2,551 results match your criteria: "Toxicity Caffeine"
Risperidone suppresses caffeine-induced hyperthermia and hyperactivity in rats.
Neurosci Lett
September 2024
Department of Psychiatry, Jichi Medical University, Japan.
Article Synopsis
- * A study investigated the effects of risperidone and other drugs on caffeine-induced symptoms in rats, finding that risperidone significantly reduced hyperthermia and hyperactivity by blocking certain receptor activities.
- * The research suggests that risperidone may be a potential treatment for caffeine intoxication by specifically affecting serotonin levels, while other drugs had varied effects on hyperthermia and activity levels.
Design, synthesis, anticancer and assessment of 8-caffeinyl chalcone hybrid conjugates.
RSC Adv
August 2024
Department of Medical Biotechnology, School of Medicine, Fasa University of Medical Sciences Fasa Iran.
Article Synopsis
- The study focuses on the design and testing of new 8-caffeinyl chalcone hybrid compounds for their potential anticancer effects against breast cancer and melanoma cell lines.
- The synthesis process involved three steps: brominating caffeine, creating chalcones, and then combining them with 8-caffeinyl.
- Results showed that some compounds were effective against cancer cells, had varying toxicity levels towards healthy cells, and exhibited favorable properties according to Lipinski's rule of five, with additional insights gained from density functional theory studies.
Subclinical brain manifestations of repeated mild traumatic brain injury are changed by chronic exposure to sleep loss, caffeine, and sleep aids.
Exp Neurol
November 2024
Neuroscience Research, Zablocki Veterans Affairs Medical Center, Milwaukee, WI, USA; Department of Neurosurgery, Medical College of Wisconsin, Milwaukee, WI, USA. Electronic address:
Article Synopsis
- The study examines how common activities like caffeine consumption, sleep deprivation, and sleep aids affect the brain after mild traumatic brain injury (mTBI), suggesting these exposures can change brain function and structure during recovery.
- Using an animal model, researchers analyzed brain changes through advanced imaging techniques after administering these treatments for 70 days following repeated mTBIs.
- Results indicate that each treatment uniquely impacted brain regions, with sleep aids showing the most significant alterations, highlighting the importance of understanding everyday habits during recovery from mTBI.
Lettuce (Lactuca sativa L.) alters its metabolite accumulation to cope with CuO nanoparticles by promoting antioxidant production and carbon metabolism.
Environ Geochem Health
August 2024
Guangdong Provincial Key Laboratory of Biotechnology for Plant Development, School of Life Science, South China Normal University, Guangzhou, 510631, China.
Article Synopsis
- * Lettuce exposed to varying concentrations of CuO-NPs showed significant copper accumulation and notable changes in metabolite profiles, including increased phenolic acids and decreased flavonoids, indicating stress responses.
- * Key metabolites related to energy and carbohydrate metabolism were enhanced, while others linked to stress resistance were reduced at high CuO-NP concentrations, signaling potential negative effects on plant growth and health.
Fabrication of smart nanogel based on carrageenan and green coffee extract as a long-term antifouling agent to improve biofilm prevention in food production.
Food Chem
December 2024
Department of Chemistry, College of Science, King Faisal University, Al-Ahsa 31982, Saudi Arabia; Department of Chemistry, Faculty of Science, Sohag University, Sohag 82524, Egypt.
Article Synopsis
- - The study explores the antibacterial and antibiofilm effects of green coffee extract (GCE) when loaded onto carrageenan nanogels (CAR NGs) at concentrations of 1% and 2%, comparing them to unloaded nanogels.
- - GC-MS analysis identified 16 bioactive compounds in GCE, with caffeine being the most abundant, contributing to significant antimicrobial properties, including impressive inhibition zones and effective bacterial inactivation.
- - Both GCE-loaded CAR NGs demonstrated remarkable reductions in biofilm cell densities from foodborne pathogens, achieving up to 95% reduction, and were found to be non-toxic and biocompatible, suggesting their potential as natural antimicrobial agents to improve food safety.
