A Bayesian Multivariate Spatial Point Pattern Model: Application to Oral Microbiome FISH Image Data.

Advances in cellular imaging technologies, especially those based on fluorescence in situ hybridization (FISH) now allow detailed visualization of the spatial organization of human or bacterial cells. Quantifying this spatial organization is crucial for understanding the function of multicellular tissues or biofilms, with implications for human health and disease. To address the need for better methods to achieve such quantification, we propose a flexible multivariate point process model that characterizes and estimates complex spatial interactions among multiple cell types.

Immunohistochemistry of carbonic anhydrases I, II and VI in the rat lingual serous salivary glands of von Ebner.

Carbonic anhydrase (CA) has been localized to many structures involved in ion transport including the acini and ducts of the major (parotid, sublingual and submandibular) salivary glands of humans and rodents. It also has been localized by enzyme histochemistry and by immunohistochemistry for CA isoenzyme VI (CA VI) to the acini and ducts of rat serous lingual glands of von Ebner. The purpose of this study was to explore the intracellular distribution by cell type of three CA isoenzymes in these glands.

Snoring Vibration: A Robust Measure for Predicting Treatment Outcome for Obstructive Sleep Apnea.

Obstructive sleep apnea (OSA) represents a prevalent condition impacting over 9% of the general adult population. Various treatment options have been clinically proposed and utilized, with a particular focus on continuous positive airway pressure (CPAP) and oral appliances due to their overall effectiveness and higher adherence rates. CPAP therapy has demonstrated greater effectiveness but lower adherence compared to oral appliances.

End-to-End Mandarin Speech Reconstruction Based on Ultrasound Tongue Images Using Deep Learning.

The loss of speech function following a laryngectomy usually leads to severe physiological and psychological distress for laryngectomees. In clinical practice, most laryngectomees retain intact upper tract articulatory organs, emphasizing the significance of speech rehabilitation that utilizes articulatory motion information to effectively restore speech. This study proposed a deep learning-based end-to-end method for speech reconstruction using ultrasound tongue images.

Five-step dynamic ultrasonographic assessment of swallowing for dysphagia.

This paper presents a five-step dynamic ultrasonography (US) technique aimed at diagnosing oropharyngeal dysphagia, which encompasses the analysis of tongue-palate contact, hyoid movement, upper esophageal sphincter opening, vocal fold closure and post-swallow residue. This protocol is implemented in a sequential manner, intending to methodically evaluate the essential phases of swallowing function. By mirroring the natural process of swallowing, this sequential method may provide a full understanding of possible dysfunctions at each stage.

Chaos-MLP: Chaotic Transform MLP-like Architecture for Medical Images Multi-label Recognition Task.

The theory of "three-stage prevention" in view of the body constitution is the key technology of modern Chinese medicine for "Preventive Treatment of Diseases". In particular, automated body constitution recognition (BCR) is an integral part of intelligent Traditional Chinese Medicine (TCM), which is extremely valuable for disease prevention and diagnosis. Actually, BCR is a challenging multi-label recognition task by the TCM composite constitution theory.

Oromandibular Dyskinesia: Diagnostic Insights From 18F-FDG PET/CT Imaging.

Oromandibular dyskinesia is an abnormal, repetitive, involuntary movement of the jaw, tongue, and lips. We report an interesting image of a 72-year-old woman, who underwent 18F- FDG PET/CT for restaging of treated colon cancer. PET/CT scan shows diffuse uptake in orbicularis oris, muscles of the lips, muscles around the mandible and in the oral cavity, and anterior tongue muscles with no abnormality seen on corresponding CT images.

Exploring Influence of Spiritual Well-being on Caregiver Burden in Head-and-Neck Malignancy: A Cross-sectional Study.

Objectives: Taking care of a patient with head-and-neck malignancy (HNM) entails enormous physical, emotional, cognitive and moral challenges. Caregivers frequently turn to spiritual practices such as prayer, offering and meditation to enhance inner strength and coping ability. Assessment of caregiver burden (CGB) would remain incomplete without considering spiritual well-being (SWB).

Lack of motor defects and ALS-like neuropathology in heterozygous Exon 2 deletion mice.

Mutations in the human gene have recently been linked to early onset amyotrophic lateral sclerosis (ALS), characterized by global atrophy, motor impairments, and symptoms such as tongue fasciculations. All known ALS-linked mutations cluster within exon 2 and a specific variant, c.58G>T, results in exon 2 skipping.

Genetic associations of polymorphisms with clinicopathologic characteristics of tongue cancer.

One of the most common malignant tumors of the head and neck region is tongue cancer. Long noncoding RNAs (lncRNAs) called nuclear enriched abundant transcript 1 (Neat1) are linked to tumor growth, survival, and apoptosis in a variety of cancer types; however, it is unclear how these factors relate to tongue cancer. Furthermore, it is unknown how polymorphisms and clinicopathological traits in individuals with tongue cancer relate to one another.

Oral manifestations of undiscovered systemic amyloidosis: a series of seven cases.

Amyloidosis derived from abnormal extracellular fibril deposits may contribute to multiple organ dysfunctions. The recognition of amyloidosis-associated orofacial changes may be beneficial for the early diagnosis of this systemic pathology and the underlying diseases. This retrospective study aimed to determine the characteristics of orofacial amyloidosis to aid dentists in the recognition of this disease.

Skull Base Squamous Cell Carcinoma Presenting as Collet-Sicard Syndrome: A Rare Cause of Multicranial Nerve Dysfunction.

