Sci Rep
January 2025
Golestan Research Center of Gastroentrology and Hepatology & Stem Cell Research Center, Golestan University of Medical Sciences, Gorgan, Iran.
Children are highly sensitive to toxins which can damage their organs and lead to death. Investigating the main causes of intoxication could reduce mortality and morbidity in children. In this cross-sectional study, the documents of all poisoned patients (214 cases) admitted to the emergency department of Taleghani children`s Hospital between April 2020 and 2023 were investigated.
View Article and Find Full Text PDFMethamphetamine (METH) is a highly addictive and dangerous drug that mainly affects neurotransmitters in the brain and leads to feelings of alertness and euphoria. The METH use can lead to addiction, which has become a worldwide problem, resulting in a slew of public health and safety issues. Recent studies showed that chronic METH use can lead to neurotoxicity, neuro-inflammation and oxidative stress which can lead to neuronal injury.
View Article and Find Full Text PDFInt J Dev Neurosci
February 2025
Department of Anatomical Sciences and Cognitive Neurosciences, Faculty of Medicine, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran.
The increasing prevalence of methamphetamine abuse among women, particularly pregnant females, is a global concern. Methamphetamine can readily cross anatomical barriers like the blood-placenta barrier and cause detrimental impacts on the growing fetus. The current research evaluated the effects of prenatal methamphetamine exposure on helping behaviour and neuroinflammatory cascade in the amygdala of male offspring.
View Article and Find Full Text PDFInt J Mol Sci
December 2024
Department of Pharmaceutical Sciences, Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University, 259 Mack Ave., Detroit, MI 48201, USA.
In recent years, methamphetamine (METH) misuse in the US has been rapidly increasing, and there is no FDA-approved pharmacotherapy for METH use disorder (MUD). In addition to being dependent on the drug, people with MUD develop a variety of neurological problems related to the toxicity of this drug. A variety of molecular mechanisms underlying METH neurotoxicity has been identified, including the dysfunction of the neuroprotective protein parkin.
View Article and Find Full Text PDFToxicol Rep
December 2024
Department of Pathology, College of Medicine, University of Baghdad, Baghdad, Iraq.
Acta Neuropathol Commun
November 2024
Institute of Neuroscience, State Key Laboratory of Neuroscience, CAS Center for Excellence in Brain Science and Intelligence Technology, Shanghai, 200031, China.
Chronic methamphetamine (METH) use, a prevalent psychostimulant, is known to impair attention, yet the cellular mechanisms driving these deficits remain poorly understood. Here, we employed a rat model of repeated passive METH injections and evaluated attentional performance using the 5-choice serial reaction time task (5-CSRTT). Using single-nucleus RNA sequencing, immunofluorescence and in situ hybridization, we characterized the response of neurons in the reticulotegmental nucleus (RtTg) to METH exposure.
View Article and Find Full Text PDFMetab Brain Dis
November 2024
School of Pharmacy, Health Science Center, Ningbo University, Ningbo, 315211, China.
Chronic exposure to methamphetamine (METH) has been suggested to cause METH use disorder and severe cognitive impairment. Paeoniflorin (PF) is a monoterpenoid glycoside with various beneficial effects, including anti-inflammatory, antioxidant and antidepressant. The current study was designed to investigate the effect of PF (30 mg/kg, i.
View Article and Find Full Text PDFAquat Toxicol
December 2024
Department of Fisheries, Faculty of Agriculture and Technology, Rajamangala University of Technology Isan Surin Campus, Surin 32000 Thailand. Electronic address:
J Neuroimmune Pharmacol
November 2024
Department of Pharmacology, Rush University Medical Center, 1735 W. Harrison Street Cohn Research Building Suite #424, Chicago, IL, 60612, USA.
Infection with human immunodeficiency virus (HIV) increases risk for maladies of the gut barrier, which promotes sustained systemic inflammation even in virally controlled patients. We previously revealed morphological disorganization of colon epithelial barrier proteins in HIV-1 transgenic (Tg) rats. The current study evaluated mechanisms that may underlie gut barrier pathology induced by toxic HIV-1 proteins.
