A randomized clinical trial to compare ketamine-butorphanol-azaperone-medetomidine and detomidine-etorphine-acepromazine for anesthesia of captive Przewalski horses (Equus przewalskii).

Objective: To compare ketamine-butorphanol-azaperone-medetomidine (KBAM) to detomidine-etorphine-acepromazine (DEA) for field anesthesia in captive Przewalski horses (Equus przewalskii).

Animals: 10 adult Przewalski horses.

Procedures: A prospective randomized crossover trial was conducted.

Comparison of the effect of three intramuscular sedation protocols on packed cell volume and total protein in cats.

Objectives: The aim of this study was to evaluate the change in packed cell volume (PCV) and total protein following intramuscular preanesthetic sedation with one of three drug combinations in cats.

Methods: Thirty client-owned cats were enrolled in this prospective, randomized, blinded, clinical study. A venous blood sample was obtained prior to administration of any sedation and PCV, total protein, electrolytes (Na, K, Cl, iCa), glucose and lactate were measured.

Evaluation of the analgesic effect of fentanyl-ketamine and fentanyl-lidocaine constant rate infusions in isoflurane-anesthetized dogs undergoing thoracolumbar hemilaminectomy.

Objective: To evaluate anesthetic conditions and postoperative analgesia with the use of intraoperative constant rate infusions (CRIs) of fentanyl-lidocaine or fentanyl-ketamine in dogs undergoing thoracolumbar hemilaminectomy.

Study Design: Prospective, randomized, blinded, clinical study.

Animals: A total of 32 client-owned dogs.

The role of the DFF40/CAD endonuclease in genomic stability.

Maintenance of genomic stability in cells is primordial for cellular integrity and protection against tumor progression. Many factors such as ultraviolet light, oxidative stress, exposure to chemical reagents, particularly mutagens and radiation, can alter the integrity of the genome. Thus, human cells are equipped with many mechanisms that prevent these irreversible lesions in the genome, as DNA repair pathways, cell cycle checkpoints, and telomeric function.

Sympathomimetics in veterinary species under anesthesia.

Sympathomimetic drugs mimic the physiological action of the sympathetic nervous system through interaction with adrenergic receptors. These drugs are commonly used to provide cardiovascular support in many veterinary species. Despite their common use, the literature evaluating their effectiveness can be somewhat limited depending on the species.

Review of non-invasive blood pressure measurement in animals: Part 2 - Evaluation of the performance of non-invasive devices.

Arterial blood pressure is a common parameter evaluated in conscious and anesthetized veterinary patients for a variety of reasons. Non-invasive blood pressure measurement techniques, such as Doppler ultrasound and oscillometry, are attractive in certain veterinary patients due to their availability and ease of use. The greatest limitation to non-invasive blood pressure monitoring can be its inaccuracy, particularly in hypotensive or hypertensive patients and in certain species.

Non-invasive blood pressure measurement in animals: Part 1 - Techniques for measurement and validation of non-invasive devices.

Arterial blood pressure is a common parameter evaluated in conscious and anesthetized veterinary species. Non-invasive blood pressure measurement techniques, such as Doppler ultrasonic flow detector and oscillometry, are attractive in certain animals due to their availability and ease of use. The greatest limitation to non-invasive blood pressure monitoring can be its inaccuracy, particularly in hypotensive or hypertensive patients and in certain species.

Alternatives to Opioid Analgesia in Small Animal Anesthesia: Alpha-2 Agonists.

Alpha-2 agonists have potent analgesic effects, in addition to their sedative actions. Alpha-2 agonists provide analgesia through any of several routes of administration, including parenteral, oral, epidural or intrathecal and intraarticular, because of spinal and supraspinal actions. Systemic doses are short acting, whereas local administration at the site of action result in longer analgesic effects.