Comprehending the Efficacy of Whitlock's Caffeine-Pincered Molecular Tweezer on β-Amyloid Aggregation.
ACS Chem Neurosci
September 2024
Department of Chemistry, Indian Institute of Technology, Guwahati, Assam 781039, India.
Article Synopsis
- Alzheimer's disease (AD) is a common neurodegenerative disorder caused by the misfolding and aggregation of amyloid-β (Aβ) peptides, resulting in cognitive decline and no current cure.
- This study examines Whitlock's caffeine-armed molecular tweezer as a potential treatment to reduce Aβ aggregation effects, employing molecular dynamics simulations to analyze peptide interactions in varying environments.
- Findings reveal that the presence of the tweezer diminishes harmful interpeptide interactions and hinders self-aggregation, potentially preventing the formation of neurotoxic β-amyloid plaques.
Comprehensive Biosafety Profile of Carbomer-Based Hydrogel Formulations Incorporating Phosphorus Derivatives.
Gels
July 2024
Department of Toxicology, Drug Industry, Management and Legislation, Faculty of Pharmacy, "Victor Babes" University of Medicine and Pharmacy Timisoara, 2nd Eftimie Murgu Square, 300041 Timisoara, Romania.
Article Synopsis
- * In vitro tests on healthy skin cell lines showed that the hydrogels had a good biosafety profile, with no significant toxicity or harmful effects observed after exposure.
- * Additional in vivo studies on mice and chicken embryos confirmed the hydrogels' biocompatibility, but further research is necessary to assess their long-term therapeutic effects and clinical application potential.
Acute exposure to caffeine improves foraging in an invasive ant.
iScience
June 2024
Animal Comparative Economics Laboratory, Department of Zoology and Evolutionary Biology, University of Regensburg, 93053 Regensburg, Germany.
Article Synopsis
- Argentine ants are a problematic invasive species, and existing control methods often fail due to insufficient bait consumption.
- Research shows that using caffeine can enhance the ants' learning and navigation skills, leading to better recruitment for toxic baits.
- Experiments revealed that moderate caffeine levels significantly increased the ants' foraging speed, while high doses negated these benefits, suggesting that caffeine could improve bait effectiveness without affecting their homing behavior.
Occurrence, removal and risk assessment of chemicals of emerging concern in selected rivers and wastewater treatment plants in western Kenya.
Sci Total Environ
October 2024
Department of Biological Sciences, School of Sciences and Aerospace Studies, Moi University, P.O. Box 3900, Eldoret, Kenya; Stellenbosch Institute for Advanced Study, Marais Rd, Mostertsdrift, Stellenbosch 7600, South Africa. Electronic address:
Article Synopsis
- * The study identified 333 CECs in rivers and 352 in WWTPs, with pharmaceuticals and pesticides prevalent; high concentrations were found for compounds like caffeine and saccharin.
- * Risk assessments revealed crustaceans at the highest toxicity risk due to compounds like diazinon, indicating significant environmental and potential human health concerns tied to CECs in water sources.
Metabolomics in Radiotherapy-Induced Early Adverse Skin Reactions of Breast Cancer Patients.
Breast Cancer (Dove Med Press)
July 2024
Department of Public Health Sciences, University of Miami Miller School of Medicine, Miami, FL, USA.
Article Synopsis
- Early adverse skin reactions (EASRs) from radiotherapy can reduce the quality of life for breast cancer patients, and this study used metabolomics to identify related metabolic pathways and biomarkers.
- Researchers analyzed urine samples from 60 breast cancer patients (30 with high EASRs and 30 with low EASRs) to pinpoint significant metabolic pathways linked to these skin reactions before radiotherapy.
- The study found seven important metabolic pathways associated with EASRs, notably highlighting the alanine, aspartate, and glutamate metabolism pathway, suggesting that larger future studies could help develop targeted interventions to reduce these side effects.
Safety Assessment of Methylxanthines as Used in Cosmetics.
Int J Toxicol
October 2024
Cosmetic Ingredient Review Executive Director.
