[Research progress of corneal epithelial basal cells and basement membrane].

The cylinder cells at the bottom of corneal epithelial cells are basal cells. Their cytoplasm contains keratin intermediate filament which is important in secretion of basement membrane. Corneal epithelial dysfunction due to diabetes or ocular surgery is intimately related with basal cell abnormality.

[Diagnosis and treatment of ocular hypertension].

Ocular hypertension is popular among people, with a prevalence of 3% to 10% in those older than 40 years old. Without proper intervention, over 10% of the patients with ocular hypertension would develop glaucoma in the following 5 to 10 years. Glaucoma has become one of the leading causes of blindness all over the world, which makes it essential for us to pay enough attention to the prevention and treatment of ocular hypertension.

[A preliminary analysis on potentially targeted genes of induced chemotherapy in supraglottic laryngeal squamous cell carcinoma].

Objective: To analyze the differentially expressed genes produced by paclitaxel, cisplatin and 5-fluorouracil(TPF) regimen induction chemotherapy and the potentially functionally targeted genes of the induced chemotherapy in supraglottic laryngeal squamous cell carcinoma.

Methods: A total of 11 tissue samples from patients diagnosed as supraglottic carcinoma who didn't receive any treatment before were analyzed with microarray. The patients were divided into two groups based on their responses to the induction chemotherapy: 7 were sensitive to chemotherapy and 4 were non-sensitive.

[The progress of studies on intraocular lens implantation in cataract with high myopia].

With development of the technology of cataract surgery, combined phacoemulsification and intraocular lens implantation in cataract with high myopia has been widely carried out in clinical treatment. Due to the particularity of high myopia, phacoemulsification in patients with cataract and high myopia is difficult and has recently received a lot of attentions. In this paper, preoperative examinations, the selection of intraocular lenses, surgery methods and surgical complications of cataract surgery in patients with cataract and high myopia are briefly reviewed.

[Characteristics of refractive status of mutant Lumican transgenic mice].

Objective: To investigate the change of refractive status in transgenic mice with mutant Lumican (bright proteoglycan) gene at different ages.

Methods: Experimental Study. Fifty-four 3-week-old with mutant Lumican gene (cDNA 596T > C) mice (27 male and 27 female) were randomly divided into 9 groups (n = 6, half male and half female) by random number table.

[Enlightenment and thinking of blinding trachoma elimination in China].

Trachoma had been the leading infectious cause of blindness. After years of hard work and unremitting efforts, blinding trachoma would never been a public health problem in China by 2015. Discovery and research of Chlamydia trachoma provide a scientific way for the prevention and control of trachoma.

The Effects of Acupuncture at Real or Sham Acupoints on the Intrinsic Brain Activity in Mild Cognitive Impairment Patients.

Accumulating neuroimaging studies in humans have shown that acupuncture can modulate a widely distributed brain network in mild cognitive impairment (MCI) and Alzheimer's disease (AD) patients. Acupuncture at different acupoints could exert different modulatory effects on the brain network. However, whether acupuncture at real or sham acupoints can produce different effects on the brain network in MCI or AD patients remains unclear.

Excitotoxic effects of glutamate on cochlear organotypic cultures.

Glutamate (Glu) is the major afferent excitatory neurotransmitter in the auditory system, and excessive Glu may play an important role in cochlear dysfunction. It is unclear how excessive Glu plays roles in cochlear dysfunction in cochlear organotypic cultures. In this study neonatal rat cochlear organotypic cultures were prepared, and then the cochlear tissues were incubated with a new medium containing specific concentrations of Glu (0.

Development and evaluation of the Nurotron 26-electrode cochlear implant system.

Although the cochlear implant has been widely acknowledged as the most successful neural prosthesis, only a fraction of hearing-impaired people who can potentially benefit from a cochlear implant have actually received one due to its limited awareness, accessibility, and affordability. To help overcome these limitations, a 26-electrode cochlear implant has been developed to receive China's Food and Drug Administration (CFDA) approval in 2011 and Conformité Européenne (CE) Marking in 2012. The present article describes design philosophy, system specification, and technical verification of the Nurotron device, which includes advanced digital signal processing and 4 current sources with multiple amplitude resolutions that not only are compatible with perceptual capability but also allow interleaved or simultaneous stimulation.

[Attach importance to choroidal research with enhanced depth imaging spectral-domain optical coherence tomography].

With the enhanced depth imaging spectral-domain optical coherence tomography occurs, choroidal structures and thickness can be observed accurately. So far studies about this technology are focused on the changes of the choroidal thickness and its related factors. While as a non-invasive examination, this technique can also be used to observe structural features of choroidal lesions; measure the diameter of choroidal vessels; study the pathogenesis of disease; differentiate a variety of fundus disease; and follow-up medical or surgical treatment.

Parsimonious model for blood glucose level monitoring in type 2 diabetes patients.

To establish the parsimonious model for blood glucose monitoring in patients with type 2 diabetes receiving oral hypoglycemic agent treatment. One hundred and fifty-nine adult Chinese type 2 diabetes patients were randomized to receive rapid-acting or sustained-release gliclazide therapy for 12 weeks. Their blood glucose levels were measured at 10 time points in a 24 h period before and after treatment, and the 24 h mean blood glucose levels were measured.

Safety evaluation of rabbit eyes on scleral collagen cross-linking by riboflavin and ultraviolet A.

Background: To evaluate the safety of the scleral collagen cross-linking (CXL) transferred from corneal CXL in rabbit eyes using histology and electroretinography (ERG).

