastroduodenal fibroscopy to assess the severity of esophageal and stomach lesions according to Zargar stages.
Do Asymptomatic Patients Need Endoscopy after Caustic Ingestion?
J Med Toxicol
July 2024
Harvard Medical Toxicology Fellowship, Boston, MA, USA.
Pediatric Esophageal Foreign Bodies and Caustic Ingestions.
Otolaryngol Clin North Am
August 2024
Department of Otolaryngology-Head and Neck Surgery, Eastern Virginia Medical School, Children's Hospital of the King's Daughters, Norfolk, VA, USA. Electronic address:
Article Synopsis
- - Foreign body ingestions are common in kids under 6, with serious complications being rare but possible, especially with specific items like sharp objects, caustics, magnets, and button batteries.
- - Complications from these ingestions can include gastrointestinal obstruction, perforation, necrosis, and fistula formation, leading to worse health outcomes.
- - The initial assessment involves taking a patient's history, conducting a physical exam, and using X-rays to find radiopaque objects; removal of the foreign body is necessary in high-risk cases or when the patient shows symptoms.
Evaluation of effects of curcumin on acute esophagitis in the corrosive esophagitis model in rats.
Naunyn Schmiedebergs Arch Pharmacol
September 2024
Department of Thoracic Surgery, Faculty of Medicine, Yozgat Bozok University, Yozgat, Turkey.
Article Synopsis
- Ingestion of corrosive substances can lead to corrosive esophagitis, and this study investigates the potential protective effects of curcumin, which has anti-inflammatory properties.
- Twenty-seven Wistar Albino rats were tested in different groups, where those exposed to corrosive sodium hydroxide and treated with curcumin showed reduced esophageal damage compared to the control group.
- The results indicate that curcumin may help to alleviate the severity of corrosive esophagitis in a dose-dependent way, with higher doses leading to greater healing benefits.
Corrosive induced esophageal and gastric injury: Histopathological evaluation of surgically resected specimens over a decade in a tertiary care center.
Indian J Pathol Microbiol
April 2024
Department of Gastroenterology, Post-graduate Institute of Medical Education and Research (PGIMER), Chandigarh, India.
Article Synopsis
- Caustic ingestion can cause serious long-term health issues, including esophageal stricture and increased cancer risk, yet only a few studies have looked into the detailed tissue changes caused by such injuries.
- A retrospective study evaluated 39 surgical specimens from patients who experienced complications due to caustic ingestion between 2008 and 2020, finding that most had significant tissue damage such as deep inflammation and structural changes.
- The findings suggest that caustic ingestion primarily results in severe mucosal damage and inflammation, contributing to complications like refractory stricture, but no cases of dysplasia were identified in the examined tissues.
Oral Ingestion of an Iron-Containing Hand Warmer in a Pediatric Patient.
Wilderness Environ Med
March 2024
Division of Medical Toxicology, Department of Emergency Medicine, UC San Diego Health, San Diego, CA.
Article Synopsis
- Hand warmer packets, commonly containing iron powder, can cause serious health issues if ingested, as demonstrated by a case involving a three-year-old who experienced high serum iron levels and gastrointestinal injury after consuming one.
- The child underwent emergency treatments, including endoscopic removal of the packet, gastric lavage, and medications to manage the situation.
- This case highlights the potential risks of even partial ingestion of hand warmer packets in young children, emphasizing the importance of prompt multidisciplinary medical response and intervention.
Can we predict the risk of esophageal stricture after caustic injury?
Dis Esophagus
April 2024
Department of Digestive Surgery and Transplantation, University Hospital of Lille Nord de France, Lille, France.
Article Synopsis
- Nonoperative treatment for serious injuries caused by harmful substances can be effective and usually doesn't require surgery, leading to low death rates.
- However, keeping damaged tissue can raise the chance of narrowing in the esophagus.
- The study looked at 184 patients and found that voluntary ingestion of the harmful substance, high injury scores, and serious throat issues were key risk factors for developing esophageal narrowing after ingestion.
Factors affecting quality of life among patients with corrosive injury.
Medicine (Baltimore)
January 2024
Department of Nursing, Linkou Chang Gung Memorial Hospital, Taoyuan, Taiwan.
Article Synopsis
- This study focused on understanding the factors that affect the quality of life (QOL) for patients who suffered from corrosive injuries, particularly in the context of increasing cases in developing countries.
- Using a sample of 82 patients in Taiwan, researchers employed various scales to measure perceived stress, coping strategies, and overall QOL between June 2018 and July 2020.
- The findings indicated that patients with a mental illness history experienced higher stress levels, which negatively impacted their QOL, highlighting the need for consistent assessment and monitoring of these individuals.
Hepatic Portal Venous Gas (HPVG) after Ingestion of Chlorine Bleach: A Transient Phenomenon.
Diagnostics (Basel)
December 2023
Radiology Unit, "Papardo" Hospital, 98158 Messina, ME, Italy.
Article Synopsis
- - A case study of a 32-year-old man who ingested chlorine bleach illustrates the potential health risks, from mild burns to severe complications, including the development of hepatic portal venous gas (HPVG), which can be alarming but is not always life-threatening.
