2,748 results match your criteria: "Toxicity Beta-blocker"
Development of Timolol Maleate-Loaded Poloxamer-co-Poly (acrylic acid) based hydrogel for controlled drug delivery.
PLoS One
December 2024
Department of Social and Clinical Pharmacy, Faculty of Pharmacy in Hradec Králové, Charles University in Prague, Prague, Czech Republic.
Free radical polymerization technique was used to formulate Poloxamer-188 based hydrogels for controlled delivery. A total of seven formulations were formulated with varying concentrations of polymer, monomer ad cross linker. In order to assess the structural properties of the formulated hydrogels, Fourier Transform Infrared Spectroscopy (FTIR), Thermogravimetric analysis (TGA), Differential Scanning Calorimetry (DSC), Scanning electron microscopy (SEM), and X-ray diffraction (XRD) were carried out.
View Article and Find Full Text PDFAdverse Effects of Aβ Oligomers: Impaired Contextual Memory and Altered Intrinsic Properties of CA1 Pyramidal Neurons.
Biomolecules
November 2024
Department of Physiology, Yamaguchi University Graduate School of Medicine, Yamaguchi 755-8505, Japan.
Article Synopsis
Cardiac arrhythmias during and after thoracic irradiation for malignancies.
Cardiooncology
November 2024
Department for Cardiology, Angiology, and Pneumology, Heidelberg University Hospital, Heidelberg, Germany.
Article Synopsis
Outcomes of Radiofrequency Ablation for Autonomously Functioning Thyroid Adenomas-Mayo Clinic Experience.
J Endocr Soc
October 2024
Department of Endocrinology, Diabetes, Metabolism and Nutrition, Mayo Clinic, Rochester, MN 55905, USA.
Article Synopsis
Near-fatal pheochromocytoma crisis after beta-blocker and tumour haemorrhage.
BMJ Case Rep
October 2024
Tallahassee Memorial HealthCare, Tallahassee, Florida, USA.
Article Synopsis
- * Although some people may not show symptoms, adrenal hemorrhage is a rare but serious complication that could be missed until autopsy.
- * The report discusses a case of a woman in her 30s whose undiagnosed pheochromocytoma led to hemorrhagic conversion, highlighting the importance of quick diagnosis and treatment.
Magnetic particle spray mass spectrometry for the determination of beta-blockers in plasma samples.
Mikrochim Acta
September 2024
Laboratory of Toxicant and Drug Analyses, Faculty of Pharmaceutical Sciences, Federal University of Alfenas, Alfenas, MG, 37130-001, Brazil.
Article Synopsis
Toxicity Risks Associated With the Beta-Blocker Metoprolol in Marine and Freshwater Organisms: A Review.
Environ Toxicol Chem
December 2024
Department of Physiological Sciences, College of Veterinary Medicine, University of Florida, Gainesville, Florida, USA.
Article Synopsis
The metabolic profiles of endogenous and exogenous substances in a poor metabolizer of humanized CYP2D6 model.
Eur J Pharm Sci
December 2024
School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang 325035, PR China; State Key Laboratory of Macromolecular Drugs and Large-scale Manufacturing, School of Pharmaceutical Sciences, Wenzhou Medical University, PR China. Electronic address:
Article Synopsis
β-ionone inhibits the grazing of Daphnia sinensis by reducing the activity of acetylcholinesterase.
J Hazard Mater
November 2024
College of Fisheries, Huazhong Agricultural University, Wuhan 430070, China. Electronic address:
Article Synopsis
- * Transcriptomic analysis showed that β-ionone inhibits the expression of acetylcholinesterase (AchE) mRNA, resulting in higher acetylcholine (Ach) levels, indicating its role as an AchE inhibitor.
- * Experiments confirmed that β-ionone reduces AchE activity, causing increased Ach levels that affect Daphnia's physiological functions, including heart rate, feeding, and digestion.
In situ forming hydrogels based on modified gellan gum/chitosan for ocular drug delivery of timolol maleate.
Int J Biol Macromol
October 2024
Research Center for Pharmaceutical Nanotechnology, Biomedicine Institute, Tabriz University of Medical Sciences, Tabriz, Iran.
Article Synopsis
- In situ forming hydrogels made from oxidized gellan gum and chitosan show promise for enhancing drug delivery in the eyes by prolonging the drug's presence.
