4,260 results match your criteria: "Toxicity Antihistamine"
Hymenoptera venom allergy in children.
Ital J Pediatr
December 2024
Department of Health Sciences, University of Florence, Florence, 50139, Italy.
From a taxonomic point of view, Hymenoptera are subclassified into families: Apidae, including honeybees (Apis mellifera) and bumblebees (Bombus), and Vespidae, which, in turn, are divided into the subfamilies of Vespinae (wasps, including hornets, vespules, dolichovespules) and Polistinae (paper wasp). Hypersensitivity to Hymenoptera venom can be linked to immunological (IgE-mediated or non-IgE-mediated) and non-immunological mechanisms. Reactions are classified into local reactions, large local reactions, systemic reactions, toxic reactions, and unusual reactions.
View Article and Find Full Text PDFMeclizine seasickness medication and its effect on central nervous system oxygen toxicity in a murine model.
Diving Hyperb Med
December 2024
Motion Sickness and Human Performance Laboratory, The Israel Naval Medical Institute, IDF Medical Corps, Haifa, Israel.
Introduction: Diving utilising closed circuit pure oxygen rebreather systems has become popular in professional settings. One of the hazards the oxygen diver faces is central nervous system oxygen toxicity (CNS-OT), causing potentially fatal convulsions. At the same time, divers frequently travel by boat, often suffering seasickness.
View Article and Find Full Text PDFInvestigation of the effects of rainbow trout (Oncorhynchus mykiss) skin mucus against indomethacin-induced gastric damage in rats.
J Mol Histol
December 2024
Faculty of Pharmacy, Department of Biochemistry, Ataturk University, Erzurum, 25240, Turkey.
A peptic ulcer is a stomach lesion. It is generally caused by malnutrition, the use of anti-inflammatory medications, and an imbalance between mucosal defense systems. In fishes, the lubricous substance that called mucus secreted from the skin, prevents the entry of microorganisms that can enter the body through the skin.
View Article and Find Full Text PDFEffect of sodium butyrate on kidney and liver mitochondrial dysfunction in a lipopolysaccharide mouse model.
FASEB J
December 2024
Critical Care Mitochondrial Unit, Nemours Biomedical Research, Nemours Children's Hospital, Wilmington, Delaware, USA.
Sodium butyrate can reduce inflammation, but it is not known if butyrate can improve mitochondrial dysfunction during sepsis. We tested butyrate to prevent or reverse lipopolysaccharide (LPS)-induced mitochondrial dysfunction in murine kidney and liver. C57BL/6 mice were grouped as control (n = 9), intraperitoneal (IP) LPS (n = 8), pretreatment with IP butyrate 600 (n = 3) or 1200 mg/kg (n = 8) followed 2 h later by LPS, posttreatment with IP butyrate 600 (n = 3) or 1200 mg/kg (n = 7) 1 h after LPS, or butyrate 1200 mg/kg only (n = 8).
View Article and Find Full Text PDFA Singular Case Analysis: Lamotrigine-Associated Stevens-Johnson Syndrome.
Case Rep Crit Care
November 2024
Department of Clinical Pharmacy, Nepal Cancer Hospital and Research Center, Harisiddhi, Lalitpur, Nepal.
Article Synopsis
Preparing Nurses for CD20-CD3 Bispecific Antibody Treatment in Patients With Non-Hodgkin Lymphoma: A Scoping Review of Adverse Events and Management Strategies From Early Phase and Pivotal Trials.
Cancer Nurs
December 2024
Author Affiliations: Parkville Cancer Clinical Trials Unit, Peter MacCallum Cancer Centre (Mss van der Linde and Robertson, Messrs Minson and Dickinson, and Dr Krishnasamy); Barwon Health, University Hospital Geelong (Ms Knights); Department of Health Services Research, Peter MacCallum Cancer Centre, Parkville (Dr Krishnasamy); and Victorian Comprehensive Cancer Centre Alliance (Dr Krishnasamy); and Sir Peter MacCallum Department of Oncology, University of Melbourne (Dr Krishnasamy), Australia.
Article Synopsis
Mitigating effect of Bifidobacterium longum CCFM1077 on nonylphenol toxicity: An integrative in vitro and in vivo analysis.
J Hazard Mater
December 2024
State Key Laboratory of Food Science and Resources, Jiangnan University, Wuxi, Jiangsu 214122, China; School of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu 214122, China. Electronic address:
Article Synopsis
Evaluation of Antivenom Therapy for Middle East Scorpion Envenomations.
Pediatr Emerg Care
November 2024
Division of Clinical Toxicology, Sourasky Medical Center, Tel Aviv University, Tel Aviv, Israel.
Article Synopsis
Diphenhydramine Overdose: A Case Report and Topic Review of Prehospital Diagnosis and Treatment.
Cureus
October 2024
Emergency Medicine, Florida State University College of Medicine, Sarasota, USA.