Article Synopsis
- - The Expert Panel evaluated the safety of three methylxanthines: Caffeine, Theobromine, and Theophylline, used in cosmetics as skin-conditioning agents.
- - After reviewing relevant safety data, the Panel determined that these ingredients are safe for current cosmetic use and concentrations.
- - The conclusion supports the continued use of Caffeine, Theobromine, and Theophylline in cosmetics without concerns for consumer safety.
Recording of hippocampal activity on the effect of convulsant doses of caffeine.
Biomed Pharmacother
September 2024
Laboratory of Pharmacology and Toxicology of Natural Products, Biological Sciences Institute, Federal University of Para, Belem, Para, Brazil. Electronic address:
Article Synopsis
- Seizures are triggered by excessive excitement and synchrony among neurons in the brain, affecting about 50 million people worldwide, with many resistant to current treatments.
- Caffeine, a common psychoactive stimulant found in coffee and pain relievers, was studied in Wistar rats to analyze its effects at a toxic dose equivalent to over 12 cups of coffee.
- The study revealed that high doses of caffeine increased brain activity in various frequency bands and led to seizure-like activity, while common anticonvulsants like phenytoin, diazepam, and phenobarbital were effective in managing this caffeine-induced convulsant activity.
Antagonistic interaction between caffeine and ketamine in zebrafish: Implications for aquatic toxicity.
Environ Sci Ecotechnol
September 2024
Yunnan Provincial Key Laboratory of Soil Carbon Sequestration and Pollution Control, Faculty of Environmental Science & Engineering, Kunming University of Science & Technology, Kunming, 650500, PR China.
Article Synopsis
- The study investigates the combined effects of caffeine (CF) and ketamine (KET) on zebrafish larvae, highlighting that KET can alleviate the negative impacts of CF, particularly on locomotor activity and circadian rhythms.
- KET reduces developmental abnormalities in zebrafish exposed to CF, demonstrating a significant decrease in incidence rates from 26.7% to 6.7% with the presence of KET.
- The findings suggest a need for further exploration of environmental risks associated with the coexistence of CF and KET, and propose using fish nighttime behavior as a potential indicator for assessing toxicity of such substances.
Phytoactive drugs used in the treatment of Alzheimer's disease and dementia.
Naunyn Schmiedebergs Arch Pharmacol
November 2024
Drugs Testing Laboratory Avam Anusandhan Kendra Raipur, Raipur, 490024, India.
Article Synopsis
- Alzheimer's disease and other dementia forms are becoming more common globally, creating a pressing need for effective treatments.
- Natural bioactive drugs show promise as potential therapies due to their ability to affect multiple biological pathways and their lower toxicity compared to synthetic drugs.
- The review covers various natural compounds like curcumin and ginseng, discussing their effects on brain health and identifying challenges, such as bioavailability, while also calling for more comprehensive research and better delivery methods for these treatments.
Design and Biocompatibility of Biodegradable Poly(octamethylene suberate) Nanoparticles to Treat Skin Diseases.
Pharmaceutics
June 2024
Instituto de Tecnologia Química e Biológica António Xavier, Universidad Nova de Lisboa, 2780-157 Oeiras, Portugal.
Article Synopsis
- Biodegradable POS nanoparticles (POS-NPs) can effectively encapsulate different drugs for treating skin disorders, with a focus on caffeine, quercetin, hydrocortisone, and adapalene.
- The size and charge of the nanoparticles varied significantly based on the drug used, affecting their stability and encapsulation efficiency.
- While some formulations, like hydrocortisone and caffeine, showed unsuitable skin penetration, adapalene had a high permeation rate and low toxicity in tests with reconstructed human epidermis.
Caffeine upregulates SIRT3 expression to ameliorate astrocytes-mediated HIV-1 Tat neurotoxicity via suppression of EGR1 signaling pathway.
J Neurovirol
June 2024
Medical Research Center, Affiliated Hospital 2 of Nantong University, No. 666, Shengli Road, Nantong, 226001, Jiangsu, People's Republic of China.