- The synthesized hydrogels exhibited beneficial properties like high swelling, self-healing, and mucoadhesion, confirmed through various tests including FT-IR and SEM studies.
- In vitro tests indicated that hydrogels with more oxidized gellan gum released drugs faster and were non-toxic to bone marrow stem cells, proving their potential for glaucoma treatment.
A Reversible Etiology of Progressive Motor Decline in a Previously Healthy Child.
Pediatrics
September 2024
Department of Pediatrics, Guerin Children's at Cedars-Sinai Medical Center, Los Angeles, California.
Article Synopsis
- A 10-year-old boy experienced progressive muscle weakness, atrophy, and weight loss, along with symptoms like tachycardia, tremor, and learning issues.
- Electromyography showed chronic myopathic changes, and lab tests indicated undetectable thyroid stimulating hormone, high thyroid peroxidase antibodies, and thyroid stimulating immunoglobulins.
- After treatment with atenolol and methimazole, the boy's strength and cognitive abilities improved, emphasizing the need to consider reversible causes for neurologic symptoms in children.
Combined diosmin and bisoprolol attenuate cobalt chloride-induced cardiotoxicity and endothelial dysfunction through modulating miR-143-3P/MAPK/MCP-1, ERK5/CXCR4, Orai-1/STIM-1 signaling pathways.
Int Immunopharmacol
October 2024
Pharmacology and Toxicology Department, Nahda University, Beni Suef, Egypt.
Article Synopsis
- The study investigates how bisoprolol and diosmin might protect the heart from damage caused by cobalt chloride (CoCl2), which induces hypoxia and accelerates heart cell death.
- Researchers divided rats into various groups to examine cardiac function and tissue changes over 21 days, particularly focusing on oxidative stress and inflammatory markers.
- Results show that both drugs improve heart function, reduce harmful cardiac changes, and may protect heart cells by targeting specific biochemical pathways related to inflammation and oxidative stress.
Carvedilol alleviates the detrimental effects of azathioprine on hepatic tissues in experimental rats: Focusing on redox system, inflammatory and apoptosis pathways.
Hum Exp Toxicol
July 2024
Pharmacology and Toxicology Department, Faculty of Pharmacy, Al-Azhar University, Assiut, Egypt.
Article Synopsis
- - The study investigates the protective effects of carvedilol (CAR) against liver injury caused by the drug azathioprine (AZA), which is known for its harmful effects on the liver, in a rat model.
- - Results showed that CAR significantly improved liver function and reduced damage caused by AZA, restoring the balance of oxidants and antioxidants while also lowering inflammation and apoptosis in liver cells.
- - The findings suggest that CAR could be a valuable addition to AZA treatment to help mitigate liver damage, enhancing the safety and effectiveness of this immunosuppressant.
Waterborne atenolol disrupts neurobehavioral and neurochemical responses in adult zebrafish.
Environ Sci Pollut Res Int
August 2024
Laboratory of Experimental Neuropsychobiology, Department of Biochemistry and Molecular Biology, Natural and Exact Sciences Center, Federal University of Santa Maria, Camobi, 1000 Roraima Avenue, Santa Maria, RS, 97105-900, Brazil.
Article Synopsis
- Environmental contamination from pharmaceuticals like atenolol negatively affects non-target organisms, specifically adult zebrafish, which were exposed to varying concentrations for seven days.
- The fish exhibited anxiety-like behaviors (e.g., increased bottom-dwelling and decreased vertical exploration) and showed heightened aggression without changing their social preferences.
- Biochemical analyses revealed that atenolol disrupted antioxidant enzyme activities, caused oxidative stress, altered specific mRNA expressions (increased tph1 and decreased bdnf), and affected energy metabolism, which could threaten the fish's health and survival in their environment.
Efficacy of anthocyanin, kaolinite and cabbage leaves-derived biochar for simultaneous removal of lead, copper and metoprolol from water.
Environ Pollut
October 2024
Department of Civil and Environmental Engineering, The Faculty of Engineering, The University of Auckland, Private Bag 92019, Auckland 1142, New Zealand. Electronic address:
Article Synopsis
- The study explores the effective removal of toxic elements (Lead and Copper) and pharmaceutical compounds (metoprolol) from water using modified biochar made from waste cabbage leaves, kaolinite, and anthocyanin.