The lower cranial nerves (CNs) - IX, X, XI, and XII - are affected by lesions of the skull base that impact the hypoglossal canal and jugular foramen in Collet-Sicard Syndrome (CSS), a rare disorder. Loss of posterior tongue taste sensation (IX nerve), paralysis of the vocal cords and difficulty swallowing (resulting from the X nerve), weakness in the sternocleidomastoid and trapezius muscles (due to the XI nerve), and atrophy and weakness of the tongue muscles (caused by the XII nerve) are all signs of this condition. The purpose of this report is to describe a case of squamous cell carcinoma (SCC), presenting features of multiple CN palsies.

Evaluation of ultrasound measured tongue thickness, tongue thickness-thyromental distance ratio, and skin-to-epiglottis distance in predicting unanticipated difficult laryngoscopy.

Background And Aims: The contemporary literature review suggests upper airway ultrasound can help us to diagnose an unanticipated difficult airway before laryngoscopy. The primary objective of this study was to compare ultrasonography (USG) and clinical airway indices across easy and difficult laryngoscopy groups.

Material And Methods: This prospective observational study included 258 patients scheduled to undergo surgery under general anesthesia with endotracheal intubation.

Dis-ease of Mother Tongue.

I wrote this poem titled "Dis-ease of Mother Tongue" as a grandson and health communication scholar. It was animated by an experience my grandmother- an 89 year old African American woman- endured in a hospital wherein she was misdiagnosed with early-stage dementia 15 years ago. The cause, a doctor's misinterpretation of her verbal and written responses to a standardized health assessment.

Efficacy and safety of ciprofol for gastroscopy in patients with obesity: a randomised clinical controlled trial using different weight-based dosing scales.

Background: This study aimed to compare the efficacy and safety of ciprofol-induced doses based on three indices: total body weight (TBW), ideal body weight (IBW), and lean body weight (LBW) in patients with obesity undergoing gastroscopy.

Methods: In a single-centre, prospective, randomised study conducted at an endoscopy centre, a total of 108 patients aged 18-65 years who underwent painless gastroscopy and had a body mass index (BMI) of 28-39.9 kg/m were included.

Stratification of the immunotypes of tongue squamous cell carcinoma to improve prognosis and the response to immune checkpoint inhibitors.

Objectives: An understanding of the tumor immune microenvironment is required to improve treatment, especially the selection of immune checkpoint inhibitors (ICIs). In this study, we stratified the immunotypes of tongue squamous cell carcinoma (TSCC) based on the results of comprehensive immune profiling.

Methods: We enrolled 87 therapy-naïve TSCC and 17 ICI-treated TSCC patients who underwent glossectomy without any other prior therapy.

Tongue shape classification based on IF-RCNet.

The classification of tongue shapes is essential for objective tongue diagnoses. However, the accuracy of classification is influenced by numerous factors. First, considerable differences exist between individuals with the same tongue shape.

[Causes of taste hyposensitivity in daily life and health risks: including the taste of ‍fatty acids].

The sensory system detects the internal and external environment of the body and the stimulus trigger feedback loops toward the set point to maintain homeostasis, but if taste sensitivity has changed, we may consume more nutrients or loss of appetite. These can lead metabolic syndrome or malnutrition, which can lead to frailty. In this review, we examined which of the five basic tastes (sweet, umami, bitter, sour, and salty) is affected by aging.

Identification and taste presentation characteristics of umami peptides from soybean paste based on peptidomics and virtual screening.

This research concentrated on soybean paste fermented with Tetragenococcus halophilus, employing peptidomics and machine learning methodologies to screen for novel umami peptides. Taste characteristics of umami peptides were evaluated through sensory evaluation and electronic tongue analysis. The mechanism of taste presentation of the umami peptides was investigated through T1R1/T1R3 molecular docking techniques.

Machine learning-based classification and prediction of typical Chinese green tea taste profiles.

The taste of Chinese green tea is highly diverse. In this study, a combination of unsupervised and supervised learning methods was utilized to develop a model for classifying and predicting typical Chinese green tea taste. Three clustering methods were assessed based on quantitative descriptive analysis (QDA) results, with the Hierarchical-K means method chosen to classify 88 tea infusions into seven distinct taste types.

Application of biomimetic tongue substrate to investigate the role of friction and vibration in sensory texture perception.

This study proposed a novel biomimetic tongue substrate to better understand food texture perception, expanding the scope of this mechanism from merely friction to also include vibration in oral lubrication. With our bioinspired setup, friction and vibration signals were simultaneously acquired using the polyvinyl alcohol (PVA) hydrogel substrates fabricated with different parameters of surface roughness and thickness. Results showed that the feature parameters of friction coefficient and vibration amplitude were positively correlated to surface roughness, while substrate thickness had little effect on these features.

An extralingual Ectomesenchymal chondromyxoid tumor with RREB1::MRTFB fusion: a rare case report of plantar fascia involvement.

Background: Ectomesenchymal chondromyxoid tumor (ECT) is a rare benign intraoral tumor that almost exclusively presents as a small mass on the anterior dorsal tongue. Recently, the ras-responsive element-binding protein 1::myocardin-related transcription factor B (RREB1::MRTFB; previously known as MKL2) fusion gene has been identified in 90% of ECTs, all localized to the tongue, highlighting its genetic distinctiveness. Herein, we report a mesenchymal tumor involving the plantar fascia of the left foot in a young woman, harboring the RREB1::MRTFB fusion gene.

Association between oral health and physio-cognitive decline syndrome of older adults in China and its sex differences: a cross-sectional study.

Background: Physio-Cognitive Decline Syndrome (PCDs) is characterized by the coexistence of MIND (mobility impairment, no disability) and CIND (cognitive impairment, no dementia), which predicts dementia risk. Deteriorating oral health can contribute to malnutrition, cognitive decline, and physical frailty, all of which may exacerbate PCDs symptoms. This study investigates the association between oral health and PCDs, exploring sex differences in this relationship.