Article Synopsis
- * The study found that caffeine treatment improved astrocyte health and reduced negative outcomes like oxidative stress and inflammation caused by Tat, while also enhancing the expression of SIRT3, a protective protein.
- * The research suggests that caffeine could serve as a promising therapeutic option for HAND, as it targets the EGR1/SIRT3 signaling pathway to alleviate neurotoxicity linked to Tat.
Efficient decaffeination with recyclable magnetic microporous carbon from renewable sources: Kinetics and isotherm analysis.
Environ Res
October 2024
Department of Chemistry and Biochemistry and the Centre for NanoScience Research, Concordia University, Montreal, QC, H4B 1R6, Canada; Quebec Centre for Advanced Materials, Department of Chemistry and Biochemistry, Concordia University, Montreal, QC, H4B 1R6, Canada. Electronic address:
Article Synopsis
Update: Protective and risk factors for Parkinson disease.
Parkinsonism Relat Disord
August 2024
Dept. of Neurology, University of Michigan, Ann Arbor, MI, 48109, USA; GRECC & Neurology Service, VAAAHS, Ann Arbor, MI, 48105, USA; University of Michigan Morris K. Udall Center of Excellence for Parkinson's Disease Research, Ann Arbor, MI, 48109, USA; University of Michigan Parkinson's Foundation Research Center of Excellence, USA. Electronic address:
Article Synopsis
- The review explores various protective and risk factors associated with Parkinson's Disease (PD), identifying factors such as tobacco use, physical activity, and certain medications as potential protectors and issues like brain injury and pesticide exposure as risks.
- Some protective factors may be influenced by reverse causation, meaning it’s unclear if they genuinely prevent PD or are related due to the disease itself.
- Despite identifying these factors, the research has not yet produced effective prevention strategies or interventions for PD, suggesting that addressing broader public health concerns like Type 2 Diabetes and air pollution could be key to reducing PD incidence.
A Review of the Protective Effects of Alkaloids Against Alpha-synuclein toxicity in Parkinson's disease.
Mini Rev Med Chem
June 2024
Department of Traditional Pharmacy, School of Pharmacy, Mashhad University of Medical Sciences, Azadi Square, Pardis University Campus, Mashhad, Iran. P.O. Box: 9188617871, Mashhad, Iran.
Background: Alpha-synuclein (α-syn) aggregation products may cause neural injury and several neurodegenerative disorders (NDs) known as α-synucleinopathies. Alkaloids are secondary metabolites present in a variety of plant species and may positively affect human health, particularly α-synucleinopathy-associated NDs.
Aim: To summarize the latest scientific data on the inhibitory properties of alkaloids in α- synucleinopathies, especially in Parkinson's disease.
Impacts of caffeine on fathead minnow behaviour and physiology.
Aquat Toxicol
August 2024
Department of Psychology, Neuroscience & Behaviour, McMaster University, 1280 Main Street West, Hamilton ON L8S 4K1, Canada.
Pollution from regularly used substances such as pharmaceuticals, cleaning agents, and even food and beverages is an increasing problem in the environment. Caffeine, a commonly ingested stimulant, is one such contaminant that has been detected in aquatic environments worldwide. Yet, little is known about how ecologically relevant concentrations of caffeine influence the morphology, behaviour, and physiology of exposed organisms.
View Article and Find Full Text PDFArsenite-Induced Drug-Drug Interactions in Rats.
Drug Metab Dispos
July 2024
State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Provincial Key Laboratory of Pharmaceutics (J.Z., W.L., Y.L., Y.H., Z.C., X.L., Y.C., A.Z., J.Z.), School of Pharmacy (J.Z., W.L., Y.L., Y.H., Z.C., X.L., Y.C., A.Z., J.Z.), Guizhou Medical University, Guiyang, Guizhou, P. R. China; State Key Laboratory of Environmental Pollution Monitoring and Disease Control, Ministry of Education, Department of Toxicology, School of Public Health, Guizhou Medical University, Guiyang, Guizhou, P. R. China (A.Z.); and Wuya College of Innovation, Shenyang Pharmaceutical University, Shenyang, Liaoning, P. R. China (Y.P., J.Z.)
