8,588 results match your criteria: "Toxicity Antidepressant"

Many freshwater systems are continuously exposed to waste streams like municipal wastewater and agricultural runoff, leading to exposure to chemicals that can cause mortality and behavioural changes in aquatic organisms. While research has advanced our understanding of pesticide effects on behaviour of aquatic organisms, the impacts of pharmaceuticals are less understood. Psychopharmaceuticals are particularly interesting because they can act on nervous systems, potentially affecting the behaviour of aquatic organisms.

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Self-Harm as a Contributor to the Opioid Epidemic: Data From the Toxicology Investigators Consortium Registry.

J Addict Med

December 2024

From the Translational Addiction Medicine Branch, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD (STW); Biostatistics and Clinical Epidemiology Service, National Institutes of Health, Bethesda, MD (XL); Toxicology Investigators Consortium, American College of Medical Toxicology, Phoenix, AZ (KA, PMW); and Departments of Medicine and Emergency Medicine, University of Colorado School of Medicine and Colorado School of Public Health, Aurora, CO (JB).

Objectives: Although considerable focus has been placed on understanding the causes of opioid drug overdoses, the intentions for such overdoses are not well characterized. We investigated the motivations behind nonfatal opioid exposures resulting in serious adverse health outcomes.

Methods: We analyzed prospectively collected data on nonfatal opioid overdoses in the multicenter Toxicology Investigators Consortium (ToxIC) Core Registry between 2014 and 2021.

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Norlignans and Phenolics from and Their Neuroprotection Against Glutamate-Induced Oxidative Injury in SH-SY5Y Cells.

Molecules

November 2024

Anhui Key Laboratory of Bioactivity of Natural Products, School of Pharmacy, Anhui Medical University, Hefei 230032, China.

The herb (Lour.) Ktze is widely distributed in southern and southwestern China. The genus and its primary chemical constituents exhibit remarkable antidepressant activities.

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Background: Adverse cutaneous drug reactions have been reported with most drugs, including antidepressants (ADs) and second-generation antipsychotics (SGAs). The lack of extensive research on the relationship between ADs and SGAs, and cutaneous toxicity remains troubling. Our study aimed to assess the cutaneous toxicity of ADs and SGAs and provide valuable insights for clinical applications and scientific investigations.

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Aim: Serotonin-norepinephrine reuptake inhibitors (SNRIs) have been extensively utilized for the treatment of depression and anxiety disorders. Clinical trials and real-world data suggest that SNRIs may cause reproductive toxicity. To comprehensively assess this association, we conducted a pharmacovigilance study.

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Pharmaceutical pollution poses an increasing threat to global wildlife populations. Psychoactive pharmaceutical pollutants (e.g.

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Bupropion is used as smoking cessation drug and antidepressant. Drug overdose has multi-system involvement including neurotoxicity and cardiovascular collapse. Use of haemoperfusion in bupropion toxicity is generally not useful, however in life-threatening condition it could be a life saver.

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Deciphering the inhibitory mechanisms of didecyldimethylammonium chloride on microalgal removal of fluoxetine: Insights from the alterations in cell surface properties and the physio-biochemical and molecular toxicity.

Sci Total Environ

December 2024

State Key Laboratory of Environmental Criteria and Risk Assessment, Chinese Research Academy of Environmental Sciences, Beijing 100012, China.

The COVID-19 pandemic has increased the co-occurrence of quaternary ammonium compounds (QACs) and antidepressants in aquatic environments. Microalgae are sustainable and cost-effective candidates for removing emerging pollutants. QACs have a robust ability to adsorb on cell surface and alter membrane permeability, but little is known about the influence of QACs on microalgal bioremediation of co-existing pollutants like antidepressants.

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Article Synopsis
  • * An evaluation of 88 phytochemicals identified five (Genistein, Kaempferol, Daidzein, Peonidin, and glycitein) with strong pharmacokinetic properties and effective binding to serotonin receptors.
  • * The study suggests these phytochemicals, commonly found in soybeans and various plants, could lead to natural depression treatments, but more research is needed to confirm their effectiveness in real-world applications.
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Transferrin-modified carboxymethyl chitosan-chitosan nanoparticles as an efficient delivery carrier for targeted therapy of depression.

Int J Biol Macromol

December 2024

School of Chemistry and Chemical Engineering, Key Laboratory of Chemistry and Engineering of Forest Products, State Ethnic Affairs Commission, Guangxi Key Laboratory of Chemistry and Engineering of Forest Products, Guangxi Collaborative Innovation Center for Chemistry and Engineering of Forest Products, Guangxi Minzu University, Nanning 530006, China. Electronic address:

Limitations of the blood-brain barrier (BBB) are responsible for the low efficacy and high toxicity of many antidepressants. However, strategies to enhance BBB targeting to improve the efficacy and safety of antidepressants remain challenging. In this study, we prepared transferrin (Tf)-functionalized chitosan (CS)-N,O-carboxymethy chitosan (NOCMS) nanosystems (NPs) (NOCMS-CS-Tf NPs), which can enhance BBB targeting in the depressive environment and allow more NPs to enter the brain.