- Ball milling is used to enhance the surface area and functional properties of biochar, resulting in significant increases in adsorption capacities for Lead (105%), Copper (71%), and metoprolol (213%).
- The research indicates that the removal processes work through various mechanisms such as surface complexation and H-bonding, with the best performance seen in the ball-milled composites, particularly for Lead and Copper.
Lipid Emulsions Inhibit Labetalol-Induced Vasodilation in the Isolated Rat Aorta.
Int J Mol Sci
June 2024
Institute of Medical Science, Gyeongsang National University, Jinju-si 52727, Gyeongsangnam-do, Republic of Korea.
Article Synopsis
- Lipid emulsions are explored for their potential to counteract cardiovascular issues caused by excessive labetalol, indicating their role as therapeutic agents against drug toxicity.
- The study found that the presence of intact endothelial cells enhances labetalol-induced vasodilation, while lipid emulsions significantly decrease this effect, regardless of endothelial presence.
- The mechanisms behind this inhibition include reducing cyclic guanosine monophosphate (cGMP) levels, modulating endothelial nitric oxide synthase (eNOS) activity, and lowering the concentration of labetalol itself.
Population study of pupillary unrest in ambient light.
Auton Neurosci
August 2024
Department of Anesthesia and Perioperative Care, University of California San Francisco (UCSF), San Francisco, CA, United States of America.
Article Synopsis
- Pupillary unrest in ambient light (PUAL) refers to changes in pupil size experienced by normal, awake individuals under standard lighting, and is less pronounced during opioid intoxication in young, healthy people.
- The study involved participants aged 18 and older, categorizing them by age groups and assessing factors like diabetes, beta-blocker use, and recent opioid use, using various statistical methods to analyze PUAL values.
- Results showed that PUAL decreased with age, diabetes, and beta-blocker use, indicating a potential decline in autonomic function, while opioid use also affected PUAL, but its significance depended on the analytical approach used.
Mechanistic insights into carvedilol's potential protection against doxorubicin-induced cardiotoxicity.
Eur J Pharm Sci
September 2024
Department of Pharmacology, Faculty of Pharmacy, Delta University for Science and Technology, Gamasa 11152, Egypt.
Article Synopsis
- Doxorubicin (DOX) is a chemotherapy drug that effectively treats various cancers but can lead to harmful heart damage (cardiotoxicity) which limits its use.
- The review examines how carvedilol, a medication, protects the heart from the toxic effects of DOX by targeting several harmful processes like oxidative stress, DNA damage, and calcium imbalance.
- Carvedilol's protective mechanisms include neutralizing free radicals, managing iron levels, and preventing cell death, suggesting its potential as a strategy for reducing chemotherapy-induced heart damage.
Spatiotemporal dynamics of reactive oxygen species and its effect on beta-blockers' degradation in aquatic plants' rhizosphere.
J Hazard Mater
September 2024
State Key Laboratory of Environmental Aquatic Chemistry, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China; University of Chinese Academy of Sciences, Beijing 100049, China.
Article Synopsis
- A new rootchip system was developed to study the role of reactive oxygen species (ROS) in degrading pollutants in the rhizosphere of Iris tectorum, revealing significant contributions to the breakdown of beta-blockers like atenolol.
- Mass balance analysis showed that ROS were responsible for a substantial percentage of rhizodegradation, with atenolol being transformed into less toxic products during phytoremediation.
- Experiments indicated that the concentration of ROS was highest in the rhizosphere around the roots, influenced by the local chemistry and microbiome, providing insights for improving phytoremediation techniques.
Early Intravenous Beta-Blockade with Esmolol in Adults with Severe Traumatic Brain Injury: A Phase 2a Intervention Design Study.
Neurocrit Care
December 2024
School of Physiology, Pharmacology and Neuroscience, University of Bristol, Bristol, UK.
Article Synopsis
- Targeted beta-blockade using esmolol after severe traumatic brain injury may help reduce secondary brain damage by managing the body's stress response.
- A study involved 16 adults with severe traumatic brain injury, determining the optimal starting dose of esmolol to safely lower their heart rate without causing harmful side effects.
