[18F]FDG- PET/CT in Staging and Restaging of Fetal Type Adenocarcinoma of the Lung: A Case Report and a Review of the Literature.

Fetal type adenocarcinoma (FTA) is a rare malignant tumor of the lung that histologically resembles an embryonic lung. Due to its rarity, no studies had investigated the possible role of the F-fluorodeoxyglucose positron emission tomography/computed tomography ([F]FDG PET/CT) in the initial assessment and/or in the restaging of the disease yet. We present a case of a male patient with tongue carcinoma and incidental findings of well-differentiated FTA at [F]FDG PET/CT.

Cellular morphometry of the neoplastic microenvironment and its association with the immunoexpression of interleukin-4.

The objective of this research is to perform a cellular morphometric analysis, identify nuclear malignant keratinocyte irregularities, compare the immunoexpression of interleukin-4 (IL-4) and investigate neoplastic invasion depth in Lower Lip Squamous Cell Carcinoma (LLSCC) and Oral Tongue Squamous Cell Carcinoma (OTSCC) cases. A total of 60 cases were analyzed (30 on the lower lip and 30 on the oral tongue). Concerning the cellular morphometry analysis, 16 malignant keratinocytes from each case were analyzed.

Multi-omics driven paradigm for construction of traditional Chinese Medicine Zheng (syndrome) diagnosis and treatment model, taking Shi Zheng (syndrome of dampness) as an example.

Background: Shi Zheng (SZ, syndrome of dampness) is a major syndrome type in traditional Chinese Medicine (TCM), the ambiguity of its pathomechanism and the lack of blood diagnostic indicators have limited the understanding of the development of SZ.

Purpose: To explore the pathological mechanism of SZ and establish a symptom-centered diagnosis and treatment model.

Methods: We recruited 250 participants, including healthy individuals and patients diagnosed with SZ.

TCM-KLLaMA: Intelligent generation model for Traditional Chinese Medicine Prescriptions based on knowledge graph and large language model.

Traditional Chinese medicine (TCM) prescriptions are a basic component of TCM treatment, developed by assessing patient symptoms and prescribing a mix of herbs. Accurate prescription generation is critical for enhancing treatment outcomes and maintaining patient safety. However, conventional methods based on Large Language Models (LLMs) focus mainly on symptom information, neglecting other TCM diagnostic expertise, such as tongue and pulse diagnosis, and are prone to hallucination, which is unacceptable in medical applications.

Neurological Soft Signs at Presentation in Patients With Pediatric Acute-Onset Neuropsychiatric Syndrome.

Importance: Studies of brain imaging and movements during rapid eye movement sleep indicate basal ganglia involvement in pediatric acute-onset neuropsychiatric syndrome (PANS). Characterizing neurological findings that commonly present among patients with PANS could improve diagnostic accuracy.

Objectives: To evaluate the prevalence of neurological soft signs (NSSs) that may be associated with basal ganglia dysfunction among youths presenting with PANS and assess whether clinical characteristics of PANS correlate with NSSs that may be associated with basal ganglia dysfunction.

The wound healing effects of linearly polarized irradiation in photobiomodulation.

We report the fabrication of a polarization-based photobiomodulation (PBM) system and its performance on wound healing effects. The light source for PBM was a 625 nm LED and two different linear polarizations (P-wave and S-wave) were generated using the wire grid linear polarizers. To confirm the effect of PBM on polarization, wounds were created on hairless mice, and the healing process was compared.

Lingual Bronchogenic Cyst: A Case Report and Literature Review of a Rare Pathology.

Choristomas are rare, benign embryonic tumors characterized by normal tissue appearing in abnormal sites. When lined with respiratory epithelium, they are classified as bronchogenic cysts. While these cysts most commonly occur in the mediastinum or other thoracic regions, their occurrence on the tongue is exceedingly rare.

Early detection of Alzheimer's disease using the MEMORIES mnemonic.

The rising incidence and death rates linked to Alzheimer's disease (AD) highlight an urgent issue. Genetic screening is celebrated as a significant advancement for its early detection capabilities, pinpointing those at risk before the emergence of symptoms. Yet, the limited availability of these technologies highlights a critical gap in widespread application.

A KD with multiple pseudocystic lesions in oropharynx and literature review.

