734 results match your criteria: "Topiwala National Medical College & B. Y. L. Nair Charitable Hospital[Affiliation]"

The N-acetyltransferase 2 (NAT2) gene exhibits substantial genetic diversity, leading to distinct acetylator phenotypes among individuals. In this study, we determine NAT2 gene polymorphisms in tuberculosis (TB) patients and analyze serum isoniazid (INH) concentrations across the various genotypes. An observational prospective cohort study involving 217 patients with pulmonary or extrapulmonary TB was carried out.

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A 12-year-old female, resident of western India, presented with a history of pruritus associated with jaundice for two months. On presentation, she had icterus with mild palpable hepatomegaly. Investigations revealed direct hyperbilirubinemia and elevated transaminases, while gamma-glutamyl transferase levels were normal.

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Diagnosing hereditary spastic paraplegia (HSP) in paediatric patients can be challenging, especially when there is no positive family history. Children are often initially misdiagnosed with cerebral palsy due to the gradual progression of the disease and non-specific neuroimaging findings, despite the absence of perinatal insult. This misdiagnosis can prevent timely prenatal diagnosis, limiting the ability to make informed decisions about the pregnancy and to plan early interventions.

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Introduction Fixed-dose combinations (FDCs) have the potential in glaucoma management to improve efficacy due to the complementary mechanism of action of the drugs as well as compliance while reducing adverse effects by minimizing exposure to preservatives and the financial burden on the patients. FDC of brinzolamide/timolol has demonstrated efficacy and safety in multinational phase 3 studies in primary open-angle glaucoma (POAG) and ocular hypertension. However, efficacy and safety in the Indian population are not known.

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Sir Macfarlane Burnet-Immunologist.

J Assoc Physicians India

December 2024

Professor of Medicine (Retd), Topiwala National Medical College and Bai Yamunabai Laxman Nair Charitable Hospital; Hon. Physician, Bhatia Hospital, Mumbai, Maharashtra, India.

Frank Macfarlane Burnet (1899-1985) was born in Victoria, Australia, and obtained his MD in 1924 from the University of Melbourne. Burnet spent 2 years in England at the Lister Institute, where he studied bacteriophages and earned a PhD in 1928. Returning to Australia, he worked at the Walter and Eliza Hall Institute; as a bacteriologist, he continued his research on phages.

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Corneille Heymans and Carotid Body.

J Assoc Physicians India

November 2024

Professor (Retired), Department of Medicine, Topiwala National Medical College and Bai Yamunabai Laxman Nair Charitable Hospital; Honorable Physician, Bhatia Hospital, Mumbai, Maharashtra, India.

Corneille Heymans (1892-1968) was born in 1892 in Ghent, Belgium. Heymans received his doctor's degree in 1920 from the University of Ghent. He studied physiology in Paris, Lausanne, Vienna, and London under EH Starling and in the United States after graduation.

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Fetus in fetu (FIF) is a rare anomaly characterized by the presence of a monozygotic twin that becomes incorporated into the abdomen of its sibling during fetal development. FIF is a rare congenital condition typically identified in infancy. We present a case of FIF in a 16-year-old male, which is an extremely rare presentation during adolescence.

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Background: Meningococcal disease remains an important public health problem globally. We assessed the non-inferiority and the lot-to-lot consistency of a pentavalent meningococcal ACYWX conjugate vaccine (NmCV-5; Serum Institute of India, Pune, India) versus a quadrivalent meningococcal ACWY conjugate vaccine (MenACWY-D) in healthy adults.

Methods: In this observer-blind, randomised, active-controlled, phase 2/3 study, healthy adults aged 18-85 years were recruited from nine hospitals across seven cities in India.

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Malignant gastrointestinal neuroectodermal tumor (GNET) are rare malignant mesenchymal tumors. The tumor can present with various symptoms like abdominal pain, anorexia, or small bowel obstruction. Here, we present a case of small intestinal GNET who presented with gastrointestinal bleed and hemoperitoneum, a rare presentation of this disease.

