Just the Tip of the Iceberg: a Brief Report of the Tip-of-the-Tongue Score as an Embedded Validity Indicator for the Children's Auditory and Visual Naming Tests.

Objective: Explore the tip-of-the-tongue (TOT) scores from the Children's Auditory and Visual Naming Tests (cANT, cVNT) as embedded validity indicators (EVIs).

Method: A retrospective design of 98 consecutively referred youth aged 6-15 years (M = 11.28, SD = 2.

Exploring the Role of Ccn3 in Type III Cell of Mice Taste Buds.

Different taste cells express unique cell-type markers, enabling researchers to distinguish them and study their functional differentiation. Using single-cell RNA-Seq of taste cells in mouse fungiform papillae, we found that Cellular Communication Network Factor 3 (Ccn3) was highly expressed in Type III taste cells but not in Type II taste cells. Ccn3 is a protein-coding gene involved in various biological processes, such as cell proliferation, angiogenesis, tumorigenesis, and wound healing.

Radiological Sublingual Space Invasion in Tongue Squamous Cell Carcinoma: Clinicopathological Associations and Impact on Survival.

Objectives: We investigate if sublingual space invasion (SLI) determined on magnetic resonance imaging confers differences in clinicopathological manifestations and treatment outcomes of oral tongue squamous cell carcinoma (OTSCC).

Study Design: Retrospective cohort study.

Setting: Tertiary Academic Medical Center.

Pediatric Sublingual Dermoid Cyst: Diagnostic Challenges and Surgical Management in a 13-Year-Old Boy.

BACKGROUND Ranulas are typical causes of sublingual cysts in children. However, our case was histopathologically confirmed to be a dermoid cyst. Epidermoid and dermoid cysts of the floor of the mouth account for <0.

Evolutionary dynamics and regulatory site analysis of AMP family genes in cattle and sheep.

Background: Ruminants possess a rich repository of natural antimicrobial peptides(AMPs) within their bodies, surpassing those found in humans and mice. These peptides, including Defensin, Cathelicidin, and Lysozyme, are integral to the body's innate and adaptive immune responses and represent promising alternatives to antibiotics with significant application potential.

Results: In the present study, we conducted a systematic analysis of 40 Defensins, 38 Cathelicidins, and 61 Lysozymes in cattle and sheep.

Clinical and biochemical footprints of inherited metabolic diseases: XVII. Dysmorphisms.

Dysmorphisms, or physical abnormalities in appearance, can vary in frequency and severity among individuals with inherited metabolic disorders (IMD). The prevalence of dysmorphisms in these disorders can range from rare occurrences to more common features, depending on the specific disorder and its genetic characteristics. It is important to note that not all individuals with IMDs will exhibit dysmorphic features, and the presence of such features may vary widely among different types of metabolic disorders.

Clinical and dosimetric feasibility of sparing submandibular gland in patients with oral cavity squamous cell carcinoma.

Background: To investigate the incidence of submandibular gland (SMG) involvement and explore the feasibility of sparing SMG in the oral cavity squamous cell carcinoma (OSCC).

Methods: This study retrospectively analyzed patients between January 2018 to October 2022. Ten patients with tongue squamous cell carcinoma receiving postoperative radiotherapy were replanned to investigate the feasibility of sparing SMG.

'Some parts of the consent form are written using complex scientific language': community perspectives on informed consent for research with pregnant and lactating mothers in Uganda.

Background: Appropriate language use is essential to ensure inclusion of diverse populations in research. We aimed to identify possible language-related barriers regarding the informed consent process and propose interventions to improve clarity and understanding of pregnant and breastfeeding women participating in research.

Methods: A cross-sectional qualitative study employing focus group discussions (FGD) was conducted in Uganda from August 2023 to September 2023, involving a diverse group of stakeholders from the community, including community members, research participants, and Community Advisory Board members.

Epidemiological landscape of tongue cancer in younger patients in a National Cancer Center in Brazil.