Article Synopsis
Classics in Chemical Neuroscience: Deliriant Antihistaminic Drugs.
ACS Chem Neurosci
November 2024
Institute of Translational Biomedicine (ITBM), St. Petersburg State University, St. Petersburg 199034, Russia.
Article Synopsis
Giant Erythema in a Child with Lyme Disease.
Infect Drug Resist
October 2024
Department of Internal Medicine II, Ivan Horbachevsky Ternopil National Medical University, Ternopil, Ukraine.
Article Synopsis
- - An 11-year-old girl presented with high fever, headaches, abdominal pain, and a unique skin rash, leading to a challenging diagnosis of Lyme borreliosis.
- - Despite no recollection of a tick bite and atypical rash symptoms, Lyme disease was confirmed through serologic testing, indicating early disseminated infection.
- - The case highlights the importance of thorough patient history and diagnostic methods for accurately identifying atypical presentations of Lyme borreliosis in pediatric patients.
Design, synthesis and biological evaluation of arylpropylamine derivatives as potential multi-target antidepressants.
Bioorg Med Chem
November 2024
School of Pharmacy, Nanjing Tech University, 30th South Puzhu Road, Nanjing 211816, China. Electronic address:
Article Synopsis
- This study focuses on a new series of arylpropylamine compounds designed as potential multi-target antidepressants, with a highlight on compound (R)-13j.
- Compound (R)-13j showed strong inhibition of serotonin and noradrenaline transporters while having low affinity for certain receptors, potentially minimizing side effects.
- In animal tests, (R)-13j significantly reduced signs of depression compared to duloxetine, demonstrating a favorable safety and effectiveness profile, suggesting it could be a promising new treatment for depression.
Sodium butyrate alleviates T-2 toxin-induced liver toxicity and renal toxicity in quails by modulating oxidative stress-related Nrf2 signaling pathway, inflammation, and CYP450 enzyme system.
J Food Sci
November 2024
College of Life Science and Engineering, Foshan University/Foshan University Veterinary Teaching Hospital, Foshan, Guangdong, People's Republic of China.
Article Synopsis
Therapeutic potential of histamine H receptor antagonist as a preventive treatment for diabetic retinopathy in mice.
Sci Rep
September 2024
Macrophage Lab, Department of Microbiology and ImmunologyInstitute of Endemic Disease, Seoul National University College of Medicine, Seoul, Republic of Korea.
Article Synopsis
- Diabetic retinopathy (DR) is a serious complication of diabetes that can lead to vision loss and blindness, with current treatments often being invasive and having side effects.
- This study explores the use of a histamine H receptor (HRH4) antagonist as a potential preventive therapy for DR in a mouse model, highlighting its effects on inflammation and retinal vascular leakage.
- Results show that the HRH4 antagonist effectively reduces macrophage infiltration and retinal damage without causing toxicity, suggesting that targeting HRH4 could be a new strategy for preventing and treating DR.
Sodium Butyrate Ameliorates Postoperative Delirium by Regulating Gut Microbiota Dysbiosis to Inhibit Astrocyte Activation in Aged Mice.
Neurochem Res
December 2024
Department of Anesthesiology and Perioperative Medicine, General Hospital of Ningxia Medical University, Yinchuan, 750004, China.
Article Synopsis
Improved higher resolution cryo-EM structures reveal the binding modes of hERG channel inhibitors.
Structure
November 2024
Department of Chemistry, Graduate School of Science, Chiba University, 1-33 Yayoi-cho, Inage, Chiba 263-8522, Japan; Membrane Protein Research Center, Chiba University, 1-33 Yayoi-cho, Inage, Chiba 263-8522, Japan. Electronic address:
Article Synopsis
- Excluding toxic compounds is vital in drug discovery, with the hERG channel being a key target due to its impact on cardiac health and potential arrhythmias.
- Inhibition of hERG can cause serious heart problems, like Torsades de Pointes, highlighting the need to understand how these inhibitors work.
- By using digitonin, researchers improved the resolution of hERG's structure and analyzed its interactions with various inhibitors, providing insights that could lead to safer drug designs.
[Chronic urticaria as an atypical reaction after a vespid bite].
Rev Alerg Mex
June 2024
Unidad de Alergia, Hospital Universitario Fundación Alcorcón, Madrid, España.
Article Synopsis
- - A 56-year-old woman experienced severe itching and widespread hives after being stung by wasps, which required extensive treatment over 12 weeks with antihistamines and corticosteroids.
- - Allergy testing indicated that she had a normal tryptase level and was sensitized to venom from Polistes dominula, a type of wasp.
- - The patient began venom immunotherapy specific to Polistes dominula, which successfully prevented any further episodes of hives after treatment.
Article Synopsis
- - Cinnarizine (CIN) is a recognized antihistamine that hasn’t been previously studied for its degradation products or pathways; this research addresses that gap by developing a method for identifying those products.