Background: Kawasaki disease (KD), also known as mucocutaneous lymph node syndrome, is an acute febrile exanthematous illness primarily affecting children under 5 years of age. It is characterized by systemic vasculitis of medium and small arteries. KD can present with cervical lymphadenopathy and fever as initial symptoms, often making it difficult to distinguish from acute bacterial lymphadenitis, parapharyngeal abscess or other cervical cystic lesions.

Oral mucosal lesions in Polish patients with acute myeloid leukemia after allogeneic hematopoietic cell transplantation.

The number of allogeneic hematopoietic cell transplantation constantly increases. Therefore, there is an urgent need to carefully analyze the general and oral health state of people with acute myeloid leukemia who underwent this procedure. This study aimed to investigate the type and frequency of oral mucosal lesions in patients with acute myeloid leukemia after allogeneic hematopoietic cell transplantation, depending on the intensity of the conditioning regimen.

High prevalence of Sarcocystis and Trichinella infections in skeletal muscles of gray wolves (Canis lupus arctos) from Alaska, USA.

Although cysts of Sarcocystis spp. (sarcocysts) are considered uncommon in muscles of canids, we identified mature sarcocysts in tongues of 20 (40.8 %) of 49 gray wolves (Canis lupus arctos) from Alaska, USA.

It tastes sweeter when melted: Exploring the impact of food temperature on tongue temperature and perceived sweetness/vanilla.

The relationship between perceived sweetness intensity and temperature of food is complex. Previous research on the effect of temperature on sweetness perception primarily focused on single solutions. This study aimed to address the gap by using an infrared camera to measure tongue surface temperature, explore tongue temperature ranges, the relationship between sweet/flavour and tongue temperature at different serving temperatures during real food consumption.

Influence of Feeding Systems on the Microbial Community and Flavor Characteristics of Raw Milk: A Comparative Analysis.

This study analyzed the composition of the microbial community in raw milk and its effects on flavor compounds by comparing samples from cows raised on pasture (PXN) and in housing (HXN). In August 2023, 9 raw milk samples from Holstein cows were collected from a pasture in the Xilin Gol League, Inner Mongolia, China, and labeled as the PXN group. Simultaneously, 9 raw milk samples were collected from Holstein cows raised by individual farmers in the region and labeled as the HXN group.

Electronic Cigarettes Versus Combustible Cigarettes in Oral Squamous Cell Cancer Patients: A Systematic Review.

Introduction: Oral squamous cell carcinoma (OSCC) is associated with tobacco. In order to reduce the burden of smoking, e-cigarettes emerge as devices to aid cessation of tobacco addiction. However, growing evidence shows that e-cigarettes can lead to harmful effects.

Evaluating fusion models for predicting occult lymph node metastasis in tongue squamous cell carcinoma.

Objectives: This study evaluated and compared the effectiveness of various predictive models for forecasting occult lymph node metastasis (LNM) in tongue squamous cell carcinoma (TSCC) patients.

Methods: In this retrospective diagnostic experiment, 268 patients were recruited from three medical centers. Based on the different hospitals from which the patients were recruited, they were divided into a training set, an internal testing set, and two external testing sets, comprising 107, 53, 63, and 45 patients, respectively.

Management of Postoperative Hematoma Following a Lingual Frenectomy: A Case Report.

Ankyloglossia, commonly known as tongue-tie, is a congenital condition characterized by a short, thick lingual frenum that restricts tongue mobility, leading to functional and developmental issues. Surgical intervention, such as a lingual frenectomy, is commonly used to restore tongue function. However, postoperative complications like hematomas can pose significant risks.

Dural arteriovenous fistulas of the anterior condylar confluence involving the anterior condylar vein within the hypoglossal canal: Two case reports.

Background: Dural arteriovenous fistulas (DAVFs) of the anterior condylar confluence (ACC) are rare vascular lesions at the skull base, often characterized by complex venous anatomy and variable clinical presentations. Their symptoms may overlap with those of cavernous sinus (CS) DAVFs, leading to potential misdiagnosis. Advanced imaging techniques and individualized treatment approaches are essential for accurate diagnosis and effective management.

Tissue-specified reconstruction modeling of the head and neck structure and its application in simulating airway obstruction.