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Status of sperm mitochondrial functions and DNA methylation in infertile men with clinical varicocele before and after treatment.

Mol Cell Endocrinol

January 2025

Department of Neuroendocrinology, ICMR-National Institute for Research in Reproductive and Child Health, Parel, Mumbai, 400012, India; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, 201002, India. Electronic address:

Varicocele has been associated with reduced male fertility potential. Treatment modalities for varicocele improve semen parameters, yet more than 50% of cases remain infertile. Varicocele-induced heat and hypoxia stress may affect sperm mitochondrial functions, possibly leading to aberrant epigenetic modifications.

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Background: There is a lack of information on the long-term course and outcomes of bipolar disorder (BD) patients with seasonal affective disorder (SAD).

Aim: To compare the demographic and clinical profile of BD patients with and without SAD.

Methodology: Data from 773 BD patients with an illness duration of at least 10 years were collected from 14 tertiary care centers.

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Paraduodenal hernias, especially right sided, are extremely rare entities that are difficult to diagnose due to their uncommon presentation. Some may experience small bowel obstruction. Such patients will have a guarded prognosis if complicated by sepsis due to strangulation or perforation.

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Brudziński and His Signs.

J Assoc Physicians India

October 2024

Family Physician, Bengaluru, Karnataka, India.

Article Synopsis
  • Some students and individuals have unique ways of remembering eponyms, which are terms named after people in fields like clinical medicine.
  • It's not always crucial to memorize these names as long as you understand their meanings.
  • Józef Brudziński is known for four medical signs related to reflexes linked to meningeal irritation, along with Kernig's sign.
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Article Synopsis
  • Scaphoid dislocations are very rare injuries, and this report focuses on a 60-year-old male patient who underwent surgery for this condition.
  • The treatment involved open reduction, fixation with Kirschner wires, and stabilising the scapholunate ligament.
  • The case report aims to provide detailed insights into this uncommon injury, covering treatment methods, long-term outcomes, and a literature review for assisting surgeons dealing with similar cases.
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Emphysematous pyelonephritis (EPN) is a rare infectious disease affecting the renal and perirenal tissues, wherein gas formation occurs in the renal parenchyma, perinephric tissues, or collecting systems. It can be life threatening with mortality rates upto 60%. Here, we report a case series of EPN during the COVID pandemic with COVID test-positive patients who were diagnosed based on clinical signs, symptoms, and CT scans.

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Nikola Tesla-Father of Our Energy Systems.

J Assoc Physicians India

September 2024

Professor (Retired), Department of Medicine, Topiwala National Medical College and Bai Yamunabai Laxman Nair Charitable Hospital; Honorable Physician, Bhatia Hospital, Mumbai, Maharashtra, India.

Nikola Tesla (1856-1943) was an American-Croatian electrical engineer who studied at Graz and Prague. He emigrated to the USA in 1884, where he worked for Thomas Edison. After a period of time, apart from having differences of opinion, Edison did not pay him the promised remuneration, so he left the job and set up on his own.

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Acute liver failure (ALF) is usually due to viral hepatitis and toxins. We have recently seen a patient with diffuse large B-cell lymphoma (DLBCL) presenting with ALF. High clinical suspicion is necessary for making a diagnosis of this rare etiology presenting as ALF.

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Tuberculosis (TB) is one of the main contributors to global mortality and morbidity. Prevalence of TB is more in developing countries. It is one of the airborne diseases that has always been a major health problem.

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Pediatric palliative care is a holistic care of children suffering from life-threatening or life-limiting illnesses and encompasses care of a child's body, mind, and spirit and involves giving support to the family. According to the Global Atlas of Palliative Care, 6% of the global need for palliative care is in children. In order to provide palliative care, one needs to identify and diagnose the conditions requiring palliative care.

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