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Article Synopsis
  • Sertraline, a commonly used antidepressant, has seen increased usage, particularly during the COVID-19 pandemic, prompting a study on its transgenerational effects using the aquatic microcrustacean Daphnia magna.
  • The study found that exposure to sertraline influenced reproductive traits and molting behaviors in D. magna, with effects being inherited across three generations, including increased fecundity and body size reduction in offspring.
  • Results indicated that sertraline's reproductive toxicity may be linked to serotonin dysregulation and that it triggered a self-defense reproductive response, although male offspring were not produced in the study across generations, suggesting complex interactions between the drug and population dynamics.
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Green synthesis and in vitro photodynamic efficacy of hypericin: Cytotoxicity assessment on MCF-7 breast cancer cells.

Photodiagnosis Photodyn Ther

December 2024

Deapartment of Physics, School of Advanced Sciences, Vellore Institute of Technology, Vellore, Tamil Nadu 632014, India. Electronic address:

Article Synopsis
  • Photodynamic therapy (PDT) is a non-invasive cancer treatment that uses light and a natural component called photosensitizer, with hypericin from St. John's Wort showing promise for this purpose.
  • Traditional production of hypericin is harmful to the environment and human health, prompting researchers to develop a more eco-friendly green synthesis method that uses fewer toxic chemicals.
  • The study demonstrated that hypericin effectively induces cancer cell death in MCF7 breast cells through apoptosis and oxidative stress, highlighting its potential as a natural photosensitizer for future cancer therapies.
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Depression in pregnant women raises concerns about the safety of antidepressants use, particularly its impact on offspring's neurocognition. This study investigates the effects of maternal exposure to vortioxetine (VOX) on the neurocognitive development of rat offspring. Pregnant Wistar rats were administered clinically pertinent doses of VOX, 1 mg/kg/day or 2 mg/kg/day from gestational day 6-21.

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Exposure to amitriptyline disturbs behaviors in adult zebrafish and their offspring via altering neurotransmitter levels.

Comp Biochem Physiol C Toxicol Pharmacol

February 2025

School of the Environment and Safety Engineering, Jiangsu University, Zhenjiang, Jiangsu 212013, China; Jiangsu Collaborative Innovation Center of Technology and Material of Water Treatment, Suzhou University of Science and Technology, Suzhou 215009, China. Electronic address:

Amitriptyline (AMI), one of the widely used tricyclic antidepressants (TCAs), has become a pharmaceutical contaminant frequently detected in aquatic ecosystems. However, the impacts of AMI exposure and underlying mechanisms on fish are still limited. In this study, adult zebrafish (F0) were exposed to AMI at 0 (control), 0.

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A physical perspective on lithium therapy.

Prog Biophys Mol Biol

December 2024

The Niels Bohr Institute, Copenhagen University, Copenhagen, Denmark. Electronic address:

Lithium salts have strong medical properties in neurological disorders such as bipolar disorder and lithium-responsive headaches. They have recently gathered attention due to their potential preventive effect in viral infections. Though the therapeutic effect of lithium was documented by Cade in the late 1940s, its underlying mechanism of action is still disputed.

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Bupropion is a norepinephrine-dopamine reuptake inhibitor that is commonly used as an antidepressant and for smoking cessation. Bupropion overdose can lead to serious side effects which include seizures, status epilepticus, and fatal arrhythmias. Managing bupropion toxicity is challenging as there is no effective antidote and treatment is largely supportive.

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The high prevalence of major depressive disorder (MDD) among women of childbearing age necessitates careful consideration of antidepressant use during pregnancy. Although newer antidepressants, such as Vilazodone (VLZ), are preferred for their enhanced therapeutic profiles; however, their safety during pregnancy and long-term effects on offspring brains remain inadequately addressed. Therefore, this study aimed to investigate the reproductive and developmental neurotoxicity of VLZ given at equivalent therapeutic doses during gestation in a rat model.

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Chronic treatment of mixture of two iridoids proportional to prescriptional dose of Yueju improves hippocampal PACAP-related neuroinflammation and neuroplasticity signaling in the LPS-induced depression model.

J Ethnopharmacol

February 2025

Interdisciplinary Institute for Personalized Medicine in Brain Disorders, School of Chinese Medicine, Jinan University, Guangzhou, 510632, China; Zhuhai Institute of Jinan University, Zhuhai, 519070, China; Departments of Psychiatry & Clinical and Translational Institute of Psychiatric Disorders, First Affiliated Hospital of Jinan University, Guangzhou, 510632, China; Guangdong-Hong Kong-Macau Joint Laboratory of Traditional Chinese Medicine on Brain-Peripheral omeostasis and Comprehensive Health, Jinan University, Guangzhou, 510632, China. Electronic address:

Article Synopsis
  • Geniposide (GP) and shanzhiside methyl ester (SM) are key compounds in the Yueju Pill, a traditional Chinese herbal medicine known for its antidepressant effects, and their combined action may enhance these effects.
  • This study examined how chronic treatment with GP and SM influences antidepressant-like responses linked to the neuropeptide PACAP in a model of depression induced by neuroinflammation.
  • Results showed that GP and SM treatment improved depression-related behaviors, increased PACAP expression, and altered inflammatory and neuroplasticity signaling pathways in the brains of mice, suggesting a synergistic effect and supporting the potential of these compounds as antidepressants.
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