- Results indicated that the optimal starting dosage was 10 μg/kg/min, with a low 12.5% mortality rate at 6 months and minimal adverse effects observed.
Iodinated Contrast Induced Parotitis: A Case Report.
Mymensingh Med J
July 2024
Dr Samsun Nahar, Associate Consultant (Cardiology), United Hospital Limited, Dhaka, Bangladesh; E-mail:
Article Synopsis
- - A 70-year-old man with a history of heart issues, diabetes, and hypertension was admitted for chest pain and shortness of breath, and diagnosed with NSTEMI following a recent Covid-19 infection.
- - He underwent successful coronary angioplasty two years prior and was on multiple medications, with normal physical and lab findings except for elevated Troponin I levels.
- - Following the angioplasty procedure, he developed bilateral parotitis, likely linked to the iodine-based contrast material, which resolved with conservative treatment.
Propranolol Alleviates Cardiac Injury After Acute Catecholamine Infusion Through p38-MAPK Pathways.
J Cardiovasc Pharmacol
July 2024
Department of Pediatrics, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan.
Article Synopsis
- Hypercatecholaminergic conditions can lead to heart failure and cardiac fibrosis, and this study aimed to assess how beta-blockade (specifically with propranolol) impacts heart health under these conditions.
- Rats were infused with epinephrine and norepinephrine to induce heart failure, and treatment with propranolol demonstrated significant improvements in cardiac markers related to fibrosis and apoptosis.
- The findings suggest that propranolol effectively mitigates the harmful effects of excessive catecholamines via the p-38 pathway and helps prevent heart damage by reducing profibrotic changes.
Biomorphometric and hematobiochemical alterations in the juvenile african catfish Clarias gariepinus exposed to propranolol.
BMC Zool
June 2024
Department of Zoology and Environmental Biology, University of Nigeria, Nsukka, Nigeria.
Article Synopsis
- Propranolol (PRO) is a beta-blocker used for various health issues, and this study examined its effects on juvenile Clarias gariepinus (African catfish) when exposed to sublethal concentrations of the drug.
- The experiment established a median lethal concentration (LC) of 9.48 mg/L and tested lower concentrations over 21 days, measuring fish growth and various blood and biochemical parameters.
- Results showed significant changes in blood cell counts and some liver enzyme activity due to PRO exposure, but most health indicators returned to normal after a 7-day recovery in clean water, suggesting that monitoring PRO levels in water environments is important.
Label-Free Screening of Drug-Induced Liver Injury Using Stimulated Raman Scattering Microscopy and Spectral Phasor Analysis.
Anal Chem
July 2024
Centre for Nanometrology, Department of Pure and Applied Chemistry, Technology and Innovation Centre, University of Strathclyde, Glasgow G1 1RD, U.K.
Article Synopsis
- Hepatic toxicity is a major reason for stopping clinical trials and withdrawing drugs, so it's crucial to detect drug-induced liver injury (DILI) for patient safety and drug effectiveness.
- This study introduces hyperspectral stimulated Raman scattering (SRS) microscopy, a new method to distinguish between two types of DILI: drug-induced steatosis (DIS) and drug-induced phospholipidosis (DIPL), by analyzing lipid levels in cells.
- The researchers created a set of alkyne-tagged propranolol analogues with different DILI effects, and their hyperspectral SRS technique successfully verified traditional fluorescence assays, making it a promising tool for evaluating liver toxicity early in drug development.
Effect of carvedilol on pharmacokinetics of sofosbuvir and its metabolite GS-331007: role of P-glycoprotein.
J Pharm Pharmacol
August 2024
Pharmacology & Toxicology Department, Faculty of Pharmacy, Ain Shams University, Cairo, Egypt.
Article Synopsis
- - Sofosbuvir (SOF) interacts with carvedilol (CAR), which inhibits P-glycoprotein (P-gp), potentially affecting how SOF is absorbed and its safety profile.
- - In a study with rats, the presence of CAR increased the blood concentrations of SOF and its metabolite GS-331007, indicating that CAR significantly inhibits P-gp in the intestines.
- - Although GS-331007's pharmacokinetics remained mostly unchanged, the increased bioavailability of SOF was linked to notable changes in kidney function, suggesting the need for further safety studies on the CAR/SOF combination.