- - A stability-indicating assay method was established to analyze CIN's degradation using advanced techniques like LC-HRMS/MS and H-NMR, revealing that CIN is prone to oxidation but stable under other conditions.
- - The study identified two new degradation products (DP-1 and DP-2) formed during oxidative stress and validated the assay method according to ICH guidelines, making it useful for quality control in pharmaceuticals and research.
Sodium butyrate protect bone mass in lipopolysaccharide-treated rats by reducing oxidative stress and inflammatory.
Redox Rep
December 2024
Department of Orthopedics, The First Affiliated Hospital of Wannan Medical College, Yijishan Hospital, Wuhu, People's Republic of China.
Article Synopsis
- * Various assays were used to measure changes in cellular functions and gene expression related to bone health after NaB treatment in both in vitro and in vivo settings.
- * Results indicate that NaB alleviates inflammation and oxidative stress, enhances bone formation, and prevents bone loss by improving key markers and functions in LPS-treated rats.
Effects of diphenhydramine on crayfish cytochrome P450 activity and antioxidant defence mechanisms: First evidence of CYP2C- and CYP3A-like activity in marbled crayfish.
Ecotoxicol Environ Saf
October 2024
University of South Bohemia in České Budějovice, Faculty of Fisheries and Protection of Waters, South Bohemian Research Center of Aquaculture and Biodiversity of Hydrocenoses, Zátiší 728/II, Vodňany 389 25, Czech Republic. Electronic address:
Article Synopsis
- A study investigated the effects of diphenhydramine (DPH), an antihistamine found in global water sources, on marbled crayfish (Procambarus virginalis) over a 96-hour exposure period, focusing on CYP metabolism and oxidative stress.* -
- The crayfish showed CYP activity through specific substrates, indicating functions similar to mammalian detoxification, but higher DPH concentrations led to a slight reduction in transformation activities.* -
- Antioxidant enzyme responses were significantly altered in the gills and hepatopancreas due to DPH exposure, with gills identified as the key tissue for assessing DPH toxicity in these aquatic organisms.*
Symptomatic aseptic sinusitis induced by immune checkpoint inhibitors for metastatic melanoma treatment.
Immunotherapy
October 2024
Department of Dermatology, Avicenne University Hospital, AP-HP, Sorbonne-Paris-Nord University, Bobigny, France.
Article Synopsis
- * A study analyzed 12 patients, highlighting key signs like lack of response to antibiotics, symptom improvement after immunosuppressants, and concurrent immune-related issues, suggesting that this sinusitis is noninfectious.
- * There is a need for more studies to determine how common this condition is and its potential impact on patients' outcomes when treated with ICIs.
High-risks drug adverse events associated with Cetirizine and Loratadine for the treatment of allergic diseases: A retrospective pharmacovigilance study based on the FDA adverse event reporting system database.
Clin Transl Allergy
September 2024
Department of Otolaryngology-Head & Neck Surgery, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
Article Synopsis
- Cetirizine and Loratadine are popular antihistamines used for allergies, and this study compares their adverse drug events (ADEs) to help doctors choose the safest option for patients.
- The analysis of ADE reports from the FDA showed that Loratadine is more frequently linked to respiratory issues, while both drugs lead to drowsiness, with Cetirizine showing higher risks for serious psychiatric effects and some uncommon cardiac issues.
- The findings suggest that Cetirizine may have a higher potential for serious ADEs compared to Loratadine, indicating a need for cautious prescribing of Cetirizine and awareness of its cardiac toxicity.
Mitigating lead-induced osteoporosis: The role of butyrate in gut-bone axis restoration.
Ecotoxicol Environ Saf
September 2024
Department of Occupational Medicine, Wuxi Center for Disease Control and Prevention, Wuxi, Jiangsu, China. Electronic address:
Article Synopsis
- Lead (Pb) can make bones weak and is found in many places in the environment.
- Butyric acid, a substance made by bacteria in our gut from certain foods, helps keep bones healthy.
- The study found that taking butyric acid can help fix the bone problems caused by lead exposure in mice and may also help people who consume it.
Toxic epidermal necrolysis caused by phenobarbital: a case report and literature review.
Front Pharmacol
August 2024
Department of Clinical Pharmacy, The First Affiliated Hospital of Shandong First Medical University and Shandong Provincial Qianfoshan Hospital, Shandong Medicine and Health Key Laboratory of Clinical Pharmacy, Jinan, China.
Article Synopsis
- Toxic epidermal necrolysis (TEN) and Stevens-Johnson syndrome (SJS) are serious immune reactions, and this study focused on a case involving a woman taking phenobarbital for seizures who developed TEN.
- The case was analyzed alongside existing literature, revealing that there were 19 reported cases of phenobarbital-induced SJS/TEN, with a notable portion resulting in fatalities, particularly among younger patients.
- The findings emphasize the need for close monitoring of patients starting phenobarbital treatment, especially those with a history of asthma, since severe skin reactions can occur early in treatment even in patients who test negative for certain genetic markers.