This study investigates the changing epidemiological profile of tongue squamous cell carcinoma (SCC) to young patients, highlighting its rising incidence among non-traditional risk groups. A retrospective descriptive study was conducted, covering data from medical records between 2000 and 2012. Patients were categorised into two age groups (≤ 40 years; 41-50 years).

Endosonography in head and neck imaging and surgery.

This CME article explores the evolving role of endosonography in otorhinolaryngology and head and neck surgery. Endosonography offers significant potential to improve imaging inside the upper respiratory tract, particularly with advancements in probe technology and imaging resolution. The article will describe the sonoanatomy of the oral cavity, pharynx, and larynx and the selection of probes and scanning techniques used for the various anatomical sites.

Effect of cooking conditions on sea urchin dumplings.

The objective of this study was to investigate the changes in flavour and taste of sea urchin dumplings subjected to different cooking methods, utilising gas chromatography-ion mobility spectrometry (GC-IMS), electronic tongue (E-tongue) analysis, free amino acid content assessment and sensory evaluation. The GC-IMS technique successfully detected 69 volatile compounds in the skin and 60 volatile compounds in the filling of the boiled dumplings. From the established fingerprints, it was found that there were significant differences in the flavour compounds of dumplings skins among the groups.

Diagnostic performance of depth of invasion, thickness, and styloglossus and hyoglossus muscle invasion on magnetic resonance imaging in predicting potential neck lymph node metastasis in clinical N0 tongue cancer.

Objectives: To evaluate previously reported quantitative (tumor thickness 11 mm and depth of invasion [DOI] 7.5 mm) and qualitative (styloglossus/hyoglossus muscle invasion [SHMI]) magnetic resonance imaging (MRI) parameters for predicting occult neck node metastasis in clinical N0 oral tongue squamous cell carcinoma.

Methods: This single-center retrospective study included 76 patients.

Silent signals: how -acyl homoserine lactones drive oral microbial behaviour and health outcomes.

Background: -acyl homoserine lactones (AHLs) are small signalling molecules predominantly secreted in Gram-negative bacteria.

Objective: The aim is to provide a comprehensive overview of AHLs in oral health.

Methods: Two independent researchers conducted a systematic search of English language publications up to 30 June 2024 in PubMed, Scopus and Web of Science.

Protective effects of quercetin against tongue injury and oxidative stress triggered by irinotecan: a histopathological, biochemical and molecular study.

Introduction: About 80% of patients receiving chemotherapeutics suffer from side effects related to the gastrointestinal tract. Irinotecan (CPT-11) is a chemotherapeutic agent usually used in treating solid tumors. Quercetin (QRT), a bioflavonoid, is an antioxidant and scavenger reactive oxygen species scavenger.

Mandibular tongue-shaped flap reconstruction for lip defects following lip tumor surgery.

Lip defects due to lip tumor surgery need proper reconstruction to preserve their function. Traditional methods offer various options for lip repair, but each has limitations, and can lead to deformity, asymmetry, or functional impairment. This study aimed to investigate the clinical application of mandibular tongue-shaped flap reconstruction for postoperative defects following lip tumor surgery.

[Interpretation of connotation of Yuebi Plus Banxia Decoction based on severe cases and modern pathophysiological mechanisms and experience of treating severe pulmonary infection, acute exacerbation of chronic obstructive pulmonary disease, and respiratory failure with this decoction].

Yuebi Plus Banxia Decoction is derived from the Synopsis of the Golden Chamber(Jin Gui Yao Lue) by ZHANG Zhong-jing. With the effects of ventilating lung, discharging heat, descending adverse Qi, and relieving cough and asthma, this prescription is mainly used to treat pulmonary distension caused by phlegm heat obstructing the lungs. Currently, it is commonly used in clinical practice for the treatment of acute exacerbation of chronic obstructive pulmonary disease, acute bronchitis, pneumonia, bronchial asthma, pulmonary heart disease, and pertussis.

