1,084 results match your criteria: "Tourette Syndrome and Other Tic Disorders"
Front Neurol
December 2024
Department of Psychosomatic Medicine, Beijing Children's Hospital, Capital Medical University, National Center for Children Healthy, Beijing, China.
Background: Tic disorder, a chronic neurodevelopmental disorder that typically onsets during childhood, is characterized by sudden, involuntary, rapid, and non-rhythmic motor and vocal tics. Individuals with tic disorders often experience physical health issues. The purpose of our retrospective analysis was to elucidate the common comorbid physical diseases and mental disorders and their characteristics of outpatient children with tic disorders in a large public children's hospital in China over the past 5 years.
View Article and Find Full Text PDFNat Commun
December 2024
Department of Neurology, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.
Gilles de la Tourette Syndrome (GTS) is a chronic tic disorder, characterized by unwanted motor actions and vocalizations. While brain stimulation techniques show promise in reducing tic severity, optimal target networks are not well-defined. Here, we leverage datasets from two independent deep brain stimulation (DBS) cohorts and a cohort of tic-inducing lesions to infer critical networks for treatment and occurrence of tics by mapping stimulation sites and lesions to a functional connectome derived from 1,000 healthy participants.
View Article and Find Full Text PDFSante Ment Que
December 2024
Université du Québec à Montréal, Québec, Canada; Centre intégré universitaire de santé et de services sociaux du Nord-de-l'Île-de-Montréal, Québec, Canada.
Background Researcher and psychologist Kieron Philip O'Connor (1950-2019) pioneered the cognitive and behavioural approach at the Institut universitaire en santé mentale de Montréal (IUSMM). It was there that he began a career as a clinical researcher studying Tourette's syndrome (TS) and obsessive-compulsive and related disorder (OCD). At the time, apart from some behavioural approaches, little cognitive intervention was available to treat chronic tics and obsessive-compulsive disorder.
View Article and Find Full Text PDFBMC Pediatr
December 2024
Department of Pediatrics, China-Japan Friendship Hospital, No.2 Yinghua East Street, Chaoyang District, Beijing, 100029, China.
Objective: Tic disorders (TD) often present with associated neuropsychiatric comorbidities. This study aims to examine the clinical manifestations of TD in pediatric patients and explore the spectrum and features of neuropsychiatric comorbidities among Chinese children diagnosed with TD.
Methods: A retrospective analysis was conducted on pediatric TD cases newly diagnosed at our institution, using the Mini International Neuropsychiatric Interview for Children and Adolescents 5.
J Child Adolesc Psychopharmacol
November 2024
Neurology and Neurosurgery, Medical Director, Movement Disorders Neuromodulation & Brain Circuit Therapeutics, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
J Am Acad Child Adolesc Psychiatry
November 2024
Yale University School of Medicine, New Haven, Connecticut. Electronic address:
Clin Neurophysiol
December 2024
Department of Pediatrics, Marcus Autism Center, Emory University School of Medicine, 1920 Briarcliff Rd, NE, Atlanta, GA 30329, USA. Electronic address:
F1000Res
September 2024
Department of Psychiatry, Washington University in St Louis, St. Louis, Missouri, USA.
J Child Adolesc Psychopharmacol
October 2024
Division of Child Neurology, Department of Neurology, University of Rochester Medical Center (URMC), Rochester, NY, USA.
Tourette disorder (TD) is a neurodevelopmental disorder characterized by childhood onset of tics lasting more than one year, with multiple motor tics and at least one phonic tic at some point during the course of the symptoms. Treatment of tics may include psychoeducation, non-pharmacologic treatment, or pharmacologic treatment. We review pharmacologic treatment here.
View Article and Find Full Text PDFCells
July 2024
EuMentis Therapeutics Inc., 275 Grove Street, 2-400, Newton, MA 02466, USA.
Expert Rev Neurother
October 2024
Department of Neurology, Parkinson's Disease Center and Movement Disorders Clinic, Baylor College of Medicine, Houston, TX, USA.
J Psychiatr Res
September 2024
Clinic of Psychiatry, Social Psychiatry and Psychotherapy, Hannover Medical School, Germany. Electronic address:
Mol Psychiatry
January 2025
School of Philosophy, Psychology and Language Sciences, University of Edinburgh, Edinburgh, UK.