Article Synopsis
- * The study revealed that this exposure significantly reduced the areas under the curves (AUC) of probe substrates for cytochrome P450 enzymes, indicating decreased drug absorption and effectiveness.
- * Mechanisms for reduced drug absorption were linked to decreased intestinal permeability and impaired gut motility, suggesting potential drug-drug interactions that could lower the effectiveness of coadministered medications.
Occurrence, removal, and prioritization of organic micropollutants in four full-scale wastewater treatment plants in Korea.
Chemosphere
August 2024
School of Earth Sciences and Environmental Engineering, Gwangju Institute of Science and Technology (GIST), Gwangju, 61005, Republic of Korea. Electronic address:
This study investigated the occurrence, removal rate, and potential risks of 43 organic micropollutants (OMPs) in four municipal wastewater treatment plants (WWTPs) in Korea. Results from two-year intensive monitoring confirmed the presence of various OMPs in the influents, including pharmaceuticals such as acetaminophen (pain relief), caffeine (stimulants), cimetidine (H-blockers), ibuprofen (non-steroidal anti-inflammatory drugs- NSAIDs), metformin (antidiabetics), and naproxen (NSAIDs) with median concentrations of >1 μg/L. Some pharmaceuticals (carbamazepine-anticonvulsants, diclofenac-NSAIDs, propranolol-β-blockers), corrosion inhibitors (1H-benzotriazole-BTR, 4-methyl-1H-benzotriazole-4-TTR), and perfluorinated compounds (PFCs) were negligibly removed during WWTP treatment.
View Article and Find Full Text PDFBeyond the buzz: the fatal consequences of caffeine overconsumption.
J Anal Toxicol
October 2024
Toxicological Services, NMS Labs, 200 Welsh Rd, Horsham, PA 19044, United States.
Article Synopsis
- - Caffeine is a common stimulant found in plants like coffee and tea that boosts alertness and mood but can pose risks when consumed in high amounts, especially through energy drinks and supplements.
- - Toxic effects from caffeine can include agitation, insomnia, and in extreme cases, seizures or death, with some individuals unknowingly consuming dangerous levels due to easy online access to pure caffeine.
- - A study from 2019 to 2023 revealed that while most caffeine levels in tested blood cases were low (<25 µg/mL), a small percentage exceeded 100 µg/mL, highlighting the need for careful analysis in medicolegal investigations regarding caffeine’s role in deaths.
The influence of temperature on the impacts of caffeine in mussels: Evaluating subcellular impacts and model predictions.
Sci Total Environ
August 2024
Department of Biology, University of Aveiro, 3810-193 Aveiro, Portugal; Centre for Environmental and Marine Studies (CESAM), University of Aveiro, 3810-193 Aveiro, Portugal. Electronic address:
In aquatic ecosystems, the presence of pharmaceuticals, particularly caffeine (CAF), has been linked to wastewater discharge, hospital waste, and the disposal of expired pharmaceutical products containing CAF. Additionally, rising temperatures due to climate change are anticipated in aquatic environments. This study aimed to assess the toxicity of various CAF concentrations under current (17 °C) and projected (21 °C) temperature conditions, using the mussel Mytilus galloprovincialis as a bioindicator species.
View Article and Find Full Text PDFAmended Vegetation Filters as Nature-Based Solutions for the Treatment of Pharmaceuticals: Infiltration Experiments Coupled to Reactive Transport Modelling.
Toxics
May 2024
Department of Geology, Geography and Environment, University of Alcala, 28802 Alcalá de Henares, Madrid, Spain.
In small populations and scattered communities, wastewater treatment through vegetation filters (VFs), a nature-based solution, has proved to be feasible, especially for nutrient and organic matter removal. However, the presence of pharmaceuticals in wastewater and their potential to infiltrate through the vadose zone and reach groundwater is a drawback in the evaluation of VF performances. Soil amended with readily labile carbon sources, such as woodchips, enhances microbial activity and sorption processes, which could improve pharmaceutical attenuation in VFs.
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