Prognostic Implications of the Number of Lymph Node Metastases in Oral Tongue Squamous Cell Carcinoma: A Population Study of the SEER Database and an Institutional Registry.

Background: To investigate the impact of the number of positive lymph nodes (PLNs) on long-term survival and pathological nodal stage in patients with oral tongue squamous cell carcinoma (OTSCC).

Materials And Methods: Newly diagnosed and nonmetastatic adult patients with OTSCC who underwent curative resection were identified between January 2010 and December 2020. External validation was performed via the SEER registry.

The influence of the structure of the masticatory system on the presence and severity of the gag reflex in children with cerebral palsy.

Background: Dysphagia, prevalent in 90% of children with neurological disorders, poses risks of medical complications and is associated with cognitive and psychosocial challenges. The absence of the sucking-swallowing reflex and variations in the gag reflex contribute to feeding difficulties.

Objectives: This study focuses on examining the impact of the gag reflex on the masticatory system structure in children with cerebral palsy, aiming to assess its significance.

A Case of Refractory Kawasaki Disease With Yersinia pseudotuberculosis Infection Successfully Treated With Cefotaxime Following Immunosuppressive Therapy.

Kawasaki disease (KD) is a vasculitis mainly affecting children under five, with symptoms such as persistent fever, rash, red lips, strawberry tongue, conjunctivitis, and swollen hands and feet. Diagnosis is based on a fever lasting over five days plus at least four of these symptoms. Treatment includes intravenous immunoglobulin (IVIG) and aspirin to reduce complications, especially coronary artery issues.

Macro-vacuolar steatosis in a cirrhotic liver mimicking metastatic disease.

Multinodular steatosis represents a relatively uncommon manifestation of fatty liver disease (FLD). Co-morbidities such as metabolic syndrome or cirrhosis are often associated. Despite typical features of imaging (ultrasound, CT, and MRI), core biopsy sometimes remains the gold standard for diagnosis.

Clinical features of taste disorders in Cronkhite-Canada syndrome: A report of 10 cases.

Cronkhite-Canada syndrome (CCS) is a very rare gastrointestinal disorder with ectodermal abnormalities. Taste abnormalities appear in more than 80% of cases. Our objective was to investigate the characteristics of CCS.

Intraperitoneal delivery of cannabidiol (CBD) and Δ-tetrahydocannabinol (THC) promotes papillomavirus infections in athymic nude mice.

We used our mouse papillomavirus (MmuPV1) model to test the hypothesis that two primary psychoactive ingredients of marijuana, Δ-tetrahydrocannabinol (THC) and cannabidiol (CBD), promote papillomavirus persistence in the oral mucosa of infected mice. We conducted intraperitoneal (ip) injections of a moderate dose (3 mg/kg) of either CBD and/or THC in both male and female athymic nude mice and followed the mice up to 20 weeks post-infection. These doses are comparable to what is estimated for human conventional cannabis consumption.

Dichloroacetate and chloroquine in combination with arsenite suppress ROS-induced oral squamous cell carcinoma (OSCC) development and improve BALB/c mice survival.

Oral squamous cell carcinoma (OSCC) is a disabling tumor with poor response to chemotherapy. Here, we sought to explore a new chemotherapeutic approach based on a combined induction of cytotoxic ROS and targeting of autophagy and aerobic glycolysis as central contributors to OSCC carcinogenesis and chemoresistance. To this end, tongue OSCC was generated in BALB/c mice using 4NQO.

Predictive equations in determining resting energy expenditure in patients with head and neck cancer receiving home enteral nutrition.

Objective: It is important to cover energy targets among patients with head and neck cancer (HNC) to minimize weight and skeletal muscles loss. This study aimed to assess the agreement between indirect calorimetry (IC) and predictive equations for determining resting energy expenditures (REE) in HNC patients receiving home enteral nutrition (HEN).

Research Methods And Procedures: Patients included in the study had to be diagnosed with HNC, be adults, have artificial access to the digestive tract, and participate in HEN.