Methods: Stress-strain measurement was performed five rabbits 1 week after scleral CXL. Dark-adapted ERG was repeatedly applied on bilateral eyes of 10 rabbits before, and 1 week, 1 month and 3 months after the CXL operation.

[A preliminary study on genome-wide expression profiling of laryngeal squamous cell carcinoma].

Objective: To identify the genes differentially expressed and underlying molecular mechanism in laryngeal squamous cell carcinoma by using cDNA microarrays.

Methods: Using Illumina Human HT-12 BeadChip, gene expressions were detected in ten pairs of laryngeal cancer tissues and adjacent normal tissues. Total RNA was extracted and reverse-transcribed into cDNA.

Multidisciplinary collaborative therapy for 30 children with orbital rhabdomyosarcoma.

Objective: To explore clinical experience and propose new ideas for treating children diagnosed with orbital rhabdomyosarcoma (RMS).

Methods: We retrospectively analyzed the clinical data for30 patients (16 males and 14 females, with a median age of 6.2 years) with primary orbital RMS who were enrolled in the Department of Eye Oncology and Pediatrics of our hospital from November 2004 to December 2012.

Influence of chronic hyperglycemia on cerebral microvascular remodeling: an in vivo study using perfusion computed tomography in acute ischemic stroke patients.

Background And Purpose: To investigate the effect of chronic hyperglycemia on cerebral microvascular remodeling using perfusion computed tomography.

Methods: We retrospectively identified 26 patients from our registry of 2453 patients who underwent a perfusion computed tomographic study and had their hemoglobin A1c (HbA1c) measured. These 26 patients were divided into 2 groups: those with HbA1c>6.

Investigation on delivery analgesia effect of combined spinal epidural anesthesia plus Doula and safety of mother and baby.

Objective: To explore the effect of patient-controlled lumbar epidural combined anesthesia with Doula for labor analgesia with ropivacaine and sufentanil, and its influence on the progress of labor, and outcomes of mother and infant.

Materials And Methods: Two hundred parturients that requested labor analgesia were randomly selected by patient-controlled lumbar epidural combined anesthesia with Doula as the observation group, meanwhile another 200 parturients were selected as the control group without any analgesic measurements. Labor pain score, labor duration, blood gas analysis results, the incidence of cesarean section, neonatal asphyxia, and postpartum hemorrhage were compared between the two groups.

[Clinical examination of olfactory and gustatory function].

Objective: To explore changes of olfactory and gustatory functions in patients with olfactory dysfunction.

Method: The 284 study subjects included 92 healthy volunteers, 92 with hyposmia and 100 with functional anosmia. Their olfactory and gustatory functions were examined using T&T olfactometer, olfactory event-related potentials (OERPs) and triple drop method, respectively.

[The application of vibrant sound bridge in microtia whose reconstructive external auditory canal occurred atresia].

Objective: To investigate the effect of vibrant sound bridge implantation in microtia whose reconstructive external auditory canal occurred atresia.

Method: Three cases (2 males and 1 female) of microtia had underwent hearing reconstruction operation (Include the external ear canal reconstructive surgery and tympanoplasty). The age ranged from 15 to 18 years and the average age was 17 years.

[Detection of differentially expressed lumican gene mRNA level in scleral tissue in human eye].

Objective: To identify differentially expressed lumican in scleral tissue of eyes with primary open-angle glaucoma (POAG) and high myopia (HM).

Methods: Total RNA was isolated from scleral tissue of cadaveric eyes derived from normal donors, patient's eyes with diagnosed glaucoma and high myopia who accepted trabeculectomy. RNA was amplified, RT-PCR was used to measure the levels of mRNA.

[Etiologic analysis of 487 cases of ophthalmoplegia].

Objective: To study the etiology of ophthalmoplegia cases.

Methods: A retrospective case series study. We summarized and analyzed etiological diagnosis of 487 ophthalmoplegia patients from January 2005 to September 2010 in Beijing Tongren Hospital of Capital Medical University and Beijing Tongren Eye Center.

[Assessment of cochlear implant performance with Mandarin Hearing In Noise Test].

Objective: To evaluate the abilities speech perception of post-lingual cochlear implant patients by Mandarin Hearing In Noise Test(MHINT), get the performance-intensity function (P-I function).

Method: The material was MHINT adults' version, including 12 lists, 20 sentences per list. Twenty-two cochlear implant patients were the subjects, age from 14 to 56.

[Audiometric configuration distribution of hearing loss in a clinical population].

Objective: Audiometric configuration distribution of hearing loss was analyzed for public policy efforts of hearing loss prevention and rehabilitation.

Method: According to the archived records of the Clinical Audiology Center of Beijing Tongren Hospital, Capital Medical University, audiometric configuration distribution was analyzed by different type,degree of hearing loss and age factor.

Result: 1.

[Clinical findings of a group of children with auditory neuropathy spectrum disorder].

Objective: In order to extend the knowledge of auditory neuropathy spectrum disorder (ANSD), the clinical data of a group of infants and young children with this disorder was reported.

Method: This retrospective study involved 84 cases (151 ears). The subjects aged from 2 months to 6 years old.

[Whether does the granular corneal dystrophy indicate for the excimer laser ablation surgery or not].

With the development of excimer laser technologies, the corneal refractive surgical procedures are improved constantly and the indication of excimer laser keratectomy is expanded. In clinic, PRK or LASEK or PTK or LASIK were performed on the eyes of granular corneal dystrophy with refractive error and the early results were satisfied, but the reoccurrence and server opacity of cornea are worried. Is this corneal disease the indication of excimer laser keratectomy? Nowadays, the exact indication for the disease should be declared in clinic.