Background And Objective: Three-dimensional (3D) reconstruction of head and neck tissues has extensive clinical applications, but due to the complexity and variability of tissue structure, there is still a lack of a complete scheme to reconstruct the head and neck tissues. This study aims to establish a tissue-specified multi-directional cross-sectional image sequence construction method to capture diverse tissue contour information.

Methods: The image sequences that are most conducive to acquiring the boundary contours of the target tissue are constructed from 3D MRI images of the head and neck in a non-traditional way based on the characteristics of each target tissue, and an effective registration strategy is used to integrate the boundaries of the target tissue segmented from multiple image sequences.

Extraction of patients subpopulations with psychiatric symptoms using a transformer architecture.

In this paper, we demonstrate a novel pipeline for identifying and extracting patient subpopulations from unstructured physician's notes. We validate the method by extracting patients with psychiatric issues from a general patient population. This method first uses a clinical metathesaurus to select terms of interest from reports, then vectorizes the terms using a transformer model.

Rat Tongue Kinematics with Markerless XROMM Using DeepLabCut and Marker Masking.

X-ray Reconstruction of Moving Morphology (XROMM) enables 3D tracking of implanted radiopaque markers in animals to study biomechanics. In recent years, DeepLabCut (DLC) has emerged as an important tool for markerless pose estimation in areas of the biological sciences such as neuroscience or behavioral research. While the XROMM markers can be detected and tracked using traditional image processing, DLC has been proven to improve XMALab-based workflows.

Mandarin Speech Reconstruction from Tongue Motion Ultrasound Images based on Generative Adversarial Networks.

Speech impairment resulting from laryngectomy causes severe physiological and psychological distress to laryngectomee. In clinical practice, the upper vocal tract articulatory organs function normally in most laryngectomee. The potential to reconstruct speech by leveraging articulatory information is of significant importance, offering a meaningful contribution to the effective rehabilitation of speech in these patients.

Biophysical models of slowly and rapidly adapting mechanosensitive tactile afferents in human tongue.

Upon contact, the spike firing patterns of touch afferents encode object attributes such as force, vibration, and spatial geometry. Computational models in cutaneous skin have sought to emulate firing patterns of slowly and rapidly adapting afferents. Herein, for the tongue, we develop biophysical versions of such models, and which rely upon functions and parameters with physiological relevance, as opposed to stimulus features, and are extendable to a broad range of object interactions.

A case report of palatal tremor in progressive supranuclear palsy.

Introduction: Progressive supranuclear palsy (PSP) is a sporadic, adult-onset neurodegenerative disease and the second most common form of neurodegenerative parkinsonism after idiopathic Parkinson's disease. Palatal tremor (PT), characterized by brief, involuntary, rhythmic contractions of the soft palate, is a rare movement disorder and an even more exceptional finding in PSP.

Case Report: We present an 85-year-old, Filipino male who manifested with progressive gait imbalance, postural instability leading to multiple falls, ocular motor dysfunction, axial rigidity, bradykinesia, and cognitive impairment.

Enhancing surimi gel properties in silver carp with innovative ultra-micro crayfish shell powder.

This study investigated the preparation and application of ultra-micro crayfish shell powder to enhance the quality of surimi gels. A combination of ball milling and irradiation techniques produced an innovative powder (MID) with reduced particle size and enhanced zeta potential, dispersibility, Ca release, and hydrogen bonding energy (p < 0.05), while maintaining its composition.

Volatile and non-volatile compound analysis of ginkgo chicken soup during cooking using a combi oven.

This study employed a range of analytical techniques to evaluate the changes in both volatile and non-volatile compounds during different cooking times (30, 60, 90, 120, and 150 min) of ginkgo chicken soup prepared using a multifunctional combi oven, and comparedthese results with those obtained from the traditional ceramic pot method.The techniques included electronic nose (e-nose), electronic tongue (e-tongue), gas chromatography-ion mobility spectrometry (GC-IMS), high-performance liquid chromatography (HPLC), gas chromatography-mass spectrometry (GC-MS), and automated amino acid analysis. A total of 64 volatile compounds, primarily aldehydes, ketones, esters, and alcohols, were detected, with 23 key aroma components identified.