- - HPVG in this case resolved without intervention within 24 hours, highlighting its transient nature, while the exact reasons for its occurrence after ingesting toxic substances are not fully understood.
- - Although HPVG can indicate serious conditions, it may also arise in less severe cases that can be treated conservatively, with hyperbaric oxygen therapy recommended for cases presenting neurological symptoms.
Epidemiologic features and outcomes associated with caustic ingestion among adults admitted in intensive care unit from 2013 to 2019: a French national observational study.
Eur J Trauma Emerg Surg
June 2024
Service Information Médicale, Méthodes Et Recherche (SIMMER), Pôle Pharmacie, Santé Publique, CHU Nîmes, University of Montpellier, Nîmes, France.
Article Synopsis
- * Out of 569 patients, 90% had intentional caustic ingestion, with a 9.8% in-hospital mortality rate and 74% experiencing complications during their ICU stay.
- * Factors like age (especially over 40) and a specific health score (SAPS II) were found to significantly correlate with the likelihood of mortality in these patients.
A simple machine learning approach for preoperative diagnosis of esophageal burns after caustic substance ingestion in children.
Pediatr Surg Int
December 2023
Department of Pediatric Surgery, Diyarbakır Gazi Yaşargil Training and Research Hospital, Diyarbakir, Turkey.
Article Synopsis
- * The research included data from 1839 patients over 18 years, finding that about 7.7% had burns and identifying key predictors like the type of caustic substance and specific blood parameters.
- * The use of machine learning showed promising accuracy, with the prediction models achieving up to 91.66% accuracy, highlighting the potential for AI to improve treatment decisions for young patients who have ingested harmful substances.
[Histological evaluation of esophageal stricture in children with caustic burn].
Khirurgiia (Mosk)
December 2023
Alexandrov National Center of Oncology and Medical Radiology, Minsk, Belarus.
Article Synopsis
- - The study examines the histological changes in esophageal strictures in children who suffered caustic burns from household products containing sodium (potassium) hypochlorite and sodium (potassium) hydroxide.
- - Three children around 2 years old underwent ineffective dilatation procedures, leading to surgical interventions such as esophageal resection and esophagocoloplasty, with tissue samples stained for analysis.
- - Findings show that severe burns cause irreversible damage, resulting in non-dilatable strictures characterized by atrophy of the mucous membrane, muscle layer replacement with connective tissue, and overall sclerosis of the esophageal wall.
Hydrogen cyanamide exposure: a case series from Pavia Poison Control Centre.
Occup Med (Lond)
December 2023
Toxicology Unit, Istituti Clinici Scientifici Maugeri SpA SB IRCCS, Pavia Poison Control Centre, National Toxicology Information Centre, Clinical and Experimental Lab, Pavia 27100, Italy.
Article Synopsis
- Hydrogen cyanamide, a plant growth regulator introduced in Italy, was recalled in 2008 and is currently unauthorized in Europe due to its potential for causing serious health issues, including irritation, organ damage, and dangerous reactions with alcohol.
- A study covering exposures from 2007 to 2021 found that most cases (79%) occurred after the product's market withdrawal, primarily in Sicily, with all instances being unintentional and work-related; a significant portion (41%) involved alcohol co-ingestion.
- Common symptoms included flushing, dyspnoea, and burns, but all patients treated symptomatically fully recovered; the findings highlight ongoing illegal usage and the need for heightened awareness of the risks
Outcomes of pneumatic dilation in pediatric caustic esophageal strictures: a descriptive and analytic study from a developing country.
Surg Endosc
December 2023
Pediatric Surgery Department, Fattouma Bourguiba University Hospital, Monastir, Tunisia.
Article Synopsis
- Corrosive substance ingestion in children poses serious long-term health risks, particularly esophageal stricture, which can be managed through pneumatic dilation or esophageal replacement.
- A study from January 2005 to December 2020 evaluated the effectiveness of pneumatic balloon dilation in treating pediatric patients with caustic esophageal stenosis, finding a successful dilation rate of 80.4%.
- The severity of the stricture and the number of dilation sessions were significant risk factors for failure, suggesting that surgeons should consider early surgical intervention to improve outcomes.
Endoscopic dilation with bougies versus balloons in caustic esophageal strictures: 17-year experience from a tertiary care center.
Surg Endosc
November 2023
Department of Gastroenterology, Nehru Hospital, Postgraduate Institute of Medical Education and Research (PGIMER), Sector-12, Chandigarh, 160012, India.
Article Synopsis
- Endoscopic dilation is highlighted as the main method for treating caustic esophageal strictures (CES), and this study aims to compare the effectiveness of bougie versus balloon dilators.
- Data from 189 CES patients over 16 years was analyzed, showing that bougie dilators had significantly better outcomes in terms of technical success and both short- and long-term clinical success compared to balloon dilators.
- Despite similar adverse event rates in both groups, results indicated that bougie dilators are the preferred choice due to their higher success rates in treating CES.