Dyslexia is a learning difficulty with neurodevelopmental origins, manifesting as reduced accuracy and speed in reading and spelling. It is substantially heritable and frequently co-occurs with other neurodevelopmental conditions, particularly attention deficit-hyperactivity disorder (ADHD). Here, we investigate the genetic structure underlying dyslexia and a range of psychiatric traits using results from genome-wide association studies of dyslexia, ADHD, autism, anorexia nervosa, anxiety, bipolar disorder, major depressive disorder, obsessive compulsive disorder, schizophrenia, and Tourette syndrome.
View Article and Find Full Text PDFCortex
September 2024
2nd Department of Neurology, Comenius University Faculty of Medicine, University Hospital Bratislava, Bratislava, Slovakia. Electronic address:
J Psychiatr Res
August 2024
Department of Psychiatry, Neurology, Psychosomatics, and Psychotherapy in Childhood and Adolescence, Rostock University Medical Center, Rostock, Germany. Electronic address:
JAMA Netw Open
May 2024
Centre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.
Br J Pharmacol
September 2024
Department of Pharmacology and Toxicology, College of Pharmacy, University of Utah, Salt Lake City, Utah, USA.
Eur Child Adolesc Psychiatry
November 2024
Department of Neurology, Linyi People's Hospital, 27 East Section of Jiefang Road Lanshan District, Linyi, 276000, Shandong, China.
Biomed J
December 2024
Department of Medical Research, China Medical University Hospital, Taichung, Taiwan; School of Chinese Medicine, China Medical University, Taichung, Taiwan; Division of Genetics and Metabolism, China Medical University Children's Hospital, Taichung, Taiwan; Department of Medical Genetics, China Medical University Hospital, Taichung, Taiwan; Department of Medical Laboratory Science and Biotechnology, Asia University, Taichung, Taiwan. Electronic address:
Background: Tourette syndrome (TS) is a neurodevelopmental disorder characterized by motor and vocal tics. Several susceptibility loci associated with TS have been identified previously in populations of European descent using genome-wide association studies (GWAS). However, the exact pathogenic mechanism underlying TS is unknown; additionally, the results of previous GWAS for TS were based on Western populations, which may not translate to other populations.
View Article and Find Full Text PDFPediatr Neurol
June 2024
Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.
Background: To examine the association between race, ethnicity, and parental educational attainment on tic-related outcomes among Tourette Syndrome (TS) participants in the Tourette Association of America International Consortium for Genetics (TAAICG) database.
Methods: 723 participants in the TAAICG dataset aged ≤21 years were included. The relationships between tic-related outcomes and race and ethnicity were examined using linear and logistic regressions.
Eur Child Adolesc Psychiatry
November 2024
Academic Center for Child and Adolescent Psychiatry, Levvel, Amsterdam, The Netherlands.
Tics can have a serious impact on the quality of life of children and their families. Behavioural therapy is an evidence-based first line treatment for tic disorders. This randomised controlled trial studied the efficacy of a brief, condensed group-based programme for children with tics (Dutch Trial Registry NL8052, 27 September 2019).
View Article and Find Full Text PDFNeurosci Biobehav Rev
May 2024
Department of Pharmacology and Toxicology, College of Pharmacy, University of Utah, Salt Lake City, UT, USA. Electronic address:
Tics are sudden, repetitive movements or vocalizations. Tic disorders, such as Tourette syndrome (TS), are contributed by the interplay of genetic risk factors and environmental variables, leading to abnormalities in the functioning of the cortico-striatal-thalamo-cortical (CSTC) circuitry. Various neurotransmitter systems, such as gamma-aminobutyric acid (GABA) and dopamine, are implicated in the pathophysiology of these disorders.
View Article and Find Full Text PDFNeurol Sci
August 2024
Department of Neurosurgery, Ministry of Education Key Laboratory of Child Development and Disorders, National Clinical Research Center for Child Health and Disorders, Children's Hospital of Chongqing Medical University, No. 136, Zhongshan 2Nd Road, Yuzhong District, Chongqing, 400010, China.
Background: Observational studies have indicated that psychiatric disorders are the most common comorbidities in pediatric epilepsy. However, the existence and direction of a causal relationship between the two remains controversial. This study aims to investigate the association between common childhood psychiatric disorders and epilepsy using a two-sample, bidirectional Mendelian randomization (MR) approach.
View Article and Find Full Text PDFJ Psychiatr Res
May 2024
Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA. Electronic address:
There is growing enthusiasm for the treatment of neuropsychiatric disorders using neuromodulation. While some reports claim that transcranial magnetic stimulation (TMS) can be used to treat Tourette Syndrome (TS), little research exists to support this assertion. This meta-analysis examined the efficacy of TMS to reduce tic severity in patients with TS.
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