104 results match your criteria: "Toxic Nutritional Optic Neuropathy"
Medicina (B Aires)
October 2024
Servicio de Nutrición y Diabetes, Hospital de Pediatría S.A.M.I.C. Prof. Dr. Juan P. Garrahan, Buenos Aires, Argentina.
Vision (Basel)
September 2024
Ophthalmology Department, Pierre-Paul Riquet Hospital, Toulouse University Hospital, 31059 Toulouse, France.
Toxics
July 2024
Department of Ophthalmology, Hanyang University Hospital, Hanyang University College of Medicine, Seoul 04763, Republic of Korea.
J Neurogenet
June 2024
Department of Neurology, National Institute of Mental Health and Neurosciences, Bengaluru, India.
Eye (Lond)
August 2024
Department of Electrophysiology, Moorfields Eye Hospital, London, UK.
Curr Neurol Neurosci Rep
July 2024
Faculty of Medicine and Health Sciences, McGill University, Montreal, Canada.
Semin Ophthalmol
May 2024
Nikookari Eye Center, Tabriz University of Medical Sciences, Tabriz, Iran.
J Transl Med
May 2024
Université d'Angers, Unité Mixte de Recherche (UMR) MITOVASC, Institut National de la Santé et de la Recherche Médicale (INSERM U-1083), Centre National de la Recherche Scientifique (CNRS 6015), 49000, Angers, France.
Background: The pathophysiology of toxico-nutritional optic neuropathies remains debated, with no clear understanding of the respective roles played by the direct alcohol toxicity, smoking and the often associated vitamin deficiencies, which are risk factors for optic neuropathy. Our aim was to investigate genetic susceptibility in patients with bilateral infraclinical optic neuropathy associated with chronic alcohol use disorder.
Methods: This retrospective cohort study included 102 visually asymptomatic patients with documented alcohol use disorder from a French reference center.
Front Vet Sci
February 2024
Department of Small Animal Clinical Sciences, College of Veterinary Medicine, Michigan State University, East Lansing, MI, United States.
Neuroophthalmology
September 2023
Department of Ophthalmology and Visual Neurosciences, University of Minnesota Medical School, Minneapolis, Minnesota, USA.
Mercury has been described as been in daily household items such as soaps, skin-lightening creams (SLC), and topical disinfectants. Mercury exposure can reportedly cause damage to the optic nerve and retina. A 30-year-old Somali woman presented with decreased vision and was found to have bilateral optic atrophy.
View Article and Find Full Text PDFHandb Clin Neurol
August 2023
Department of Neurology, Methodist Neurological Institute, Weill Cornell Medical College, Houston Methodist Hospital, Houston, TX, United States. Electronic address:
A large number of causative agents can result in spinal cord disorders in the tropics including etiologies similar to those of temperate regions such as trauma, spinal bone and disc lesions, tumors, epidural abscess, and congenital malformations. Yet infectious and nutritional disorders differ in their higher prevalence in tropical regions including Pott's disease; brucellosis; neuroborreliosis; various parasitic diseases such as schistosomiasis, neurocysticercosis, and eosinophilic meningitis. Notably, the retrovirus HTLV-1 is the causeof tropical spastic paraparesis/paraplegia or TSP.
View Article and Find Full Text PDFJ Fr Ophtalmol
October 2023
Clinical Epidemiology Deparment. Consorci Sanitari Integral, Hospitalet de Llobregat, Barcelona, Spain; Department of Pediatrics, Obstetrics and Gynecology, and Preventive Medicine and Public Health, School of Medicine, Universitat Autònoma de Barcelona (UAB), Barcelona, Spain. Electronic address:
Objective: To assess the ability of optic nerve head (ONH) parameters, peripapillary retinal nerve fiber layer (pRNFL), and macular ganglion cell layer (GCL) thickness measurements with swept-source optical coherence tomography (SS-OCT), to discriminate between glaucomatous and non-glaucomatous optic neuropathy (GON and NGON).
Methods: This retrospective cross-sectional study involved 189 eyes of 189 patients, 133 with GON and 56 with NGON. The NGON group included ischemic optic neuropathy, previous optic neuritis, and compressive, toxic-nutritional, and traumatic optic neuropathy.
Mult Scler Relat Disord
April 2023
Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China. Electronic address:
Background: Demyelinating optic neuritis (DON) causes rapid vision loss in young and middle-aged people. The limited efficacy of treatment and the toxic side effects of drugs significantly affect the quality of life of patients with DON. Therefore, DON pathogenesis has always been a research hotspot in terms of prevention and treatment.
View Article and Find Full Text PDFDoc Ophthalmol
April 2023
Department of Ophthalmology and Visual Sciences, University of Illinois at Chicago, 1905 W. Taylor St, M/C 648, Chicago, IL, 60612, USA.