View Article and Find Full Text PDFNeuroscience
December 2024
Department of Biology, Faculty of Basic Sciences, University of Guilan, Rasht, Iran. Electronic address:
Alzheimer's disease (AD) is the most common form of neurodegeneration that results in memory disorders and cognitive impairment. The present study investigated the neuroprotective effects of the synthesized thiazolidine-2,4-dione derivative, (E)-5-(4-chlorobenzylidene)-3-(2-oxo-2-phenylethyl)thiazolidine-2,4-dione (TZ4C), an inhibitor of p-Tau and memory impairment, using a SH-SY5Y cell model of methamphetamine-induced tauopathy and a scopolamine-induced memory impairment model in Wistar rats. In the present study, the neuroprotective effect of TZ4C was studied in a SH-SY5Y cellular model of methamphetamine-induced (2 mM) tauopathy and a scopolamine-induced (1.
View Article and Find Full Text PDFHerz
December 2024
Department of Psychosomatic Medicine and Psychotherapy, University of Göttingen, Waldweg 33, 37073, Göttingen, Germany.
Crystalline methamphetamine hydrochloride is an illegal drug with a high addictive potential, better known by its colloquial name "ice" or "crystal meth". The abuse of this drug has led to significant health problems worldwide. Like other amphetamine-type stimulants, chronic consumption of methamphetamine leads to direct toxic effects on the central nervous system, causing cognitive impairment, depressive behavior, and other severe neurological or psychiatric symptoms.
View Article and Find Full Text PDFSci Total Environ
December 2024
Centre for Research and Technology of Agro-Environmental and Biological Sciences (CITAB), University of Trás-os-Montes and Alto Douro (UTAD), Quinta de Prados, 5000-801 Vila Real, Portugal; Inov4Agro, Institute for Innovation, Capacity Building and Sustainability of Agri-food Production, 5000-801 Vila Real, Portugal. Electronic address:
The increased detection of the recreational drug 3,4-methylenedioxymethamphetamine (MDMA) in aquatic ecosystems, has raised concern worldwide about its possible negative impacts on wildlife. MDMA is produced as racemate but its enantioselective effects on non-target organisms are poorly understood. Therefore, this study aimed to provide a comprehensive study of the toxicity of MDMA and its enantiomers in the early life stages of zebrafish (Danio rerio).
View Article and Find Full Text PDFInt J Mol Sci
September 2024
Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Neuromed, 86077 Pozzilli, Italy.
Methamphetamine (METH) is a drug of abuse, which induces behavioral sensitization following repeated doses. Since METH alters blood pressure, in the present study we assessed whether systolic and diastolic blood pressure (SBP and DBP, respectively) are sensitized as well. In this context, we investigated whether alterations develop within A1/C1 neurons in the vasomotor center.
View Article and Find Full Text PDFSci Rep
October 2024
Department of Pharmacology and Toxicology, College of Pharmacy, Qassim University, Al Qassim, 51452, Buraydah, Saudi Arabia.
Bol Med Hosp Infant Mex
October 2024
Servicio de Pediatría, Hospital Civil de Guadalajara Dr. Juan I. Menchaca.
Neuropharmacology
December 2024
Department of Immunology and Pathogenic Biology, College of Basic Medicine, Xi'an Jiaotong University Health Science Center, Xi'an, China. Electronic address:
Toxics
September 2024
Division of Clinical Toxicology, Poison Centre Munich, School of Medicine and Health, Technical University of Munich, 81675 Munich, Germany.
Zhong Nan Da Xue Xue Bao Yi Xue Ban
June 2024
Blood Purification Center, Third Xiangya Hospital, Central South University, Changsha 410013, China.
Cureus
August 2024
Intensive Care Unit, King Fahad Specialist Hospital, Dammam, SAU.
BMJ Open
August 2024
Emergency Medicine, University of Calgary, Calgary, Alberta, Canada
Int J Drug Policy
September 2024
School of Public Health and Preventive Medicine, Faculty of Medicine, Nursing and Health Sciences, Monash University, Melbourne, Australia; Harm and Risk Reduction Program, Burnet Institute, Melbourne, Australia.
Int J Pharm
September 2024
Department of Geriatircs, First Affiliated Hospital of Nanjing Medical University, 300 Guangzhou Road, Nanjing 210029, Jiangsu, China. Electronic address:
Cell Mol Biol (Noisy-le-grand)
July 2024
Department of Physiology, Faculty of Medicine, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran.
J Anal Toxicol
October 2024
Department of Pathology, University of Alabama at Birmingham, Birmingham, AL 35249, United States.
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