Background/purpose: Medication-induced ocular toxicity is an important consideration in the differential diagnosis of unexplained visual disturbance. We present a case of visual disturbance after starting treatment with glecaprevir/pibrentasvir (Mavyret), a therapy for Hepatitis C virus approved by the FDA in 2017.
Methods: A 50-year-old male with no significant ocular history experienced bilateral visual disturbance, including visual field and acuity loss, shortly after initiating treatment with Mavyret for Hepatitis C.
Doc Ophthalmol
April 2023
Clinical and Academic Department of Ophthalmology, Visual Electrophysiology Unit, Great Ormond Street Hospital for Children, NHS Trust, 40-41 Queen Square, London, WC1N 3AJ, UK.
Purpose: To report an unexpectedly asymmetric, progressive nutritional optic neuropathy associated with vitamin A deficient optic canal hyperostosis in a 15-year-old female with a long history of a restricted diet.
Methods: We performed comprehensive ophthalmic assessments in a fifteen-year-old female with a long history of restricted eating who presented with suspected nutritional optic neuropathy, predominantly affecting the right eye vision.
Results: A review of computerised tomography and magnetic resonance imaging revealed bilateral optic canal hyperostosis likely associated with vitamin A deficiency.
J Clin Med
September 2022
Ophthalmic Research Unit "Santiago Grisolia", FISABIO (Foundation for Research in Health and Biomedicine), 46017 Valencia, Spain.
Open-angle glaucoma (OAG), the most prevalent clinical type of glaucoma, is still the main cause of irreversible blindness worldwide. OAG is a neurodegenerative illness for which the most important risk factor is elevated intraocular pressure (IOP). Many questions remain unanswered about OAG, such as whether nutritional or toxic habits, other personal characteristics, and/or systemic diseases influence the course of glaucoma.
View Article and Find Full Text PDFInt Ophthalmol
December 2022
CHU St Pierre and Brugmann, Department of Ophthalmology, 322 rue Haute, 1000, Brussels, Belgium.
Purpose: To identify the underlying etiologies and to evaluate the differential diagnostic value of posterior segment spectral domain OCT measurements and their correlation with best-corrected visual acuity (BCVA) in a group of patients with OCT documented bilateral optic neuropathy limited to the temporal quadrants.
Methods: Retrospective study.
Results: We included 61 patients: 35 presented with presumed "classic" acquired mitochondrial optic neuropathy (MON) (18 nutritional, 11 toxic, 6 mixed toxic-nutritional) and 2 with suspected hereditary MON.
Clin Genet
October 2022
Departamento de Bioquímica, Biología Molecular y Celular, Universidad de Zaragoza, Zaragoza, Spain.
Leber hereditary optic neuropathy is a mitochondrial disease mainly due to pathologic mutations in mitochondrial genes related to the respiratory complex I of the oxidative phosphorylation system. Genetic, physiological, and environmental factors modulate the penetrance of these mutations. We report two patients suffering from this disease and harboring a m.
View Article and Find Full Text PDFAnn Med Surg (Lond)
May 2022
Kist Medical College and Teaching Hospital, Lalitpur, 284403, Nepal.
Introduction: Ethambutol is a drug used against tuberculosis and causes side effects like problems with vision, which may lead to optic neuropathy. It has a low prevalence of 1% and typically develops after 4-12 months of its medications.
Case Presentation: Here, we report a case of a 42-year-old male with ethambutol-induced optic neuropathy after six weeks of initiations of ethambutol.
Surv Ophthalmol
June 2023
Division of Neuro-Ophthalmology, Baylor College of Medicine, Houston, Texas, USA.
A 77-year-old man presented with the complaint of a painless decrease in vision in both eyes for 1 year. He underwent bilateral cataract surgery without improvement. Neuro-imaging and genetic testing for mitochondrial disease was negative.
View Article and Find Full Text PDFInt J Environ Res Public Health
March 2022
Department of Analytical Chemistry, Medical University of Lublin, Chodźki 4A, 20-093 Lublin, Poland.
Optic neuropathies constitute a group of conditions with various etiologies and might be caused by different factors; we can distinguish the genetic and acquired causes of optic neuropathies. Even though the symptoms are not highly specific, this condition is primarily characterized by unilateral or bilateral vision loss with worsening color detection. The loss may be acute or gradual depending on the causation.
View Article and Find Full Text PDFAm J Ophthalmol Case Rep
March 2022
Department of Ophthalmology, University General Hospital of Castellón, Avenida de Benicàssim, 128, 12004, Castellón de La Plana, Spain.
A 36-year-old man presented complaining of bilateral painless vision loss. He was admitted with chronic ethanol abuse, as well as sporadic cocaine consumption three days before symptom onset. General medical evaluation dismissed cerebral and cardiovascular events.
View Article and Find Full Text PDFAdv Ophthalmol Pract Res
December 2021
Department of Ophthalmology, Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, NY, USA.